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Catalase Inhibitors with Dual Pro-Oxidant Effect as New Therapeutic Agents in Castration-Resistant Prostate Cancer

Advanced Therapeutics
2021 | Journal article
EID:

2-s2.0-85103140897

Part of ISSN: 23663987
Contributors: Chen, Y.-Y.; Liang, H.-Q.; Liu, M.-T.; Huang, W.; Yi, P.-F.; Yuan, S.-Q.; Mei, L.-C.; Hu, Y.-H.; Cao, Y.-Y.; Hao, G.-F. et al.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Erratum to: LARMD: integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor

Briefings in bioinformatics
2021 | Journal article
EID:

2-s2.0-85100280752

Part of ISSN: 14774054
Contributors: Yang, J.-F.; Wang, F.; Chen, Y.-Z.; Hao, G.-F.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Expanding the Chemical Space of Succinate Dehydrogenase Inhibitors via the Carbon-Silicon Switch Strategy

Journal of agricultural and food chemistry
2021 | Journal article
EID:

2-s2.0-85104047802

Part of ISSN: 15205118
Contributors: Wei, G.; Huang, M.-W.; Wang, W.-J.; Wu, Y.; Mei, S.-F.; Zhou, L.-M.; Mei, L.-C.; Zhu, X.-L.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Genetic Engineering and Chemical Control Related to Abscisic Acid for Improving Plant Drought Tolerance

Journal of Agricultural and Food Chemistry
2021 | Journal article
EID:

2-s2.0-85103670944

Part of ISSN: 15205118 00218561
Contributors: Yang, J.-F.; Hao, G.-F.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

PIIMS Server: A Web Server for Mutation Hotspot Scanning at the Protein-Protein Interface

Journal of Chemical Information and Modeling
2021 | Journal article
EID:

2-s2.0-85099644078

Part of ISSN: 15205142 15499596
Contributors: Wu, F.-X.; Yang, J.-F.; Mei, L.-C.; Wang, F.; Hao, G.-F.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Redox probes tagged electrochemical aptasensing device for simultaneous detection of multiple cytokines in real time

Sensors and Actuators, B: Chemical
2021 | Journal article
EID:

2-s2.0-85102538764

Part of ISSN: 09254005
Contributors: Shen, Z.; Ni, S.; Yang, W.; Sun, W.; Yang, G.; Liu, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Structure-Guided Discovery of Silicon-Containing Subnanomolar Inhibitor of Hydroxyphenylpyruvate Dioxygenase as a Potential Herbicide

Journal of Agricultural and Food Chemistry
2021 | Journal article
EID:

2-s2.0-85100070516

Part of ISSN: 15205118 00218561
Contributors: Qu, R.-Y.; Nan, J.-X.; Yan, Y.-C.; Chen, Q.; Ndikuryayo, F.; Wei, X.-F.; Yang, W.-C.; Lin, H.-Y.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

The structure of 4-hydroxylphenylpyruvate dioxygenase complexed with 4-hydroxylphenylpyruvic acid reveals an unexpected inhibition mechanism

Chinese Chemical Letters
2021 | Journal article
EID:

2-s2.0-85101981170

Part of ISSN: 10018417
Contributors: Wang, X.; Lin, H.; Liu, J.; Zhao, X.; Chen, X.; Yang, W.; Yang, G.; Zhan, C.-G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Where are the new herbicides?

Pest Management Science
2021 | Journal article
EID:

2-s2.0-85100267798

Part of ISSN: 15264998 1526498X
Contributors: Qu, R.-Y.; He, B.; Yang, J.-F.; Lin, H.-Y.; Yang, W.-C.; Wu, Q.-Y.; Li, Q.X.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

LARMD: Integration of bioinformatic resources to profile ligand-driven protein dynamics with a case on the activation of estrogen receptor

Briefings in Bioinformatics
2020 | Journal article
EID:

2-s2.0-85097211356

Part of ISSN: 14774054 14675463
Contributors: Yang, J.-F.; Wang, F.; Chen, Y.-Z.; Hao, G.-F.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Near-Infrared Fluorescence/Photoacoustic Agent with an Intensifying Optical Performance for Imaging-Guided Effective Photothermal Therapy

