Personal information

ion channel, Steroidogenesis, Keratin, ENaC, epithelia, Cytochrome P450, Protein structure, Cytoskeleton

Biography

I was born and raised in Istanbul, Turkey, and moved to Israel in 1970 after completing high school in Wisconsin, USA, through an AFS International Scholarship. I graduated cum laude from the Hebrew University of Jerusalem, earning a B.A. with a double major in biology and psychology. For my graduate studies, I returned to the University of Wisconsin-Madison, where I received my Ph.D. in Endocrinology in 1980. Following this, I joined the Department of Biochemistry at the University of Chicago as a research fellow, where I focused on gene cloning and sequencing projects.

In 1983, I returned to Israel and worked three years at the Technion – Israel Institute of Technology as a lecturer. Later, I joined the Weizmann Institute of Science, where I was promoted to Associate Professor in 1993. In 1995, I relocated my laboratory to the College of Judea and Samaria (now Ariel University) to establish a Department of Biology. As part of this initiative, I designed and authored Israel's first B.Sc. degree program in Molecular Biology, which was officially approved by the Council for Higher Education in 2003. From 2003 to 2008, I served as Chairman of the Department of Molecular Biology.

Over the past three decades, my research has focused on the molecular genetics of hereditary diseases, particularly pseudo-hypoaldosteronism, a disorder identified by my brother, Prof. Aaron Hanukoglu of Tel Aviv University Medical School. In collaboration with him and other researchers, our lab was among the first to identify mutations in the genes encoding epithelial sodium channel (ENaC) subunits, which are responsible for this condition.

In total, I have cloned approximately ten novel genes and characterized the structure and function of the proteins they encode. My contributions include elucidating enzyme systems that convert cholesterol to steroid hormones and determining the first sequences of keratins, which form the fibrous skeleton of epidermal cells and hair. My structural predictions for keratin filaments were confirmed nearly 20 years later through crystallography. My current research continues to advance in the areas of cytoskeletal proteins and epithelial ion channels.

Throughout my career, I have mentored 14 trainees at the M.Sc., Ph.D., and postdoctoral levels, with two graduates now serving as professors in the United States and one in India. I have been honored with several prestigious awards, including:

The Hans Lindner Prize in Endocrinology from the Israel Endocrine Society.
The Henri Gutwirth Award for Excellence in Research at the Technion.
The Lubell Prize for outstanding young scientists at the Weizmann Institute of Science.
Recognition for my peer-review contributions, ranking in the top 1% globally (22nd worldwide) in Molecular Biology and Genetics, according to Clarivate/Publons (Web of Science).

Activities

Employment (3)

Ariel University: Ariel, IL

2014 to 2020-10 | Professor of Biochemistry and Molecular Biology (Laboratory of Cell Biology)
Employment
Source: Self-asserted source
Israel Hanukoglu

Ariel University: Ariel, IL

1995 to 2014 | Professor of Biochemistry and Molecular Biology (Department of Molecular Biology)
Employment
Source: Self-asserted source
Israel Hanukoglu

Weizmann Institute of Science: Rehovot, IL

1987 to 1995 | Senior Scientist - Associate Professor (Hormone Research)
Employment
Source: Self-asserted source
Israel Hanukoglu

Education and qualifications (4)

The University of Chicago: Chicago, IL, US

1980 to 1983-08-31 | Post-doc (Department of Biochemistry)
Education
Source: Self-asserted source
Israel Hanukoglu

University of Wisconsin Madison: Madison, WI, US

1976 to 1980 | Ph.D. (Endocrinology)
Education
Source: Self-asserted source
Israel Hanukoglu

University of Wisconsin Madison: Madison, WI, US

1975 to 1976 | M.Sc. (Endocrinology - Reproductive Physiology)
Education
Source: Self-asserted source
Israel Hanukoglu

Hebrew University of Jerusalem: Jerusalem, IL

1970 to 1974 | B.A. (Biology and Psychology, cum laude)
Education
Source: Self-asserted source
Israel Hanukoglu

Professional activities (6)

American Physiological Society: Bethesda, Maryland, US

Membership
Source: Self-asserted source
Israel Hanukoglu

Clarivate Analytics: Philadelphia, PA, US

2016 | Sentinel of Science Award
Distinction
Source: Self-asserted source
Israel Hanukoglu

Weizmann Institute of Science: Rehovot, IL

1991 | Lubell Award for outstanding young scientist
Distinction
Source: Self-asserted source
Israel Hanukoglu

Israel Endocrine Society: Jerusalem, IL

1988 | Hans Lindner Prize in Biochemical Endocrinology
Distinction
Source: Self-asserted source
Israel Hanukoglu

Damon Runyon Cancer Research Foundation: New York, New York, US

1981 | Damon Runyon Cancer Fund Fellowship Award in Biochemistry
Distinction
Source: Self-asserted source
Israel Hanukoglu

AFS-USA Inc: New York, NY, US

1970 | AFS International Scholarship
Distinction
Source: Self-asserted source
Israel Hanukoglu

Works (50 of 85)

Items per page:
Page 1 of 2

Mapping the cytoskeletal architecture of renal tubules and surrounding peritubular capillaries in the kidney.

