Personal information

Human Pluripotent Stem Cells, Retina, Photoreceptors, Retinal development, Retinal degeneration
Australia

Activities

Employment (5)

The University of Western Australia: Perth, AU

Employment
Source: check_circle
University of Western Australia

Lions Eye Institute: Nedlands, WA, AU

2017-01-09 to present | Brian King Post-Doctoral Fellow
Employment
Source: Self-asserted source
Carla Mellough

Newcastle University: Newcastle upon Tyne, Newcastle upon Tyne, GB

2007-12-05 to 2016-12-31 | Senior Research Associate (Institute of Genetic Medicine)
Employment
Source: Self-asserted source
Carla Mellough

Durham University: Durham, Durham, GB

2006-09-01 to 2007-12-04 | Senior Demonstrator (Biological and Biomedical Sciences)
Employment
Source: Self-asserted source
Carla Mellough

Durham University Faculty of Science: Durham, Durham, GB

2003-10-31 to 2006-08-31 | Research Associate (Biological and Biomedical Sciences)
Employment
Source: Self-asserted source
Carla Mellough

Education and qualifications (5)

The University of Western Australia: Perth, AU

Education
Source: check_circle
University of Western Australia

Durham University: Durham, Durham, GB

2006-09 to 2007-09 | Postgraduate Certificate in Teaching in Higher Education (Education)
Education
Source: Self-asserted source
Carla Mellough

University of Western Australia: Crawley, WA, AU

1999-06-01 to 2005-08-08 | PhD (Anatomy & Human Biology)
Education
Source: Self-asserted source
Carla Mellough

University of Western Australia Faculty of Science: Crawley, WA, AU

1997-11-31 to 1998-10-31 | Honours (Anatomy and Human Biology)
Education
Source: Self-asserted source
Carla Mellough

University of Western Australia: Crawley, WA, AU

1995-01-01 to 1997-11-31 | Bachelor of Science (Human Biology and Physiology)
Education
Source: Self-asserted source
Carla Mellough

Professional activities (2)

Ophthalmic Research Institute of Australia: Sydney, New South Wales, AU

2018 to present | Review Panel Member
Invited position
Source: Self-asserted source
Carla Mellough

Association for Research in Vision and Ophthalmology: Rockville, Maryland, US

2010 to present
Membership
Source: Self-asserted source
Carla Mellough

Funding (6)

Dual AAV retinal gene therapy approach for Ush1F treatment.

2019-01 to 2019-12 | Grant
Retina Australia Fighting Blindness (Greensborough, VIC, GB)
Source: Self-asserted source
Carla Mellough

Stargardt macular degeneration: finding new genetic mutations and preparing patients for clinical trials

2018-01 to 2019-12 | Grant
Macular Disease Foundation Australia (NSW, NSW, AU)
Source: Self-asserted source
Carla Mellough

Utilising patient-specific retinal organoids in vitro to investigate the effects of an SNRNP200 mutation causing early onset retinitis pigmentosa

2018-01 to 2018-12 | Grant
Retina Australia Fighting Blindness (Greensborough, VIC, AU)
Source: Self-asserted source
Carla Mellough

Investigating the genetic and environmental factors involved in early onset myopia.

2018 to 2020 | Grant
Channel 7 Telethon Trust (WA, WA, AU)
Source: Self-asserted source
Carla Mellough

Exploiting the power of Sendai RNA viruses to generate fully functional laminated retina from a wide range of patient-specific pluripotent stem cells.

2016-04 to 2016-09 | Award
Medical Research Council (Newcastle upon Tyne, GB)
Source: Self-asserted source
Carla Mellough

Identification of cell surface markers for human stem cell-derived photoreceptors using the BD lyoplate screening panel.

2011-07 to 2014-06 | Award
BD Biosciences (Oxford, GB)
Source: Self-asserted source
Carla Mellough

Works (34)

Compensatory Cone-Mediated Mechanisms in Inherited Retinal Degeneration Mouse Models

Advances in Experimental Medicine and Biology
2023 | Book chapter | Author
SOURCE-WORK-ID:

a1fb970d-bc33-4eda-be9e-8f99c58a058d

EID:

2-s2.0-85164844929

Part of ISBN: 978-3-031-27681-1
Part of ISBN: 978-3-031-27680-4
Contributors: Alicia Brunet; David M. Hunt; Carla Mellough; Alan; Livia Carvalho
Source: check_circle
University of Western Australia

