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ResearcherID: KCV-6171-2024

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Masaryk University: Brno, CZ

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Tomasz Radaszkiewicz

Works (30)

Armed with PRICKLE(3)s: Stabilizing WNT/PCP complexes against RNF43-mediated ubiquitination

2025-03-25 | Preprint
DOI: 10.1101/2025.03.24.644882
Contributors: Katarzyna A. Radaszkiewicz; Tomasz W. Radaszkiewicz; Pavla Kolářová; Petra Paclíková; Kristína Gömöryová; Tomáš Bárta; Kateřina Hanáková; Zbyněk Zdráhal; Jakub Harnoš
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A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology

Nature Communications
2023 | Journal article
DOI: 10.1038/S41467-023-38663-7
WOSUID: WOS:001029731000007
Contributors: Petersen, Julian; Englmaier, Lukas; Artemov, Artem V.; Poverennaya, Irina; Mahmoud, Ruba; Bouderlique, Thibault; Tesarova, Marketa; Deviatiiarov, Ruslan; Szilvasy-Szabo, Anett; Akkuratov, Evgeny E. et al.
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Author Correction: A previously uncharacterized Factor Associated with Metabolism and Energy (FAME/C14orf105/CCDC198/1700011H14Rik) is related to evolutionary adaptation, energy balance, and kidney physiology (vol 14, 3092, 2023)

Nature Communications
2023 | Journal article
DOI: 10.1038/S41467-023-39373-W
WOSUID: WOS:001026275700035
Contributors: Petersen, Julian; Englmaier, Lukas; Artemov, Artem V.; Poverennaya, Irina; Mahmoud, Ruba; Bouderlique, Thibault; Tesarova, Marketa; Deviatiiarov, Ruslan; Szilvasy-Szabo, Anett; Akkuratov, Evgeny E. et al.
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Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

Science Advances
2023-11-24 | Journal article
DOI: 10.1126/sciadv.adh9673
Contributors: Gabriele Colozza; Heetak Lee; Alessandra Merenda; Szu-Hsien Sam Wu; Andrea Català-Bordes; Tomasz W. Radaszkiewicz; Ingrid Jordens; Ji-Hyun Lee; Aileen-Diane Bamford; Fiona Farnhammer et al.
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Intestinal Paneth cell differentiation relies on asymmetric regulation of Wnt signaling by Daam1/2

2023-01-25 | Preprint
DOI: 10.1101/2023.01.24.525366
Contributors: Gabriele Colozza; Heetak Lee; Alessandra Merenda; Szu-Hsien Sam Wu; Andrea Català-Bordes; Tomasz W. Radaszkiewicz; Ingrid Jordens; Ji-Hyun Lee; Aileen-Diane Bamford; Fiona Farnhammer et al.
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Dual specificity phosphatase 7 drives the formation of cardiac mesoderm in mouse embryonic stem cells

Plos One
2022 | Journal article
DOI: 10.1371/JOURNAL.PONE.0275860
WOSUID: WOS:000924819300068
Contributors: Sladecek, Stanislava; Radaszkiewicz, Katarzyna Anna; Bohmova, Martina; Gybel, Tomas; Radaszkiewicz, Tomasz Witold; Pachernik, Jiri
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Dual Specificity Phosphatase 7 Drives the Formation of Cardiac Mesoderm in Mouse Embryonic Stem Cells

BioRxiv
2022 | Journal article
DOI: 10.1101/2022.01.18.476715
WOSUID: PPRN:9265203
Contributors: Sladecek, S.; Radaszkiewicz, K. A.; Bohmova, M.; Gybel, T.; Radaszkiewicz, T. W.; Pachernik, J.
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LuminoCell: a versatile and affordable platform for real-time monitoring of luciferase-based reporters

Life Science Alliance
2022-08 | Journal article
DOI: 10.26508/lsa.202201421
Contributors: Kamila Weissová; Bohumil Fafílek; Tomasz Radaszkiewicz; Canan Celiker; Petra Macháčková; Tamara Čechová; Jana Šebestíková; Aleš Hampl; Vítězslav Bryja; Pavel Krejčí et al.
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RNF43 inhibits WNT5A driven signaling and suppresses melanoma invasion

BioRxiv
2021 | Journal article
DOI: 10.1101/2021.02.08.430210
Contributors: Tomasz Radaszkiewicz; Michaela Nosková; Kristína Gömöryová; Olga Vondálová Blanářová; Katarzyna Anna Radaszkiewicz; Markéta Picková; Ráchel Víchová; Tomáš Gybel’; Karol Kaiser; Lucia Demková et al.
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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

eLife
2021 | Journal article
DOI: 10.7554/ELIFE.65759.SA2
WOSUID: WOS:000712036700001
Contributors: Radaszkiewicz, Tomasz; Noskova, Michaela; Gomoryova, Kristina; Blanarova, Olga Vondalova; Radaszkiewicz, Katarzyna Anna; Pickova, Marketa; Vichova, Rachel; Gybel, Tomas; Kaiser, Karol; Demkova, Lucia et al.
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Roles of individual human Dishevelled paralogs in the Wnt signalling pathways

