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Employment (9)

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University: Cleveland, OH, US

2019-08 to present | Associate Professor (Molecular Medicine and Biomedical Engineering)
Employment
Source: Self-asserted source
Chaitali Ghosh

Lerner Research Institute, Cleveland Clinic: OH, OH, US

2018 to present | Staff Scientist (Biomedical Engineering)
Employment
Source: Self-asserted source
Chaitali Ghosh

Cleveland Clinic Lerner College of Medicine of Case Western Reserve University: Cleveland, OH, US

2014 to 2019-07 | Assistant Professor (Molecular Medicine)
Employment
Source: Self-asserted source
Chaitali Ghosh

Cleveland Clinic Lerner Research Institute: Cleveland, OH, US

2014 to 2017-12 | Project Scientist (Biomedical Engineering)
Employment
Source: Self-asserted source
Chaitali Ghosh

Cleveland Clinic Lerner Research Institute: Cleveland, OH, US

2011-03 to 2013 | Research Associate (Cellular and Molecular Biology)
Employment
Source: Self-asserted source
Chaitali Ghosh

Cleveland Clinic Lerner Research Institute: Cleveland, OH, US

2007-08 to 2011-02 | Senior Postdoctoral Fellow (Cellular and Molecular Biology)
Employment
Source: Self-asserted source
Chaitali Ghosh

Northeastern Ohio Medical University: Rootstown, OH, US

2006-01-01 to 2007-07-01 | Postdoctoral Research Fellow (Neurobiology)
Employment
Source: Self-asserted source
Chaitali Ghosh

Indian Institute of Toxicology Research CSIR: Lucknow, Uttar Pradesh, IN

2001 to 2005 | Research Scholar (Developmental Toxicology)
Employment
Source: Self-asserted source
Chaitali Ghosh

Sanjay Gandhi Post Graduate Institute of Medical Sciences: Lucknow, Uttar Pradesh, IN

2000 to 2001 | Research Assistant (Neuology)
Employment
Source: Self-asserted source
Chaitali Ghosh

Education and qualifications (3)

Jamia Hamdard: New Delhi, Delhi, IN

2001-10 to 2005-05 | Ph.D in Toxicology (Science)
Education
Source: Self-asserted source
Chaitali Ghosh

Dayalbagh Educational Institute Faculty of Science: Agra, Uttar Pradesh, IN

1997-06 to 1999-06 | MS (Zoology (Specialization in Toxicology))
Education
Source: Self-asserted source
Chaitali Ghosh

Dayalbagh Educational Institute Faculty of Science: Agra, Uttar Pradesh, IN

1994-05-01 to 1997-06-01 | BS (Zoology, Botany, Chemistry)
Education
Source: Self-asserted source
Chaitali Ghosh

Professional activities (2)

American Heart Association: TX, TX, US

2012 to present
Membership
Source: Self-asserted source
Chaitali Ghosh

American Epilepsy Society: Chicago, Illinois, US

2007 to present | Professional member
Membership
Source: Self-asserted source
Chaitali Ghosh

Funding (7)

Molecular Mechanism of Glucocorticoid Receptor, Cytochrome P450, and PGlycoprotein Axis on Drug Regulation at the Blood-Brain Barrier in Epilepsy with Focal Cortical Dysplasia

2024-12 to 2029-11 | Grant
NIH (Bethesda, US)
Source: Self-asserted source
Chaitali Ghosh

Cytochrome P450-mediated drug interactions at the human blood-brain barrier

2017 to 2021 | Grant
National Institute of Neurological Disorders and Stroke/National Institutes of Health (Bethesda , Maryland, US)
GRANT_NUMBER:

R01NS095825
Source: Self-asserted source
Chaitali Ghosh

Bioavailability of drug targeting the brain across the blood-brain barrier: Role of Cytochrome P450s

2013-01 to 2016-12 | Grant
American Heart Association Scientist Development Grant (Cleveland, National Center, US)
GRANT_NUMBER:

13SDG13950015
Source: Self-asserted source
Chaitali Ghosh

Detection of antidepressants and their metabolites in human brain: Role of Blood-Brain Barrier Cytochrome P450 enzymes

2013 to 2016 | Grant
Brain and Behavior Research Foundation (NY, US)
GRANT_NUMBER:

18815
Source: Self-asserted source
Chaitali Ghosh

Drug brain biotransformation in human refractory epilepsy

Grant
NIH-NINDS (Bethesda, MD, USA, US)
Part of GRANT_NUMBER:

R01 NS078307
Source: Self-asserted source
Chaitali Ghosh

Human Brain-on-a-Chip: Regional Chemical Communication, Drug and Toxin Responses

Grant
U H2TR000491-4 (Bethesda, Maryland, USA, US)
Part of GRANT_NUMBER:

U H2TR000491
Source: Self-asserted source
Chaitali Ghosh

Neurovascular humanized in vitro system to assess drug-induced neurotoxicity

Award
Alternative Research & Development Foundation Grant (Baltimore, MD, USA, US)
Source: Self-asserted source
Chaitali Ghosh

Works (46)

Regional variations in allergen‐induced airway inflammation correspond to changes in soluble guanylyl cyclase heme and expression of heme oxygenase‐1

The FASEB Journal
2024-03-31 | Journal article
DOI: 10.1096/fj.202301626RRR
Contributors: Mamta P. Sumi; Rosemary Westcott; Eric Stuehr; Chaitali Ghosh; Dennis J. Stuehr; Arnab Ghosh
Source: check_circle
Crossref

Genetic and molecular features of seizure-freedom following surgical resections for focal epilepsy: A pilot study

Frontiers in Neurology
2022-09-16 | Journal article
DOI: 10.3389/fneur.2022.942643
Part of ISSN: 1664-2295
Contributors: Chaitali Ghosh; Shreya Louis et al.
Source: Self-asserted source
Chaitali Ghosh

Cytochrome P450-mediated antiseizure medication interactions influence apoptosis, modulate the brain BAX/Bcl-XL ratio and aggravate mitochondrial stressors in human pharmacoresistant epilepsy

Frontiers in Pharmacology
2022-08-22 | Journal article
DOI: 10.3389/fphar.2022.983233
Part of ISSN: 1663-9812
Contributors: Chaitali Ghosh; Rosemary Westcott, Emilio Perucca, Mohammed Hossain, William Bingaman, Imad Najm
Source: Self-asserted source
Chaitali Ghosh

Cortical Dysplasia in Rats Provokes Neurovascular Alterations, GLUT1 Dysfunction, and Metabolic Disturbances That Are Sustained Post-Seizure Induction

Molecular Neurobiology
2022-04 | Journal article
DOI: 10.1007/s12035-021-02624-2
Contributors: Chaitali Ghosh; Rosemary Myers; Christina O’Connor; Sherice Williams; Xuefeng Liu; Mohammed Hossain; Michael Nemeth; Imad M. Najm
Source: check_circle
Crossref

Glucocorticoid Receptor β Isoform Predominates in the Human Dysplastic Brain Region and Is Modulated by Age, Sex, and Antiseizure Medication

International Journal of Molecular Sciences
2022-04-29 | Journal article
DOI: 10.3390/ijms23094940
Contributors: Rosemary Westcott; Natalie Chung; Arnab Ghosh; Lisa Ferguson; William Bingaman; Imad M. Najm; Chaitali Ghosh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Drug Delivery Challenges in Brain Disorders across the Blood–Brain Barrier: Novel Methods and Future Considerations for Improved Therapy

Biomedicines
2021-12-04 | Journal article
DOI: 10.3390/biomedicines9121834
Contributors: Aneesha Achar; Rosemary Myers; Chaitali Ghosh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Multiple hurdle mechanism and blood-brain barrier in epilepsy: glucocorticoid receptor-heat shock proteins on drug regulation.

Neural regeneration research
2021-12-01 | Journal article
DOI: 10.4103/1673-5374.313046
PMID: 33907029
Source: Self-asserted source
Chaitali Ghosh

Heat Shock Proteins Accelerate the Maturation of Brain Endothelial Cell Glucocorticoid Receptor in Focal Human Drug-Resistant Epilepsy

Molecular Neurobiology
2020-11-03 | Journal article
DOI: 10.1007/s12035-020-02043-9
Contributors: Mohammed Hossain; Sherice Williams; Lisa Ferguson; William Bingaman; Arnab Ghosh; Imad M. Najm; Chaitali Ghosh
Source: check_circle
Crossref

COVID-19-Associated Neurological Disorders: The Potential Route of CNS Invasion and Blood-Brain Barrier Relevance

Cells
2020-10-27 | Journal article
DOI: 10.3390/cells9112360
Contributors: Aneesha Achar; Chaitali Ghosh
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Neurovascular Drug Biotransformation Machinery in Focal Human Epilepsies: Brain CYP3A4 Correlates with Seizure Frequency and Antiepileptic Drug Therapy

Molecular Neurobiology
2019-12-26 | Journal article
DOI: 10.1007/s12035-019-01673-y
Contributors: Sherice Williams; Mohammed Hossain; Lisa Ferguson; Robyn M. Busch; Nicola Marchi; Jorge Gonzalez-Martinez; Emilio Perucca; Imad M. Najm; Chaitali Ghosh
Source: check_circle
Crossref

Neurovascular glucocorticoid receptors and glucocorticoids: implications in health, neurological disorders and drug therapy.

