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ResearcherID: A-3938-2008
Scopus Author ID: 6603296447

Keywords

cardiotoxicity, cardioprotection, anthracycline, daunorubicin, doxorubicin, dexrazoxane, topoisomerase II, iron chelation

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Employment (1)

Charles University: Prague, CZ

Professor, Vice-Dean (Faculty of Pharmacy in Hradec Kralove)
Employment
Source: Self-asserted source
Tomas Simunek

Education and qualifications (1)

Charles University: Prague, CZ

Ph.D.
Education
Source: Self-asserted source
Tomas Simunek

Works (50 of 129)

Items per page:
Page 1 of 3

Hydrophobicity-enhanced ferritin nanoparticles for efficient encapsulation and targeted delivery of hydrophobic drugs to tumor cells

Protein Science
2023 | Journal article
DOI: 10.1002/pro.4819
EID:

2-s2.0-85177462333

Part of ISSN: 1469896X 09618368
Contributors: Incocciati, A.; Kubeš, J.; Piacentini, R.; Cappelletti, C.; Botta, S.; Bertuccini, L.; Šimůnek, T.; Boffi, A.; Macone, A.; Bonamore, A.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

COMPARISON OF TOPOISOMERASE 2 INHIBITORS DEXRAZOXANE AND XK469 FOR THE PREVENTION OF ANTHRACYCLINE CARDIOTOXICITY

Military Medical Science Letters (Vojenske Zdravotnicke Listy)
2022 | Journal article
EID:

2-s2.0-85135502379

Part of ISSN: 2571113X 03727025
Contributors: Skalická, V.; Kubeš, J.; Applová, L.; Karabanovich, G.; Brázdová, P.; Lenčová, O.; Štěrba, M.; Roh, J.; Šimůnek, T.; Jirkovská, A.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Examination of diverse iron-chelating agents for the protection of differentiated PC12 cells against oxidative injury induced by 6-hydroxydopamine and dopamine

Scientific reports
2022 | Journal article
DOI: 10.1038/s41598-022-13554-x
EID:

2-s2.0-85132050337

Part of ISSN: 20452322
Contributors: Hašková, P.; Applová, L.; Jansová, H.; Homola, P.; Franz, K.J.; Vávrová, K.; Roh, J.; Šimůnek, T.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Primary prevention of chronic anthracycline cardiotoxicity with ACE inhibitor is temporarily effective in rabbits, but benefits wane in post-treatment follow-up

Clinical Science
2022 | Journal article
DOI: 10.1042/CS20210836
EID:

2-s2.0-85123393342

Part of ISSN: 14708736 01435221
Contributors: Pokorna, Z.; Kollarova-Brazdova, P.; Lencova-Popelova, O.; Jirkovsky, E.; Kubes, J.; Mazurova, Y.; Adamcova, M.; Holeckova, M.; Palicka, V.; Simunek, T. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Clinically Translatable Prevention of Anthracycline Cardiotoxicity by Dexrazoxane Is Mediated by Topoisomerase II Beta and Not Metal Chelation

Circulation: Heart Failure
2021 | Journal article
DOI: 10.1161/CIRCHEARTFAILURE.120.008209
EID:

2-s2.0-85121990891

Part of ISSN: 19413297 19413289
Contributors: Jirkovský, E.; Jirkovská, A.; Bavlovič-Piskáčková, H.; Skalická, V.; Pokorná, Z.; Karabanovich, G.; Kollárová-Brázdová, P.; Kubeš, J.; Lenčová-Popelová, O.; Mazurová, Y. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Development of water-soluble prodrugs of the bisdioxopiperazine topoisomerase IIβ inhibitor ICRF-193 as potential cardioprotective agents against anthracycline cardiotoxicity

Scientific Reports
2021 | Journal article
DOI: 10.1038/s41598-021-83688-x
EID:

2-s2.0-85101584952

Part of ISSN: 20452322
Contributors: Bavlovič Piskáčková, H.; Jansová, H.; Kubeš, J.; Karabanovich, G.; Váňová, N.; Kollárová-Brázdová, P.; Melnikova, I.; Jirkovská, A.; Lenčová-Popelová, O.; Chládek, J. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Prodrug of ICRF-193 provides promising protective effects against chronic anthracycline cardiotoxicity in a rabbit model in vivo

Clinical Science
2021 | Journal article
DOI: 10.1042/CS20210311
EID:

2-s2.0-85114070996

Part of ISSN: 14708736 01435221
Contributors: Kollárová-Brázdová, P.; Lenčová-Popelová, O.; Karabanovich, G.; Kocúrová-Lengvarská, J.; Kubeš, J.; Váňová, N.; Mazurová, Y.; Adamcová, M.; Jirkovská, A.; Holečková, M. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Structure-Activity Relationship Study of Dexrazoxane Analogues Reveals ICRF-193 as the Most Potent Bisdioxopiperazine against Anthracycline Toxicity to Cardiomyocytes Due to Its Strong Topoisomerase IIβ Interactions

Journal of Medicinal Chemistry
2021 | Journal article
DOI: 10.1021/acs.jmedchem.0c02157
EID:

2-s2.0-85104047253

Part of ISSN: 15204804 00222623
Contributors: Jirkovská, A.; Karabanovich, G.; Kubeš, J.; Skalická, V.; Melnikova, I.; Korábečný, J.; Kučera, T.; Jirkovský, E.; Nováková, L.; Bavlovič Piskáčková, H. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Investigation of structure-activity relationships of dexrazoxane analogs reveals topoisomerase IIβ interaction as a prerequisite for effective protection against anthracycline cardiotoxicity

Journal of Pharmacology and Experimental Therapeutics
2020 | Journal article
DOI: 10.1124/jpet.119.264580
EID:

2-s2.0-85084869801

Part of ISSN: 15210103 00223565
Contributors: Kollárová-Brázdová, P.; Jirkovská, A.; Karabanovich, G.; Pokorná, Z.; Piskáčková, H.B.; Jirkovský, E.; Kubeš, J.; Lenčová-Popelová, O.; Mazurová, Y.; Adamcová, M. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Cardioprotective potential of iron chelators and prochelators

Current Medicinal Chemistry
2019 | Journal article
DOI: 10.2174/0929867324666170920155439
EID:

2-s2.0-85063712756

Part of ISBN:

1875533X 09298673
Contributors: Jansová, H.; Šimůnek, T.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

In vitro and in vivo investigation of cardiotoxicity associated with anticancer proteasome inhibitors and their combination with anthracycline

Clinical Science
2019 | Journal article
DOI: 10.1042/CS20190139
EID:

2-s2.0-85071685471

Part of ISBN:

14708736 01435221
Contributors: Pokorna, Z.; Jirkovsky, E.; Hlavackova, M.; Jansova, H.; Jirkovska, A.; Lencova-Popelova, O.; Brazdova, P.; Kubes, J.; Sotakova-Kasparova, D.; Mazurova, Y. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Influence of cationic, anionic or non-charged substituents on photodynamic activity of water-soluble zinc (aza)phthalocyanines

Proceedings of SPIE - The International Society for Optical Engineering
2019 | Conference paper
DOI: 10.1117/12.2525591
EID:

2-s2.0-85075883882

Part of ISBN:

1996756X 0277786X
Contributors: MacHáček, M.; Kollár, J.; Halašková, M.; Steklá, M.; Makhseed, S.; Šimunek, T.; Zimčík, P.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Novel SPME fibers based on a plastic support for determination of plasma protein binding of thiosemicarbazone metal chelators: a case example of DpC, an anti-cancer drug that entered clinical trials

Analytical and Bioanalytical Chemistry
2019 | Journal article
DOI: 10.1007/s00216-019-01681-w
EID:

2-s2.0-85062595858

Part of ISBN:

