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Activities

Employment (1)

University of Siena: Siena, IT

1983-11-01 to present | Full Professor of Chemistry (Biotechnology, Chemistry and Pharmacy)
Employment
Source: Self-asserted source
STEFANO MANGANI

Education and qualifications (1)

University of Florence: Florence, Toscana, IT

1977-03-06 to present (Chemistry)
Education
Source: Self-asserted source
STEFANO MANGANI

Professional activities (1)

Texas A&M University: College Station, Texas, US

1979-06-01 to 1981-10-01 (Biochemistry & Biophysics)
Invited position
Source: Self-asserted source
STEFANO MANGANI

Works (24)

Identification of Innovative Folate Inhibitors Leveraging the Amino Dihydrotriazine Motif from Cycloguanil for Their Potential as Anti-Trypanosoma brucei Agents

ACS Infectious Diseases
2024-08-09 | Journal article
Contributors: Valeria Francesconi; Marco Rizzo; Cecilia Pozzi; Lorenzo Tagliazucchi; Claude U. Konchie Simo; Giulia Saporito; Giacomo Landi; Stefano Mangani; Anna Carbone; Silvia Schenone et al.
Source: check_circle
Crossref

Metal Ion Binding to Human Glutaminyl Cyclase: A Structural Perspective

International Journal of Molecular Sciences
2024-07-29 | Journal article
Contributors: Giusy Tassone; Cecilia Pozzi; Stefano Mangani
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Copper Binding and Redox Activity of α-Synuclein in Membrane-Like Environment

Biomolecules
2023-02-03 | Journal article
Contributors: Chiara Bacchella; Francesca Camponeschi; Paulina Kolkowska; Arian Kola; Isabella Tessari; Maria Camilla Baratto; Marco Bisaglia; Enrico Monzani; Luigi Bubacco; Stefano Mangani et al.
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Crossref
grade
Preferred source (of 2)‎

Structural Characterization of Human Heat Shock Protein 90 N-Terminal Domain and Its Variants K112R and K112A in Complex with a Potent 1,2,3-Triazole-Based Inhibitor

International Journal of Molecular Sciences
2022-08-21 | Journal article
Contributors: Giusy Tassone; Marco Mazzorana; Stefano Mangani; Elena Petricci; Elena Cini; Giuseppe Giannini; Cecilia Pozzi; Samuele Maramai
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Crossref
grade
Preferred source (of 2)‎

Crystal structure of the ternary complex of Leishmania major pteridine reductase 1 with the cofactor NADP+/NADPH and the substrate folic acid

Acta Crystallographica Section F Structural Biology Communications
2022-04-01 | Journal article
Contributors: Lucia Dello Iacono; Flavio Di Pisa; Stefano Mangani
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Crossref

Xanthopsin‐Like Systems via Site‐Specific Click‐Functionalization of a Retinoic Acid Binding Protein

ChemBioChem
2022-01-05 | Journal article
Contributors: Giusy Tassone; Marco Paolino; Cecilia Pozzi; Annalisa Reale; Laura Salvini; Gianluca Giorgi; Maurizio Orlandini; Federico Galvagni; Stefano Mangani; Xuchun Yang et al.
Source: check_circle
Crossref

Repurposing the Trypanosomatidic GSK Kinetobox for the Inhibition of Parasitic Pteridine and Dihydrofolate Reductases

Pharmaceuticals
2021-11-30 | Journal article
Contributors: Matteo Santucci; Rosaria Luciani; Eleonora Gianquinto; Cecilia Pozzi; Flavio di Pisa; Lucia dello Iacono; Giacomo Landi; Lorenzo Tagliazucchi; Stefano Mangani; Francesca Spyrakis et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Iron Binding in the Ferroxidase Site of Human Mitochondrial Ferritin

Chemistry – A European Journal
2021-10-21 | Journal article
Contributors: Silvia Ciambellotti; Alessandro Pratesi; Giusy Tassone; Paola Turano; Stefano Mangani; Cecilia Pozzi
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Crossref

Evidence of Pyrimethamine and Cycloguanil Analogues as Dual Inhibitors of Trypanosoma brucei Pteridine Reductase and Dihydrofolate Reductase

Pharmaceuticals
2021-06-30 | Journal article
Contributors: Giusy Tassone; Giacomo Landi; Pasquale Linciano; Valeria Francesconi; Michele Tonelli; Lorenzo Tagliazucchi; Maria Paola Costi; Stefano Mangani; Cecilia Pozzi
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Crossref
grade
Preferred source (of 2)‎

Structural Bases for the Synergistic Inhibition of Human Thymidylate Synthase and Ovarian Cancer Cell Growth by Drug Combinations

Cancers
2021-04-24 | Journal article
Contributors: Cecilia Pozzi; Matteo Santucci; Gaetano Marverti; Domenico D’Arca; Lorenzo Tagliazucchi; Stefania Ferrari; Gaia Gozzi; Lorena Losi; Giusy Tassone; Stefano Mangani et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–7

Molecules
2020-06 | Journal article | Author
Contributors: Michael Gütschow; Jean Jacques Vanden Eynde; Josef Jampilek; Congbao Kang; Arduino Aleksander Mangoni; Paola Fossa; Rafik Karaman; Andrea Trabocchi; Peter Scott; Johannes Reynisson et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

