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Employment (1)

Jyväskylän Yliopisto: Jyväskylä, FI

2005-02-01 to present | Professor (Department Biological and Environmental Science)
Employment
Source: Self-asserted source
Jari Ylänne

Education and qualifications (1)

Helsingin Yliopisto: Helsinki, FI

1990-11-29 | Ph. D. (Department of Biochemistry)
Education
Source: Self-asserted source
Jari Ylänne

Funding (4)

Novel filamin-dependent mechanosensor signaling pathways

2014-01-09 to 2018-08-31 | Grant
Academy of Finland (n/a, FI)
URL: https://grants.uberresearch.com/501100002341/278668/Novel-filamin-dependent-mechanosensor-signaling-pathways
GRANT_NUMBER: 278668
Source: Self-asserted source
Jari Ylänne via DimensionsWizard

Structures and functions of cytoskeleton-associated protein complexes regulating integrin-mediated cell adhesion

Source: Self-asserted source
Jari Ylänne via DimensionsWizard

Testing the mechanosensor function of filamin in Drosophila development

Source: Self-asserted source
Jari Ylänne via DimensionsWizard

Interactions of filamins in cell adhesion and signaling

2007-01-01 to 2010-12-31 | Grant
Academy of Finland (n/a, FI)
URL: https://grants.uberresearch.com/501100002341/114713/Interactions-of-filamins-in-cell-adhesion-and-signaling
GRANT_NUMBER: 114713
Source: Self-asserted source
Jari Ylänne via DimensionsWizard

Works (50 of 69)

Items per page:
Page 1 of 2

Novel functions for integrin-associated proteins revealed by analysis of myofibril attachment in Drosophila.

eLife
2018-07-20 | Journal article
DOI: 10.7554/eLife.35783
PMID: 30028294
PMC: PMC6092120
Source: Self-asserted source
Jari Ylänne

Phosphorylated immunoreceptor tyrosine-based activation motifs and integrin cytoplasmic domains activate spleen tyrosine kinase via distinct mechanisms.

The Journal of biological chemistry
2018-02-12 | Journal article
DOI: 10.1074/jbc.RA117.000660
PMID: 29440271
PMC: PMC5880128
Source: Self-asserted source
Jari Ylänne

Skeletal Dysplasia Mutations Effect on Human Filamins' Structure and Mechanosensing.

Scientific reports
2017-06-26 | Journal article
DOI: 10.1038/s41598-017-04441-x
PMID: 28652603
PMC: PMC5484675
Source: Self-asserted source
Jari Ylänne

Evidence for the mechanosensor function of filamin in tissue development.

Scientific reports
2016-09-06 | Journal article
DOI: 10.1038/srep32798
PMID: 27597179
PMC: PMC5011733
Source: Self-asserted source
Jari Ylänne

Flexible Structure of Peptide-Bound Filamin A Mechanosensor Domain Pair 20-21.

2015 | Journal article
DOI: 10.1371/journal.pone.0136969
PMID: 26322797
PMC: PMC4554727
Contributors: Seppälä J; Tossavainen H; Rodic N; Permi P; Pentikäinen U; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Small-angle X-ray scattering reveals compact domain-domain interactions in the N-terminal region of filamin C.

2014 | Journal article
DOI: 10.1371/journal.pone.0107457
PMID: 25243668
PMC: PMC4170960
Contributors: Sethi R; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

A novel structural unit in the N-terminal region of filamins.

2014-03 | Journal article
DOI: 10.1074/jbc.M113.537456
PMID: 24469451
PMC: PMC3961682
Contributors: Sethi R; Seppälä J; Tossavainen H; Ylilauri M; Ruskamo S; Pentikäinen OT; Pentikäinen U; Permi P; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Filopodia-like actin cables position nuclei in association with perinuclear actin in Drosophila nurse cells.

2013-09 | Journal article
DOI: 10.1016/j.devcel.2013.08.014
PMID: 24091012
PMC: PMC3791400
Contributors: Huelsmann S; Ylänne J; Brown NH
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Binding properties and stability of the Ras-association domain of Rap1-GTP interacting adapter molecule (RIAM).

2012 | Journal article
DOI: 10.1371/journal.pone.0031955
PMID: 22523535
PMC: PMC3327698
Contributors: Takala H; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Filamins in mechanosensing and signaling.

