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ResearcherID: N-3861-2015
Scopus Author ID: 6506578220
ResearcherID: AAE-7498-2020

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Employment (1)

University of Vienna: Vienna, AT

2015-04-15 to present | Associate Professor (Max Perutz Laboratories)
Employment
Source: Self-asserted source
Martin Leeb

Funding (7)

Execution of cell fate choice by cooperative gene activities

2023-01-01 to 2025-12-31 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.12957378
GRANT_NUMBER: I 5958
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Mechanisms of endo-mesodermal lineage choice

2022-06-01 to 2025-05-31 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.12858834
GRANT_NUMBER: P 35637
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Regulation of ES cell differentiation by NMD

2018-12-01 to 2022-11-30 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.7825312
GRANT_NUMBER: P 31334
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Systems Level Analysis of ES Cell Differentiation

2018-03-01 to 2021-02-28 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.7580117
GRANT_NUMBER: I 3786
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Execution of cell fate choice by cooperative gene activities

2018-01-01 to present | Grant
Deutsche Forschungsgemeinschaft (Bonn, DE)
URL: https://app.dimensions.ai/details/grant/grant.7518743
GRANT_NUMBER: 398882498
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Stem Cell Biology

2015-04-15 to 2023-04-14 | Grant
Vienna Science and Technology Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.9489079
GRANT_NUMBER: VRG14-006
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Mechanisms of ES cell differentiation

2013-07-01 to 2015-12-31 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.6206631
GRANT_NUMBER: J 3459
Source: Self-asserted source
Martin Leeb via DimensionsWizard

Works (37)

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

Nature Communications
2024-09-09 | Journal article
DOI: 10.1038/s41467-024-51794-9
Contributors: Laura Santini; Saskia Kowald; Luis Miguel Cerron-Alvan; Michelle Huth; Anna Philina Fabing; Giovanni Sestini; Nicolas Rivron; Martin Leeb
Source: check_circle
Crossref

FoxO transcription factors actuate the formative pluripotency specific gene expression programme

2024-01-14 | Preprint
DOI: 10.1101/2024.01.13.575494
Contributors: Laura Santini; Saskia Kowald; Giovanni Sestini; Nicolas Rivron; Martin Leeb
Source: check_circle
Crossref

Enhancers of the PAIR4 regulatory module promote distal VH gene recombination at the Igh locus

The EMBO Journal
2023-08 | Journal article
DOI: 10.15252/embj.2022112741
Contributors: Louisa Hill; Markus Jaritz; Hiromi Tagoh; Karina Schindler; Daniela Kostanova‐Poliakova; Qiong Sun; Tanja A Schwickert; Martin Leeb; Meinrad Busslinger
Source: check_circle
Crossref

Enhancer-promoter interactions are reconfigured through the formation of long-range multiway chromatin hubs as mouse ES cells exit pluripotency

2023-02-08 | Preprint | Author
DOI: 10.1101/2023.02.08.527615
Contributors: David Lando; Xiaoyan Ma; Y. Cao; A. Jartseva; T. J. Stevens; W. Boucher; Nicola Reynolds; Bertille Montibus; D. Hall; A Lackner et al.
Source: Self-asserted source
Martin Leeb

NMD is required for timely cell fate transitions by fine-tuning gene expression and regulating translation

Genes & Development
2022-03-01 | Journal article | Author
DOI: 10.1101/gad.347690.120
Part of ISSN: 0890-9369
Part of ISSN: 1549-5477
Contributors: Michelle Huth; Laura Santini; Elena Galimberti; Julia Ramesmayer; Fabian Titz-Teixeira; Robert Sehlke; Michael Oberhuemer; Sarah Stummer; Veronika Herzog; Marius Garmhausen et al.
Source: Self-asserted source
Martin Leeb

Genomic imprinting in mouse blastocysts is predominantly associated with H3K27me3

Nature Communications
2021-06-21 | Journal article | Author
DOI: 10.1038/s41467-021-23510-4
Part of ISSN: 2041-1723
Contributors: Laura Santini; Florian Halbritter; Fabian Titz-Teixeira; Toru Suzuki; Maki Asami; Xiaoyan Ma; Julia Ramesmayer; Andreas Lackner; Nick Warr; Florian Pauler et al.
Source: Self-asserted source
Martin Leeb

Novel imprints in mouse blastocysts are predominantly DNA methylation independent

2020-11 | Preprint
DOI: 10.1101/2020.11.03.366948
OTHER-ID:

PPR234457
Contributors: Santini L; Halbritter F; Titz-Teixeira F; Suzuki T; Asami M; Ramesmayer J; Ma X; Lackner A; Warr N; Pauler F et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

