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Biography

Professor Andrew Hattersley is the Professor of Molecular Medicine at the University of Exeter, UK and a practicing consultant diabetologist at the Royal Devon and Exeter hospital. He trained in Medicine at the Universities of Cambridge and Oxford. His postgraduate education was in London, Oxford and Birmingham.

Working with Professor Sian Ellard he has taken Exeter from being a centre with no genetics laboratory in 1995 to now being the top international laboratory for monogenic diabetes with over 20,000 referrals from 105 countries. They have discovered 25 genes which when mutated cause monogenic diabetes.

Importantly he has gone on from gene discovery to find the best treatment for monogenic diabetes. He has shown that the commonest forms of both familial genetic diabetes and neonatal diabetes can be treated with tablets instead of insulin resulting in better blood sugar control.

Recent work has focused on “Precision Diabetes” identifying subgroups in Type 1 and Type 2 diabetes with different treatment responses.

He has published over 600 papers with over 90,000 citations, given over 350 national and international lecturers and received many international and national awards for his work including being appointed as a fellow of The Royal Society and being awarded a CBE.

Activities

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Employment (2)

University of Exeter: Exeter, Devon, GB

1995 to present | Professor of Molecular Medicine (Institute of Biomedical & Clinical Science)
Employment
Source: Self-asserted source
Andrew Hattersley

Royal Devon & Exeter NHS Foundation Trust: Exeter, GB

1995 to present | Consultant Physician with a special interest in Diabetes and Endocrinology
Employment
Source: Self-asserted source
Andrew Hattersley

Education and qualifications (5)

University of Oxford: Oxford, Oxfordshire, GB

1998 | DM (Oxon) The Molecular genetics of Type 2 diabetes
Education
Source: Self-asserted source
Andrew Hattersley

Royal College of Physicians: London, London, GB

1987 | MRCP
Education
Source: Self-asserted source
Andrew Hattersley

University of Cambridge: Cambridge, Cambridgeshire, GB

1985 | MA (Cantab)
Education
Source: Self-asserted source
Andrew Hattersley

University of Oxford: Oxford, GB

1984 | BM BCh
Education
Source: Self-asserted source
Andrew Hattersley

University of Cambridge: Cambridge, Cambridgeshire, GB

1981 | BA Hons
Education
Source: Self-asserted source
Andrew Hattersley

Professional activities (11)

Harold Hamm International Prize for Biomedical Research in Diabetes: Oklahoma City, US

2021-04 | Harold Hamm International Prize for Biomedical Research in Diabetes (Harold Hamm Diabetes Center)
Distinction
Source: Self-asserted source
Andrew Hattersley

Canadian Society of Nephrology: Montreal, QC, CA

2020-10 | Dr. Henry Friesen Award
Distinction
Source: Self-asserted source
Andrew Hattersley

Fonds Baillet Latour: Brussels, BE

2020-04 | Baillet Latour Health Prize for outstanding achievements in biomedical research for the benefit of human health in metabolic disorders
Distinction
Source: Self-asserted source
Andrew Hattersley

European Society of Endocrinology: Bristol, GB

2018-10 | Dale Medal - in recognition of outstanding studies which have changed our understanding of endocrinology in a fundamental way
Distinction
Source: Self-asserted source
Andrew Hattersley

Diabetes UK: London, GB

2018-03 | Banting Memorial Lecture
Distinction
Source: Self-asserted source
Andrew Hattersley

Gairdner: Toronto, ON, CA

2017-11 | Rachmiel Levine Award to honor lifelong contributions focused on bettering the lives of those living with diabetes by work in the translational and clinical research fields
Distinction
Source: Self-asserted source
Andrew Hattersley

Honours Committee: London, GB

2017 | CBE
Distinction
Source: Self-asserted source
Andrew Hattersley

Novo Nordisk Foundation: Copenhagen, DK

2016-09 | EASD- Novo Nordisk Foundation Diabetes Prize for Excellence
Distinction
Source: Self-asserted source
Andrew Hattersley