Cytoskeleton (Hoboken, N.J.)
2023-11-08 | Journal article | Author
Contributors: Girishkumar Kumaran; Israel Hanukoglu
Source: Self-asserted source
Israel Hanukoglu
grade
Preferred source (of 2)‎

Epithelial sodium channel (ENaC) in GtoPdb v.2023.1

IUPHAR/BPS Guide to Pharmacology CITE
2023-04-26 | Journal article
Contributors: Israel Hanukoglu
Source: check_circle
Crossref

A retrospective evaluation of a decade of Gene Wiki Reviews and their impact.

Gene
2022-05 | Journal article
Contributors: van Wijnen AJ; Golemis E; Hanukoglu I; Kwok-Wing Tsui S; Hu E; Ul-Hasan S; Joy J; Su AI; Tsueng G
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Epithelial sodium channel (ENaC) in GtoPdb v.2021.2

IUPHAR/BPS Guide to Pharmacology CITE
2021-06-25 | Journal article
Contributors: Israel Hanukoglu
Source: check_circle
Crossref

Front Cover Image, Volume 87, Issue 2, February 2020

Molecular Reproduction and Development
2020-02 | Journal article
Contributors: Sachin Sharma; Girishkumar K. Kumaran; Israel Hanukoglu
Source: check_circle
Crossref

High-resolution imaging of the actin cytoskeleton and epithelial sodium channel, CFTR, and aquaporin-9 localization in the vas deferens.

Molecular reproduction and development
2020-01 | Journal article
Contributors: Sharma S; Kumaran GK; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central
grade
Preferred source (of 2)‎

THE CONCISE GUIDE TO PHARMACOLOGY 2019/20: Ion channels.

British journal of pharmacology
2019-12 | Journal article
Contributors: Alexander SP; Mathie A; Peters JA; Veale EL; Striessnig J; Kelly E; Armstrong JF; Faccenda E; Harding SD; Pawson AJ et al.
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Identification and classification of epithelial cells in nephron segments by actin cytoskeleton patterns.

The FEBS journal
2019-10 | Journal article
Contributors: Kumaran GK; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central
grade
Preferred source (of 2)‎

Epithelial sodium channel (ENaC) (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database

IUPHAR/BPS Guide to Pharmacology CITE
2019-09-16 | Journal article
Contributors: Israel Hanukoglu
Source: check_circle
Crossref

Mapping the sites of localization of epithelial sodium channel (ENaC) and CFTR in segments of the mammalian epididymis.

Journal of molecular histology
2019-01 | Journal article
Contributors: Sharma S; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central
grade
Preferred source (of 2)‎

Expression of the epithelial sodium channel (ENaC) in the endometrium - Implications for fertility in a patient with pseudohypoaldosteronism.

The Journal of steroid biochemistry and molecular biology
2018-06 | Journal article
Contributors: Boggula VR; Hanukoglu I; Sagiv R; Enuka Y; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

In systemic pseudohypoaldosteronism type 1 skin manifestations are not rare and the disease is not transient.

Clinical endocrinology
2018-04 | Journal article
Contributors: Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Localization of epithelial sodium channel (ENaC) and CFTR in the germinal epithelium of the testis, Sertoli cells, and spermatozoa.

Journal of molecular histology
2018-02 | Journal article
Contributors: Sharma S; Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview.

British journal of pharmacology
2017-12 | Journal article
Contributors: Alexander SP; Kelly E; Marrion NV; Peters JA; Faccenda E; Harding SD; Pawson AJ; Sharman JL; Southan C; Buneman OP et al.
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Conservation of the Enzyme-Coenzyme Interfaces in FAD and NADP Binding Adrenodoxin Reductase-A Ubiquitous Enzyme.

Journal of molecular evolution
2017-11 | Journal article
Contributors: Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Expression of epithelial sodium channel (ENaC) and CFTR in the human epidermis and epidermal appendages.

Histochemistry and cell biology
2017-01 | Journal article
Contributors: Hanukoglu I; Boggula VR; Vaknine H; Sharma S; Kleyman T; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

ASIC and ENaC type sodium channels: conformational states and the structures of the ion selectivity filters.

The FEBS journal
2016-09 | Journal article
Contributors: Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central
grade
Preferred source (of 2)‎

Gene Wiki Reviews-Raising the quality and accessibility of information about the human genome.