Generation of two induced pluripotent stem cell lines from a patient with recessive inherited retinal disease caused by compound heterozygous mutations in SNRNP200

Stem Cell Research
2021-03 | Journal article | Author
SOURCE-WORK-ID:

6ba9643d-64c9-44ed-9ad5-02350aa1651c

EID:

2-s2.0-85099019372

WOSUID:

000629039100004

Contributors: Dan Zhang; Samuel McLenachan; Shang Chih Chen; Khine Zaw; Yaqin Alziyadat; Xiao Zhang; Tina M. Lamey; Jennifer A. Thompson; Terri L. McLaren; Carla Mellough et al.
Source: check_circle
University of Western Australia

Deep clinical phenotyping and gene expression analysis in a patient with RCBTB1-associated retinopathy

Ophthalmic Genetics
2021-02-24 | Journal article | Author
SOURCE-WORK-ID:

4da45cf9-6fb4-41d6-ada0-6ddde7afa5bb

EID:

2-s2.0-85101684368

WOSUID:

000621285100001

Contributors: Zhi-Qin Huang; Dan Zhang; Jennifer A. Thompson; Saumya S. Jamuar; Danial Roshandel; Luke Jennings; Carla Mellough; Jason Charng; Shang Chih Chen; Terri L. McLaren et al.
Source: check_circle
University of Western Australia

Retinal pigment epithelium and age-related macular degeneration

Clinical and Experimental Ophthalmology
2020-11 | Journal article | Author
SOURCE-WORK-ID:

0e1bf103-c85c-4337-8aa8-ea997aed41ef

EID:

2-s2.0-85089460459

WOSUID:

000560642900001

Contributors: Shreya Somasundaran; Ian J. Constable; Carla Mellough; Livia Carvalho
Source: check_circle
University of Western Australia

A Review of Gene, Drug and Cell-Based Therapies for Usher Syndrome

Frontiers in Cellular Neuroscience
2020-07-09 | Journal article | Author
SOURCE-WORK-ID:

4ef81a05-0efb-40a0-aaa2-ab08333353c1

EID:

2-s2.0-85088497990

WOSUID:

000555707400001

Contributors: Lucy S. French; Carla Mellough; Fred; Livia Carvalho
Source: check_circle
University of Western Australia

Postmitotic Cone Migration Mechanisms in the Mammalian Retina

Retinal Degenerative Diseases
2019 | Book chapter
Part of ISBN: 9783030273774
Part of ISBN: 9783030273781
Part of ISSN: 0065-2598
Part of ISSN: 2214-8019
Source: Self-asserted source
Carla Mellough
grade
Preferred source (of 2)‎

Systematic Comparison of Retinal Organoid Differentiation from Human Pluripotent Stem Cells Reveals Stage Specific, Cell Line, and Methodological Differences

Stem Cells Translational Medicine
2019-07 | Journal article | Author
SOURCE-WORK-ID:

9859dfe7-57ed-4399-bcc4-43d54735cedd

EID:

2-s2.0-85063621988

WOSUID:

000472771800009

Contributors: Carla Mellough; Joseph Collin; Rachel Queen; Gerrit Hilgen; Birthe Dorgau; Darin Zerti; Majed Felemban; Kathryn White; Evelyne Sernagor; Majlinda Lako
Source: check_circle
University of Western Australia

Utilising patient-specific retinal organoids to investigate the role of SNRNP200 variants of unknown significance in severe early onset retinitis pigmentosa

Investigative ophthalmology & visual science
2019-07 | Other | Author
SOURCE-WORK-ID:

a0724877-ef4b-498a-a0e7-a1d64d488abb

WOSUID:

000488628107011

Contributors: Carla Mellough; Mariska Ackerman; Jennifer A. Thompson; John De Roach; Terri McLaren; Tina Lamey; Anthony Akkari; Ramesh Ram; Shay Leary; Abha Chopra et al.
Source: check_circle
University of Western Australia

An integrated transcriptional analysis of the developing human retina

Development
2019-01-15 | Journal article | Author
SOURCE-WORK-ID:

01e8c46f-bb26-42e6-bce7-06367627c196

WOSUID:

000457418100011

EID:

2-s2.0-85060821768

Contributors: Carla Mellough; Roman Bauer; Joseph Collin; Birthe Dorgau; Darin Zerti; David W. P. Dolan; Carl M. Jones; Osagie G. Izuogu; Min Yu; Dean Hallam et al.
Source: check_circle
University of Western Australia

