Personal information

Activities

Employment (1)

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

1991-10-01 to 2017-01-01 | Docente-Investigador (Quimica)
Employment
Source: Self-asserted source
Jaime Charris

Education and qualifications (1)

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

1993-06-04 to present | Dr. Medicinal Chemistry (Quimica)
Qualification
Source: Self-asserted source
Jaime Charris

Professional activities (1)

Universidad Central de Venezuela: Caracas, Distrito Capital, VE

2016-11-24 | Reconocimiento Merito al trabajo (Orden José María Vargas)
Distinction
Source: Self-asserted source
Jaime Charris

Works (35)

Synthesis, evaluation of the biological activity against Trypanosoma cruzi and Leishmania donovani. Preliminary in silico ADMET studies of 5-nitroimidazole derivatives

European Journal of Medicinal Chemistry Reports
2025-04 | Journal article
Contributors: Miguel A. Rodríguez; Ali Mijoba; Nereida J. Parra-Giménez; Zuleyma Blanco; Katiuska Chávez; Alirica I. Suárez; Esteban Fernandez-Moreira; Hegira Ramírez; Jaime E. Charris
Source: check_circle
Crossref

Synthesis of Hybrid Molecules with Imidazole-1,3,4-thiadiazole Core and Evaluation of Biological Activity on Trypanosoma cruzi and Leishmania donovani

Molecules
2024-08-30 | Journal article
Contributors: Ali Mijoba; Nereida Parra-Giménez; Esteban Fernandez-Moreira; Hegira Ramírez; Xenón Serrano; Zuleima Blanco; Sandra Espinosa; Jaime E. Charris
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Crossref
grade
Preferred source (of 2)‎

Synthesis, Antimalarial, Antileishmanial, and Cytotoxicity Activities and Preliminary In Silico ADMET Studies of 2-(7-Chloroquinolin-4-ylamino)ethyl Benzoate Derivatives

Pharmaceuticals
2023-12 | Journal article | Author
Contributors: Joyce E. Gutiérrez; HEGIRA RAMIREZ; Esteban Fernandez-Moreira; María E. Acosta; Michael Rodney Mijares Tussaint; Juan Bautista De Sanctis; Soňa Gurská; Petr Dzubak; Marian Hajduch; Liesangerli Labrador et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Synthesis of Benzocycloalkanone-Based Michael Acceptors and Biological Activities as Antimalarial and Antitrypanosomal Agents

Molecules
2023-07-21 | Journal article
Contributors: Ali Mijoba; Esteban Fernandez-Moreira; Nereida Parra-Giménez; Sandra Espinosa-Tapia; Zuleyma Blanco; Hegira Ramírez; Jaime E. Charris
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Crossref
grade
Preferred source (of 2)‎

Molecular Mechanisms of Chloroquine and Hydroxychloroquine Used in Cancer Therapy

Anti-Cancer Agents in Medicinal Chemistry
2023-06 | Journal article
Contributors: Juan Bautista De Sanctis; Jaime Charris; Zuleyma Blanco; Hegira Ramírez; Gricelis Patricia Martínez; Michael Rodney Mijares
Source: check_circle
Crossref

Optimization of the synthesis, in silico ADME/Tox profiling studies, and evaluation of the antimalarial activity of (7-chloroquinolin-4-ylthio)alkylbenzoate derivatives

Journal of Chemical Research
2023-05 | Journal article
Contributors: Joyce E Gutiérrez; Esteban Fernandez-Moreira; María E Acosta; Hegira Ramírez; Jaime E Charris
Source: check_circle
Crossref

Efecto del compuesto N-2,6-dicloro-aralquil-2-Aminoindano en la conducta estereotipada de ratas. Acción dopaminérgica selectiva central sobre los ganglios basales más que en las estructuras límbicas.

Investigación Clínica
2023-03-03 | Journal article
Contributors: Marienmy del V. Velásquez; Alexander E. Albarracín; Kelvin Boscán; Ligia B. Angel; Rodolfo E. Izquierdo; María M. Ramírez; Biagina del C. Migliore; Jaime E. Charris; María del R. Garrido; Anita Israel et al.
Source: check_circle
Crossref

Novel 7-Chloro-(4-thioalkylquinoline) Derivatives: Synthesis and Antiproliferative Activity through Inducing Apoptosis and DNA/RNA Damage

