Personal information

innate immunity, inflammation, inflammasome, cell death, synthetic biology, immunometabolism

Activities

Employment (1)

Ragon Institute of MGH, MIT, and Harvard: Cambridge, MA, US

2021-10-01 to present | Research Fellow
Employment
Source: Self-asserted source
Charles Evavold

Education and qualifications (3)

Harvard University: Cambridge, Massachusetts, US

2014-09 to 2021-07-28 | Ph.D. (Immunology)
Education
Source: Self-asserted source
Charles Evavold

Emory University: Atlanta, Georgia, US

2009-08 to 2013-05 | B.S. (Physics)
Education
Source: Self-asserted source
Charles Evavold

Emory University: Atlanta, Georgia, US

2009-08 to 2013-05 | B.S. (Chemistry)
Education
Source: Self-asserted source
Charles Evavold

Works (19)

Gasdermin D pore-forming activity is redox-sensitive

Cell Reports
2023 | Journal article
EID:

2-s2.0-85146548887

Part of ISSN: 22111247
Contributors: Devant, P.; Boršić, E.; Ngwa, E.M.; Xiao, H.; Chouchani, E.T.; Thiagarajah, J.R.; Hafner-Bratkovič, I.; Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Biting the hand that feeds: Metabolic determinants of cell fate during infection

Frontiers in Immunology
2022 | Journal article
EID:

2-s2.0-85140903909

Part of ISSN: 16643224
Contributors: Fraschilla, I.; Evavold, C.L.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Correction of age-associated defects in dendritic cell functions enables CD4<sup>+</sup> T cells to eradicate tumors in the elderly

bioRxiv
2022 | Other
EID:

2-s2.0-85146783991

Part of ISSN: 26928205
Contributors: Zhivaki, D.; Boriello, F.; Kennedy, S.N.; Evavold, C.L.; Bahleda, K.M.; Chapman, K.L.; Zanoni, I.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Diverse Control Mechanisms of the Interleukin-1 Cytokine Family

Frontiers in Cell and Developmental Biology
2022 | Journal article
EID:

2-s2.0-85133918826

Part of ISSN: 2296634X
Contributors: Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Glycine inhibits NINJ1 membrane clustering to suppress plasma membrane rupture in cell death

eLife
2022 | Journal article
EID:

2-s2.0-85146129970

Part of ISSN: 2050084X
Contributors: Borges, J.P.; Sætra, R.S.R.; Volchuk, A.; Bugge, M.; Devant, P.; Sporsheim, B.; Kilburn, B.R.; Evavold, C.L.; Kagan, J.C.; Goldenberg, N.M. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier
grade
Preferred source (of 2)‎

Putting the p(hosphor) in pyroptosis

Cell Host and Microbe
2022 | Journal article
EID:

2-s2.0-85143970377

Part of ISSN: 19346069 19313128
Contributors: Rastogi, S.; Evavold, C.L.; Briken, V.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

The pore-forming protein gasdermin D is a cellular redox sensor

bioRxiv
2022 | Other
EID:

2-s2.0-85129346889

Part of ISSN: 26928205
Contributors: Devant, P.; Boršić, E.; Ngwa, E.M.; Thiagarajah, J.R.; Hafner-Bratkovič, I.; Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Control of gasdermin D oligomerization and pyroptosis by the Ragulator-Rag-mTORC1 pathway

Cell
2021 | Journal article
EID:

2-s2.0-85112513003

Part of ISSN: 10974172 00928674
Contributors: Evavold, C.L.; Hafner-Bratkovič, I.; Devant, P.; D'Andrea, J.M.; Ngwa, E.M.; Boršić, E.; Doench, J.G.; LaFleur, M.W.; Sharpe, A.H.; Thiagarajah, J.R. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Downstream of gasdermin D cleavage, a Ragulator-Rag-mTORC1 pathway promotes pore formation and pyroptosis

bioRxiv
2020 | Other
EID:

2-s2.0-85098769184

Part of ISSN: 26928205
Contributors: Evavold, C.L.; Hafner-Bratkovič, I.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

HDAC6 mediates an aggresome-like mechanism for NLRP3 and pyrin inflammasome activation

Science
2020 | Journal article
EID:

2-s2.0-85091193147

Part of ISSN: 10959203 00368075
Contributors: Magupalli, V.G.; Negro, R.; Tian, Y.; Hauenstein, A.V.; Caprio, G.D.; Skillern, W.; Deng, Q.; Orning, P.; Alam, H.B.; Maliga, Z. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Defying Death: The (W)hole Truth about the Fate of GSDMD Pores

Immunity
2019 | Journal article
EID:

2-s2.0-85059296746

Part of ISBN:

10974180 10747613

Contributors: Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Inflammasomes: Threat-Assessment Organelles of the Innate Immune System

Immunity
2019 | Journal article
EID:

2-s2.0-85072970632

Part of ISBN:

10974180 10747613

Contributors: Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

The Effect of pH on Antibiotic Efficacy against Coxiella burnetii in Axenic Media

Scientific Reports
2019 | Journal article
EID:

2-s2.0-85075934842

Part of ISBN:

20452322

Contributors: Smith, C.B.; Evavold, C.; Kersh, G.J.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

How Inflammasomes Inform Adaptive Immunity

Journal of Molecular Biology
2018 | Journal article
EID:

2-s2.0-85032735899

Part of ISBN:

10898638 00222836

Contributors: Evavold, C.L.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

The Pore-Forming Protein Gasdermin D Regulates Interleukin-1 Secretion from Living Macrophages

Immunity
2018 | Journal article
EID:

2-s2.0-85061560626

Part of ISBN:

10974180 10747613

Contributors: Evavold, C.L.; Ruan, J.; Tan, Y.; Xia, S.; Wu, H.; Kagan, J.C.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Coxiella burnetii Infection in a community operating a large-scale cow and goat dairy, Missouri, 2013

American Journal of Tropical Medicine and Hygiene
2016 | Journal article
EID:

2-s2.0-84960904863

Part of ISBN:

00029637

Contributors: Biggs, H.M.; Turabelidze, G.; Pratt, D.; Todd, S.R.; Jacobs-Slifka, K.; Drexler, N.A.; McCurdy, G.; Lloyd, J.; Evavold, C.L.; Fitzpatrick, K.A. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Orbital solutions and absolute elements of the massive algol binary ET tauri

Publications of the Astronomical Society of the Pacific
2016 | Journal article
EID:

2-s2.0-84994493719

Part of ISBN:

00046280

Contributors: Williamon, R.M.; Dale, H.; Evavold, C.L.; Langoussis, A.; Fekel, F.C.; Muterspaugh, M.W.; Williams, S.; Napier, K.; Sowell, J.R.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

PF4 Promotes Platelet Production and Lung Cancer Growth

Cell Reports
2016 | Journal article
EID:

2-s2.0-84994387582

Part of ISBN:

22111247

Contributors: Pucci, F.; Rickelt, S.; Newton, A.P.; Garris, C.; Nunes, E.; Evavold, C.; Pfirschke, C.; Engblom, C.; Mino-Kenudson, M.; Hynes, R.O. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

SCS macrophages suppress melanoma by restricting tumor-derived vesicle-B cell interactions

Science
2016 | Journal article
EID:

2-s2.0-84961390149

Part of ISBN:

10959203 00368075

Contributors: Pucci, F.; Garris, C.; Lai, C.P.; Newton, A.; Pfirschke, C.; Engblom, C.; Alvarez, D.; Sprachman, M.; Evavold, C.; Magnuson, A. et al.
Source: Self-asserted source
Charles Evavold via Scopus - Elsevier

Peer review (7 reviews for 4 publications/grants)

Review activity for Cell chemical biology. (1)
Review activity for Cell reports. (2)
Review activity for Immunity. (3)
Review activity for Science immunology. (1)