2012 | Journal article
DOI: 10.1146/annurev-biophys-050511-102252
PMID: 22404683
Contributors: Razinia Z; Mäkelä T; Ylänne J; Calderwood DA
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Dynamic force sensing of filamin revealed in single-molecule experiments.

2012-11 | Journal article
DOI: 10.1073/pnas.1211274109
PMID: 23150587
PMC: PMC3511698
Contributors: Rognoni L; Stigler J; Pelz B; Ylänne J; Rief M
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The C-terminal rod 2 fragment of filamin A forms a compact structure that can be extended.

2012-09 | Journal article
DOI: 10.1042/BJ20120361
PMID: 22676060
Contributors: Ruskamo S; Gilbert R; Hofmann G; Jiang P; Campbell ID; Ylänne J; Pentikäinen U
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Negative regulators of integrin activity.

2012-07 | Journal article
DOI: 10.1242/jcs.093641
PMID: 22822081
Contributors: Pouwels J; Nevo J; Pellinen T; Ylänne J; Ivaska J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Model of a six immunoglobulin-like domain fragment of filamin A (16-21) built using residual dipolar couplings.

2012-04 | Journal article
DOI: 10.1021/ja2114882
PMID: 22452512
Contributors: Tossavainen H; Koskela O; Jiang P; Ylänne J; Campbell ID; Kilpeläinen I; Permi P
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Assembly of a filamin four-domain fragment and the influence of splicing variant-1 on the structure.

2011-07 | Journal article
DOI: 10.1074/jbc.M110.195958
PMID: 21636571
PMC: PMC3143651
Contributors: Pentikäinen U; Jiang P; Takala H; Ruskamo S; Campbell ID; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Characterization of the interaction between Actinin-Associated LIM Protein (ALP) and the rod domain of alpha-actinin.

2009 | Journal article
DOI: 10.1186/1471-2121-10-22
PMID: 19327143
PMC: PMC2670261
Contributors: Klaavuniemi T; Alho N; Hotulainen P; Kelloniemi A; Havukainen H; Permi P; Mattila S; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Molecular basis of filamin A-FilGAP interaction and its impairment in congenital disorders associated with filamin A mutations.

2009 | Journal article
DOI: 10.1371/journal.pone.0004928
PMID: 19293932
PMC: PMC2654154
Contributors: Nakamura F; Heikkinen O; Pentikäinen OT; Osborn TM; Kasza KE; Weitz DA; Kupiainen O; Permi P; Kilpeläinen I; Ylänne J et al.
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Structure of the human filamin A actin-binding domain.

2009-11 | Journal article
DOI: 10.1107/S0907444909037330
PMID: 19923718
Contributors: Ruskamo S; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The regulation mechanism for the auto-inhibition of binding of human filamin A to integrin.

2009-10 | Journal article
DOI: 10.1016/j.jmb.2009.08.035
PMID: 19699211
Contributors: Pentikäinen U; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Atomic structures of two novel immunoglobulin-like domain pairs in the actin cross-linking protein filamin.

2009-09 | Journal article
DOI: 10.1074/jbc.M109.019661
PMID: 19622754
PMC: PMC2757246
Contributors: Heikkinen OK; Ruskamo S; Konarev PV; Svergun DI; Iivanainen T; Heikkinen SM; Permi P; Koskela H; Kilpeläinen I; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

1H, 13C and 15N resonance assignments of the human filamin A tandem immunoglobulin-like domains 16-17 and 18-19.

2009-06 | Journal article
DOI: 10.1007/s12104-008-9140-6
PMID: 19636946
Contributors: Heikkinen O; Permi P; Koskela H; Ylänne J; Kilpeläinen I
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Solution structure of the first immunoglobulin domain of human myotilin.

2009-06 | Journal article
DOI: 10.1007/s10858-009-9320-4
PMID: 19418025
Contributors: Heikkinen O; Permi P; Koskela H; Carpén O; Ylänne J; Kilpeläinen I
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Novel structural insights into F-actin-binding and novel functions of calponin homology domains.

2008-12 | Journal article
DOI: 10.1016/j.sbi.2008.10.003
PMID: 18952167
Contributors: Sjöblom B; Ylänne J; Djinović-Carugo K
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Structural basis of the migfilin-filamin interaction and competition with integrin beta tails.