16182650 16182642
Contributors: Reimerová, P.; Stariat, J.; Bavlovič Piskáčková, H.; Jansová, H.; Roh, J.; Kalinowski, D.S.; Macháček, M.; Šimůnek, T.; Richardson, D.R.; Štěrbová-Kovaříková, P.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

UHPLC-MS/MS method for analysis of sobuzoxane, its active form ICRF-154 and metabolite EDTA-diamide and its application to bioactivation study

Scientific Reports
2019 | Journal article
DOI: 10.1038/s41598-019-40928-5
EID:

2-s2.0-85062975702

Part of ISBN:

20452322
Contributors: Reimerová, P.; Jirkovská, A.; Piskáčková, H.B.; Karabanovich, G.; Roh, J.; Šimůnek, T.; Štěrbová-Kovaříková, P.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

2,6-Dihydroxybenzaldehyde Analogues of the Iron Chelator Salicylaldehyde Isonicotinoyl Hydrazone: Increased Hydrolytic Stability and Cytoprotective Activity against Oxidative Stress

Chemical Research in Toxicology
2018 | Journal article
DOI: 10.1021/acs.chemrestox.8b00165
EID:

2-s2.0-85056299230

Part of ISBN:

15205010 0893228X
Contributors: Jansová, H.; Kubeš, J.; Reimerová, P.; Štěrbová-Kovaříková, P.; Roh, J.; Šimunek, T.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Binding of an amphiphilic phthalocyanine to pre-formed liposomes confers light-triggered cargo release

Journal of Materials Chemistry B
2018 | Journal article
DOI: 10.1039/c8tb01602j
EID:

2-s2.0-85055709935

Part of ISBN:

2050750X 20507518
Contributors: Macháček, M.; Carter, K.A.; Kostelanský, F.; Miranda, D.; Seffouh, A.; Ortega, J.; Šimůnek, T.; Zimčík, P.; Lovell, J.F.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier
grade
Preferred source (of 2)‎

Pharmacokinetics of the cardioprotective drug dexrazoxane and its active metabolite adr-925 with focus on cardiomyocytes and the hearts

Journal of Pharmacology and Experimental Therapeutics
2018 | Journal article
DOI: 10.1124/jpet.117.244848
EID:

2-s2.0-85041687174

Part of ISBN:

15210103 00223565
Contributors: Jirkovský, E.; Jirkovská, A.; Bures, J.; Chládek, J.; Lencová, O.; Stariat, J.; Pokorná, Z.; Karabanovich, G.; Roh, J.; Brázdová, P. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Structure-Activity Relationships of Nitro-Substituted Aroylhydrazone Iron Chelators with Antioxidant and Antiproliferative Activities

Chemical Research in Toxicology
2018 | Journal article
DOI: 10.1021/acs.chemrestox.7b00324
EID:

2-s2.0-85047428788

Part of ISBN:

15205010 0893228X
Contributors: Hrušková, K.; Potůčková, E.; Opálka, L.; Hergeselová, T.; Hašková, P.; Kovaříková, P.; Šimůnek, T.; Vávrová, K.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Intravenous rutin in rat exacerbates isoprenaline-induced cardiotoxicity likely due to intracellular oxidative stress

Redox Report
2017 | Journal article
DOI: 10.1080/13510002.2016.1159817
WOSUID:

WOS:000393653800003
Contributors: Filipsky, Tomas; Riha, Michal; Haskova, Pavlina; Pilarova, Veronika; Novakova, Lucie; Semecky, Vladimir; Vavrova, Jaroslava; Holeckova, Magdalena; Palicka, Vladimir; Simunek, Tomas et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Investigation of novel dexrazoxane analogue JR-311 shows significant cardioprotective effects through topoisomerase IIbeta but not its iron chelating metabolite

Toxicology
2017 | Journal article
DOI: 10.1016/j.tox.2017.09.012
EID:

2-s2.0-85030841552

Part of ISBN:

18793185 0300483X
Contributors: Bures, J.; Jirkovska, A.; Sestak, V.; Jansova, H.; Karabanovich, G.; Roh, J.; Sterba, M.; Simunek, T.; Kovarikova, P.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Anionic hexadeca-carboxylate tetrapyrazinoporphyrazine: synthesis and in vitro photodynamic studies of a water-soluble, non-aggregating photosensitizer

Rsc Advances
2016 | Journal article
DOI: 10.1039/c5ra25881b
WOSUID:

WOS:000369516100083
Contributors: Machacek, Miloslav; Kollar, Jan; Miletin, Miroslav; Kucera, Radim; Kubat, Pavel; Simunek, Tomas; Novakova, Veronika; Zimcik, Petr
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Are cardioprotective effects of NO-releasing drug molsidomine translatable to chronic anthracycline cardiotoxicity settings?

Toxicology
2016 | Journal article
DOI: 10.1016/j.tox.2016.11.002
WOSUID:

WOS:000389730700006
Contributors: Lencova-Popelova, Olga; Jansova, Hana; Jirkovsky, Eduard; Bures, Jan; Jirkovska-Vavrova, Anna; Mazurova, Yvona; Reimerova, Petra; Vostatkova, Lucie; Adamcova, Michaela; Hrochf, Milos et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications

European Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1016/j.ejmech.2016.05.015
WOSUID:

WOS:000379102800009
Contributors: Hruskova, Katerina; Potuckova, Eliska; Hergeselova, Tereza; Liptakova, Lucie; Haskova, Pavlina; Mingas, Panagiotis; Kovarikova, Petra; Simunek, Tomas; Vavrova, Katerina
Source: Self-asserted source
Tomas Simunek via ResearcherID

Aroylhydrazone iron chelators: Tuning antioxidant and antiproliferative properties by hydrazide modifications

European Journal of Medicinal Chemistry
2016 | Journal article
EID:

2-s2.0-84968836040

Part of ISBN:

17683254 02235234
Contributors: Hrušková, K.; Potůčková, E.; Hergeselová, T.; Liptáková, L.; Hašková, P.; Mingas, P.; Kovaříková, P.; Šimůnek, T.; Vávrová, K.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

BIOLOGIC CHARACTERIZATION OF IRON CHELATOR SIH, OXIDATIVE STRESS-ACTIVATED PROCHELATOR BSIH AND THEIR METABOLITES

American Journal of Hematology
2016 | Journal article
WOSUID:

WOS:000371162800080
Contributors: Jansova, Hana; Bures, Jan; Kovarikova, Petra; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID

Cardioprotective effects of inorganic nitrate/nitrite in chronic anthracycline cardiotoxicity: Comparison with dexrazoxane

Journal of Molecular and Cellular Cardiology
2016 | Journal article
DOI: 10.1016/j.yjmcc.2015.12.021
WOSUID:

WOS:000371370300014
Contributors: Lencova-Popelova, Olga; Jirkovsky, Eduard; Jansova, Hana; Jirkovska-Vavrova, Anna; Vostatkova-Tichotova, Lucie; Mazurova, Yvona; Adamcova, Michaela; Chladek, Jaroslav; Hroch, Milos; Pokorna, Zuzana et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Cardioprotective effects of iron chelator HAPI and ROS-activated boronate prochelator BHAPI against catecholamine-induced oxidative cellular injury

Toxicology
2016 | Journal article
DOI: 10.1016/j.tox.2016.10.004
WOSUID:

WOS:000390517100004
Contributors: Haskova, Pavlina; Jansova, Hana; Bures, Jan; Machacek, Miloslav; Jirkovska, Anna; Franz, Katherine J.; Kovarikova, Petra; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Characterization of cytoprotective and toxic properties of iron chelator SIH, prochelator BSIH and their degradation products

Toxicology
2016 | Journal article
DOI: 10.1016/j.tox.2016.03.004
WOSUID:

WOS:000377739500002
Contributors: Jansova, Hana; Bures, Jan; Machacek, Miloslav; Haskova, Pavlina; Jirkovska, Anna; Roh, Jaroslav; Wang, Qin; Franz, Katherine J.; Kovarikova, Petra; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Large-Scale Synthesis of Piperazine-2,6-dione and Its Use in the Synthesis of Dexrazoxane Analogues

