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Biography

Medicinal Chemistry, Drug design, Drug Discovery, Synthesis of small molecules, Computer Aided Drug Design.

Activities

Education and qualifications (9)

Al Azhar University: Cairo, Nasr city, EG

2010-06 to present | Professor (Pharmaceutical Medicinal Chemistry)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

King Abdul Aziz University Hospital: Jeddah, Makah, SA

2003-11 to 2015-06 | Associate Prof and Professor (Pharmaceutical Chemistry)
Qualification
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

New York State University at Buffalo: Buffalo, New York, US

2001-07 to 2003-10 | Visiting scholar (Natural Science complex)
Qualification
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Al Azhar University: Nasr City, Cairo, EG

1994-10-05 to 2000-06-07 | Ph.D (Pharmaceutical Chemistry Department)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Commonwealth of Virginia: Richmond, VA, US

1996-12 to 1999-01 | Research scientist (Medicinal Chemistry Dept.)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Al-Azhar University: Nasr City, Cairo, EG

1988-11-26 to 1994-10-04 | Master (Pharmaceutical Chemistry Department)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Chiba University, Faculty of Pharmaceutical sciences, Natural Product synthesis: Chiba, Japan, Chiba, Japan, JP

1991-04-01 to 1993-11-03 | Research student through channel system program between Egyptian and Japanese government (Natural Product Synthesis)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Al Azhar University: Nasr City, Cairo, EG

1983-01-06 to 1988-11-26 | Demonstrator (Pharmaceutical Chemistry Department)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Al Azhar University: Nasr City, Cairo, EG

1983-01-06 to 1988-11-26 | Demonstrator (Pharmaceutical Chemistry Department)
Education
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Works (50 of 57)

Items per page:
Page 1 of 2

Immunomodulation and anticancer evaluation of quinazoline-based thalidomide analogs: Design, synthesis, docking, and dynamic simulation

Journal of Molecular Structure
2024-12 | Journal article
Contributors: Abdallah E. Abdallah; Ibrahim H. Eissa; Ahmed B.M. Mehany; Helmy Sakr; Tamer M Sakr; K.H. Metwaly; Ismail Celik; Khaled El-Adl; Mohamed Ayman El-Zahabi
Source: check_circle
Crossref

New immunomodulatory anticancer quinazolinone-based thalidomide analogs: design, synthesis and biological evaluation

Future Medicinal Chemistry
2024-12 | Journal article
Contributors: Maged Mohammed Saleh Al Ward; Abdallah E Abdallah; Mohamed F Zayed; Rezk R Ayyad; Tamer M Abdelghany; Dina Abed Bakhotmah; Mohamed Ayman El-Zahabi
Source: check_circle
Crossref

Discovery of New Immunomodulatory Anticancer Thalidomide Analogs: Design, Synthesis, Biological Evaluation and In Silico Studies

Chemistry & Biodiversity
2024-12-12 | Journal article
Contributors: Abdallah E. Abdallah; Ibrahim H. Eissa; Ahmed B. M. Mehany; Ismail Celik; Helmy Sakr; K. H. Metwaly; Khaled El‐Adl; Mohamed Ayman El‐Zahabi
Source: check_circle
Crossref

Design and synthesis of new nicotinamides as immunomodulatory VEGFR-2 inhibitors and apoptosis inducers

Future Medicinal Chemistry
2024-11-14 | Journal article
Contributors: Reda G Yousef; Ibrahim H Eissa; Hazem Elkady; Ahmed B M Mehany; Mariam Ali Abo-Saif; Mohamed M Radwan; Mahmoud A ElSohly; Ibrahim M Ibrahim; Alaa Elwan; Mohamed Ayman El-Zahabi
Source: check_circle
Crossref

Design, synthesis, anticancer evaluation, in silico docking and ADMET analysis of novel indole-based thalidomide analogs as promising immunomodulatory agents

Journal of Biomolecular Structure and Dynamics
2023-12-29 | Journal article
Contributors: Mohamed Ayman El-Zahabi; Hazem Elkady; Helmy Sakr; Adel S. Abdelraheem; Sally I. Eissa; Khaled. El-Adl
Source: check_circle
Crossref