Drug discovery today
2019-09-18 | Journal article
DOI: 10.1016/j.drudis.2019.09.009
PMID: 31541713
Source: Self-asserted source
Chaitali Ghosh

Expression and Functional Relevance of Death-Associated Protein Kinase in Human Drug-Resistant Epileptic Brain: Focusing on the Neurovascular Interface

Molecular Neurobiology
2019-07-09 | Journal article
DOI: 10.1007/s12035-018-1415-z
Contributors: Sherice Williams; Mohammed Hossain; Saurabh Mishra; Jorge Gonzalez-Martinez; Imad Najm; Chaitali Ghosh
Source: check_circle
Crossref

IFN-γ, IL-17A, or zonulin rapidly increase the permeability of the blood-brain and small intestinal epithelial barriers: Relevance for neuro-inflammatory diseases.

Biochem Biophys Res Commun.
2018-12 | Journal article
DOI: DOI: 10.1016/j.bbrc.2018.11.021
Source: Self-asserted source
Chaitali Ghosh

Modulation of glucocorticoid receptor in human epileptic endothelial cells impacts drug biotransformation in an in vitro blood-brain barrier model

Epilepsia
2018-09 | Journal article
DOI: DOI: 10.1111/epi.14567
Source: Self-asserted source
Chaitali Ghosh

Pregnane X Receptor Deletion Modifies Recognition Memory and Electroencephalographic Activity

Neuroscience
2018-02 | Journal article
DOI: 10.1016/j.neuroscience.2017.07.038
Part of ISSN: 0306-4522
Source: Self-asserted source
Chaitali Ghosh

Hepatic and hippocampal cytochrome P450 enzyme overexpression during spontaneous recurrent seizures

Epilepsia
2018-01 | Journal article
DOI: 10.1111/epi.13942
Part of ISSN: 0013-9580
Source: Self-asserted source
Chaitali Ghosh

Sterile Neuroinflammation and Strategies for Therapeutic Intervention

International Journal of Inflammation
2017 | Journal article
DOI: 10.1155/2017/8385961
Contributors: Manoj Banjara; Chaitali Ghosh
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search
grade
Preferred source (of 2)‎

Overexpression of pregnane X and glucocorticoid receptors and the regulation of cytochrome P450 in human epileptic brain endothelial cells

Epilepsia
2017-04 | Journal article
DOI: 10.1111/epi.13703
Source: Self-asserted source
Chaitali Ghosh

Lack of CAR impacts neuronal function and cerebrovascular integrity in vivo

Experimental Neurology
2016-09 | Journal article
DOI: 10.1016/j.expneurol.2016.05.018
Contributors: Baddreddine Boussadia; Giuseppe Gangarossa; Laila Mselli-Lakhal; Marie-Claude Rousset; Frederic de Bock; Frederic Lassere; Chaitali Ghosh; Jean-Marc Pascussi; Damir Janigro; Nicola Marchi
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Pathophysiological implications of neurovascular P450 in brain disorders.

Drug Discovery Today, Jun 14. pii: S1359-6446(16)30219-7
2016-06 | Journal article
DOI: 10.1016/j.drudis.2016.06.004
Source: Self-asserted source
Chaitali Ghosh
grade
Preferred source (of 2)‎

Is phosphorylated tau unique to chronic traumatic encephalopathy? Phosphorylated tau in epileptic brain and chronic traumatic encephalopathy

Brain Research
2016-01 | Journal article
DOI: 10.1016/j.brainres.2015.11.007
Contributors: Vikram Puvenna; Madeline Engeler; Manoj Banjara; Chanda Brennan; Peter Schreiber; Aaron Dadas; Ashkon Bahrami; Jesal Solanki; Anasua Bandyopadhyay; Jacqueline K. Morris et al.
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: an in vitro study.

Epilepsia. Mar; 56(3):439-49.
2015-03 | Journal article
Source: Self-asserted source
Chaitali Ghosh

Sertraline-induced potentiation of the CYP3A4-dependent neurotoxicity of carbamazepine: An in vitro study

Epilepsia
2015-02-05 | Journal article
DOI: 10.1111/epi.12923
Contributors: Chaitali Ghosh; Mohammad Hossain; Addison Spriggs; Arnab Ghosh; Gerald A. Grant; Nicola Marchi; Emilio Perucca; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Is Peripheral Immunity Regulated by Blood-Brain Barrier Permeability Changes?