Pharmaceuticals
2022-10 | Journal article | Author
Contributors: Joyce E. Gutiérrez; Esteban Fernandez-Moreira; Miguel A. Rodríguez; Michael Rodney Mijares Tussaint; Juan Bautista De Sanctis; Soňa Gurská; Petr Dzubak; Marian Hajduch; Julia Bruno-Colmenarez; Luis Rojas et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Synthesis, Leishmanicidal, Trypanocidal, Antiproliferative Assay and Apoptotic Induction of (2-Phenoxypyridin-3-yl)naphthalene-1(2<i>H</i>)-one Derivatives

Molecules
2022-08 | Journal article | Author
Contributors: Zuleima Blanco; Esteban Fernandez-Moreira; Michael R. Mijares; Carmen Celis; Gricelis Martinez; Juan Bautista De Sanctis; Soňa Gurská; Petr Dzubak; Marian Hajduch; Ali Mijoba et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Synthesis and in silico ADME/Tox profiling studies of heterocyclic hybrids based on chloroquine scaffolds with potential antimalarial activity

Parasitology Research
2022-01 | Journal article
Contributors: Hegira Ramírez; Esteban Fernandez-Moreira; Juan R. Rodrigues; Michael R. Mijares; Jorge E. Ángel; Jaime E. Charris
Source: check_circle
Crossref

In vitro evaluation and in vivo efficacy of nitroimidazole-sulfanyl ethyl derivatives against Leishmania (V.) braziliensis and Leishmania (L.) mexicana

Parasitology Research
2021-09-09 | Journal article
Contributors: Zuleima Blanco; Michael R. Mijares; Hegira Ramírez; Esteban Fernandez-Moreira; Henry J. Oviedo; Noris M. Rodríguez; Jaime E. Charris
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Crossref

Synthesis of 5H‐indeno[1,2‐b]pyridine derivatives: Antiproliferative and antimetastatic activities against two human prostate cancer cell lines

Archiv der Pharmazie
2021-08 | Journal article
Contributors: Katiuska E. Charris; Juan R. Rodrigues; Hegira Ramírez; Esteban Fernandez‐Moreira; Jorge E. Ángel; Jaime E. Charris
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Crossref

Synthesis and antimalarial and anticancer evaluation of 7‐chlorquinoline‐4‐thiazoleacetic derivatives containing aryl hydrazide moieties

Archiv der Pharmazie
2021-07 | Journal article
Contributors: Hegira Ramírez; Esteban Fernandez; Juan Rodrigues; Soriuska Mayora; Gricelis Martínez; Carmen Celis; Juan B. De Sanctis; Michael Mijares; Jaime Charris
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Crossref

The Role of Chloroquine and Hydroxychloroquine in Immune Regulation and Diseases

Current Pharmaceutical Design
2020-10-16 | Journal article
Contributors: Gricelis P. Martinez; Mercedes E. Zabaleta; Camilo Di Giulio; Jaime E. Charris; Michael R. Mijares
Source: check_circle
Crossref

Synthesis and biological activity of 2-[2-(7-chloroquinolin-4-ylthio)-4-methylthiazol-5-yl]-N-phenylacetamide derivatives as antimalarial and cytotoxic agents

Journal of Chemical Research
2020-05 | Journal article
Contributors: Hegira Rámirez; Juan R Rodrigues; Michael R Mijares; Juan B De Sanctis; Jaime E Charris
Source: check_circle
Crossref

Synthesis and antimalarial activity of (S)-methyl-(7-chloroquinolin-4-ylthio)acetamidoalquilate derivatives

Journal of Chemical Research
2020-03 | Journal article
Contributors: Custodiana Colmenarez; María Acosta; Miguel Rodríguez; Jaime Charris
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Crossref

Antimalarial, antiproliferative, and apoptotic activity of quinoline-chalcone and quinoline-pyrazoline hybrids. A dual action

Medicinal Chemistry Research
2019-11-24 | Journal article
Contributors: Jaime E. Charris; Melina C. Monasterios; María E. Acosta; Miguel A. Rodríguez; Neira D. Gamboa; Gricelis P. Martínez; Héctor R. Rojas; Michael R. Mijares; Juan B. De Sanctis
Source: check_circle
Crossref

Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives

Medicinal Chemistry Research
2019-01 | Journal article
Contributors: Jesús A. Romero; María E. Acosta; Neira D. Gamboa; Michael R. Mijares; Juan B. De Sanctis; Ligia J. Llovera; Jaime E. Charris
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Crossref

Synthesis, antimalarial, antiproliferative, and apoptotic activities of benzimidazole-5-carboxamide derivatives