Royal Society: London, GB

2010 | FRS
Distinction
Source: Self-asserted source
Andrew Hattersley

Academy of Medical Sciences: London, Devon, GB

2004 | FMedSci
Distinction
Source: Self-asserted source
Andrew Hattersley

Royal College of Physicians: London, London, GB

1999 | FRCP
Distinction
Source: Self-asserted source
Andrew Hattersley

Funding (51)

NIHR Exeter BRC

2022-12 to 2027-11 | Award
National Institute for Health Research (London, GB)
URL: http://www.exeter.ac.uk/research/biomedicalresearchcentre/
GRANT_NUMBER: NIHR203320
Source: Self-asserted source
Andrew Hattersley

Human-specific gene regulation in pancreatic beta-cell development

2022-04 to 2027-03 | Grant
Wellcome Trust (London, GB)
GRANT_NUMBER:

224600/Z/21/Z
Source: Self-asserted source
Andrew Hattersley

Developing a decision support tool to enable precision treatment of type 2 diabetes

2021-10 to 2024-09 | Grant
Medical Research Council (London, GB)
GRANT_NUMBER:

MR/W003988/1
Source: Self-asserted source
Andrew Hattersley

EPSRC Hub for Quantitative Modelling in Healthcare

2020-08-31 to 2024-08-30 | Grant
Engineering and Physical Sciences Research Council (Swindon, GB)
URL: https://app.dimensions.ai/details/grant/grant.9054881
GRANT_NUMBER: EP/T017856/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Assessing the pathogenicity, penetrance and expressivity of monogenic disease variants using large-scale population-based cohorts

2020-08-31 to 2023-02-28 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.9452486
GRANT_NUMBER: MR/T00200X/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Genetic Evaluation of Multimorbidity towards INdividualisation of Interventions - GEMINI

2020-06-30 to 2021-02-28 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.9342872
GRANT_NUMBER: MR/V005359/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Diabetes and COVID 19 – Understanding the association between diabetes and severity of COVID-19 infection

2020-05 to 2021-04 | Contract
Diabetes UK (London, GB)
GRANT_NUMBER:

20/0006220
Source: Self-asserted source
Andrew Hattersley

Precision medicine in type 2 diabetes: developing and testing a decision support tool for primary care to optimise the selection of glucose-lowering therapy

2020-04 to 2021-03 | Award
British Heart Foundation (Birmingham, GB)
Source: Self-asserted source
Andrew Hattersley

Interim funding to develop an EME grant using a precision medicine decision aid to improve glycaemic response in Type 2 diabetes

2019-07 to 2020-04 | Grant
National Institute for Health Research (London, GB)
GRANT_NUMBER:

NIHR129108
Source: Self-asserted source
Andrew Hattersley

Developing a working platform for a treatment selection algorithm for glucose lowering in Type 2 diabetes

2019-06-01 to 2019-11-30 | Grant
NIHR Evaluation Trials and Studies Coordinating Centre (Southampton, GB)
URL: https://app.dimensions.ai/details/grant/grant.9521307
GRANT_NUMBER:

NIHRDH-NIHR129108
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Research England Enabling Excellence in England (E3) award for a Diabetes Centre of Excellence based in Exeter

2019-04 to 2023-09 | Grant
Research England (London, GB)
Source: Self-asserted source
Andrew Hattersley

NIHR Global Health Research Group on improving outcomes in sub-Saharan African diabetes through better diagnosis and treatment at the University of Exeter

2018-04 to 2022-03 | Grant
National Institute for Health Research (London, GB)
Source: Self-asserted source
Andrew Hattersley

External Collaboration, Innovation and Entrepreneurism: Translational Medicine in Exeter 2 (EXCITEME2)

2018-03-30 to 2020-02-14 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.7747571
GRANT_NUMBER: MC_PC_17189
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

NIHR Funding for Clinical Research Facilities for Early Translational (Experimental Medicine) Research Competition 2016

