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Employment (1)

Zhongnan Hospital of Wuhan University: Wuhan, CN

2018-02-01 to present | Director of wet biobank (Department of Biological Repositories)
Employment
Source: Self-asserted source
Kaiyu Qian

Education and qualifications (1)

Wuhan University: Wuhan, Hubei, CN

2014-09-06 to 2017-06-22 | doctoral degree (urology)
Education
Source: Self-asserted source
Kaiyu Qian

Works (38)

Elucidating the pathogenesis of bladder cancer through single-cell chromatin accessibility and DNA methylation analysis

Genes & Diseases
2025-03 | Journal article
DOI: 10.1016/j.gendis.2025.101578
Contributors: Yu Xiao; Lingao Ju; Gang Wang; Wan Jin; Hongwei Peng; Zongning Zhou; Mengxue Yu; Yi Zhang; Kaiyu Qian; Xinghuan Wang
Source: check_circle
Crossref

RBPMS inhibits bladder cancer metastasis by downregulating MYC pathway through alternative splicing of ANKRD10

Communications Biology
2025-03-05 | Journal article
DOI: 10.1038/s42003-025-07842-1
Contributors: Jingtian Yu; Liang Chen; Gang Wang; Kaiyu Qian; Hong Weng; Zhonghua Yang; Hang Zheng; Mengxin Lu
Source: check_circle
Crossref

Mevalonate pathway inhibition reduces bladder cancer metastasis by modulating RhoB protein stability and integrin β1 localization

Communications Biology
2024-11-09 | Journal article
DOI: 10.1038/s42003-024-07067-8
Contributors: Gang Wang; Tianchen Peng; Liang Chen; Kangping Xiong; Lingao Ju; Kaiyu Qian; Yi Zhang; Yu Xiao; Xinghuan Wang
Source: check_circle
Crossref

Unveiling the association between HMG-CoA reductase inhibitors and bladder cancer: a comprehensive analysis using Mendelian randomization, animal models, and transcriptomics

The Pharmacogenomics Journal
2024-10 | Journal article
DOI: 10.1038/s41397-024-00346-x
Contributors: Houyi Wei; Zhilong Li; Kaiyu Qian; Wenzhi Du; Lingao Ju; Danni Shan; Mengxue Yu; Yayun Fang; Yi Zhang; Yu Xiao et al.
Source: check_circle
Crossref

Evaluation of DNA extracted from residual blood clots after serological testing

Cell Biochemistry and Function
2024-06 | Journal article
DOI: 10.1002/cbf.4023
Contributors: Shanshan Zhang; Xiangqun Cheng; Gui Yang; Hongwei Peng; Cong Zou; Dongai Yao; Kaiyu Qian
Source: check_circle
Crossref

The impact of preanalytical variables on the analysis of cell-free DNA from blood and urine samples.

Frontiers in cell and developmental biology
2024-05-09 | Review
DOI: 10.3389/fcell.2024.1385041
PMID: 38784382
PMC: PMC11111958
Contributors: Peng H; Pan M; Zhou Z; Chen C; Xing X; Cheng S; Zhang S; Zheng H; Qian K
Source: Self-asserted source
Kaiyu Qian

Tracking single-cell evolution using clock-like chromatin accessibility loci

Nature Biotechnology
2024-05-09 | Journal article
DOI: 10.1038/s41587-024-02241-z
Contributors: Yu Xiao; Wan Jin; Lingao Ju; Jie Fu; Gang Wang; Mengxue Yu; Fangjin Chen; Kaiyu Qian; Xinghuan Wang; Yi Zhang
Source: check_circle
Crossref

Integrative Single Cell Atlas Revealed Intratumoral Heterogeneity Generation from an Adaptive Epigenetic Cell State in Human Bladder Urothelial Carcinoma.

Advanced science (Weinheim, Baden-Wurttemberg, Germany)
2024-04-06 | Journal article
DOI: 10.1002/advs.202308438
PMID: 38582099
Contributors: Yu Xiao; Wan Jin; Qian K; Lingao Ju; Wang G; Wu K; Cao R; Chang L; Xu Z; Luo J et al.
Source: Self-asserted source
Kaiyu Qian

DLGAP5 triggers proliferation and metastasis of bladder cancer by stabilizing E2F1 via USP11

Oncogene
2024-02-16 | Journal article
DOI: 10.1038/s41388-023-02932-y
Contributors: Fenfang Zhou; Zhao Deng; Dexin Shen; Mengxin Lu; Mingxing Li; Jingtian Yu; Yu Xiao; Gang Wang; Kaiyu Qian; Lingao Ju et al.
Source: check_circle
Crossref

