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Works (5)

Leveraging dual-ligase recruitment to enhance degradation via a heterotrivalent PROTAC

2024-08-21 | Preprint
DOI: 10.26434/chemrxiv-2024-lvvhf
Contributors: Adam G. Bond; Miquel Muñoz i Ordoño; Celia M. Bisbach; Conner Craigon; Nikolai Makukhin; Elizabeth A. Caine; Manjula Nagala; Marjeta Urh; Georg E. Winter; Kristin M. Riching et al.
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The importance of cellular degradation kinetics for understanding mechanisms in targeted protein degradation

Chemical Society Reviews
2022 | Journal article
DOI: 10.1039/D2CS00339B
Contributors: Kristin M. Riching; Elizabeth A. Caine; Marjeta Urh; Danette L. Daniels
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Modeling the CRL4A ligase complex to predict target protein ubiquitination induced by cereblon-recruiting PROTACs

Journal of Biological Chemistry
2022-04 | Journal article
DOI: 10.1016/j.jbc.2022.101653
Contributors: Nan Bai; Kristin M. Riching; Aman Makaju; Hao Wu; Timothy M. Acker; Shu-Ching Ou; Yaru Zhang; Xiaomeng Shen; Daryl N. Bulloch; Huan Rui et al.
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Translating PROTAC chemical series optimization into functional outcomes underlying BRD7 and BRD9 protein degradation

Current Research in Chemical Biology
2021 | Journal article
DOI: 10.1016/j.crchbi.2021.100009
Contributors: Kristin M. Riching; James D. Vasta; Scott J. Hughes; Vittoria Zoppi; Chiara Maniaci; Andrea Testa; Marjeta Urh; Alessio Ciulli; Danette L. Daniels
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Trivalent PROTACs enhance protein degradation via combined avidity and cooperativity

Nature Chemical Biology
2021-11-21 | Journal article
DOI: 10.1038/s41589-021-00878-4
Contributors: Satomi Imaide; Kristin M. Riching; Nikolai Makukhin; Vesna Vetma; Claire Whitworth; Scott J. Hughes; Nicole Trainor; Sarah D. Mahan; Nancy Murphy; Angus D. Cowan et al.
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Peer review (1 review for 1 publication/grant)

Review activity for Nature communications (1)
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