Advanced Therapeutics
2020 | Journal article
EID:

2-s2.0-85101974614

Part of ISSN: 23663987
Contributors: Ye, F.; Huang, W.; Li, C.; Li, G.; Yang, W.-C.; Liu, S.H.; Yin, J.; Sun, Y.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Identification, evolution and alternative splicing profile analysis of the splicing factor 30 (SPF30) in plant species

Planta
2019 | Journal article
EID:

2-s2.0-85064157624

Part of ISSN: 14322048 00320935
Contributors: Zhang, D.; Yang, J.-F.; Gao, B.; Liu, T.-Y.; Hao, G.-F.; Yang, G.-F.; Fu, L.-J.; Chen, M.-X.; Zhang, J.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

An update on poly(ADP-ribose)polymerase-1 (PARP-1) inhibitors: Opportunities and challenges in cancer therapy

Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84994908887

Part of ISSN: 15204804 00222623
Contributors: Wang, Y.-Q.; Wang, P.-Y.; Wang, Y.-T.; Yang, G.-F.; Zhang, A.; Miao, Z.-H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A comprehensive study on micellization of dissymmetric pyrrolidinium headgroup-based gemini surfactants

Physical Chemistry Chemical Physics
2015 | Journal article
EID:

2-s2.0-84926443424

Part of ISSN: 14639076
Contributors: Zou, M.; Dong, J.; Yang, G.; Li, X.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

PH-responsive surface activity and solubilization with novel pyrrolidone-based gemini surfactants

Langmuir
2012 | Journal article
EID:

2-s2.0-84860711118

Part of ISSN: 07437463 15205827
Contributors: Jiang, Z.; Li, X.; Yang, G.; Cheng, L.; Cai, B.; Yang, Y.; Dong, J.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Erratum: Axially 4,4′-di-tert-butyl TunePhos-type chiral diphosphine ligand: Synthesis and applications in asymmetric hydrogenation (Tetrahedron Letters (2009) 50 (1038-1040))

Tetrahedron Letters
2011 | Journal article
EID:

2-s2.0-78650241580

Part of ISSN: 00404039
Contributors: Wang, C.-J.; Wang, C.-B.; Chen, D.; Yang, G.; Wu, Z.; Zhang, X.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Axially 4,4′-di-tert-butyl TunePhos-type chiral diphosphine ligand: synthesis and applications in asymmetric hydrogenation

Tetrahedron Letters
2009 | Journal article
EID:

2-s2.0-58149499430

Part of ISSN: 00404039
Contributors: Wang, C.-J.; Wang, C.-B.; Chen, D.; Yang, G.; Wu, Z.; Zhang, X.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Supramolecular rhombic grids formed from bimolecular building blocks

Journal of the American Chemical Society
2009 | Journal article
EID:

2-s2.0-69049102048

Part of ISSN: 00027863
Contributors: She, N.-F.; Gao, M.; Meng, X.-G.; Yang, G.-F.; Elemans, J.A.A.W.; Wu, A.-X.; Isaacs, L.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis and oxidation-induced DNA cross-linking capabilities of bis(catechol) quaternary ammonium derivatives

Chemistry - A European Journal
2008 | Journal article
EID:

2-s2.0-53849105066

Part of ISSN: 09476539 15213765
Contributors: Song, Z.; Weng, X.; Weng, L.; Huang, J.; Wang, X.; Bai, M.; Zhou, Y.; Yang, G.; Zhou, X.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

High-throughput screening: Establishing mathematical and physical models for bio-target immobilization

Journal of Mathematical Chemistry
2007 | Journal article
EID:

2-s2.0-33947574471

Part of ISSN: 02599791
Contributors: Li, S.; Li, W.; Hao, X.; Chen, P.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Structure-based rational quest for potential novel inhibitors of human HMG-CoA reductase by combining CoMFA 3D QSAR modeling and virtual screening

Journal of Combinatorial Chemistry
2007 | Journal article
EID:

2-s2.0-33846601387

Part of ISSN: 15204766
Contributors: Zhang, Q.Y.; Wan, J.; Xu, X.; Yang, G.F.; Ren, Y.L.; Liu, J.J.; Wang, H.; Guo, Y.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