TRAIP suppresses bladder cancer progression by catalyzing K48-linked polyubiquitination of MYC

Oncogene
2024-02-09 | Journal article
DOI: 10.1038/s41388-023-02922-0
Contributors: Jingtian Yu; Mingxing Li; Lingao Ju; Fenfang Zhou; Yejinpeng Wang; Yi Zhang; Renjie Zhang; Wenzhi Du; Ruoyu Huang; Kaiyu Qian et al.
Source: check_circle
Crossref

UPP1 enhances bladder cancer progression and gemcitabine resistance through AKT.

International journal of biological sciences
2024-01-27 | Journal article
DOI: 10.7150/ijbs.83774
PMID: 38385072
PMC: PMC10878145
Contributors: Du W; Tu S; Zhang W; Zhang Y; Wei Liu; Xiong K; Zhou F; Li N; Zhang R; Yu J et al.
Source: Self-asserted source
Kaiyu Qian

Pectolinarigenin inhibits bladder urothelial carcinoma cell proliferation by regulating DNA damage/autophagy pathways

Cell Death Discovery
2023-07-01 | Journal article
DOI: 10.1038/s41420-023-01508-9
Contributors: Zhao Deng; Dexin Shen; Mengxue Yu; Fenfang Zhou; Danni Shan; Yayun Fang; Wan Jin; Kaiyu Qian; Shenjuan Li; Gang Wang et al.
Source: check_circle
Crossref

Aspartoacylase suppresses prostate cancer progression by blocking LYN activation.

Military Medical Research
2023-06-05 | Journal article
DOI: 10.1186/s40779-023-00460-0
PMID: 37271807
PMC: PMC10240701
Contributors: Hong Weng; Xiong KP; Wang W; Qian KY; Yuan S; Wang G; Yu F; Luo J; Lu MX; Yang ZH et al.
Source: Self-asserted source
Kaiyu Qian

DNA polymerase POLD1 promotes proliferation and metastasis of bladder cancer by stabilizing MYC

Nature Communications
2023-04-27 | Journal article
DOI: 10.1038/s41467-023-38160-x
Contributors: Yejinpeng Wang; Lingao Ju; Gang Wang; Kaiyu Qian; Wan Jin; Mingxing Li; Jingtian Yu; Yiliang Shi; Yongzhi Wang; Yi Zhang et al.
Source: check_circle
Crossref

Melatonin inhibits bladder tumorigenesis by suppressing PPARγ/ENO1-mediated glycolysis

Cell Death & Disease
2023-04-06 | Journal article
DOI: 10.1038/s41419-023-05770-8
Contributors: Dexin Shen; Zhao Deng; Wei Liu; Fenfang Zhou; Yayun Fang; Danni Shan; Gang Wang; Kaiyu Qian; Mengxue Yu; Yi Zhang et al.
Source: check_circle
Crossref

Effects of Freezing and Rewarming Methods on RNA Quality of Blood Samples

Biopreservation and Biobanking
2023-04-01 | Journal article
DOI: 10.1089/bio.2022.0007
Contributors: Cong Zou; Chundong Ji; Yuan Zhu; Nan Liu; Shanshan Zhang; Hongwei Peng; Xin Zhang; Hui Wang; Yanhua Deng; Kaiyu Qian
Source: check_circle
Crossref

MYBL2 promotes proliferation and metastasis of bladder cancer through transactivation of CDCA3

Oncogene
2022-10-07 | Journal article
DOI: 10.1038/s41388-022-02456-x
Contributors: Wei Liu; Dexin Shen; Lingao Ju; Renjie Zhang; Wenzhi Du; Wan Jin; Kangping Xiong; Gang Wang; Kaiyu Qian; Yi Zhang et al.
Source: check_circle
Crossref

Ultrasensitive tumour-agnostic non-invasive detection of colorectal cancer recurrence using ctDNA methylation.

Clinical and translational medicine
2022-09-01 | Journal article
DOI: 10.1002/ctm2.1015
PMID: 36103400
PMC: PMC9473485
Contributors: Yu Xiao; Wang X; Hong Weng; Ding Z; Qian K; Wan Jin; Lu S; Lingao Ju; He Z; Wang G et al.
Source: Self-asserted source
Kaiyu Qian

Non-invasive diagnosis and surveillance of bladder cancer with driver and passenger DNA methylation in a prospective cohort study.