2017-04 to 2022-03 | Grant
National Institute for Health Research (London, GB)
GRANT_NUMBER:

CRF-2016-10027
Source: Self-asserted source
Andrew Hattersley

NIHR Global Health Research Group on improving outcomes in sub-Saharan African diabetes through better diagnosis and treatment at the University of Exeter

2017-04 to 2022-03 | Grant
National Institute for Health Research (London, GB)
Source: Self-asserted source
Andrew Hattersley

NIHR Senior Investigator Award

2017-04 to 2020-03 | Grant
National Institute for Health Research (London, GB)
Source: Self-asserted source
Andrew Hattersley

Development of a multi-faceted diagnostic and predictive tool to characterise type of diabetes, therapeutic progression and outcome

2017-01-01 to 2018-12-31 | Grant
National Health and Medical Research Council (Canberra, AU)
URL: https://app.dimensions.ai/details/grant/grant.7879176
GRANT_NUMBER: 1126886
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Understanding Genetic Causes of Diabetes

2016-10 to 2021-09 | Award
Novo Nordisk (Hellerup, DK)
Source: Self-asserted source
Andrew Hattersley

Assessing the glycaemic and CNS response to sulphonylurea therapy in patients with KCNJ11 mutations.

2016-07 to 2020-05 | Grant
Diabetes UK (London, GB)
Source: Self-asserted source
Andrew Hattersley

Precision Medicine Exeter Innovation Platform (PMEI Platform): Proof of Concept Funds

2016-03-01 to 2018-02-28 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.5073090
GRANT_NUMBER: MC_PC_15047
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Precision Medicine Exeter Innovation Platform (PMEI Platform)

2016-03-01 to 2017-08-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.5072633
GRANT_NUMBER: MC_PC_15054
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Understanding beta-cell destruction through the study of Extremely EarLy-Onset Autoimmune Diabetes (EXE-T1D)

2016-02 to 2017-02 | Grant
Leona M. and Harry B. Helmsley Charitable Trust (NY, NY, US)
Source: Self-asserted source
Andrew Hattersley

MICA: MRC APBI STratification and Extreme Response Mechanism IN Diabetes - MASTERMIND

2015-07-31 to 2021-05-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.4576496
GRANT_NUMBER: MR/N00633X/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Accelerated discovery of functional non-coding genomic variation using single molecule real-time (SMRT) sequencing.

2015-03-31 to 2016-03-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.4107247
GRANT_NUMBER: MR/M008924/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Identifying non-coding mutations in early-onset diabetes

2014-11-30 to 2017-11-29 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3957195
GRANT_NUMBER: MR/M005070/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Potential mechanisms of persistent C-peptide in Type 1 diabetes

2014-10-01 to 2018-09-30 | Grant
Juvenile Diabetes Research Foundation (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8529432
GRANT_NUMBER:

3-SRA-2014-314-M-R
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Defining the molecular and physiological mechanisms of pancreatic islet dysfunction which lead to type 2 diabetes

2014-08-31 to 2019-05-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3959313
GRANT_NUMBER: MR/L020149/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Using Next-Generation Sequencing and Proteomics to Improve Diagnosis and Treatment in Diabetes

2014-01-01 to 2017-12-31 | Grant
Western Norway Regional Health Authority (Stavanger, NO)
URL: https://app.dimensions.ai/details/grant/grant.9420738
GRANT_NUMBER: 911879
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Maximizing South West Biomedical Sequencing and Informatics Capability.

2013-07-01 to 2016-06-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3639604
GRANT_NUMBER:

101650/Z/13/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

MRC APBI STratification and Extreme Response Mechanism IN Diabetes - MASTERMIND

2013-02-25 to 2016-06-29 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.2765998
GRANT_NUMBER: MR/K005707/1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

New insights from Neonatal Diabetes.