Med Chem Res
2019-01-15 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis and pharmacological evaluation of novel central dopaminergic agents analogues of N-dichloroaralkyl-2-aminoindane

Revista de la Facultad de Farmacia-UCV
2018-12-01 | Journal article
Source: Self-asserted source
Jaime Charris

Agentes dopaminérgicos centrales análogos N-aralquil metoxilados del 2-aminoindano

Rev. Colomb. Cienc. Quím. Farm., Vol. 47(2), 233-253, 2018
2018-04-02 | Journal article
Source: Self-asserted source
Jaime Charris

Novel 11,12H-dihydronaphthalene[1,2-b]quinoline as Atypical Antipsychotic

Letters in Drug Design & Discovery, 2018, 15, 294-303
2018-03-01 | Journal article
Source: Self-asserted source
Jaime Charris

Optimization of antimalarial, and anticancer activities of (E)-methyl 2-(7-chloroquinolin-4-ylthio)-3-(4-hydroxyphenyl) acrylate

Bioorganic Medicinal Chemistry 26 (2018) 815–823
2018-03-01 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis, Antiproliferative, and Antiangiogenic Activities of Benzochromene and Benzoquinoline Derivatives on Prostate Cancer in vitro

Lett. Drug Des. Dis. 14, 398-413 (2017
2017-11-16 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis of trans- and cis-2-acetyl-3-phenyl-3,3a,4,5-tetrahydro-2H-benzo[g] indazoles: evaluation as inhibitors of β-hematin formation

JOURNAL CHEMICAL RESEARCH 2017, 41, 668-672
2017-11-01 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis, Characterization, Crystal Structure and Antimalarial Activity of (2E)-2-(1-{4-[(7-chloroquinolin-4-yl)amino]phenyl} ethylidene)hydrazine Carbothioamide

Orbital: Electron. J. Chem. 9 (4): 308-314, 2017
2017-06-30 | Journal article
Source: Self-asserted source
Jaime Charris

Síntesis de análogos de 7-cloro-N-3-(fenilsustituido)-4-aminoquinolina con posible actividad antineoplasica

Revista de Investigaciones Instituto de Pedagógico de Caracas 2017, 41, 155-178
2017-04-01 | Journal article
Source: Self-asserted source
Jaime Charris

Novedoso profármaco derivado de la lilolidina con actividad dopaminérgica central.

Invest Clin 58(3): 259 - 273, 2017
2017-03-31 | Journal article
Source: Self-asserted source
Jaime Charris

Síntesis y actividad antimicrobiana de derivados de pirimidinas. análogas de uracilo

Avances en Química, 11, 17-24 (2016).
2016-11-05 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis and biological evaluation of benzothiazole-6-carbohydrazide derivatives as antiparasitic agents.

Revista de la Facultad de Farmacia-UCV. 78, 51-61 (2015).
2015-12-01 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis, β-hematin inhibition studies and antimalarial evaluation of dehydroxy Isotebuquine derivatives against Plasmodium berghei.

. Bioorg. Med. Chem. 23, 4755-4762 (2015)
2015-09-17 | Journal article
Source: Self-asserted source
Jaime Charris

Effects of 5,8-dimethylthieno[2,3-b]quinoline-2-carboxylic acid on the antioxidative defense and lipid membranes in Plasmodium berghei-infected erythrocytes.

Exp. Parasitol. 155, 26-34 (2015).
2015-08-01 | Journal article
Source: Self-asserted source
Jaime Charris

Design, synthesis and preliminary pharmacologic evaluation of 2-aminoindane-quinoline analogs as dopaminergic agents.

Der Pharm. Chem. 7, 130-135 (2015).
2015-07-27 | Journal article
Source: Self-asserted source
Jaime Charris

Novedosos agentes dopaminérgicos centrales derivados del 2-aminoindano-4,7-disustituido atípico. Síntesis y perfil farmacológico central

Invest. Clin. 56, 137-154, (2015).
2015-07-02 | Journal article
Source: Self-asserted source
Jaime Charris

Synthesis, crystal structure and effect of indeno[1,2-b]indole derivatives on prostate cancer in vitro. Potential effect against MMP-9

Eur. J. Med. Chem. 96, 281-295 (2015).
2015-04-01 | Journal article
Source: Self-asserted source
Jaime Charris

Peer review (6 reviews for 4 publications/grants)

Review activity for Chemistry Africa. (1)
Review activity for European journal of medicinal chemistry reports. (1)
Review activity for European journal of medicinal chemistry. (1)
Review activity for Medicinal chemistry research. (3)