Clinical and translational medicine
2022-08-01 | Journal article
DOI: 10.1002/ctm2.1008
PMID: 35968916
PMC: PMC9377153
Contributors: Yu Xiao; Lingao Ju; Qian K; Wan Jin; Wang G; Zhao Y; Jiang W; Liu N; Wu K; Peng M et al.
Source: Self-asserted source
Kaiyu Qian

PRR11 promotes ccRCC tumorigenesis by regulating E2F1 stability

JCI Insight
2021-10-08 | Journal article
DOI: 10.1172/jci.insight.145172
Contributors: Siming Chen; Zhiwen He; Tianchen Peng; Fenfang Zhou; Gang Wang; Kaiyu Qian; Lingao Ju; Yu Xiao; Xinghuan Wang
Source: check_circle
Crossref

The cholesterol esterification inhibitor avasimibe suppresses tumour proliferation and metastasis via the E2F-1 signalling pathway in prostate cancer.

Cancer cell international
2021-08-30 | Journal article
DOI: 10.1186/s12935-021-02175-5
PMID: 34461908
PMC: PMC8407011
Contributors: Xiong K; Wang G; Peng T; Zhou F; Chen S; Wei Liu; Lingao Ju; Yu Xiao; Qian K; Xinghuan Wang
Source: Self-asserted source
Kaiyu Qian

E3 ubiquitin ligase RNF126 affects bladder cancer progression through regulation of PTEN stability

Cell Death & Disease
2021-03-04 | Journal article
DOI: 10.1038/s41419-021-03521-1
Contributors: Huimin Xu; Lingao Ju; Yaoyi Xiong; Mengxue Yu; Fenfang Zhou; Kaiyu Qian; Gang Wang; Yu Xiao; Xinghuan Wang
Source: check_circle
Crossref

Effects of Warm Ischemia Time, Cryopreservation, and Grinding Methods on RNA Quality of Mouse Kidney Tissues.

Biopreservation and biobanking
2021-02-12 | Journal article
DOI: 10.1089/bio.2020.0129
PMID: 33577406
Contributors: Liu N; Luo Y; Zhu Y; Peng H; Zou C; Zhou Z; Chen W; Wang H; Liu H; Hu Y et al.
Source: Self-asserted source
Kaiyu Qian

Mutational burden and chromosomal aneuploidy synergistically predict survival from radiotherapy in non-small cell lung cancer

Communications Biology
2021-01-29 | Journal article
DOI: 10.1038/s42003-021-01657-6
Contributors: Qingzhu Jia; Qian Chu; Anmei Zhang; Jing Yu; Fangfang Liu; Kaiyu Qian; Yu Xiao; Xue Wang; Ying Yang; Yi Zhao et al.
Source: check_circle
Crossref

A novel germline EGFR variant p.R831H causes predisposition to familial CDK12-mutant prostate cancer with tandem duplicator phenotype

Oncogene
2020-10-29 | Journal article
DOI: 10.1038/s41388-020-01476-9
Contributors: Kaiyu Qian; Gang Wang; Lingao Ju; Jiyan Liu; Yongwen Luo; Yejinpeng Wang; Tianchen Peng; Fangjin Chen; Yi Zhang; Yu Xiao et al.
Source: check_circle
Crossref

<p>TRPM8 Inhibition Regulates the Proliferation, Migration and ROS Metabolism of Bladder Cancer Cells</p>

OncoTargets and Therapy
2020-09 | Journal article
DOI: 10.2147/OTT.S257056
Contributors: Gang Wang; Rui Cao; Kaiyu Qian; Tianchen Peng; Lushun Yuan; Liang Chen; Songtao Cheng; Yaoyi Xiong; Lingao Ju; Xinghuan Wang et al.
Source: check_circle
Crossref

PPARα gene is a diagnostic and prognostic biomarker in clear cell renal cell carcinoma by integrated bioinformatics analysis.

Journal of Cancer
2019-05-22 | Journal article
DOI: 10.7150/jca.29178
PMID: 31258735
PMC: PMC6584416
Contributors: Luo Y; Chen L; Wang G; Qian G; Liu X; Yu Xiao; Wang X; Qian K
Source: Self-asserted source
Kaiyu Qian

Long non-coding RNA SNHG6 is upregulated in prostate cancer and predicts poor prognosis.

