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lysosomal channels, TRPML1, lysosome, TMEM175, Calcium signaling, lysosomal physiology, organell channel, organell physiology, calcium signaling, lysosomal storage disease, parkinson's disease
United States, China

Activities

Employment (2)

Liangzhu Laboratory & School of Basic Medical Sciences, Zhejiang University: Hangzhou, CN

2022-06-01 to present | Chair Professor & Dean
Employment
Source: Self-asserted source
Haoxing Xu

University of Michigan: Ann Arbor, MI, US

2007-01-01 to present | Assistant Professor, Associate Professor, Professor, Visiting Professor
Employment
Source: Self-asserted source
Haoxing Xu

Education and qualifications (3)

Children's Hospital Boston, Harvard Medical School: Boston, MA, US

2001-07 to 2007-01 | Postdoc Research Follow, Instructor
Education
Source: Self-asserted source
Haoxing Xu

Georgia State University: Atlanta, US

1996-09 to 2001-06 (Biology)
Education
Source: Self-asserted source
Haoxing Xu

Peking University: Beijing, Beijing, CN

1988-09-01 to 1992-07-03 | B.A.
Education
Source: Self-asserted source
Haoxing Xu

Works (50 of 53)

Items per page:
Page 1 of 2

Cryo-EM reveals cholesterol binding in the lysosomal GPCR-like protein LYCHOS.

Nature structural & molecular biology
2025-01-17 | Journal article | Author
Contributors: Jie Zhao; Qingya Shen; Yong Xihao; Li X; Tian X; Sun S; Zheng Xu; Zhang X; Zhang L; Hao Yang et al.
Source: Self-asserted source
Haoxing Xu

Activation of lysosomal Ca2+ channels mitigates mitochondrial damage and oxidative stress

Journal of Cell Biology
2025-01-06 | Journal article
Contributors: Xinghua Feng; Weijie Cai; Qian Li; Liding Zhao; Yaping Meng; Haoxing Xu
Source: check_circle
Crossref

TFEB links the cGAS-STING pathway to lysosome biogenesis

Trends in Cell Biology
2024-12 | Journal article
Contributors: Yaping Meng; Xinran Li; Haoxing Xu
Source: check_circle
Crossref

Lysosomal catabolic activity promotes the exit of murine totipotent 2-cell state by silencing early-embryonic retrotransposons.

Developmental cell
2024-11-15 | Journal article
Contributors: Wu H; Cao L; Wen X; Fan J; Wang Y; Hu H; Ji S; Zhang Y; Ye C; Xie W et al.
Source: Self-asserted source
Haoxing Xu

DNA nanodevices map intracellular ions

Nature Biotechnology
2024-07 | Journal article
Contributors: Haoxing Xu
Source: check_circle
Crossref

The Ion Channels of Endomembranes.

Physiological reviews
2024-03-07 | Journal article
Contributors: Hu M; Feng X; Liu Q; Liu S; Huang F; Xu H
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Structural basis for sugar perception by <i>Drosophila</i> gustatory receptors.

Science (New York, N.Y.)
2024-02-02 | Journal article | Author
Contributors: Demin Ma; Meiqin Hu; Xiaotong Yang; Liu Qiang; Ye Fan; weijie Cai; Yong Wang; Ximing XU; Shenghai Chang; Ruiying Wang et al.
Source: Self-asserted source
Haoxing Xu

Not just protons: Chloride also activates lysosomal acidic hydrolases

Journal of Cell Biology
2023-06-05 | Journal article
Contributors: Xinghua Feng; Siyu Liu; Haoxing Xu
Source: check_circle
Crossref

Lysosomal solute and water transport.

The Journal of cell biology
2022-10-11 | Journal article | Author
Contributors: Meiqin Hu; Zhou N; Cai W; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

The Acid Gate in the Lysosome.

Autophagy
2022-09-29 | Journal article | Author
Contributors: Meiqin Hu; Jingzhi Chen; Siyu Liu; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Parkinson's disease-risk protein TMEM175 is a proton-activated proton channel in lysosomes.

Cell
2022-06-01 | Journal article
Contributors: Meiqin Hu; Ping Li; Ce Wang; Feng X; Qi Geng; Wei Chen; Marthi M; Zhang W; Chenlang Gao; Reid W et al.
Source: Self-asserted source
Haoxing Xu

Lysosomal Zn<sup>2+</sup> release triggers rapid, mitochondria-mediated, non-apoptotic cell death in metastatic melanoma.