Novel promising benzoxazole/benzothiazole‐derived immunomodulatory agents: Design, synthesis, anticancer evaluation, and in silico ADMET analysis

Archiv der Pharmazie
2023-09 | Journal article
Contributors: Hazem Elkady; Khaled El‐Adl; Helmy Sakr; Adel S. Abdelraheem; Sally I. Eissa; Mohamed Ayman El‐Zahabi
Source: check_circle
Crossref

Design, Synthesis, and Biological Evaluation of New Potential Unusual Modified Anticancer Immunomodulators for Possible Non-Teratogenic Quinazoline-Based Thalidomide Analogs

International Journal of Molecular Sciences
2023-08-04 | Journal article
Contributors: Reda Mabrouk; Abdallah Abdallah; Hazem Mahdy; Samar El-Kalyoubi; Omar Kamal; Tamer Abdelghany; Mohamed Zayed; Heba Alshaeri; Moudi Alasmari; Mohamed El-Zahabi
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Immunomodulatory quinazoline-based thalidomide analogs: Design, synthesis, apoptosis and anticancer evaluations

Journal of Molecular Structure
2023-06 | Journal article
Contributors: Abdallah E. Abdallah; Ibrahim H. Eissa; Ahmed B.M. Mehany; Helmy Sakr; Ahmed Atwa; Khaled El-Adl; Mohamed Ayman El-Zahabi
Source: check_circle
Crossref

New immunomodulatory anticancer quinazolinone based thalidomide analogs: Design, synthesis and biological evaluation

2023-05-22 | Preprint
Contributors: Maged Al Ward; Abdallah E. Abdallah; Mohamed Zayed; Rezk Ayyad; Mohamed El-Zahabi
Source: check_circle
Crossref

Design, synthesis, anticancer evaluation, and <i>in silico</i> ADMET analysis of novel thalidomide analogs as promising immunomodulatory agents

RSC Advances
2023-03-27 | Journal article
Part of ISSN: 2046-2069
Contributors: Anas Ramadan Kotb; Abdallah E. Abdallah; Hazem Elkady; Ibrahim H. Eissa; Mohammed S. Taghour; Dina Abed Bakhotmah; Tamer M. Abdelghany; Mohamed Ayman El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents

RSC Advances
2022 | Journal article
Part of ISSN: 2046-2069
Contributors: Mohamed Ayman Aly El-Zahabi; Anas Ramadan Kotb; Dina A. Bakhotmah; Abdallah E. Abdallah; Hazem Elkady; Mohammed S. Taghour; Ibrahim H. Eissa; Mohamed Ayman El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

New quinoline and isatin derivatives as apoptotic VEGFR-2 inhibitors: design, synthesis, anti-proliferative activity, docking, ADMET, toxicity, and MD simulation studies

Journal of Enzyme Inhibition and Medicinal Chemistry
2022-12-31 | Journal article
Part of ISSN: 1475-6366
Part of ISSN: 1475-6374
Contributors: Mohamed Ayman Aly El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi
grade
Preferred source (of 2)‎

Synthesis, biological evaluation, and molecular docking of new series of antitumor and apoptosis inducers designed as VEGFR-2 inhibitors

Journal of Enzyme Inhibition and Medicinal Chemistry
2022-12-31 | Journal article
Part of ISSN: 1475-6366
Part of ISSN: 1475-6374
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents† Anas Ramadan Kotb,a Dina A. Bakhotmah,*b Abdallah E. Abdallah, a Hazem Elkady, a Mohammed S. Taghour,a Ibrahim. H. Eissa *a and Mohamed Ayman El-Zahabi*a

RSC advances
2022-11-14 | Journal article
Contributors: Mohamed Ayman Aly El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, synthesis, and biological evaluation of novel bioactive thalidomide analogs as anticancer immunomodulatory agents† Anas Ramadan Kotb,a Dina A. Bakhotmah,*b Abdallah E. Abdallah, a Hazem Elkady, a Mohammed S. Taghour,a Ibrahim. H. Eissa *a and Mohamed Ayman El-Zahabi*a

