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Machine perfusion, Drug targeting, Renal transplantation, Fibrosis, Proteomics, Protein degradation
Netherlands, United Kingdom

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Employment (3)

Faculteit Medische Wetenschappen/UMCG: Groningen, NL

Employment
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University of Groningen

University Medical Center Groningen: Groningen, Groningen, NL

2022-05-01 to present | Postdoctoral researcher (Department of Surgery)
Employment
Source: Self-asserted source
Leonie van Leeuwen, PhD

University Medical Center Groningen: Groningen, Groningen, NL

2018-09-01 to 2022-05-01 | PhD Student (Department of Surgery)
Employment
Source: Self-asserted source
Leonie van Leeuwen, PhD

Works (19)

Normothermic machine perfusion of explanted livers: Exploratory study of an alternative translational model for end‐stage liver disease

Artificial Organs
2025-03 | Journal article
Contributors: Rachel Todd; L. Leonie van Leeuwen; Matthew Holzner; Leona Kim‐Schluger; Maria Isabel Fiel; Daniel Puleston; Sander S. Florman; M. Zeeshan Akhtar
Source: check_circle
Crossref

The potential of machine learning to predict early allograft dysfunction after normothermic machine perfusion in liver transplantation

Journal of Hepatology
2024-12 | Journal article
Contributors: L. Leonie van Leeuwen; Haritz Irizar; Leona Kim-Schluger; Sander Florman; M. Zeeshan Akhtar
Source: check_circle
Crossref

Unlocking the Promise of Liver Perfusion Technologies for Pediatric Transplantation: A State‐of‐the‐Art Review

Pediatric Transplantation
2024-12 | Journal article
Part of ISSN: 1397-3142
Part of ISSN: 1399-3046
Contributors: Cole Brown; L. Leonie van Leeuwen; M. Zeeshan Akhtar; Joseph DiNorcia
Source: Self-asserted source
Leonie van Leeuwen, PhD

An iterative design approach to development of an ex-vivo normothermic multivisceral perfusion platform

2024-10-05 | Preprint
Contributors: L. Leonie van Leeuwen; Matthew L. Holzner; Ceilidh McKenney; Rachel Todd; Jamie K. Frost; S. Gudibendi; Leona Kim-Schluger; Thomas Schiano; Sander Florman; M. Zeeshan Akhtar
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Crossref

The association between hemoglobin levels and renal function parameters during normothermic machine perfusion: A retrospective cohort study using porcine kidneys

Artificial Organs
2024-08 | Journal article
Contributors: L. Annick van Furth; Tobias M. Huijink; L. Leonie van Leeuwen; Hanno Maassen; Veerle A. Lantinga; Baran Ogurlu; Tim L. Hamelink; Merel B. F. Pool; Rianne Schutter; Susanne Z. J. Veldhuis et al.
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Crossref
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A Decade of Liver Transplantation in the United States: Drivers of Discard and Underutilization

Transplantation Direct
2024-05-03 | Journal article
Part of ISSN: 2373-8731
Contributors: Julia Torabi; Rachel Todd; L. Leonie van Leeuwen; Yuki Bekki; Matthew Holzner; Jang Moon; Tom Schiano; Sander S. Florman; Mohammed Akhtar
Source: Self-asserted source
Leonie van Leeuwen, PhD

Wasted Potential: Decoding the Trifecta of Donor Kidney Shortage, Underutilization, and Rising Discard Rates

Transplantology
2024-03-28 | Journal article
Contributors: Ceilidh McKenney; Julia Torabi; Rachel Todd; M. Zeeshan Akhtar; Fasika M. Tedla; Ron Shapiro; Sander S. Florman; Matthew L. Holzner; L. Leonie van Leeuwen
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Crossref
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Targeted delivery of galunisertib using machine perfusion reduces fibrogenesis in an integrated ex vivo renal transplant and fibrogenesis model

British Journal of Pharmacology
2024-02 | Journal article
Contributors: L. Leonie van Leeuwen; Mitchel J. R. Ruigrok; Benedikt M. Kessler; Henri G. D. Leuvenink; Peter Olinga
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Crossref
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Expanding the Horizons of Pre-Transplant Renal Vascular Assessment Using Ex Vivo Perfusion