Molecular biology reports
2019-03-25 | Journal article | Author
DOI: 10.1007/s11033-019-04723-9
PMID: 30911973
Contributors: Yan Y; Chen Z; Yu Xiao; Xinghuan Wang; Kaiyu Qian
Source: Self-asserted source
Kaiyu Qian
grade
Preferred source (of 2)‎

PPARγ inhibition regulates the cell cycle, proliferation and motility of bladder cancer cells.

Journal of cellular and molecular medicine
2019-03-25 | Journal article
DOI: 10.1111/jcmm.14280
PMID: 30912275
PMC: PMC6484405
Contributors: songtao cheng; Qian K; Wang Y; Wang G; Liu X; Yu Xiao; Wang X
Source: Self-asserted source
Kaiyu Qian

Establishing a prediction model for prostate cancer bone metastasis.

International journal of biological sciences
2019-01-01 | Journal article
DOI: 10.7150/ijbs.27537
PMID: 30662360
PMC: PMC6329914
Contributors: Chen S; Wang L; Qian K; Jiang W; Deng H; Zhou Q; Wang G; Liu X; Wu CL; Yu Xiao et al.
Source: Self-asserted source
Kaiyu Qian

Identification of Biomarkers Associated With Pathological Stage and Prognosis of Clear Cell Renal Cell Carcinoma by Co-expression Network Analysis.

Frontiers in Physiology
2018 | Journal article
DOI: 10.3389/fphys.2018.00399
PMID: 29720944
PMC: PMC5915556
Contributors: Chen L; Yuan L; Qian K; Qian G; Zhu Y; Wu CL; Dan HC; Xiao Y; Wang X
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

Bioinformatics and functional analyses of key genes and pathways in human clear cell renal cell carcinoma.

Oncology letters
2018-06 | Journal article
DOI: 10.3892/ol.2018.8473
PMID: 29805645
PMC: PMC5958663
Contributors: Wang J; Yuan L; Liu X; Wang G; Zhu Y; Qian K; Xiao Y; Wang X
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

A novel correlation between ATP5A1 gene expression and progression of human clear cell renal cell carcinoma identified by co‑expression analysis.

Oncology reports
2018-02 | Journal article
DOI: 10.3892/or.2017.6132
PMID: 29207195
PMC: PMC5783621
Contributors: Yuan L; Chen L; Qian K; Wang G; Lu M; Qian G; Cao X; Jiang W; Xiao Y; Wang X
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

TM4SF1 regulates apoptosis, cell cycle and ROS metabolism via the PPARγ-SIRT1 feedback loop in human bladder cancer cells.

Cancer letters
2018-02 | Journal article
DOI: 10.1016/j.canlet.2017.11.015
PMID: 29175458
Contributors: Cao R; Wang G; Qian K; Chen L; Ju L; Qian G; Wu CL; Dan HC; Jiang W; Wu M et al.
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

Silencing of HJURP induces dysregulation of cell cycle and ROS metabolism in bladder cancer cells via PPARγ-SIRT1 feedback loop.

Journal of Cancer
2017 | Journal article
DOI: 10.7150/jca.19967
PMID: 28819432
PMC: PMC5560147
Contributors: Cao R; Wang G; Qian K; Chen L; Qian G; Xie C; Dan HC; Jiang W; Wu M; Wu CL et al.
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

Co-expression network analysis identified six hub genes in association with progression and prognosis in human clear cell renal cell carcinoma (ccRCC).

Genomics data
2017-12 | Journal article
DOI: 10.1016/j.gdata.2017.10.006
PMID: 29159069
PMC: PMC5683669
Contributors: Yuan L; Chen L; Qian K; Qian G; Wu CL; Wang X; Xiao Y
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

Overexpression of COL3A1 confers a poor prognosis in human bladder cancer identified by co-expression analysis.

Oncotarget
2017-09 | Journal article
DOI: 10.18632/oncotarget.19733
PMID: 29050298
PMC: PMC5642573
Contributors: Yuan L; Shu B; Chen L; Qian K; Wang Y; Qian G; Zhu Y; Cao X; Xie C; Xiao Y et al.
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central

Capsaicin Suppresses Cell Proliferation, Induces Cell Cycle Arrest and ROS Production in Bladder Cancer Cells through FOXO3a-Mediated Pathways.

Molecules (Basel, Switzerland)
2016-10 | Journal article
DOI: 10.3390/molecules21101406
PMID: 27775662
Contributors: Qian K; Wang G; Cao R; Liu T; Qian G; Guan X; Guo Z; Xiao Y; Wang X
Source: Self-asserted source
Kaiyu Qian via Europe PubMed Central
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