Gene
2016-05 | Journal article
Contributors: Tsueng G; Good BM; Ping P; Golemis E; Hanukoglu I; van Wijnen AJ; Su AI
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Epithelial sodium channel (ENaC) family: Phylogeny, structure-function, tissue distribution, and associated inherited diseases.

Gene
2016-01 | Journal article
Contributors: Hanukoglu I; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Proteopedia: Rossmann fold: A beta-alpha-beta fold at dinucleotide binding sites.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
2015-02 | Journal article
Contributors: Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Conserved charged residues at the surface and interface of epithelial sodium channel subunits--roles in cell surface expression and the sodium self-inhibition response.

The FEBS journal
2014-03 | Journal article
Contributors: Edelheit O; Ben-Shahar R; Dascal N; Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Proteopedia entry: coiled-coil structure of keratins.

Biochemistry and molecular biology education : a bimonthly publication of the International Union of Biochemistry and Molecular Biology
2013-11 | Journal article
Contributors: Hanukoglu I; Ezra L
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Epithelial sodium channels (ENaC) are uniformly distributed on motile cilia in the oviduct and the respiratory airways.

Histochemistry and cell biology
2011-12 | Journal article
Contributors: Enuka Y; Hanukoglu I; Edelheit O; Vaknine H; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Identification of the roles of conserved charged residues in the extracellular domain of an epithelial sodium channel (ENaC) subunit by alanine mutagenesis.

American journal of physiology. Renal physiology
2011-01 | Journal article
Contributors: Edelheit O; Hanukoglu I; Dascal N; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Autosomal recessive hyponatremia due to isolated salt wasting in sweat associated with a mutation in the active site of Carbonic Anhydrase 12.

Human genetics
2010-12 | Journal article
Contributors: Muhammad E; Leventhal N; Parvari G; Hanukoglu A; Hanukoglu I; Chalifa-Caspi V; Feinstein Y; Weinbrand J; Jacoby H; Manor E et al.
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Clinical improvement in patients with autosomal recessive pseudohypoaldosteronism and the necessity for salt supplementation.

Clinical and experimental nephrology
2010-07 | Journal article
Contributors: Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Truncated beta epithelial sodium channel (ENaC) subunits responsible for multi-system pseudohypoaldosteronism support partial activity of ENaC.

The Journal of steroid biochemistry and molecular biology
2010-01 | Journal article
Contributors: Edelheit O; Hanukoglu I; Shriki Y; Tfilin M; Dascal N; Gillis D; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Simple and efficient site-directed mutagenesis using two single-primer reactions in parallel to generate mutants for protein structure-function studies.

BMC biotechnology
2009-06 | Journal article
Contributors: Edelheit O; Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Renin-aldosterone response, urinary Na/K ratio and growth in pseudohypoaldosteronism patients with mutations in epithelial sodium channel (ENaC) subunit genes.

The Journal of steroid biochemistry and molecular biology
2008-06 | Journal article
Contributors: Hanukoglu A; Edelheit O; Shriki Y; Gizewska M; Dascal N; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Antioxidant protective mechanisms against reactive oxygen species (ROS) generated by mitochondrial P450 systems in steroidogenic cells.

Drug metabolism reviews
2006-01 | Journal article
Contributors: Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Novel mutations in epithelial sodium channel (ENaC) subunit genes and phenotypic expression of multisystem pseudohypoaldosteronism.

Clinical endocrinology
2005-05 | Journal article
Contributors: Edelheit O; Hanukoglu I; Gizewska M; Kandemir N; Tenenbaum-Rakover Y; Yurdakök M; Zajaczek S; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

ACTH induces TIMP-1 expression and inhibits collagenase in adrenal cortex cells.

Molecular and cellular endocrinology
2004-02 | Journal article
Contributors: Reichenstein M; Reich R; LeHoux JG; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Novel mutations responsible for autosomal recessive multisystem pseudohypoaldosteronism and sequence variants in epithelial sodium channel alpha-, beta-, and gamma-subunit genes.

The Journal of clinical endocrinology and metabolism
2002-07 | Journal article
Contributors: Saxena A; Hanukoglu I; Saxena D; Thompson RJ; Gardiner RM; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Amiloride-sensitive epithelial sodium channel subunits are expressed in human and mussel immunocytes.

Developmental and comparative immunology
2002-06 | Journal article
Contributors: Ottaviani E; Franchini A; Mandrioli M; Saxena A; Hanukoglu A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Structures of Mitochondrial P450 System Proteins

Molecular and Applied Aspects of Oxidative Drug Metabolizing Enzymes
1999 | Book chapter
Part of ISBN: 9781461372028
Part of ISBN: 9781461548553
Source: Self-asserted source
Israel Hanukoglu

The structure of adrenodoxin reductase of mitochondrial P450 systems: electron transfer for steroid biosynthesis.