INDUCED PLURIPOTENT STEM CELL MODELS OF RETINITIS PIGMENTOSA CAUSED BY RP1 MUTATION

Clinical and Experimental Ophthalmology
2018-11 | Other | Author
SOURCE-WORK-ID:

21c7faf9-badd-4dcb-ba93-a033c4b26fea

WOSUID:

000450083500207

Contributors: Sang Yoon Moon; Xiao Zhang; Dana Zhang; Shang-Chih Chen; John De Roach; Tina Lamey; Carla Mellough; Stuart Hodgetts; Fred; Samuel McLenachan
Source: check_circle
University of Western Australia

Human iPSC-derived RPE and retinal organoids reveal impaired alternative splicing of genes involved in pre-mRNA splicing in PRPF31 autosomal dominant retinitis pigmentosa

Nature Communications
2018-08 | Journal article
Source: Self-asserted source
Carla Mellough

3D retina organoids produced from CRX-GFP human embryonic stem cells (hESCs) processed into retinal sheets and transplanted into immunodeficient retinal degenerate (RD) rats

Investigative ophthalmology & visual science
2018-07 | Other | Author
SOURCE-WORK-ID:

2f73cab9-57e4-4b40-8bf5-9840dfef546b

WOSUID:

000442912501173

Contributors: Magdalene J. Seiler; Bryce T. McLelland; Joseph Collin; Carla Mellough; Majlinda Lako; Robert B. Aramant; Gabriel Nistor; Hans S. Keirstead
Source: check_circle
University of Western Australia

Laminin gamma 3 expression and its functional role during human retinal morphogenesis

Investigative ophthalmology & visual science
2018-07 | Other | Author
SOURCE-WORK-ID:

511ec569-69b3-4d27-ab33-f089e0ad8ba6

WOSUID:

000442912501188

Contributors: Birthe Dorgau; Alex Sharpe; Majed Felemban; Dean Hallam; David Steel; Susan Lindsay; Carla Mellough; Majlinda Lako
Source: check_circle
University of Western Australia

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix

Acta Biomaterialia
2018-07-01 | Journal article | Author
SOURCE-WORK-ID:

fd4d4906-c1f8-48da-96ce-d3d44da1a401

EID:

2-s2.0-85047263761

WOSUID:

000437998200015

Contributors: Majed Felemban; Birthe Dorgau; Nicola Claire Hunt; Dean Hallam; Darin Zerti; Roman Bauer; Yuchun Ding; Joseph Collin; David Steel; Natalio Krasnogor et al.
Source: check_circle
University of Western Australia

Laminin γ3 plays an important role in retinal lamination, photoreceptor organisation and ganglion cell differentiation

Cell Death and Disease
2018-06-01 | Journal article | Author
SOURCE-WORK-ID:

de384d89-58de-46b6-8510-331a39aeb358

EID:

2-s2.0-85047417900

WOSUID:

000433095700002

Contributors: Birthe Dorgau; Majed Felemban; Alexander Sharpe; Roman Bauer; Dean Hallam; David H. Steel; Susan Lindsay; Carla Mellough; Majlinda Lako
Source: check_circle
University of Western Australia

Extracellular matrix component expression in human pluripotent stem cell-derived retinal organoids recapitulates retinogenesis in vivo and reveals an important role for IMPG1 and CD44 in the development of photoreceptors and interphotoreceptor matrix.

Acta Biomaterialia
2018-05-17 | Journal article
Source: Self-asserted source
Carla Mellough

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular

BMC Genomics
2018-04-20 | Journal article | Author
SOURCE-WORK-ID:

4df07d75-ab79-4355-9e80-e146dff17219

WOSUID:

000430807100004

EID:

2-s2.0-85045621916

Contributors: Osagie G. Izuogu; Abd A. Alhasan; Carla Mellough; Joseph Collin; Richard Gallon; Jonathon Hyslop; Francesco K. Mastrorosa; Ingrid Ehrmann; Majlinda Lako; David J. Elliott et al.
Source: check_circle
University of Western Australia

Analysis of human ES cell differentiation establishes that the dominant isoforms of the lncRNAs RMST and FIRRE are circular.

BMC Gemonics
2018-04-20 | Journal article
Source: Self-asserted source
Carla Mellough

An Induced Pluripotent Stem Cell Patient Specific Model of Complement Factor H (Y402H) Polymorphism Displays Characteristic Features of Age-Related Macular Degeneration and Indicates a Beneficial Role for UV Light Exposure.