RSC advances
2022-11-14 | Journal article
Contributors: Mohamed Ayman Aly El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, Synthesis, Molecular Modeling and Anti‐Hyperglycemic Evaluation of Quinazoline‐Sulfonylurea Hybrids as Peroxisome Proliferator‐Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists

Int. J. Mol. Sci.
2022-08-24 | Journal article
Contributors: Mohamed Ayman Aly El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, Synthesis, Molecular Modeling and Anti-Hyperglycemic Evaluation of Quinazoline-Sulfonylurea Hybrids as Peroxisome Proliferator-Activated Receptor Gamma (PPARγ) and Sulfonylurea Receptor (SUR) Agonists

International Journal of Molecular Sciences
2022-08-24 | Journal article
Part of ISSN: 1422-0067
Contributors: Mohamed Ayman Aly El-Zahabi
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

DESIGN, MOLECULAR MODELING AND SYNTHESIS OF NEW IMMUNOMODULATORY AGENTS FOR BIOLOGICAL STUDIES

Al-Azhar Journal of Pharmaceutical Sciences
2021-09-01 | Journal article
Part of ISSN: 2535-1958
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

NATURALLY OCCURRING AND SYNTHETIC IMMUNOMODULATORS WITH DIFFERENT BIOLOGICAL ACTIVITIES: LITERATURE SURVEY AND HISTORICAL INSIGHT

Al-Azhar Journal of Pharmaceutical Sciences
2021-09-01 | Journal article
Part of ISSN: 2535-1958
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

REVIEW ON THE SIGNIFICANCE OF QUINAZOLINE DERIVATIVES AS BROAD SPECTRUM ANTI-CANCER AGENTS.

Al-Azhar Journal of Pharmaceutical Sciences
2021-09-01 | Journal article
Part of ISSN: 2535-1958
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, synthesis and molecular modeling of new quinazolin-4(3H)-one based VEGFR-2 kinase inhibitors for potential anticancer evaluation

Bioorganic Chemistry
2021-04 | Journal article
Part of ISSN: 0045-2068
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi
grade
Preferred source (of 4)‎

DESIGN, SYNTHESIS, AND BIOLOGICAL TRACING OF 99MTC- DPDQA AS A POTENTIAL MARKER FOR TUMOR IMAGING

Al-Azhar Journal of Pharmaceutical Sciences
2021-03-01 | Journal article
Part of ISSN: 2535-1958
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi
grade
Preferred source (of 2)‎

Design, synthesis, and biological evaluation of new challenging thalidomide analogs as potential anticancer immunomodulatory agents

Bioorganic Chemistry
2020-11 | Journal article
Part of ISSN: 0045-2068
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Discovery of new pyrimidine-5-carbonitrile derivatives as anticancer agents targeting EGFRWT and EGFRT790M†

Org. Biomol. Chem
2020-09-11 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Antidiabetic compounds

US 10, 683, 267 B1
2020-07-17 | Patent
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Antidiabetic compounds

US10683267B1
2020-06-16 | Patent
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Antidiabetic compounds

US 10, 654,800 B1
2020-05-19 | Patent
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Substituted [1,2,4]triazolo[4,3-a]pyrazines as antidiabetics

US10894794B1
2020-01-19 | Patent
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design, synthesis, molecular modeling and anti-hyperglycemic evaluation of phthalimide-sulfonylurea hybrids as PPARγ and SUR agonists

Bioorganic Chemistry
2019-10 | Journal article
Part of ISSN: 0045-2068
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi
grade
Preferred source (of 2)‎

Synthesis of new cyclic imides derivatives with potential hypolipidemic activity

Medicinal Chemistry Research
2012-01 | Journal article
Part of ISSN: 1054-2523
Part of ISSN: 1554-8120
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis, Physiochemical Properties, Photochemical Probe, and Antimicrobial Effects of Novel Norfloxacin Analogues

ISRN Organic Chemistry
2011-03-06 | Journal article
Part of ISSN: 2090-5149
Part of ISSN: 2090-5157
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis of Some Novel Naphthalimide Derivatives for Antihyperlipidemic Activity.