High-resolution crystal structure of Trypanosoma brucei pteridine reductase 1 in complex with an innovative tricyclic-based inhibitor

Acta Crystallographica Section D Structural Biology
2020-06-01 | Journal article
Contributors: Giacomo Landi; Pasquale Linciano; Giusy Tassone; Maria Paola Costi; Stefano Mangani; Cecilia Pozzi
Source: check_circle
Crossref

Cover Feature: Iron Biomineral Growth from the Initial Nucleation Seed in L‐Ferritin (Chem. Eur. J. 26/2020)

Chemistry – A European Journal
2020-05-07 | Journal article
Contributors: Silvia Ciambellotti; Cecilia Pozzi; Stefano Mangani; Paola Turano
Source: check_circle
Crossref

Iron Biomineral Growth from the Initial Nucleation Seed in L‐Ferritin

Chemistry – A European Journal
2020-05-07 | Journal article
Contributors: Silvia Ciambellotti; Cecilia Pozzi; Stefano Mangani; Paola Turano
Source: check_circle
Crossref

Breakthroughs in Medicinal Chemistry: New Targets and Mechanisms, New Drugs, New Hopes–6

Molecules
2019-12 | Journal article | Author
Contributors: Jean Jacques Vanden Eynde; Arduino Aleksander Mangoni; Jarkko Rautio; Jérôme Leprince; Yasu-Taka Azuma; Alfonso T. García-Sosa; Christopher Hulme; Josef Jampilek; Rafik Karaman; Wei Li et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Fibrils of α-Synuclein Abolish the Affinity of Cu2+-Binding Site to His50 and Induce Hopping of Cu2+ Ions in the Termini

Inorganic Chemistry
2019-08-19 | Journal article
Contributors: Daniel N. Bloch; Paulina Kolkowska; Isabella Tessari; Maria Camilla Baratto; Adalgisa Sinicropi; Luigi Bubacco; Stefano Mangani; Cecilia Pozzi; Daniela Valensin; Yifat Miller
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Crossref

Small Molecules as Potential Inhibitors of the 14-3-3/c-Abl Interaction for the Treatment of CML

2019-08-07 | Conference paper
Contributors: Leire Iralde-Lorente; Giusy Tassone; Ylenia Cau; Claire Munier; Lorenzo Franci; Cecilia Pozzi; Adriano Angelucci; Mario Chiariello; Matthew Perry; Stefano Mangani et al.
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Crossref

Targeting Methyltransferases in Human Pathogenic Bacteria: Insights into Thymidylate Synthase (TS) and Flavin-Dependent TS (FDTS)

Molecules
2019-04-25 | Journal article
Contributors: Cecilia Pozzi; Ludovica Lopresti; Giusy Tassone; Stefano Mangani
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Structural and Functional Characterization of the Human Thymidylate Synthase (hTS) Interface Variant R175C, New Perspectives for the Development of hTS Inhibitors

Molecules
2019-04-07 | Journal article
Contributors: Cecilia Pozzi; Stefania Ferrari; Rosaria Luciani; Maria Paola Costi; Stefano Mangani
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Crossref
grade
Preferred source (of 2)‎

Evidence of Destabilization of the Human Thymidylate Synthase (hTS) Dimeric Structure Induced by the Interface Mutation Q62R

Biomolecules
2019-04-03 | Journal article
Contributors: Cecilia Pozzi; Ludovica Lopresti; Matteo Santucci; Maria Paola Costi; Stefano Mangani
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Crossref

Structural Comparison of Enterococcus faecalis and Human Thymidylate Synthase Complexes with the Substrate dUMP and Its Analogue FdUMP Provides Hints about Enzyme Conformational Variabilities

Molecules
2019-03-31 | Journal article
Contributors: Cecilia Pozzi; Stefania Ferrari; Rosaria Luciani; Giusy Tassone; Maria Paola Costi; Stefano Mangani
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Crossref
grade
Preferred source (of 2)‎

The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders

JBIC Journal of Biological Inorganic Chemistry
2018-12-21 | Journal article
Contributors: Cecilia Pozzi; Flavio Di Pisa; Manuela Benvenuti; Stefano Mangani
Source: check_circle
Crossref

Atomic‐Resolution Structure of a Class C β‐Lactamase and Its Complex with Avibactam

ChemMedChem
2018-07-18 | Journal article
Contributors: Cecilia Pozzi; Flavio Di Pisa; Filomena De Luca; Manuela Benvenuti; Jean Denis Docquier; Stefano Mangani
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Crossref

Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory‐Iron‐Binding Sites in the Catalytic Cavity

Chemistry – A European Journal
2016-11-02 | Journal article
Contributors: Caterina Bernacchioni; Cecilia Pozzi; Flavio Di Pisa; Stefano Mangani; Paola Turano
Source: check_circle
Crossref

Peer review (11 reviews for 9 publications/grants)

Review activity for ACS chemical biology. (1)
Review activity for ACS infectious diseases. (1)
Review activity for ACS omega. (1)
Review activity for Cellular and molecular life sciences (1)
Review activity for ChemMedChem. (1)
Review activity for Crystals. (1)
Review activity for Inorganic chemistry. (2)
Review activity for International journal of biological macromolecules. (2)
Review activity for Journal of medicinal chemistry. (1)