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Employment (5)

HHMI/Columbia University: New York, New York, US

2008-04-01 to present | Professor (Biochemistry and Molecular Biophysics)
Employment
Source: Self-asserted source
Joachim Frank

HHMI/Wadsworth Center: Albany, NY, US

1998-11-01 to 2008-03-31 | Lab Chief
Employment
Source: Self-asserted source
Joachim Frank

Division of Labs and Research/Wadsworth Center: Albany, New York, US

1975-09-01 to 1998-10-31 | Senior Research Scientist
Employment
Source: Self-asserted source
Joachim Frank

Cavendish Laboratory: Cambridge, Cambridgeshire, GB

1973-05-01 to 1975-07-30 | Research assistant (Electron Microscopy)
Employment
Source: Self-asserted source
Joachim Frank

Commonwealth Fund: NY, NY, US

1971-01-01 to 1972-12-31 | Postdoctoral Fellow (Harkness Fellowship)
Employment
Source: Self-asserted source
Joachim Frank

Education and qualifications (3)

Thechnical University of Munich: Munich, Bavaria, DE

1967-06-01 to 1970-09-15 | Dr. rer. nat. (Ph.D.) (Biophysics)
Education
Source: Self-asserted source
Joachim Frank

University of Munich: Munich, Bavaria, DE

1963-09-01 to 1967-04-30 | Diplom (Physics)
Education
Source: Self-asserted source
Joachim Frank

University Freiburg: Freiburg, Baden-Wuertenberg, DE

1960-09-01 to 1963-06-01 | Vordiplom (no department)
Education
Source: Self-asserted source
Joachim Frank

Professional activities (5)

Nobel Foundation: Stockholm, SE

2017 Nobel Prize in Chemistry
Distinction
Source: Self-asserted source
Joachim Frank

National Academy of Sciences: Washington, DC, US

Membership
Source: Self-asserted source
Joachim Frank

Biophysical Society: Rockville, Maryland, US

Membership
Source: Self-asserted source
Joachim Frank

American Association for the Advancement of Science: DC, DC, US

distinguished member
Membership
Source: Self-asserted source
Joachim Frank

American Academy of Arts and Sciences: Cambridge, MA, US

Membership
Source: Self-asserted source
Joachim Frank

Funding (2)

Structural Studies of Macromolecular Assemblies

Grant
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

NIH R01 GM29169
Source: Self-asserted source
Joachim Frank

Time-resolved Cryo-EM of Short-lived States in Eukaryotic Translation

Grant
National Institutes of Health (Md., Md., US)
GRANT_NUMBER:

NIH R01 GM55440
Source: Self-asserted source
Joachim Frank

Works (25)

Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering

RNA
2025-03-06 | Journal article
DOI: 10.1261/rna.080294.124
Contributors: Swastik De; Michelle Zhou; Zuben P Brown; Raymond N Burton-Smith; Yaser Hashem; Tatyana Pestova; Christopher U.T. Hellen; Joachim Frank
Source: check_circle
Crossref

Structural identification of the RY12 domain of RyR1 as an ADP sensor and the target of the malignant hyperthermia therapeutic dantrolene

2024-12-18 | Preprint
DOI: 10.21203/rs.3.rs-5604712/v1
Contributors: Oliver Clarke; Kookjoo Kim; Huan Li; Qi Yuan; Zephan Melville; Ran Zalk; Amedee des Georges; Joachim Frank; Wayne Hendrickson; Andrew Marks
Source: check_circle
Crossref

Time-resolved cryo-EM (TRCEM) sample preparation using a PDMS-based microfluidic chip assembly

2024-12-09 | Preprint
DOI: 10.1101/2024.12.08.627437
Contributors: Xiangsong Feng; Joachim Frank
Source: check_circle
Crossref

Passage through micro-sprayer increases functional activity – implications for activity assays in time-resolved cryo-EM

2024-12-04 | Preprint
DOI: 10.1101/2024.12.01.624867
Contributors: Priyanka Garg; Xiangsong Feng; Swastik De; Joachim Frank
Source: check_circle
Crossref

Inconsistencies in the published rabbit ribosomal rRNAs: a proposal for uniformity in sequence and site numbering

2024-10-12 | Preprint
DOI: 10.1101/2024.10.11.617640
Contributors: Swastik De; Michelle Zhou; Zuben P Brown; Raymond N. Burton-Smith; Yaser Hashem; Tatyana Pestova; Christopher U T Hellen; Joachim Frank
Source: check_circle
Crossref

Recovery of Conformational Continuum From Single-Particle Cryo-EM Images: Optimization of ManifoldEM Informed by Ground Truth

IEEE Transactions on Computational Imaging
2022 | Journal article
DOI: 10.1109/TCI.2022.3174801
Contributors: Evan Seitz; Francisco Acosta-Reyes; Suvrajit Maji; Peter Schwander; Joachim Frank
Source: check_circle
Crossref

CRYO-EM

2022-10 | Book
DOI: 10.1021/acsinfocus.7e5026
Contributors: Zuben P. Brown; Joachim Frank
Source: check_circle
Crossref

Molecular architecture of 40S translation initiation complexes on the hepatitis C virus IRES

The EMBO Journal
2022-08-16 | Journal article
DOI: 10.15252/embj.2022110581
Contributors: Zuben P Brown; Irina S Abaeva; Swastik De; Christopher U T Hellen; Tatyana V Pestova; Joachim Frank
Source: check_circle
Crossref

Contributions of single-particle cryoelectron microscopy toward fighting COVID-19

Trends in Biochemical Sciences
2022-02 | Journal article
DOI: 10.1016/j.tibs.2021.10.005
Contributors: Micah Rapp; Lawrence Shapiro; Joachim Frank
Source: check_circle
Crossref