Cell reports
2021-10-01 | Journal article
Contributors: Wanlu Du; Gu M; Hu M; Pinchi P; Wei Chen; Ryan M; Nold T; Bannaga A; Xu H
Source: Self-asserted source
Haoxing Xu

A  conserved ubiquitin- and ESCRT-dependent pathway internalizes human lysosomal membrane proteins for degradation.

PLoS biology
2021-07-23 | Journal article | Author
Contributors: Weichao Zhang; Xi Yang; Liang Chen; Yun-Yu Liu; Venkatarangan V; Lucas Reist; Hanson P; Haoxing Xu; Yanzhuang Wang; Ming Li
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

TRP channels in health and disease at a glance.

Journal of cell science
2021-07-13 | Journal article | Author
Contributors: Lixia Yue; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Stac protein regulates release of neuropeptides.

Proceedings of the National Academy of Sciences of the United States of America
2020-11-09 | Journal article | Author
Contributors: I-Uen Hsu; Jeremy Linsley; Xiaoli Zhang; Jade Varineau; Berkhoudt DA; Lilly Reid; Lum MC; Orzel AM; Leflein A; Haoxing Xu et al.
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

LRRC8 family proteins within lysosomes regulate cellular osmoregulation and enhance cell survival to multiple physiological stresses.

Proceedings of the National Academy of Sciences of the United States of America
2020-11-02 | Journal article | Author
Contributors: Ping Li; Meiqin Hu; Ce Wang; Xinghua feng; Zhao Z; Ying Yang; Nirakar Sahoo; Mingxue Gu; Yexin Yang; Shiyu Xiao et al.
Source: Self-asserted source
Haoxing Xu

LC3 lipidation is essential for TFEB activation during the lysosomal damage response to kidney injury.

Nature cell biology
2020-09-28 | Journal article | Author
Contributors: Shuhei Nakamura; Shigeyama S; Minami S; Shima T; Akayama S; Matsuda T; Esposito A; Napolitano G; Kuma A; Tomoko Namba-Hamano et al.
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Sulforaphane Activates a lysosome-dependent transcriptional program to mitigate oxidative stress.

Autophagy
2020-03-15 | Journal article
Contributors: Li D; Rong Shao; Wang N; Zhou N; Du K; Shi J; Wang Y; 壮壮 赵; Ye X; Zhang X et al.
Source: Self-asserted source
Haoxing Xu

Small-molecule activation of lysosomal TRP channels ameliorates Duchenne muscular dystrophy in mouse models.

Science advances
2020-02-07 | Journal article | Author
Contributors: Lu Yu; Xiaoli Zhang; Yang Y; Li D; Tang K; Zhao Z; He W; Ce Wang; Nirakar Sahoo; Kimber et al.
Source: Self-asserted source
Haoxing Xu

Agonist-specific voltage-dependent gating of lysosomal two-pore Na+ channels.

eLife
2019-12-11 | Journal article | Author
Contributors: Xiaoli Zhang; Wei Chen; Ping Li; Calvo R; Noel Southall; Hu X; Bryant-Genevier M; Feng X; Geng Q; Gao C et al.
Source: Self-asserted source
Haoxing Xu

Sub-nanomolar sensitive GZnP3 reveals TRPML1-mediated neuronal Zn<sup>2+</sup> signals.

Nature communications
2019-10-22 | Journal article | Author
Contributors: Taylor F. Minckley; Zhang C; Fudge DH; Dischler AM; LeJeune KD; Haoxing Xu; Yan Qin
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Cell-autonomous regulation of epithelial cell quiescence by calcium channel Trpv6.

eLife
2019-09-17 | Journal article | Author
Contributors: Xin Y; Malick A; Meiqin Hu; Liu C; Batah H; Haoxing Xu; Cunming Duan
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Rapamycin directly activates lysosomal mucolipin TRP channels independent of mTOR.

PLoS biology
2019-05-21 | Journal article | Author
Contributors: Xiaoli Zhang; Wei Chen; Qiong Gao; Junsheng Yang; Yan X; Zhao H; Su L; Yang M; Chenlang Gao; Yao Y et al.
Source: Self-asserted source
Haoxing Xu

Lysosomal Ion Channels as Decoders of Cellular Signals.

Trends in biochemical sciences
2018-11-10 | Journal article
Contributors: Ping Li; Gu M; Xu H
Source: Self-asserted source
Haoxing Xu

Organellar TRP channels.

Nature structural & molecular biology
2018-10-29 | Journal article | Author
Contributors: Zhang X; Meiqin Hu; Yang Y; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Release and uptake mechanisms of vesicular Ca2+ stores.