Synthesis-Stuttgart
2016 | Journal article
DOI: 10.1055/s-0035-1562618
WOSUID:

WOS:000389330400024
Contributors: Roh, Jaroslav; Karabanovich, Galina; Novakova, Veronika; Simunek, Tomas; Vavrova, Katerina
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Protective Effects of D-Penicillamine on Catecholamine-Induced Myocardial Injury

Oxidative Medicine and Cellular Longevity
2016 | Journal article
DOI: 10.1155/2016/5213532
WOSUID:

WOS:000369247400001
Contributors: Riha, Michal; Haskova, Pavlina; Martin, Jan; Filipsky, Tomas; Vanova, Katerina; Vavrova, Jaroslava; Holeckova, Magdalena; Homola, Pavel; Vitek, Libor; Palicka, Vladimir et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model (vol 339, pg 174, 2015)

Experimental Cell Research
2016 | Journal article
DOI: 10.1016/j.yexcr.2016.02.007
WOSUID:

WOS:000375967400017
Contributors: Lenco, Juraj; Lencova-Popelova, Olga; Link, Marek; Jirkovska, Anna; Tambor, Vojtech; Potuckova, Eliska; Stulik, Jiri; Simunek, Tomas; Sterba, Martin
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Tetra(3,4-pyrido)porphyrazines Caught in the Cationic Cage: Toward Nanomolar Active Photosensitizers

Journal of Medicinal Chemistry
2016 | Journal article
DOI: 10.1021/acs.jmedchem.6b01140
WOSUID:

WOS:000386641300013
Contributors: Machacek, Miloslav; Demuth, Jiri; Cermak, Pavel; Vavreckova, Magda; Hruba, Lenka; Jedlickova, Adela; Kubat, Pavel; Simunek, Tomas; Novakova, Veronika; Zimcik, Petr
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Far-Red-Absorbing Cationic Phthalocyanine Photosensitizers: Synthesis and Evaluation of the Photodynamic Anticancer Activity and the Mode of Cell Death Induction

Journal of Medicinal Chemistry
2015 | Journal article
DOI: 10.1021/jm5014852
WOSUID:

WOS:000351186700009
Contributors: Machacek, Miloslav; Cidlina, Antonin; Novakova, Veronika; Svec, Jan; Rudof, Emil; Miletin, Miroslav; Kucera, Radim; Simunek, Tomas; Zimcik, Petr
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Heteroatom-substituted tetra(3,4-pyrido)porphyrazines: a stride toward near- infrared-absorbing macrocycles

Organic & Biomolecular Chemistry
2015 | Journal article
DOI: 10.1039/c5ob00651a
WOSUID:

WOS:000354438400006
Contributors: Vachova, Lenka; Machacek, Miloslav; Kucera, Radim; Demuth, Jiri; Cermak, Pavel; Kopecky, Kamil; Miletin, Miroslav; Jedlickova, Adela; Simunek, Tomas; Novakova, Veronika et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

In Vitro Characterization of the Pharmacological Properties of the Anti-Cancer Chelator, Bp4eT, and Its Phase I Metabolites

Plos One
2015 | Journal article
DOI: 10.1371/journal.pone.0139929
WOSUID:

WOS:000362962300038
Contributors: Potuckova, Eliska; Roh, Jaroslav; Machacek, Miloslav; Sahni, Sumit; Stariat, Jan; Sestak, Vit; Jansova, Hana; Haskova, Pavlina; Jirkovska, Anna; Vavrova, Katerina et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
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LC-UV/MS methods for the analysis of prochelator-Boronyl salicylaldehyde isonicotinoyl hydrazone (BSIH) and its active chelator salicylaldehyde isonicotinoyl hydrazone (SIH)

Journal of Pharmaceutical and Biomedical Analysis
2015 | Journal article
DOI: 10.1016/j.jpba.2014.11.044
WOSUID:

WOS:000349064600008
Contributors: Bures, Jan; Jansova, Hana; Stariat, Jan; Filipsky, Tomas; Mladenka, Premysl; Simunek, Tomas; Kucera, Radim; Klimes, Jiri; Wang, Qin; Franz, Katherine J. et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
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Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

Oncotarget
2015 | Journal article
WOSUID:

WOS:000369907900003
Contributors: Sestak, Vit; Stariat, Jan; Cermanova, Jolana; Potuckova, Eliska; Chladek, Jaroslav; Roh, Jaroslav; Bures, Jan; Jansova, Hana; Prusa, Petr; Sterba, Martin et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID

Novel and potent anti-tumor and anti-metastatic di-2-pyridylketone thiosemicarbazones demonstrate marked differences in pharmacology between the first and second generation lead agents

Oncotarget
2015 | Journal article
DOI: 10.18632/oncotarget.6389
EID:

2-s2.0-84952361788

Part of ISBN:

19492553
Contributors: Sestak, V.; Stariat, J.; Cermanova, J.; Potuckova, E.; Chladek, J.; Roh, J.; Bures, J.; Jansova, H.; Prusa, P.; Sterba, M. et al.
Source: Self-asserted source
Tomas Simunek via Scopus - Elsevier

Proteomic investigation of embryonic rat heart-derived H9c2 cell line sheds new light on the molecular phenotype of the popular cell model

Experimental Cell Research
2015 | Journal article
DOI: 10.1016/j.yexcr.2015.10.020
WOSUID:

WOS:000366618700002
Contributors: Lenco, Juraj; Lencova-Popelova, Olga; Link, Marek; Jirkovska, Anna; Tambor, Vojtech; Potuckova, Eliska; Stulik, Jiri; Simunek, Tomas; Sterba, Martin
Source: Self-asserted source
Tomas Simunek via ResearcherID
grade
Preferred source (of 2)‎

Synthesis and analysis of novel analogues of dexrazoxane and its open-ring hydrolysis product for protection against anthracycline cardiotoxicity in vitro and in vivo

Toxicology Research
2015 | Journal article
DOI: 10.1039/c5tx00048c
WOSUID:

WOS:000356612300031
Contributors: Jirkovska-Vavrova, Anna; Roh, Jaroslav; Lencova-Popelova, Olga; Jirkovsky, Eduard; Hruskova, Katerina; Potuckova-Mackova, Eliska; Jansova, Hana; Haskova, Pavlina; Martinkova, Pavla; Eisner, Tomas et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID
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ANTHRACYCLINE CARDIOTOXICITY: THE PHARMACOKINETICS AND PHARMACODYNAMICS OF DEXRAZOXANE AND ITS OPEN RING METABOLITE

Heart
2014 | Journal article
DOI: 10.1136/heartjnl-2014-306916.20
WOSUID:

WOS:000360000800021
Contributors: Jirkovska-Vavrova, A.; Jirkovsky, E.; Stariat, J.; Jansova, H.; Roh, J.; Lencova-Popelova, O.; Kovarikova, P.; Sterba, M.; Simunek, T.
Source: Self-asserted source
Tomas Simunek via ResearcherID

CAN INORGANIC NITRATE/NITRITE EFFECTIVELY OVERCOME CHRONIC ANTHRACYCLINE CARDIOTOXICITY IN RABBITS?

Heart
2014 | Journal article
DOI: 10.1136/heartjnl-2014-306916.23
WOSUID:

WOS:000360000800024
Contributors: Lencova, O.; Jirkovsky, E.; Mazurova, Y.; Adamcova, M.; Chladek, J.; Hroch, M.; Simunek, T.; Gersl, V.; Sterba, M.
Source: Self-asserted source
Tomas Simunek via ResearcherID

COMPARISON OF IRON CHELATOR SIH AND OXIDATIVE STRESS-ACTIVATED PROCHELATOR BSIH AGAINST OXIDATIVE STRESS-INDUCED CARDIOMYOCYTE DAMAGE