2-(1,3-Dioxo-4,5,6,7-tetrahydro-1 H-isoindol-2-yl)-N-[7-fluoro-3-oxo-4-(prop-2-ynyl)-3, 4-dihydro-2H-benzoxazin-6-yl]-acetamide monohydrate

Acta Crystallographica Section E: Structure Reports Online
2006 | Journal article
EID:

2-s2.0-33644752662

Part of ISSN: 16005368 16005368
Contributors: Min, Z.-C.; Huang, M.-Z.; Chen, W.-M.; Zhang, Q.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A time-dependent density functional theory investigation of the spectroscopic properties of the β-subunit in C-phycocyanin

Journal of Physical Chemistry B
2006 | Journal article
EID:

2-s2.0-84961983993

Part of ISSN: 15206106
Contributors: Ren, Y.; Wan, J.; Xu, X.; Zhang, Q.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Establishing mathematical and physical models for the adsorption of biomacromolecules

Applied Biochemistry and Biotechnology
2006 | Journal article
EID:

2-s2.0-33748365216

Part of ISSN: 02732289
Contributors: Li, S.; Chen, P.; Li, W.; Hao, X.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis and activity of novel oxime ether-acylamides

Chemistry Bulletin / Huaxue Tongbao
2006 | Journal article
EID:

2-s2.0-33947158612

Part of ISSN: 04413776
Contributors: Cheng, H.; Liu, X.; Wei, Z.; Ling, L.; Liu, Y.; Hu, C.; Yang, G.; Liu, A.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis and biological activity of 1-(pyrimidin-4-yl)-3-(2,6- difluorobenzoyl)urea derivatives

Chinese Journal of Organic Chemistry
2006 | Journal article
EID:

2-s2.0-33749872145

Part of ISSN: 02532786
Contributors: Wei, Z.-Z.; Pang, H.-L.; Liu, A.-P.; Cheng, H.; Lin, L.-Z.; Liu, Y.; Hu, C.-H.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis of 5-aryltriazole ribonucleosides via Suzuki coupling and promoted by microwave irradiation

Tetrahedron Letters
2006 | Journal article
EID:

2-s2.0-33747152193

Part of ISSN: 00404039
Contributors: Wan, J.; Zhu, R.; Xia, Y.; Qu, F.; Wu, Q.; Yang, G.; Neyts, J.; Peng, L.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Theoretical study of electronic excited states of photosynthetic reaction center in Rhodopseudomonas viridis

Science in China, Series B: Chemistry
2006 | Journal article
EID:

2-s2.0-33645769286

Part of ISSN: 10069291
Contributors: Ren, Y.; Cheng, L.; Wan, J.; Li, Y.; Liu, J.; Yang, G.; Zhang, L.; Yang, S.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

1-(2-Methylpropyl)-1H-imidazo[4,5-c]-quinolin-4-amine

Acta Crystallographica Section E: Structure Reports Online
2005 | Journal article
EID:

2-s2.0-32244442690

Part of ISSN: 16005368
Contributors: Cheng, J.; Liu, Z.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

2,2-Dichloro-N-{1-(fluoromethyl)-2-hydroxy-2-[4-(methylsulfonyl)phenyl] ethyl}acetamide

Acta Crystallographica Section E: Structure Reports Online
2005 | Journal article
EID:

2-s2.0-33144476184

Part of ISSN: 16005368
Contributors: Cheng, J.; Wang, N.-X.; Yang, G.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

4-[4-(Benzhydryloxy)piperidin-1-yl]-1-(4-tert-butylphenyl)butan-1-one

Acta Crystallographica Section E: Structure Reports Online
2005 | Journal article
EID:

2-s2.0-33144487819

Part of ISSN: 16005368
Contributors: Cheng, J.; Zhou, Z.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A time dependent density functional theory study of α-84 phycocyanobilin chromophore in C-phycocyanin

Journal of Physical Chemistry B
2005 | Journal article
EID:

2-s2.0-84962382718

Part of ISSN: 15206106
Contributors: Wan, J.; Xu, X.; Ren, Y.; Yang, G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis, fugicidal activity and quantitative structure-activity relationships of novel flavanone derivatives