2008-12 | Journal article
DOI: 10.1074/jbc.M802592200
PMID: 18829455
PMC: PMC2596399
Contributors: Lad Y; Jiang P; Ruskamo S; Harburger DS; Ylänne J; Campbell ID; Calderwood DA
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Beta2 integrin phosphorylation on Thr758 acts as a molecular switch to regulate 14-3-3 and filamin binding.

2008-09 | Journal article
DOI: 10.1182/blood-2007-12-127795
PMID: 18550856
Contributors: Takala H; Nurminen E; Nurmi SM; Aatonen M; Strandin T; Takatalo M; Kiema T; Gahmberg CG; Ylänne J; Fagerholm SC
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Structure of three tandem filamin domains reveals auto-inhibition of ligand binding.

2007-09 | Journal article
DOI: 10.1038/sj.emboj.7601827
PMID: 17690686
PMC: PMC1948075
Contributors: Lad Y; Kiema T; Jiang P; Pentikäinen OT; Coles CH; Campbell ID; Calderwood DA; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Backbone NMR assignment of the internal interaction site of ALP.

2007-07 | Journal article
DOI: 10.1007/s12104-007-9024-1
PMID: 19636834
Contributors: Alho N; Klaavuniemi T; Ylänne J; Permi P; Mattila S
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Crystal structure of human filamin C domain 23 and small angle scattering model for filamin C 23-24 dimer.

2007-05 | Journal article
DOI: 10.1016/j.jmb.2007.02.018
PMID: 17379241
Contributors: Sjekloća L; Pudas R; Sjöblom B; Konarev P; Carugo O; Rybin V; Kiema TR; Svergun D; Ylänne J; Djinović Carugo K
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Conformation-specific blockade of the integrin GPIIb/IIIa: a novel antiplatelet strategy that selectively targets activated platelets.

Circulation research
2006-06-15 | Journal article
DOI: 10.1161/01.res.0000232317.84122.0c
PMID: 16778135
Source: Self-asserted source
Jari Ylänne

Zasp/Cypher internal ZM-motif containing fragments are sufficient to co-localize with alpha-actinin--analysis of patient mutations.

2006-05 | Journal article
DOI: 10.1016/j.yexcr.2005.12.036
PMID: 16476425
Contributors: Klaavuniemi T; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The structure of the GPIb-filamin A complex.

2006-03 | Journal article
DOI: 10.1182/blood-2005-10-3964
PMID: 16293600
PMC: PMC1895705
Contributors: Nakamura F; Pudas R; Heikkinen O; Permi P; Kilpeläinen I; Munday AD; Hartwig JH; Stossel TP; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The molecular basis of filamin binding to integrins and competition with talin.

2006-02 | Journal article
DOI: 10.1016/j.molcel.2006.01.011
PMID: 16455489
Contributors: Kiema T; Lad Y; Jiang P; Oxley CL; Baldassarre M; Wegener KL; Campbell ID; Ylänne J; Calderwood DA
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Structural basis for vertebrate filamin dimerization.

2005-01 | Journal article
DOI: 10.1016/j.str.2004.10.014
PMID: 15642266
Contributors: Pudas R; Kiema TR; Butler PJ; Stewart M; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Expression, purification and preliminary crystallographic characterization of a novel segment from the neurofibromatosis type 1 protein.

2004-12 | Journal article
DOI: 10.1107/S0907444904026861
PMID: 15583390
Contributors: Bonneau F; D'Angelo I; Welti S; Stier G; Ylänne J; Scheffzek K
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Distinct roles of ligand affinity and cytoskeletal anchorage in alphaIIbbeta3 (GP IIb/IIIa)-mediated cell aggregation and adhesion.

2004-11 | Journal article
DOI: 10.1080/09587100410001723179
PMID: 15745314
Contributors: Peter K; Ahrens I; Schwarz M; Bode C; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The ZASP-like motif in actinin-associated LIM protein is required for interaction with the alpha-actinin rod and for targeting to the muscle Z-line.