Protein & cell
2018-03-16 | Journal article | Author
Contributors: Junsheng Yang; 壮壮 赵; Mingxue Gu; Xinghua feng; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

Structure of mammalian endolysosomal TRPML1 channel in nanodiscs.

Nature
2017-10-11 | Journal article
Contributors: Chen Q; She J; Zeng W; Guo J; Xu H; Xiao-chen Bai; Jiang Y
Source: Self-asserted source
Haoxing Xu

A voltage-dependent K<sup>+</sup> channel in the lysosome is required for refilling lysosomal Ca<sup>2+</sup> stores.

The Journal of cell biology
2017-05-03 | Journal article | Author
Contributors: Wuyang Wang; Zhang X; Qiong Gao; Lawas M; Yu L; Cheng X; Gu M; Nirakar Sahoo; Li X; Li P et al.
Source: Self-asserted source
Haoxing Xu

Gastric Acid Secretion from Parietal Cells Is Mediated by a Ca<sup>2+</sup> Efflux Channel in the Tubulovesicle.

Developmental cell
2017-05-01 | Journal article
Contributors: Sahoo N; Gu M; Zhang X; Raval N; Junsheng Yang; Bekier M; Calvo R; Patnaik S; Wang W; King G et al.
Source: Self-asserted source
Haoxing Xu

A painful TR(i)P to lysosomes.

The Journal of cell biology
2016-10-31 | Journal article
Contributors: Gu M; Xu H
Source: Self-asserted source
Haoxing Xu

MCOLN1 is a ROS sensor in lysosomes that regulates autophagy.

Nature communications
2016-06-30 | Journal article
Contributors: Zhang X; Cheng X; Yu L; Yang J; Calvo R; Patnaik S; Hu X; Qiong Gao; Yang M; Lawas M et al.
Source: Self-asserted source
Haoxing Xu

The endoplasmic reticulum, not the pH gradient, drives calcium refilling of lysosomes.

eLife
2016-05-23 | Journal article | Author
Contributors: Garrity AG; Wuyang Wang; Collier CM; Levey SA; Qiong Gao; Haoxing Xu
Source: Self-asserted source
Haoxing Xu
grade
Preferred source (of 2)‎

A molecular mechanism to regulate lysosome motility for lysosome positioning and tubulation.

Nature cell biology
2016-03-07 | Journal article
Contributors: Li X; Rydzewski N; Hider A; Zhang X; Junsheng Yang; Wuyang Wang; Gao Q; Cheng X; Xu H
Source: Self-asserted source
Haoxing Xu

A TRP Channel Senses Lysosome Neutralization by Pathogens to Trigger Their Expulsion.

Cell
2015-05-28 | Journal article
Contributors: Miao Y; Li G; Zhang X; Xu H; Abraham SN
Source: Self-asserted source
Haoxing Xu

Up-regulation of lysosomal TRPML1 channels is essential for lysosomal adaptation to nutrient starvation.

Proceedings of the National Academy of Sciences of the United States of America
2015-03-02 | Journal article
Contributors: Wuyang Wang; Qiong Gao; Yang M; Zhang X; Yu L; Lawas M; Li X; Bryant-Genevier M; Noel Southall; Marugan J et al.
Source: Self-asserted source
Haoxing Xu

Lysosomal calcium signalling regulates autophagy through calcineurin and ​TFEB.

Nature cell biology
2015-03-01 | Journal article
Contributors: Diego L. Medina; Simone Di Paola; Peluso I; Andrea Armani; Diego De Stefani; Rossella Venditti; Montefusco S; Scotto Rosato, Anna; Prezioso C; Alison Forrester et al.
Source: Self-asserted source
Haoxing Xu

Lysosomal physiology.

Annual review of physiology
2015-01-01 | Journal article
Contributors: Xu H; Ren D
Source: Self-asserted source
Haoxing Xu

The intracellular Ca²⁺ channel MCOLN1 is required for sarcolemma repair to prevent muscular dystrophy.

Nature medicine
2014-09-14 | Journal article
Contributors: Cheng X; Zhang X; Qiong Gao; Ali Samie M; Azar M; Tsang WL; Dong L; Nirakar Sahoo; Li X; Yue Zhuo et al.
Source: Self-asserted source
Haoxing Xu

Genetically encoded fluorescent probe to visualize intracellular phosphatidylinositol 3,5-bisphosphate localization and dynamics.

Proceedings of the National Academy of Sciences of the United States of America
2013-12-09 | Journal article
Contributors: Li X; Wang X; Zhang X; Zhao M; Tsang WL; Zhang Y; Yau RG; Weisman LS; Xu H
Source: Self-asserted source
Haoxing Xu

A TRP channel in the lysosome regulates large particle phagocytosis via focal exocytosis.