NMD is required for timely cell fate transitions by fine-tuning gene expression and controlling translation

2020-07 | Preprint
DOI: 10.1101/2020.07.07.180133
OTHER-ID:

PPR185062
Contributors: Galimberti E; Sehlke R; Huth M; Garmhausen M; Romeike M; Ramesmayer J; Stummer S; Titz-Teixeira F; Herzog V; Chugunova A et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Detailed temporal dissection of an enhancer cluster reveals two distinct roles for individual elements

2020-05 | Preprint
DOI: 10.1101/2020.05.06.080564
OTHER-ID:

PPR160027
Contributors: Thomas H; Kotova E; Pilz A; Romeike M; Lackner A; Bock C; Leeb M; Wysocka J; Buecker C
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Cooperative genetic networks drive a mammalian cell state transition

2020-03 | Preprint
DOI: 10.1101/2020.03.23.000109
OTHER-ID:

PPR126774
Contributors: Lackner A; Sehlke R; Garmhausen M; Stirparo GG; Huth M; Titz-Teixeira F; van der Lelij P; Ramesmayer J; Thomas HF; Ralser M et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

PHF3 regulates neuronal gene expression through the new Pol II CTD reader domain SPOC

2020-02 | Preprint
DOI: 10.1101/2020.02.11.943159
OTHER-ID:

PPR112846
Contributors: Appel L; Franke V; Bruno M; Grishkovskaya I; Kasiliauskaite A; Schoeberl UE; Puchinger MG; Kostrhon S; Beltzung E; Mechtler K et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Combining fluorescence imaging with Hi-C to study 3D genome architecture of the same single cell.

Nature protocols
2018-04 | Journal article
DOI: 10.1038/nprot.2018.017
PMID: 29674753
Contributors: Lando D; Basu S; Stevens TJ; Riddell A; Wohlfahrt KJ; Cao Y; Boucher W; Leeb M; Atkinson LP; Lee SF et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

3D structures of individual mammalian genomes studied by single-cell Hi-C.

Nature
2017-03 | Journal article
DOI: 10.1038/nature21429
PMID: 28289288
PMC: PMC5385134
Contributors: Stevens TJ; Lando D; Basu S; Atkinson LP; Cao Y; Lee SF; Leeb M; Wohlfahrt KJ; Boucher W; O'Shaughnessy-Kirwan A et al.
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Histone H3 Lysine 36 Trimethylation Is Established over the Xist Promoter by Antisense Tsix Transcription and Contributes to Repressing Xist Expression.

Molecular and cellular biology
2015-09 | Journal article
DOI: 10.1128/mcb.00561-15
PMID: 26370508
PMC: PMC4609750
Contributors: Ohhata T; Matsumoto M; Leeb M; Shibata S; Sakai S; Kitagawa K; Niida H; Kitagawa M; Wutz A
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Genetic exploration of the exit from self-renewal using haploid embryonic stem cells

Cell Stem Cell
2014 | Journal article
DOI: 10.1016/j.stem.2013.12.008
Contributors: Leeb, M.; Dietmann, S.; Paramor, M.; Niwa, H.; Smith, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Haploid genomes illustrate epigenetic constraints and gene dosage effects in mammals

Epigenetics Chromatin
2013 | Journal article
DOI: 10.1186/1756-8935-6-41
Contributors: Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

The histone deacetylase inhibitor sodium valproate causes limited transcriptional change in mouse embryonic stem cells but selectively overrides Polycomb-mediated Hoxb silencing

Epigenetics Chromatin
2013 | Journal article
DOI: 10.1186/1756-8935-6-11
Contributors: Boudadi, E.; Stower, H.; Halsall, J. A.; Rutledge, C. E.; Leeb, M.; Wutz, A.; O'Neill, L. P.; Nightingale, K. P.; Turner, B. M.
Source: Self-asserted source
Martin Leeb via ResearcherID

Gene dosage in mammals: characterization of haploid embryonic stem cells.