Current Issues in Molecular Biology
2023-06 | Journal article | Author
Contributors: Carolina Campos Pamplona; Cyril Moers; Henri G. D. Leuvenink; Leonie van Leeuwen, PhD
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Multidisciplinary Digital Publishing Institute
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Slice of Life: Porcine Kidney Slices for Testing Antifibrotic Drugs in a Transplant Setting

Transplantology
2023-04-14 | Journal article
Contributors: L. Leonie van Leeuwen; Mitchel J. R. Ruigrok; Henri G. D. Leuvenink; Peter Olinga
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Crossref
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Molecular signatures underlying kidney transplantation

2022 | Dissertation or Thesis | Author
SOURCE-WORK-ID:

b4bef847-5b67-433f-a393-1da71c318f15

Contributors: Leonie van Leeuwen, PhD
Source: check_circle
University of Groningen

Impact of Red Blood Cells on Function and Metabolism of Porcine Deceased Donor Kidneys During Normothermic Machine Perfusion

Transplantation
2022-06 | Journal article | Author
SOURCE-WORK-ID:

4bc67e47-3be6-4ca9-aacc-0e30a1118018

WOSUID:

000800303100030

EID:

2-s2.0-85131299952

Contributors: COPE consortium; Leonie H Venema; Leonie van Leeuwen, PhD; Rene Posma; Harry van Goor; Rutger J Ploeg; Patrick Hannaert; Thierry Hauet; Thomas Minor; Henri Leuvenink
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University of Groningen

Exploring Porcine Precision-Cut Kidney Slices as a Model for Transplant-Related Ischemia-Reperfusion Injury

Transplantology
2022-04-26 | Journal article
Contributors: L. Annick van Furth; Henri G. D. Leuvenink; Lorina Seras; Inge A. M. de Graaf; Peter Olinga; L. Leonie van Leeuwen
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Crossref
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Targeted delivery of galunisertib attenuates fibrogenesis in an integrated ex vivo renal transplant and fibrosis model

2022-03-23 | Preprint
Contributors: L. Leonie van Leeuwen; Henri G.D. Leuvenink; Benedikt M. Kessler; Peter Olinga; Mitchel J.R. Ruigrok
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Crossref

Doxycycline Alters the Porcine Renal Proteome and Degradome during Hypothermic Machine Perfusion

Current Issues in Molecular Biology
2022-01-23 | Journal article
Part of ISSN: 1467-3045
Source: Self-asserted source
Leonie van Leeuwen, PhD
grade
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Shifting Paradigms for Suppressing Fibrosis in Kidney Transplants

Frontiers in Medicine
2022-01-10 | Journal article
Part of ISSN: 2296-858X
Source: Self-asserted source
Leonie van Leeuwen, PhD
grade
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Proteomic analysis of machine perfusion solution from brain dead donor kidneys reveals that elevated complement, cytoskeleton and lipid metabolism proteins are associated with 1‐year outcome

Transplant International
2021-09 | Journal article
Contributors: L. Leonie Leeuwen; Nora A. Spraakman; Aukje Brat; Honglei Huang; Adam M. Thorne; Sarah Bonham; Bas W. M. van Balkom; Rutger J. Ploeg; Benedikt M. Kessler; Henri G.D. Leuvenink
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Crossref
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Complement is activated during normothermic machine perfusion of porcine and discarded human kidneys

Transplant International
2021-08 | Other | Author
SOURCE-WORK-ID:

b18e9afa-7ca2-418f-9e1e-47250c843f70

WOSUID:

000689725500408

Contributors: Leonie Venema; Tina Jager; Leonie van Leeuwen, PhD; Asel Arykbaeva; Cyril Moers; R.A. Pol; Ian Alwayn; Soren Pischke; Henri Leuvenink
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University of Groningen

Potential protective effects of doxycycline on renal proteome and degradome during hypothermic machine perfusion and reperfusion of porcine kidneys

Transplantation
2020-09 | Other | Author
SOURCE-WORK-ID:

c5c829e9-d97d-4557-b4db-58f923a51dac

WOSUID:

000618872100254

Contributors: Leonie van Leeuwen, PhD; Leonie Venema; Henri Leuvenink; Benedikt Kessler
Source: check_circle
University of Groningen