Gaodeng Xuexiao Huaxue Xuebao/Chemical Journal of Chinese Universities
2004 | Journal article
EID:

2-s2.0-1842556101

Part of ISSN: 02510790
Contributors: Yang, G.-F.; Ding, Y.; Yang, H.-Z.; Wu, X.-J.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A facile synthesis of fused phosphorus-heterocycle with bioactivity via Lawesson's reagent

Phosphorus, Sulfur and Silicon and the Related Elements
2002 | Journal article
EID:

2-s2.0-0036862449

Part of ISSN: 10426507
Contributors: He, L.; Luo, Y.; Li, K.; Yang, G.; Ding, M.; Liu, X.; Wu, T.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A convenient synthesis of derivatives of 1,3,2-dioxaphosphocane-2-sulfide with bioacitivity via Lawesson's reagent

Heterocyclic Communications
2001 | Journal article
EID:

2-s2.0-0347138394

Part of ISSN: 07930283
Contributors: Luo, Y.; He, L.; Ding, M.; Yang, G.; Luo, A.; Liu, X.; Wu, T.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Syntheses and properties of new herbicidal 2-arylthio-1,2,4-triazolo[1,5-a] pyrimidine derivatives

Chinese Journal of Chemistry
2000 | Journal article
EID:

2-s2.0-0033834781

Part of ISSN: 1001604X
Contributors: Yang, G.-F.; Lu, R.-J.; Fei, X.-N.; Yang, H.-Z.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

A facile synthesis of 3-aryl-5-cyano-6-methylthiopyrimidine-2, 4-diones

Synthetic Communications
1999 | Journal article
EID:

2-s2.0-0032768585

Part of ISSN: 00397911
Contributors: Liu, H.; Yang, G.; Chen, K.; Yang, H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Acidity Constants of Herbicidal Sulfonylureas and Sulfonamides from Potentiometric Determinations in Aqueous Dimethyl Sulfoxide

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
1999 | Journal article
EID:

2-s2.0-0347667710

Part of ISSN: 02510790
Contributors: Yang, G.-F.; Liu, H.-Y.; Yang, H.-Z.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

CoMFA Studies on Herbicidal 1,2,4-Triazolo[1,5-a] pyrimidine-2-Sulfonanilides

Acta Physico - Chimica Sinica
1999 | Journal article
EID:

2-s2.0-0033442354

Part of ISSN: 10006818
Contributors: Yang, G.; Liu, H.; Yang, X.; Yang, H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, syntheses and biological activity of novel ALS inhibitors (IX) - CoMFA of sulfonylureas and triazolopyrimidine-2-sulfonamides ALS inhibitors

Science in China, Series B: Chemistry
1999 | Journal article
EID:

2-s2.0-0346541914

Part of ISSN: 10069291
Contributors: Yang, G.; Liu, H.; Yang, X.; Yang, H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, syntheses and biological activity of novel herbicides targeting ALS: VIII. Studies on structure-activity relationships of fused heterocyclic sulfonamide herbicides combined Hansch analyses and CoMFA method

Acta Chimica Sinica
1999 | Journal article
EID:

2-s2.0-0043281002

Part of ISSN: 05677351
Contributors: Yang, G.-F.; Liu, H.-Y.; Yang, X.-F.; Yang, H.-Z.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Synthesis and Structure of 3-Aryl-5-cyano-6-methylthio pyrimidin-2,4-diones

Chinese Chemical Letters
1999 | Journal article
EID:

2-s2.0-0033438846

Part of ISSN: 10018417
Contributors: Liu, H.Y.; Yang, G.F.; Yang, H.Z.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, synthesis and bioactivity of novel ALS inhibitors (V) - Initial model of the herbicidal sulfonylureas and fused heterocyclic sulfonamides binding with receptor

Science in China, Series B: Chemistry
1998 | Journal article
EID:

2-s2.0-0346361256

Part of ISSN: 10069291
Contributors: Yang, G.; Zhao, G.; Lu, R.; Liu, H.; Yang, H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, synthesis and biological activity of novel herbicides targeted ALS(XII) - Quantitative structure-activity relationships of herbicidal 1,2,4-triazolo[1,5-a]pyrimidine-2-sulfonanilides