Epigenetics & chromatin
2013-03 | Journal article
PMC: PMC3600815
Contributors: Wutz A; Leeb M
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Establishment of epigenetic patterns in development

Chromosoma
2012 | Journal article
DOI: 10.1007/s00412-012-0365-x
WOSUID:

WOS:000304136600003
Contributors: Leeb, Martin; Wutz, Anton
Source: Self-asserted source
Martin Leeb via ResearcherID

Germline potential of parthenogenetic haploid mouse embryonic stem cells

Development
2012 | Journal article
DOI: 10.1242/dev.083675 139/18/3301 [pii]
Contributors: Leeb, M.; Walker, R.; Mansfield, B.; Nichols, J.; Smith, A.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID
grade
Preferred source (of 2)‎

Derivation of haploid embryonic stem cells from mouse embryos

Nature
2011 | Journal article
DOI: 10.1038/nature10448
Contributors: Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Establishment and Use of Mouse Haploid ES Cells

Current Protocols in Mouse Biology
2011 | Book chapter
DOI: 10.1002/9780470942390.mo140214
Contributors: Leeb, Martin; Perry, Anthony C. F.; Wutz, Anton
Source: Self-asserted source
Martin Leeb via ResearcherID

Histone acetylation and the maintenance of chromatin compaction by Polycomb repressive complexes

Cold Spring Harb Symp Quant Biol
2010 | Journal article
DOI: 10.1101/sqb.2010.75.053
Contributors: Eskeland, R.; Freyer, E.; Leeb, M.; Wutz, A.; Bickmore, W. A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Mechanistic concepts in X inactivation underlying dosage compensation in mammals

Heredity (Edinb)
2010 | Journal article
DOI: 10.1038/hdy.2009.181
Contributors: Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Polycomb complexes - Genes make sense of host defense

Cell Cycle
2010 | Journal article
SOURCE-WORK-ID:

1102151631132-176
Contributors: Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Polycomb complexes act redundantly to repress genomic repeats and genes

Genes Dev
2010 | Journal article
DOI: 10.1101/gad.544410
Contributors: Leeb, M.; Pasini, D.; Novatchkova, M.; Jaritz, M.; Helin, K.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Ring1B compacts chromatin structure and represses gene expression independent of histone ubiquitination

Mol Cell
2010 | Journal article
DOI: 10.1016/j.molcel.2010.02.032
Contributors: Eskeland, R.; Leeb, M.; Grimes, G. R.; Kress, C.; Boyle, S.; Sproul, D.; Gilbert, N.; Fan, Y.; Skoultchi, A. I.; Wutz, A. et al.
Source: Self-asserted source
Martin Leeb via ResearcherID

The Trithorax group protein Ash2l and Saf-A are recruited to the inactive X chromosome at the onset of stable X inactivation

Development
2010 | Journal article
DOI: 10.1242/dev.035956
Contributors: Pullirsch, D.; Hartel, R.; Kishimoto, H.; Leeb, M.; Steiner, G.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Polycomb complexes - Genes make sense of host defense.

Cell cycle (Georgetown, Tex.)
2010-07 | Journal article
DOI: 10.4161/cc.9.14.12455
PMID: 20581452
Contributors: Leeb M; Wutz A
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

SATB1 defines the developmental context for gene silencing by Xist in lymphoma and embryonic cells

Dev Cell
2009 | Journal article
DOI: 10.1016/j.devcel.2009.03.006
Contributors: Agrelo, R.; Souabni, A.; Novatchkova, M.; Haslinger, C.; Leeb, M.; Komnenovic, V.; Kishimoto, H.; Gresh, L.; Kohwi-Shigematsu, T.; Kenner, L. et al.
Source: Self-asserted source
Martin Leeb via ResearcherID

X chromosome inactivation sparked by non-coding RNAs

RNA Biol
2009 | Journal article
SOURCE-WORK-ID:

1102151631132-182
Contributors: Leeb, M.; Steffen, P. A.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

X chromosome inactivation sparked by non-coding RNAs.

RNA biology
2009-04 | Journal article
DOI: 10.4161/rna.6.2.7716
PMID: 19246991
Contributors: Leeb M; Steffen PA; Wutz A
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Ring1B is crucial for the regulation of developmental control genes and PRC1 proteins but not X inactivation in embryonic cells

J Cell Biol
2007 | Journal article
DOI: 10.1083/jcb.200612127
Contributors: Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Xist and the order of silencing

EMBO Rep
2007 | Journal article
DOI: 10.1038/sj.embor.7400871
Contributors: Ng, K.; Pullirsch, D.; Leeb, M.; Wutz, A.
Source: Self-asserted source
Martin Leeb via ResearcherID

Antibiotics: a shot in the arm.

Nature
2004-10 | Journal article
DOI: 10.1038/431892a
PMID: 15496888
Contributors: Leeb M
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Gasping for victory.

Nature
2004-08 | Journal article
DOI: 10.1038/430608a
PMID: 15295569
Contributors: Leeb M
Source: Self-asserted source
Martin Leeb via Europe PubMed Central

Critics blast 'premature' paper on adult stem cells.

Nature
2004-06 | Journal article
DOI: 10.1038/429590b
PMID: 15190319
Contributors: Schiermeier Q; Leeb M
Source: Self-asserted source
Martin Leeb via Europe PubMed Central
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