Mansoura Journal of Pharmaceutical Sciences (MJPS)
2008 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis of Some Novel Naphthalimide Derivatives for Antihyperlipidemic Activity.

Mansoura Journal of Pharmaceutical Sciences, MJPS
2008 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis and Screening of Some Diphenimide Derivatives for Antihyperlipidemic Activity.

Az. J. Pharm. Sci. (2007), 35, 16-28.
2007 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis of Certain New Dibenz [c, e] azepine-5, 7-diones of Expected Antihyperlipidemic Activity

JKAU: Med. Sci., Vol. 14 No. 4, pp: 3-17 (2007
2007 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis of Certain New Dibenz[c,e]azepine-5,7-diones of Expected Antihyperlipidemic Activity

Journal of King Abdulaziz University-Medical Sciences
2007 | Journal article
Part of ISSN: 1319-1004
Part of ISSN: 1658-4279
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

N-Methyl-1-(4-methoxyphenyl)-2-aminopropane (PMMA) and N-Methyl-1-(3,4-methylenedioxyphenyl)-2-aminopropane (MDMA) produce non-identical discriminative stimuli in rats

Pharmacology Biochemistry and Behavior
2007-03 | Journal article
Part of ISSN: 0091-3057
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Methodology for preparing combinatorial libraries based upon a bicyclic scaffold1

2005-08-11 | Patent
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

6-(2-Phenylethyl)nicotine: A novel nicotinic cholinergic receptor ligand

Bioorganic & Medicinal Chemistry Letters
2005-07 | Journal article
Part of ISSN: 0960-894X
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design and Synthesis of Dibenz [c, e] azepine-5, 7-diones as anticonvulsant agents AA El-Helby, MA El-Zahabi, MA Amin, MK Ibrahim

Egypt J Biomed Sci
2003 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

El-Helby A.A., El-Zahaby M.A. and Radwan M.F. Synthesis and anticonulsant activity of some new N-Substituted-1,8-Naphthalimide

Egypt. J. Biomed. Sci.
2003 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis of some new nitrogenous compounds for biological activity AA El-Helby, MA El-Zahabi, MA Amin, MK Ibrahim

Egypt J Biomed Sci
2003 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design and Synthesis of Some New Derivatives of 2(3H)-Sulfanylbenzoxazole For Testing as Anticonvulsant (Part 1).

Egypt. J. Biomed. Sci.
2003-11 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Design and Synthesis of Dibenz [c, e] azepine-5, 7-diones as anticonvulsant agents AA El-Helby, MA El-Zahabi, MA Amin, MK Ibrahim

Egypt J Biomed Sci
2003-04 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

(−)6-n-Propylnicotine antagonizes the antinociceptive effects of (−)Nicotine

Bioorganic & Medicinal Chemistry Letters
2002-10 | Journal article
Part of ISSN: 0960-894X
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis and hypolipidemic activity of some new Dibenz [c, e] azepine derivatives SES Barakat, MA El-Zahabi… - SAUDI …, 2000 - SAUDI PHARMACEUTICAL …

SAUDI PHARMACEUTICA JOURNAL
2000 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

“Synthesis and Biological Screening of New 2,4-(1H,3H)-Quinazolinones including mercaptoxadiazole and 5- mercaptotriazole Moieties”.

Az. J. Pharm. Sci., 23, 36-45 (1999).
1999 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis, receptor binding and QSAR studies on 6-substituted nicotine derivatives as cholinergic ligands

European Journal of Medicinal Chemistry
1999-01 | Journal article
Part of ISSN: 0223-5234
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

Synthesis and anticonvulsant activity of some new 5H-dibenz-[c, e] azepine-5, 7 (6H) dione derivatives

EGYPTIAN JOURNAL OF PHARMACEUTICAL SCIENCES
1998 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi

“Synthesis and Anticonvulsant Activity of Some Novel 4,4`-Dibromo-5H-Dibenz[c,e] azepine-5,7(6H) Diones”

Egypt. J. of Pharm. Sci., 39, No. 4-6, pp. 487-498 (1998).
1998 | Journal article
Source: Self-asserted source
Mohamed Ayman Aly El-Zahabi
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