Journal of molecular biology
1999-06 | Journal article
Contributors: Ziegler GA; Vonrhein C; Hanukoglu I; Schulz GE
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Chaperone-assisted expression of authentic bovine adrenodoxin reductase in Escherichia coli.

FEBS letters
1999-01 | Journal article
PMID: 9989598
Contributors: Vonrhein C; Schmidt U; Ziegler GA; Schweiger S; Hanukoglu I; Schulz GE
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Gene structure of the human amiloride-sensitive epithelial sodium channel beta subunit.

Biochemical and biophysical research communications
1998-11 | Journal article
PMID: 9813171
Contributors: Saxena A; Hanukoglu I; Strautnieks SS; Thompson RJ; Gardiner RM; Hanukoglu A
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Antioxidant capacity is correlated with steroidogenic status of the corpus luteum during the bovine estrous cycle.

Biochimica et biophysica acta
1998-03 | Journal article
PMID: 9545562
Contributors: Rapoport R; Sklan D; Wolfenson D; Shaham-Albalancy A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

In situ localization of ACTH receptor-like mRNA in molluscan and human immunocytes.

Cellular and molecular life sciences : CMLS
1998-02 | Journal article
PMID: 9539954
Contributors: Ottaviani E; Franchini A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Pseudohypoaldosteronism due to renal and multisystem resistance to mineralocorticoids respond differently to carbenoxolone.

The Journal of steroid biochemistry and molecular biology
1997-01 | Journal article
PMID: 9182864
Contributors: Hanukoglu A; Joy O; Steinitz M; Rosler A; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Electron Transfer Proteins of Cytochrome P450 Systems

Advances in Molecular and Cell Biology
1996 | Journal article
Part of ISBN: 9780762301133
Part of ISSN: 1569-2558
Source: Self-asserted source
Israel Hanukoglu

Mutations in subunits of the epithelial sodium channel cause salt wasting with hyperkalaemic acidosis, pseudohypoaldosteronism type 1.

Nature genetics
1996-03 | Journal article
PMID: 8589714
Contributors: Chang SS; Grunder S; Hanukoglu A; Rösler A; Mathew PM; Hanukoglu I; Schild L; Lu Y; Shimkets RA; Nelson-Williams C et al.
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Localisation of pseudohypoaldosteronism genes to chromosome 16p12.2-13.11 and 12p13.1-pter by homozygosity mapping.

Human Molecular Genetics
1996-02 | Journal article
PMID: 8824886
Contributors: Strautnieks SS; Thompson RJ; Hanukoglu A; Dillon MJ; Hanukoglu I; Kuhnle U; Seckl J; Gardiner RM; Chung E
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Tissue- and species-dependent expression of sheep lung microsomal cytochrome P4502B(LgM2).

Biochemistry and molecular biology international
1995-12 | Journal article
PMID: 8747542
Contributors: Arinç E; Hanukoglu I; Sen A; Adali O
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Exclusion of the locus for autosomal recessive pseudohypoaldosteronism type 1 from the mineralocorticoid receptor gene region on human chromosome 4q by linkage analysis.

The Journal of clinical endocrinology and metabolism
1995-11 | Journal article
PMID: 7593448
Contributors: Chung E; Hanukoglu A; Rees M; Thompson R; Dillon M; Hanukoglu I; Bistritzer T; Kuhnle U; Seckl J; Gardiner RM
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Selective increases in adrenal steroidogenic capacity during acute respiratory disease in infants.

European journal of endocrinology
1995-11 | Journal article
PMID: 7581984
Contributors: Hanukoglu A; Fried D; Nakash I; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Electron leakage from the adrenal cortex mitochondrial P450scc and P450c11 systems: NADPH and steroid dependence.

Archives of biochemistry and biophysics
1995-03 | Journal article
PMID: 7893157
Contributors: Rapoport R; Sklan D; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Routes and regulation of NADPH production in steroidogenic mitochondria.

Endocrine research
1995-02 | Journal article
PMID: 7588385
Contributors: Hanukoglu I; Rapoport R
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central

Cloning of ACTH-regulated genes in the adrenal cortex.

The Journal of steroid biochemistry and molecular biology
1994-06 | Journal article
PMID: 8043487
Contributors: Raikhinstein M; Hanukoglu I
Source: Self-asserted source
Israel Hanukoglu via Europe PubMed Central
Items per page:
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Peer review (2 reviews for 2 publications/grants)

Review activity for Cell and tissue research. (1)
Review activity for Journal of chemical information and modeling. (1)