Cellular Signalling
2021 | Journal article
DOI: 10.1016/J.CELLSIG.2021.110058
WOSUID: WOS:000685349100004
Contributors: Paclikova, Petra; Radaszkiewicz, Tomasz Witold; Potesil, David; Harnos, Jakub; Zdrahal, Zbynek; Bryja, Vitezslav
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RNF43 inhibits WNT5A-driven signaling and suppresses melanoma invasion and resistance to the targeted therapy

eLife
2021-10-27 | Journal article
DOI: 10.7554/eLife.65759
Contributors: Tomasz Radaszkiewicz; Michaela Nosková; Kristína Gömöryová; Olga Vondálová Blanářová; Katarzyna Anna Radaszkiewicz; Markéta Picková; Ráchel Víchová; Tomáš Gybeľ; Karol Kaiser; Lucia Demková et al.
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12-O-Tetradecanoylphor bol-13-acetate increases cardiomyogenesis through PKC/ERK signaling

Scientific Reports
2020 | Journal article
DOI: 10.1038/S41598-020-73074-4
WOSUID: WOS:000577348000016
Contributors: Radaszkiewicz, Katarzyna Anna; Beckerov, Deborah; Woloszczukov, Lucie; Radaszkiewicz, Tomasz Witold; Lesakov, Petra; Blanarov, Olga Vondalova; Kubala, Lukas; Humpolicek, Petr; Pachernik, Jiri
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Mutations in GRK2 cause Jeune syndrome by impairing Hedgehog and canonical Wnt signaling

EMBO Molecular Medicine
2020 | Journal article
DOI: 10.15252/EMMM.201911739
WOSUID: WOS:000577616000001
Contributors: Bosakova, Michaela; Abraham, Sara P.; Nita, Alexandru; Hruba, Eva; Buchtova, Marcela; Taylor, S. Paige; Duran, Ivan; Martin, Jorge; Svozilova, Katerina; Barta, Tomas et al.
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Protease associated domain of RNF43 is not necessary for the suppression of Wnt/β-catenin signaling in human cells

Cell Communication and Signaling
2020 | Journal article
DOI: 10.1186/S12964-020-00559-0
WOSUID: WOS:000542292400001
Contributors: Radaszkiewicz, Tomasz; Bryja, Vitezslav
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WNT signaling inducing activity in ascites predicts poor outcome in ovarian cancer

Theranostics
2020 | Journal article
DOI: 10.7150/THNO.37423
WOSUID: WOS:000498874200005
Contributors: Kotrbova, Anna; Ovesna, Petra; Gybel, Tomas; Radaszkiewicz, Tomasz; Bednarikova, Marketa; Hausnerova, Jitka; Jandakova, Eva; Minar, Lubos; Crha, Igor; Weinberger, Vit et al.
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RNF 43 truncations trap CK 1 to drive niche‐independent self‐renewal in cancer

The EMBO Journal
2020-09-15 | Journal article
DOI: 10.15252/embj.2019103932
Contributors: Maureen Spit; Nicola Fenderico; Ingrid Jordens; Tomasz Radaszkiewicz; Rik GH Lindeboom; Jeroen M Bugter; Alba Cristobal; Lars Ootes; Max van Osch; Eline Janssen et al.
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Dishevelled-3 conformation dynamics analyzed by FRET-based biosensors reveals a key role of casein kinase 1

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-09651-7
WOSUID: WOS:000464979000002
Contributors: Harnos, Jakub; Canizal, Maria Consuelo Alonso; Jurasek, Miroslav; Kumar, Jitender; Holler, Cornelia; Schambony, Alexandra; Hanakova, Katerina; Bernatik, Ondrej; Zdrahal, Zbynek; Gomoryova, Kristina et al.
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WNT5A is transported via lipoprotein particles in the cerebrospinal fluid to regulate hindbrain morphogenesis

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-09298-4
WOSUID: WOS:000462986000002
Contributors: Kaiser, Karol; Gyllborg, Daniel; Prochazka, Jan; Salasova, Alena; Kompanikova, Petra; Molina, Francisco Lamus; Laguna-Goya, Rocio; Radaszkiewicz, Tomasz; Harnos, Jakub; Prochazkova, Michaela et al.
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Casein kinase 1 is a therapeutic target in chronic lymphocytic leukemia

Blood
2018 | Journal article
DOI: 10.1182/BLOOD-2017-05-786947
WOSUID: WOS:000430687500009
Contributors: Janovska, Pavlina; Verner, Jan; Kohoutek, Jiri; Bryjova, Lenka; Gregorova, Michaela; Dzimkova, Marta; Skabrahova, Hana; Radaszkiewicz, Tomasz; Ovesna, Petra; Blanarova, Olga Vondalova et al.
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Dishevelled has a YAP nuclear export function in a tumor suppressor context-dependent manner

Nature Communications
2018 | Journal article
DOI: 10.1038/S41467-018-04757-W
WOSUID: WOS:000434927300002
Contributors: Lee, Yoonmi; Kim, Nam Hee; Cho, Eunae Sandra; Yang, Ji Hye; Cha, Yong Hoon; Kang, Hee Eun; Yun, Jun Seop; Cho, Sue Bean; Lee, Seon-Hyeong; Paclikova, Petra et al.
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The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer (vol 12, e0189864, 2017)