2004-06 | Journal article
DOI: 10.1074/jbc.M401871200
PMID: 15084604
Contributors: Klaavuniemi T; Kelloniemi A; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Adhesion of monocytes to medical steel as used for vascular stents is mediated by the integrin receptor Mac-1 (CD11b/CD18; alphaM beta2) and can be inhibited by semiconductor coating.

2003 | Journal article
DOI: 10.1080/15419060302065
PMID: 12881037
Contributors: Schuler P; Assefa D; Ylänne J; Basler N; Olschewski M; Ahrens I; Nordt T; Bode C; Peter K
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Involvement of the beta3 E749ATSTFTN756 region in stabilizing integrin alphaIIbbeta3-ligand interaction.

2003-10 | Journal article
DOI: 10.1046/j.1538-7836.2003.00394.x
PMID: 14521607
Contributors: Litjens PE; Gorter G; Ylänne J; Akkerman JW; van Willigen G
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Actin binding of a minispectrin.

2003-03 | Journal article
DOI: 10.1016/S1570-9639(02)00551-4
PMID: 12637013
Contributors: Raae AJ; Bañuelos S; Ylänne J; Olausson T; Goldie KN; Wendt T; Hoenger A; Saraste M
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Pathways and intermediates in forced unfolding of spectrin repeats.

2002-08 | Journal article
DOI: 10.1016/S0969-2126(02)00808-0
PMID: 12176386
Contributors: Altmann SM; Grünberg RG; Lenne PF; Ylänne J; Raae A; Herbert K; Saraste M; Nilges M; Hörber JK
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The spectrin repeat: a structural platform for cytoskeletal protein assemblies.

2002-02 | Journal article
DOI: 10.1016/S0014-5793(01)03304-X
PMID: 11911890
Contributors: Djinovic-Carugo K; Gautel M; Ylänne J; Young P
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Crystal structure of the alpha-actinin rod reveals an extensive torsional twist.

2001-07 | Journal article
DOI: 10.1016/S0969-2126(01)00619-0
PMID: 11470434
Contributors: Ylänne J; Scheffzek K; Young P; Saraste M
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The NITY motif of the beta-chain cytoplasmic domain is involved in stimulated internalization of the beta3 integrin A isoform.

2001-03 | Journal article
PMID: 11228154
Contributors: Gawaz M; Besta F; Ylänne J; Knorr T; Dierks H; Böhm T; Kolanus W
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

UNC-87 is an actin-bundling protein.

The Journal of biological chemistry
2000-11-28 | Journal article
DOI: 10.1074/jbc.m009561200
PMID: 11096113
Source: Self-asserted source
Jari Ylänne

Effects of mutations in the cytoplasmic domain of integrin beta(1) to talin binding and cell spreading.

1999-08 | Journal article
DOI: 10.1006/excr.1999.4533
PMID: 10413605
Contributors: Kääpä A; Peter K; Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Induction of fibrinogen binding and platelet aggregation as a potential intrinsic property of various glycoprotein IIb/IIIa (alphaIIbbeta3) inhibitors.

1998-11 | Journal article
PMID: 9787160
Contributors: Peter K; Schwarz M; Ylänne J; Kohler B; Moser M; Nordt T; Salbach P; Kübler W; Bode C
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Conserved functions of the cytoplasmic domains of integrin beta subunits.

1998-08 | Journal article
PMID: 9693157
Contributors: Ylänne J
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Expression of megakaryocytic and erythroid properties in human leukemic cells.

1996-02 | Journal article
PMID: 8641337
Contributors: Tani T; Ylänne J; Virtanen I
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

The conserved membrane-proximal region of an integrin cytoplasmic domain specifies ligand binding affinity.

1995-05 | Journal article
DOI: 10.1074/jbc.270.21.12411
PMID: 7759482
Contributors: Hughes PE; O'Toole TE; Ylänne J; Shattil SJ; Ginsberg MH
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central

Mutation of the cytoplasmic domain of the integrin beta 3 subunit. Differential effects on cell spreading, recruitment to adhesion plaques, endocytosis, and phagocytosis.

1995-04 | Journal article
DOI: 10.1074/jbc.270.16.9550
PMID: 7721884
Contributors: Ylänne J; Huuskonen J; O'Toole TE; Ginsberg MH; Virtanen I; Gahmberg CG
Source: Self-asserted source
Jari Ylänne via Europe PubMed Central
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