2012-10-01 to 2020-09-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3641053
GRANT_NUMBER:

098395/Z/12/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

NIHR Exeter Clinical Research Facility

2012-09-01 to 2017-03-31 | Grant
NIHR Central Commissioning Facility (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.5145615
GRANT_NUMBER:

NIHRDH-rdecrf-2012-1
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Wellcome Wolfson Medical Research Centre.

2012-04-01 to 2015-05-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3641444
GRANT_NUMBER:

092502/B/10/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Wellcome Wolfson Centre for Translational Medicine, Peninsula College of Medicine and Dentistry.

2012-04-01 to 2015-04-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3643684
GRANT_NUMBER:

092502/Z/10/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

The epidemiology, impact and individual assessment of low level insulin production in Type 1 diabetes

2011-08-01 to 2015-01-31 | Grant
Diabetes UK (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.5144002
GRANT_NUMBER:

DUK-11/0004171
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Using pharmacogenetics to improve treatment in young-onset diabetes (UNITED)

2010-02-26 to 2014-05-25 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3640217
GRANT_NUMBER:

091985/Z/10/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Next-Generation Disease Association Analyses: Low pass Sequencing and High Density SNP genotyping for type 2 diabetes.

2010-01-01 to 2013-06-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3642715
GRANT_NUMBER:

090367/B/09/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Next-Generation Disease Association Analyses: Low pass Sequencing and High Density SNP genotyping for type 2 diabetes.

2009-10-01 to 2013-06-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3638543
GRANT_NUMBER:

090367/Z/09/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Identifying multiple common gene variants influencing human height to provide novel insights into growth and development processes and the genetic architecture of complex traits.

2008-10-01 to 2012-09-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3640955
GRANT_NUMBER:

085301/Z/08/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Genome-wide association study of extreme obesity in young adults.

2008-07-27 to 2009-08-26 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3636330
GRANT_NUMBER:

084762/Z/08/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

An investigation of genes in key beta-cell pathways following the type 2 diabetes WTCCC genome wide association study.

2008-02-01 to 2012-01-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3637387
GRANT_NUMBER:

083270/Z/07/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Using gene-wide association data to understand the genetic basis of height.

2007-12-01 to 2008-05-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3625736
GRANT_NUMBER:

076113/H/04/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Translating genome-wide association data from the WTCCC study into biological and clinical insights in type 2 diabetes

2007-03-31 to 2010-09-29 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.2779979
GRANT_NUMBER: G0601261
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

MOLECULAR GENETIC STUDIES IN HYPERTENSION, TYPE 2 DIABETES, AND CORONARY HEART DISEASE IN PAKISTAN.

2007-02-01 to 2011-03-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3633016
GRANT_NUMBER:

080747/Z/06/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

The UK DNA Banking Network

2007-02-01 to 2010-01-31 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.2786210
GRANT_NUMBER: G0600237
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Regulation of fasting glucose and birth weight: the impact of variation in the glucokinase gene.

2005-08-31 to 2009-08-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.2762115
GRANT_NUMBER: G0500070
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

The genetic and environmental influences on plasma triglyceride concentrations in Indians and their impact on type 2 diabetes, insulin resistance and fetal growth.

2005-01-01 to 2007-12-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3634975
GRANT_NUMBER:

075223/Z/04/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

The UK Type 2 diabetes genetics consortium case-control collection: a resource for the genetic epidemiology of Type 2 diabetes.

2004-07-25 to 2009-03-24 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3629229
GRANT_NUMBER:

072960/Z/03/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

Monogenic and polygenic influences on human fetal growth and development.

2003-02-01 to 2009-06-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3626798
GRANT_NUMBER:

067463/Z/02/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

A nationwide DNA collection from index cases and families with autoimmune thyroid disease.

2002-11-01 to 2008-02-29 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3629377
GRANT_NUMBER:

068181/Z/02/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard

The Exeter Biocatalysis Centre.

2002-04-01 to 2007-07-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3632248
GRANT_NUMBER:

064679/Z/01/Z
Source: Self-asserted source
Andrew Hattersley via DimensionsWizard
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