Developmental cell
2013-08-29 | Journal article
Contributors: Samie M; Wang X; Zhang X; Goschka A; Li X; Cheng X; Gregg E; Azar M; Yue Zhuo; Garrity AG et al.
Source: Self-asserted source
Haoxing Xu

TPC proteins are phosphoinositide- activated sodium-selective ion channels in endosomes and lysosomes.

Cell
2012-10-01 | Journal article
Contributors: Wang X; Zhang X; Xian-Ping Dong; Samie M; Li X; Cheng X; Goschka A; Shen D; Zhou Y; Harlow J et al.
Source: Self-asserted source
Haoxing Xu

Phosphoinositide isoforms determine compartment-specific ion channel activity.

Proceedings of the National Academy of Sciences of the United States of America
2012-06-25 | Journal article
Contributors: Zhang X; Li X; Xu H
Source: Self-asserted source
Haoxing Xu

Lipid storage disorders block lysosomal trafficking by inhibiting a TRP channel and lysosomal calcium release.

Nature communications
2012-03-13 | Journal article
Contributors: Shen D; Wang X; Li X; Zhang X; Zepeng Yao; Dibble S; Xian-Ping Dong; Yu T; Lieberman AP; Showalter HD et al.
Source: Self-asserted source
Haoxing Xu

PI(3,5)P(2) controls membrane trafficking by direct activation of mucolipin Ca(2+) release channels in the endolysosome.

Nature communications
2010-07-13 | Journal article
Contributors: Xian-Ping Dong; Shen D; Wang X; Dawson T; Li X; Zhang Q; Cheng X; Zhang Y; Weisman LS; Delling M et al.
Source: Self-asserted source
Haoxing Xu

TRP channel regulates EGFR signaling in hair morphogenesis and skin barrier formation.

Cell
2010-04-01 | Journal article
Contributors: Cheng X; Jin J; Hu L; Shen D; Xian-Ping Dong; Samie MA; Knoff J; Eisinger B; Liu ML; Huang SM et al.
Source: Self-asserted source
Haoxing Xu

The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel.

Nature
2008-09-14 | Journal article
Contributors: Xian-Ping Dong; Cheng X; Mills E; Delling M; Fudi Wang; Kurz T; Xu H
Source: Self-asserted source
Haoxing Xu

Activating mutation in a mucolipin transient receptor potential channel leads to melanocyte loss in varitint-waddler mice.

Proceedings of the National Academy of Sciences of the United States of America
2007-11-07 | Journal article
Contributors: Xu H; Delling M; Li L; Xian-Ping Dong; David Clapham
Source: Self-asserted source
Haoxing Xu

Oregano, thyme and clove-derived flavors and skin sensitizers activate specific TRP channels.

Nature neuroscience
2006-04-16 | Journal article
Contributors: Xu H; Delling M; Jun JC; David Clapham
Source: Self-asserted source
Haoxing Xu

Camphor activates and strongly desensitizes the transient receptor potential vanilloid subtype 1 channel in a vanilloid-independent mechanism.

The Journal of neuroscience : the official journal of the Society for Neuroscience
2005-09-01 | Journal article
Contributors: Xu H; Blair NT; David Clapham
Source: Self-asserted source
Haoxing Xu

The voltage-gated Na+ channel NaVBP has a role in motility, chemotaxis, and pH homeostasis of an alkaliphilic Bacillus.

Proceedings of the National Academy of Sciences of the United States of America
2004-07-08 | Journal article
Contributors: Masahiro Ito; Xu H; Guffanti AA; Wei Y; Zvi L; David Clapham; Krulwich TA
Source: Self-asserted source
Haoxing Xu
Items per page:
Page 1 of 2

Peer review (51 reviews for 20 publications/grants)

Review activity for Cell reports. (4)
Review activity for Cell research (1)
Review activity for Cell. (3)
Review activity for eLife (7)
Review activity for EMBO reports. (2)
Review activity for Journal of cellular physiology. (2)
Review activity for Molecular cell. (4)
Review activity for Nature biotechnology. (2)
Review activity for Nature cell biology (3)
Review activity for Nature chemical biology. (1)
Review activity for Nature communications (9)
Review activity for Nature immunology. (1)
Review activity for Nature nanotechnology (1)
Review activity for Nature structural & molecular biology. (1)
Review activity for Neuron. (1)
Review activity for PLoS biology. (1)
Review activity for Proceedings of the National Academy of Sciences of the United States of America. (1)
Review activity for Structure. (2)
Review activity for The Journal of cell biology. (4)
Review activity for The journal of cell biology. (1)