Chinese Journal of Chemistry
1998 | Journal article
EID:

2-s2.0-0041616629

Part of ISSN: 1001604X
Contributors: Yang, G.-F.; Liu, H.-Y.; Yang, X.-F.; Yang, H.-Z.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, sytheses and bioiogical activity of novel herbicides targeted ALS: IV. Studies on the crystal structure, quantum chemistry and structure-activity relationship of 1,2,4-triazolo[1,5-a] pyrimidine-2-sulfonamides compounds

Acta Chimica Sinica
1998 | Journal article
EID:

2-s2.0-33749109937

Part of ISSN: 05677351
Contributors: Yang, G.-F.; Liu, H.-Y.; Yang, H.-Z.; Yang, X.-F.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Methanolysis and ring-opening isomerization reaction of 2-chloro-4-phenyl-5,5-dimethyl-1,3,2-dioxaphosphorinane 2-oxide(2-sulfide)

Acta Chimica Sinica
1998 | Journal article
EID:

2-s2.0-33748659008

Part of ISSN: 05677351
Contributors: Shao, R.-L.; Yang, G.-F.; Miao, W.-S.; Yang, M.-H.; Cheng, J.-R.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Studies on bio-rational design of photosystem II inhibitors ( II ) - The crystal and molecular structure of ethyl 3-benzylamino-2-cyano-3-methylthioacrylate

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
1998 | Journal article
EID:

2-s2.0-2842601264

Part of ISSN: 02510790
Contributors: Liu, H.-Y.; Yang, G.-F.; Lu, R.-J.; Tan, H.-F.; Yang, H.-Z.; Lai, L.-H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Studies on bio-rational design of photosystem II inhibitors ( V ) - Synthesis and hill inhibitory activities of ethyl arylamideacrylates and pyrimidone

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
1998 | Journal article
EID:

2-s2.0-2842513381

Part of ISSN: 02510790
Contributors: Liu, H.-Y.; Yang, G.-F.; Tan, H.-F.; Yang, H.-Z.; Lai, L.-H.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Crystal and molecular structure of 2-(2, 6-dinitro-4-trifluoromethyl)phenylthio-5, 7-dimethyl-1, 2, 4-triazolo [1, 5-a] pyrimidine

Jiegou Huaxue
1997 | Journal article
EID:

2-s2.0-2842561403

Part of ISSN: 02545861
Contributors: Yang, G.-F.; Lu, R.-J.; Yang, H.-Z.; Wang, H.-G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier

Design, syntheses and biological activity of novel herbicides targeted ALS(III) - Crystal and molecular structure of 5,7-dimethyl-N-(substitutedphenyl)-1,2,4-triazolo[1, 5-a]pyrimidine-2-sulfonamide

Kao Teng Hsueh Hsiao Hua Heush Hsueh Pao/ Chemical Journal of Chinese Universities
1997 | Journal article
EID:

2-s2.0-3142619667

Part of ISSN: 02510790
Contributors: Yang, G.-F.; Yang, H.-Z.; Lu, R.-J.; Wang, H.-G.
Source: Self-asserted source
Guang-Fu Yang via Scopus - Elsevier
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Peer review (170 reviews for 18 publications/grants)

Review activity for ACS biomaterials science & engineering. (1)
Review activity for ACS chemical neuroscience. (2)
Review activity for ACS infectious diseases. (1)
Review activity for ACS nano. (1)
Review activity for ACS omega. (7)
Review activity for ACS sensors. (2)
Review activity for ACS sustainable chemistry & engineering. (1)
Review activity for Advanced materials. (1)
Review activity for Analytical chemistry. (9)
Review activity for Chemical reviews. (1)
Review activity for Communications chemistry. (1)
Review activity for Journal of agricultural and food chemistry. (99)
Review activity for Journal of chemical education. (3)
Review activity for Journal of chemical information and modeling. (6)
Review activity for Journal of medicinal chemistry. (24)
Review activity for Journal of organic chemistry. (9)
Review activity for Scientific data. (1)
Review activity for Signal transduction and targeted therapy. (1)