PLoS ONE
2014-07-02 | Journal article
DOI:

10.1371/journal.pone.0101477
Contributors: Erin Bargerstock; Vikram Puvenna; Philip Iffland; Tatiana Falcone; Mohammad Hossain; Stephen Vetter; Shumei Man; Leah Dickstein; Nicola Marchi; Chaitali Ghosh et al.
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Intracellular and circulating neuronal antinuclear antibodies in human epilepsy

Neurobiology of Disease
2013-11 | Journal article
DOI:

10.1016/j.nbd.2013.07.006
Contributors: Philip H. Iffland; Juliana Carvalho-Tavares; Abhishek Trigunaite; Shumei Man; Peter Rasmussen; Andreas Alexopoulos; Chaitali Ghosh; Trine N. Jørgensen; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Expression and functional relevance of UGT1A4 in a cohort of human drug-resistant epileptic brains

Epilepsia
2013-07 | Journal article
DOI:

10.1111/epi.12318
Contributors: Chaitali Ghosh; Mohammed Hossain; Vikram Puvenna; Jorge Martinez-Gonzalez; Andreas Alexopolous; Damir Janigro; Nicola Marchi
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Consequences of Repeated Blood-Brain Barrier Disruption in Football Players

PLoS ONE
2013-03-06 | Journal article
DOI: 10.1371/journal.pone.0056805
Contributors: Nicola Marchi; Jeffrey J. Bazarian; Vikram Puvenna; Mattia Janigro; Chaitali Ghosh; Jianhui Zhong; Tong Zhu; Eric Blackman; Desiree Stewart; Jasmina Ellis et al.
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Blood-brain barrier dysfunction and epilepsy: Pathophysiologic role and therapeutic approaches

Epilepsia
2012-08 | Journal article
DOI:

10.1111/j.1528-1167.2012.03637.x
Contributors: Nicola Marchi; Tiziana Granata; Chaitali Ghosh; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

A pro-convulsive carbamazepine metabolite: Quinolinic acid in drug resistant epileptic human brain

Neurobiology of Disease
2012-06 | Journal article
DOI:

10.1016/j.nbd.2012.03.010
Contributors: Chaitali Ghosh; Nicola Marchi; Mohammed Hossain; Peter Rasmussen; Andreas V. Alexopoulos; Jorge Gonzalez-Martinez; Hu Yang; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Nanomaterial-mediated CNS delivery of diagnostic and therapeutic agents

Advanced Drug Delivery Reviews
2012-05 | Journal article
DOI:

10.1016/j.addr.2011.11.014
Contributors: Laura Biddlestone-Thorpe; Nicola Marchi; Kathy Guo; Chaitali Ghosh; Damir Janigro; Kristoffer Valerie; Hu Yang
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases

CDM
2011-10-01 | Journal article
DOI:

10.2174/138920011798357051
Contributors: Chaitali Ghosh; Vikram Puvenna; Jorge Gonzalez-Martinez; Damir Janigro; Nicola Marchi
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Blood-Brain Barrier P450 Enzymes and Multidrug Transporters in Drug Resistance: A Synergistic Role in Neurological Diseases

CDM
2011-06 | Journal article
DOI:

10.2174/1389211215689372002
Contributors: Chaitali Ghosh
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Modulation of peripheral cytotoxic cells and ictogenesis in a model of seizures

Epilepsia
2011-05 | Journal article
DOI:

10.1111/j.1528-1167.2011.03080.x
Contributors: Nicola Marchi; Aaron J. Johnson; Vikram Puvenna; Holly L. Johnson; William Tierney; Chaitali Ghosh; Luca Cucullo; Paolo F. Fabene; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Cellular localization and functional significance of CYP3A4 in the human epileptic brain

Epilepsia
2011-02-05 | Journal article
DOI:

10.1111/j.1528-1167.2010.02956.x
Contributors: Chaitali Ghosh; Nicola Marchi; Nirav K. Desai; Vikram Puvenna; Mohammed Hossain; Jorge Gonzalez-Martinez; Andreas V. Alexopoulos; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Blood–brain barrier damage, but not parenchymal white blood cells, is a hallmark of seizure activity

Brain Research
2010-09 | Journal article
DOI:

10.1016/j.brainres.2010.06.051
Contributors: Nicola Marchi; Qingshan Teng; Chaitali Ghosh; Qingyuan Fan; Minh T. Nguyen; Nirav K. Desai; Harpreet Bawa; Peter Rasmussen; Thomas K. Masaryk; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Pattern of P450 expression at the human blood-brain barrier: Roles of epileptic condition and laminar flow

Epilepsia
2010-01 | Journal article
DOI: 10.1111/j.1528-1167.2009.02428.x
Contributors: Chaitali Ghosh; Jorge Gonzalez-Martinez; Mohammed Hossain; Luca Cucullo; Vincent Fazio; Damir Janigro; Nicola Marchi
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Drug Permeation Across the Fetal Maternal Barrier

Mammalian Brain Development
2009 | Other
DOI:

10.1007/978-1-60761-287-2_8
Contributors: Chaitali Ghosh; Nicola Marchi
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Management of the patient with medically refractory epilepsy

Expert Review of Neurotherapeutics
2009 | Journal article
DOI:

10.1586/ern.09.114
Contributors: Tiziana Granata; Nicola Marchi; Erin Carlton; Chaitali Ghosh; Jorge Gonzalez-Martinez; Andreas V Alexopoulos; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Blood-brain barrier damage and brain penetration of antiepileptic drugs: Role of serum proteins and brain edema

Epilepsia
2009-04 | Journal article
DOI:

10.1111/j.1528-1167.2008.01989.x
Contributors: Nicola Marchi; Giulia Betto; Vincent Fazio; Quinyuan Fan; Chaitali Ghosh; Andre Machado; Damir Janigro
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Antagonism of peripheral inflammation reduces the severity of status epilepticus

Neurobiology of Disease
2009-02 | Journal article
DOI:

10.1016/j.nbd.2008.10.002
Contributors: Nicola Marchi; Qingyuan Fan; Chaitali Ghosh; Vincent Fazio; Francesca Bertolini; Giulia Betto; Ayush Batra; Erin Carlton; Imad Najm; Tiziana Granata et al.
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Glutamate and metabotropic glutamate receptors associated with innervation of the uterine cervix during pregnancy: Receptor antagonism inhibits c-fos expression in rat lumbosacral spinal cord at parturition

J. Neurosci. Res.
2007 | Journal article
DOI:

10.1002/jnr.21225
Contributors: Chaitali Ghosh; Megan Storey-Workley; Sharon Usip; Jen Hafemeister; Kenneth E. Miller; Raymond E. Papka
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Behavioral and neurochemical effects induced by pyrethroid-based mosquito repellent exposure in rat offsprings during prenatal and early postnatal period

Neurotoxicology and Teratology
2006-07 | Journal article
DOI:

10.1016/j.ntt.2006.03.005
Contributors: Chaitali Sinha; Kavita Seth; Fakhrul Islam; Rajnish Kumar Chaturvedi; Shubha Shukla; Neeraj Mathur; N. Srivastava; Ashok Kumar Agrawal
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Neuroprotective and neurorescue effect of black tea extract in 6-hydroxydopamine-lesioned rat model of Parkinson's disease

Neurobiology of Disease
2006-05 | Journal article
DOI: 10.1016/j.nbd.2005.12.008
Contributors: R.K. Chaturvedi; S. Shukla; K. Seth; S. Chauhan; C. Sinha; Y. Shukla; A.K. Agrawal
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Co-transplantation of carotid body and ventral mesencephalic cells as an alternative approach towards functional restoration in 6-hydroxydopamine-lesioned rats: implications for Parkinson's disease

Journal of Neurochemistry
2004-10 | Journal article
DOI: 10.1111/j.1471-4159.2004.02715.x
Contributors: S. Shukla; A. K. Agrawal; R. K. Chaturvedi; K. Seth; N. Srivastava; C. Sinha; Y. Shukla; V. K. Khanna; P. K. Seth
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Mosquito repellent (pyrethroid-based) induced dysfunction of blood–brain barrier permeability in developing brain

International Journal of Developmental Neuroscience
2004-02 | Journal article
DOI: 10.1016/j.ijdevneu.2003.10.005
Contributors: C Sinha; A.K Agrawal; F Islam; K Seth; R.K Chaturvedi; S Shukla; P.K Seth
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Species variation in pesticide-induced blood-brain barrier dysfunction

hum exp toxicol
2003 | Journal article
DOI:

10.1191/0960327103ht405oa
Contributors: Chaitali Sinha; Girja S Shukla
Source: Self-asserted source
Chaitali Ghosh via Crossref Metadata Search

Peer review (6 reviews for 1 publication/grant)

Review activity for Fluids and barriers of the CNS. (6)
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