Molecular architecture of 40S initiation complexes on the Hepatitis C virus IRES: from ribosomal attachment to eIF5B-mediated reorientation of initiator tRNA

2021-12-11 | Preprint
DOI: 10.1101/2021.12.10.472117
Contributors: Zuben P. Brown; Irina S. Abaeva; Swastik De; Christopher U.T. Hellen; Tatyana V. Pestova; Joachim Frank
Source: check_circle
Crossref

“Just in Time”: The Role of Cryo-Electron Microscopy in Combating Recent Pandemics

Biochemistry
2021-11-23 | Journal article
DOI: 10.1021/acs.biochem.1c00318
Contributors: Joachim Frank
Source: check_circle
Crossref

What is in the black box? – A perspective on software in cryoelectron microscopy

Biophysical Journal
2021-10 | Journal article
DOI: 10.1016/j.bpj.2021.09.015
Contributors: Suvrajit Maji; Joachim Frank
Source: check_circle
Crossref

Geometric machine learning informed by ground truth: Recovery of conformational continuum from single-particle cryo-EM data of biomolecules

2021-06-19 | Other
DOI: 10.1101/2021.06.18.449029
Contributors: Evan Seitz; Francisco Acosta-Reyes; Suvrajit Maji; Peter Schwander; Joachim Frank
Source: check_circle
Crossref

Retrieving functional pathways of biomolecules from single-particle snapshots

Nature Communications
2020-09-18 | Journal article
DOI: 10.1038/s41467-020-18403-x
Contributors: Ali Dashti; Ghoncheh Mashayekhi; Mrinal Shekhar; Danya Ben Hail; Salah Salah; Peter Schwander; Amedee des Georges; Abhishek Singharoy; Joachim Frank; Abbas Ourmazd
Source: check_circle
Crossref

POLARIS: Path of Least Action Analysis on Energy Landscapes

Journal of Chemical Information and Modeling
2020-05-26 | Journal article
DOI: 10.1021/acs.jcim.9b01108
Contributors: Evan Seitz; Joachim Frank
Source: check_circle
Crossref

Propagation of Conformational Coordinates Across Angular Space in Mapping the Continuum of States from Cryo-EM Data by Manifold Embedding

Journal of Chemical Information and Modeling
2020-05-26 | Journal article
DOI: 10.1021/acs.jcim.9b01115
Contributors: Suvrajit Maji; Hstau Liao; Ali Dashti; Ghoncheh Mashayekhi; Abbas Ourmazd; Joachim Frank
Source: check_circle
Crossref

The Israeli acute paralysis virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs

The EMBO Journal
2019-11-04 | Journal article
DOI: 10.15252/embj.2019102226
Contributors: Francisco Acosta‐Reyes; Ritam Neupane; Joachim Frank; Israel S Fernández
Source: check_circle
Crossref

POLARIS: path of least action analysis on energy landscapes

2019-05-17 | Other
DOI: 10.1101/633628
Contributors: Evan Seitz; Joachim Frank
Source: check_circle
Crossref

The Israeli Acute Paralysis Virus IRES captures host ribosomes by mimicking a ribosomal state with hybrid tRNAs

2019-04-11 | Other
DOI: 10.1101/606236
Contributors: Francisco Acosta-Reyes; Ritam Neupane; Joachim Frank; Israel S. Fernández
Source: check_circle
Crossref

Cryo-EM shows stages of initial codon selection on the ribosome by aa-tRNA in ternary complex with GTP and the GTPase-deficient EF-TuH84A

Nucleic Acids Research
2018-06-20 | Journal article
DOI: 10.1093/nar/gky346
Contributors: Marcus Fislage; Jingji Zhang; Zuben Patrick Brown; Chandra Sekhar Mandava; Suparna Sanyal; Måns Ehrenberg; Joachim Frank
Source: check_circle
Crossref

Identification of changing ribosome protein compositions using cryo-EM and mass spectrometry

2018-02-26 | Other
DOI: 10.1101/271833
Contributors: Ming Sun; Parimal Samir; Bingxin Shen; Wen Li; Christopher M. Browne; Rahul; Joachim Frank; Andrew J. Link
Source: check_circle
Crossref

New Opportunities Created by Single-Particle Cryo-EM: The Mapping of Conformational Space

Biochemistry
2018-02-13 | Journal article
DOI: 10.1021/acs.biochem.8b00064
Contributors: Joachim Frank
Source: check_circle
Crossref

Quantitative Characterization of Domain Motions in Molecular Machines

The Journal of Physical Chemistry B
2017-04-20 | Journal article
DOI: 10.1021/acs.jpcb.6b10732
Contributors: Suvrajit Maji; Rezvan Shahoei; Klaus Schulten; Joachim Frank
Source: check_circle
Crossref

Nmd3 is a structural mimic of eIF 5A, and activates the cp GTP ase Lsg1 during 60S ribosome biogenesis

The EMBO Journal
2017-04-03 | Journal article
DOI: 10.15252/embj.201696012
Contributors: Andrey G Malyutin; Sharmishtha Musalgaonkar; Stephanie Patchett; Joachim Frank; Arlen W Johnson
Source: check_circle
Crossref

The translation elongation cycle—capturing multiple states by cryo-electron microscopy

Philosophical Transactions of the Royal Society B: Biological Sciences
2017-03-19 | Journal article
DOI: 10.1098/rstb.2016.0180
Contributors: Joachim Frank
Source: check_circle
Crossref

Peer review (1 review for 1 publication/grant)

Review activity for ACS nano. (1)
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