Drug Metabolism Reviews
2014 | Journal article
WOSUID:

WOS:000329445700411
Contributors: Jansova, Hana; Haskova, Pavlina; Bures, Jan; Mackova, Eliska; Kovarikova, Petra; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID

Comparison of various iron chelators and prochelators as protective agents against cardiomyocyte oxidative injury

Free Radical Biology and Medicine
2014 | Journal article
DOI: 10.1016/j.freeradbiomed.2014.06.019
WOSUID:

WOS:000341274100018
Contributors: Jansova, Hana; Machacek, Miloslav; Wang, Qin; Haskova, Pavlina; Jirkovska, Anna; Potuckova, Eliska; Kielar, Filip; Franz, Katherine J.; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID
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Exploring the Anti-Cancer Activity of Novel Thiosemicarbazones Generated through the Combination of Retro-Fragments: Dissection of Critical Structure-Activity Relationships

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0110291
WOSUID:

WOS:000343210800074
Contributors: Serda, Maciej; Kalinowski, Danuta S.; Rasko, Nathalie; Potuckova, Eliska; Mrozek-Wilczkiewicz, Anna; Musiol, Robert; Malecki, Jan G.; Sajewicz, Mieczyslaw; Ratuszna, Alicja; Muchowicz, Angelika et al.
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Tomas Simunek via ResearcherID
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FIRST INSIGHT INTO PHARMACOKINETICS OF DPC - A NOVEL IRON CHELATING ANTI-CANCER THIOSEMICARBAZONE

Cece 2014: 11th International Interdisciplinary Meeting on Bioanalysis
2014 | Journal article
WOSUID:

WOS:000354547400125
Contributors: Sestak, Vit; Stariat, Jan; Potuckova, Eliska; Micuda, Stanislav; Suprunova, Vlasta; Bures, Jan; Prusa, Petr; Roh, Jaroslav; Simunek, Tomas; Klimes, Jiri et al.
Source: Self-asserted source
Tomas Simunek via ResearcherID

IN VITRO CHARACTERIZATION OF DP44MT AND BP4ET METABOLIC PRODUCTS

Drug Metabolism Reviews
2014 | Journal article
WOSUID:

WOS:000329445700209
Contributors: Mackova-Potuckova, Eliska; Roh, Jaroslav; Stariat, Jan; Sestak, Vit; Haskova, Pavlina; Kovarikova, Petra; Richardson, Des R.; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID

IRON PROCHELATOR BSIH PROTECTS CARDIAC CELLS AGAINST CATECHOLAMINE-INDUCED OXIDATIVE INJURY

Drug Metabolism Reviews
2014 | Journal article
WOSUID:

WOS:000329445700409
Contributors: Haskova, Pavlina; Jansova, Hana; Bures, Jan; Machacek, Miloslav; Kovarikova, Petra; Simunek, Tomas
Source: Self-asserted source
Tomas Simunek via ResearcherID

Molecular Remodeling of Left and Right Ventricular Myocardium in Chronic Anthracycline Cardiotoxicity and Post-Treatment Follow Up

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0096055
WOSUID:

WOS:000335728900034
Contributors: Lencova-Popelova, Olga; Jirkovsky, Eduard; Mazurova, Yvona; Lenco, Juraj; Adamcova, Michaela; Simunek, Tomas; Gersl, Vladimir; Sterba, Martin
Source: Self-asserted source
Tomas Simunek via ResearcherID
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NOVEL ZINC PHTHALOCYANINES WITH HIGH ANTITUMOR PHOTODYNAMIC ACTIVITY AND LOW DARK TOXICITY

Drug Metabolism Reviews
2014 | Journal article
WOSUID:

WOS:000329445700210
Contributors: Machacek, Miloslav; Makhseed, Saad; Alfadly, Waleed; Cidlina, Antonin; Novakova, Veronika; Zimcik, Petr; Haskova, Pavlina; Simunek, Tomas
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Tomas Simunek via ResearcherID
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