Plos One
2018 | Journal article
DOI: 10.1371/JOURNAL.PONE.0197796
WOSUID: WOS:000432348900098
Contributors: Fatima, Tram; El-Ayachi, Ikbale; Taotao, Ling; Lillo, M. Angeles; Krutilina, Raisa I.; Seagroves, Tiffany N.; Radaszkiewicz, Tomasz W.; Hutnan, Miroslav; Bryja, Viterslav; Krum, Susan A. et al.
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The planar cell polarity protein VANG-1/Vangl negatively regulates Wnt/β-catenin signaling through a Dvl dependent mechanism

PLOS Genetics
2018 | Journal article
DOI: 10.1371/JOURNAL.PGEN.1007840
WOSUID: WOS:000455099000023
Contributors: Mentink, Remco A.; Rella, Lorenzo; Radaszkiewicz, Tomasz W.; Gybel, Tomas; Betist, Marco C.; Bryja, Vitezslav; Korswagen, Hendrik C.
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A Novel Role for the BMP Antagonist Noggin in Sensitizing Cells to Non-canonical Wnt-5a/Ror2/Disheveled Pathway Activation

Frontiers in Cell and Developmental Biology
2017 | Journal article
DOI: 10.3389/FCELL.2017.00047
WOSUID: WOS:000455238900047
Contributors: Bernatik, Ondrej; Radaszkiewicz, Tomasz; Behal, Martin; Dave, Zankruti; Witte, Florian; Mahl, Annika; Cernohorsky, Nicole H.; Krejci, Pavel; Stricker, Sigmar; Bryja, Vitezslav
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Casein Kinase 1 delta/epsilon inhibition blocks CLL chemotaxis and delays leukemia onset in the Eμ-TCL1 mouse model of chronic lymphocytic leukemia

Leukemia & Lymphoma
2017 | Journal article
WOSUID: WOS:000423431100187
Contributors: Janovska, Pavlina; Verner, Jan; Kohoutek, Jiri; Bryjoval, Lenka; Dzimkova, Marta; Skabrahova, Hana; Radaszkiewicz, Tomasz; Nemcova, Tereza; Hoferova, Zuzana; Vasickova, Katerina et al.
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The N-Terminal Part of the Dishevelled DEP Domain Is Required for Wnt/<i>β</i>-Catenin Signaling in Mammalian Cells

Molecular and Cellular Biology
2017 | Journal article
DOI: 10.1128/MCB.00145-17
WOSUID: WOS:000408425300005
Contributors: Paclikova, Petra; Bernatik, Ondrej; Radaszkiewicz, Tomasz Witold; Bryja, Vitezslav
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The natural compound Jatrophone interferes with Wnt/β-catenin signaling and inhibits proliferation and EMT in human triple-negative breast cancer

Plos One
2017 | Journal article
DOI: 10.1371/JOURNAL.PONE.0189864
WOSUID: WOS:000419006200051
Contributors: Fatima, Iram; El-Ayachi, Ikbale; Taotao, Ling; Lillo, M. Angeles; Krutilina, Raya; Seagroves, Tiffany N.; Radaszkiewicz, Tomasz W.; Hutnan, Miroslav; Bryja, Viterslav; Krum, Susan A. et al.
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Gelsolin interacts with LamR, hnRNP U, nestin, Arp3 and β-tubulin in human melanoma cells as revealed by immunoprecipitation and mass spectrometry

European Journal of Cell Biology
2016 | Journal article
DOI: 10.1016/J.EJCB.2015.11.001
WOSUID: WOS:000371563200003
Contributors: Mazur, Antonina Joanna; Radaszkiewicz, Tomasz; Makowiecka, Aleksandra; Malicka-Blaszkiewicz, Maria; Mannherz, Hans Georg; Nowak, Dorota
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Asymmetry of VANGL2 in migrating lymphocytes as a tool to monitor activity of the mammalian WNT/planar cell polarity pathway

Cell Communication and Signaling
2015 | Journal article
DOI: 10.1186/S12964-014-0079-1
WOSUID: WOS:000348821900001
Contributors: Kaucka, Marketa; Petersen, Julian; Janovska, Pavlina; Radaszkiewicz, Tomasz; Smyckova, Lucie; Daulat, Avais M.; Borg, Jean-Paul; Schulte, Gunnar; Bryja, Vitezslav
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Distribution of formins in cardiac muscle: FHOD1 is a component of intercalated discs and costameres

European Journal of Cell Biology
2015 | Journal article
DOI: 10.1016/J.EJCB.2014.11.003
WOSUID: WOS:000351256200004
Contributors: Al Haj, Abdulatif; Mazur, Antonina J.; Radaszkiewicz, Katarzyna; Radaszkiewicz, Tomasz; Makowiecka, Aleksandra; Stopschinski, Barbara E.; Schoenichen, Andre; Geyer, Matthias; Mannherz, Hans Georg
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