Stem cells (Dayton, Ohio)
2017-11 | Journal article
Contributors: Hallam D; Collin J; Bojic S; Chichagova V; Buskin A; Xu Y; Lafage L; Otten EG; Anyfantis G; Mellough C et al.
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

THE GENERATION OF USEFUL HUMAN RETINAL TISSUE FROM HUMAN PLURIPOTENT STEM CELLS FOR THE STUDY OF OPHTHALMIC DEVELOPMENT, HEALTH AND DISEASE

Clinical & Experimental Ophthalmology
2017-10 | Other | Author
SOURCE-WORK-ID:

7d623005-1036-4cac-9edd-34174545d576

WOSUID:

000413690300244

Contributors: Carla Mellough; Joseph Collin; Evelyne Sernagor; Fred; Mariapia Degli-Esposti; Majlinda Lako
Source: check_circle
University of Western Australia

Gelsolin dysfunction causes photoreceptor loss in induced pluripotent cell and animal retinitis pigmentosa models.

Nature communications
2017-08 | Journal article
Contributors: Megaw R; Abu-Arafeh H; Jungnickel M; Mellough C; Gurniak C; Witke W; Zhang W; Khanna H; Mill P; Dhillon B et al.
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

How to build a human.

2016 | Journal article
Contributors: Mellough CB; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

3D culture of human pluripotent stem cells in RGD-alginate hydrogel improves retinal tissue development.

2016-11 | Journal article
Contributors: Hunt NC; Hallam D; Karimi A; Mellough CB; Chen J; Steel DH; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Using Zinc Finger Nuclease Technology to Generate CRX-Reporter Human Embryonic Stem Cells as a Tool to Identify and Study the Emergence of Photoreceptors Precursors During Pluripotent Stem Cell Differentiation.

2016-02 | Journal article
Contributors: Collin J; Mellough CB; Dorgau B; Przyborski S; Moreno-Gimeno I; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

IGF-1 Signaling Plays an Important Role in the Formation of Three-Dimensional Laminated Neural Retina and Other Ocular Structures From Human Embryonic Stem Cells.

2015-08 | Journal article
Contributors: Mellough CB; Collin J; Khazim M; White K; Sernagor E; Steel DH; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Use of induced pluripotent stem-cell technology to understand photoreceptor cytoskeletal dynamics in retinitis pigmentosa.

2015-02 | Journal article
Contributors: Megaw R; Mellough C; Wright A; Lako M; Ffrench-Constant C
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Lab generated retina: realizing the dream.

2014-09 | Journal article
Contributors: Mellough CB; Collin J; Sernagor E; Wride NK; Steel DH; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Efficient stage-specific differentiation of human pluripotent stem cells toward retinal photoreceptor cells.

2012-04 | Journal article
Contributors: Mellough CB; Sernagor E; Moreno-Gimeno I; Steel DH; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Neurite formation by neurons derived from adult rat hippocampal progenitor cells is susceptible to myelin inhibition.

2011-09 | Journal article
Contributors: Mellough CB; Cho S; Wood A; Przyborski S
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Genetic basis of inherited macular dystrophies and implications for stem cell therapy.

2009-11 | Journal article
Contributors: Mellough CB; Steel DH; Lako M
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion

Restorative Neurology and Neuroscience
2007 | Journal article | Author
SOURCE-WORK-ID:

b3d40739-578e-404d-a2e6-056c48f84544

EID:

2-s2.0-34548065507

WOSUID:

000249451100011

Contributors: Carla Mellough; Q. Cui; Alan
Source: check_circle
University of Western Australia

Treatment of adult neural progenitor cells prior to transplantation affects graft survival and integration in a neonatal and adult rat model of selective retinal ganglion cell depletion.

2007 | Journal article
Contributors: Mellough CB; Cui Q; Harvey AR
Source: Self-asserted source
Carla Mellough via Europe PubMed Central

Gene therapy and transplantation in CNS repair: the visual system.

2006-09 | Journal article
Contributors: Harvey AR; Hu Y; Leaver SG; Mellough CB; Park K; Verhaagen J; Plant GW; Cui Q
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎

Fate of multipotent neural precursor cells transplanted into mouse retina selectively depleted of retinal ganglion cells.

2004-03 | Journal article
Contributors: Mellough CB; Cui Q; Spalding KL; Symons NA; Pollett MA; Snyder EY; Macklis JD; Harvey AR
Source: Self-asserted source
Carla Mellough via Europe PubMed Central
grade
Preferred source (of 2)‎