Personal information

Activities

Employment (2)

Palacký University, Olomouc: Olomouc, CZ

2001 to present
Employment
Source: Self-asserted source
Vladimir Krystof

Medical University of Vienna: Vienna, AT

2007-09 to 2008-06 (Institute of Cancer Research)
Employment
Source: Self-asserted source
Vladimir Krystof

Funding (9)

Dual FLT3/CDK9 inhibition as a possible therapeutical approach for mixed lineage leukemia

2019-01-01 to 2021-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GA19-09086S
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Pseudopeptide proteasome inhibitors

2018-01-01 to 2020-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GA18-03847S
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Targeting BCR signalosome in B-cell malignancies

2017-01-04 to 2020-12-31 | Grant
Ministry of Health (Prague, CZ)
GRANT_NUMBER: NV17-31834A
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

New kinase inhibitors to treat acute myeloid leukemia

2015-01-05 to 2018-12-31 | Grant
Ministry of Health (Prague, CZ)
GRANT_NUMBER: NV15-28951A
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Targeted Transport of Purine Cyclin-dependent Kinase Inhibitors into Cancer Cells

2015-01-01 to 2017-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GA15-15264S
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Evaluation of cyclin-dependent kinase inhibitors in cancer cell lines with specific genetic alterations

2012-01-01 to 2014-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GAP305/12/0783
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Inhibition of hepatocellular carcinoma progression

2012-01-01 to 2013-12-31 | Grant
Ministry of Education Youth and Sports (Prague, CZ)
GRANT_NUMBER: 7AMB12AT011
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Biological activity of synthetic inhibitors of cyclin-dependent kinases

2008-01-01 to 2010-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GA204/08/0511
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Biological activity of new inhibitors of cyclin-dependent kinases

2003-01-01 to 2006-12-31 | Grant
Czech Science Foundation (Prague, CZ)
GRANT_NUMBER: GP204/03/D231
Source: Self-asserted source
Vladimir Krystof via DimensionsWizard

Works (50 of 127)

Items per page:
Page 1 of 3

Strategies for the treatment of acute myeloid leukemia with FLT3 mutations: a patent review

Expert Opinion on Therapeutic Patents
2025-02 | Journal article
Contributors: Lukas Gorecki; Eva Reznickova; Vladimir Krystof; Martina Rezacova; Martina Ceckova; Jan Korabecny
Source: check_circle
Crossref

Synthesis and photodynamic activity of new 5‐[(E)‐2‐(3‐alkoxy‐1‐phenyl‐1H‐pyrazol‐4‐yl)ethenyl]‐2‐phenyl‐3H‐indoles

Archiv der Pharmazie
2024-10 | Journal article
Contributors: Gabrielė Varvuolytė; Eva Řezníčková; Aurimas Bieliauskas; Neringa Kleizienė; Veronika Vojáčková; Alena Opichalová; Asta Žukauskaitė; Vladimír Kryštof; Algirdas Šačkus
Source: check_circle
Crossref

Strategies for overcoming resistance to Bruton's tyrosine kinase inhibitor zanubrutinib

Hematological Oncology
2024-07 | Journal article
Contributors: Hana Dostálová; Vladimír Kryštof
Source: check_circle
Crossref

New Inhibitors of Bcr-Abl Based on 2,6,9-Trisubstituted Purine Scaffold Elicit Cytotoxicity in Chronic Myeloid Leukemia-Derived Cell Lines Sensitive and Resistant to TKIs

Pharmaceutics
2024-05-11 | Journal article
Contributors: Thalia Delgado; Denisa Veselá; Hana Dostálová; Vladimír Kryštof; Veronika Vojáčková; Radek Jorda; Alejandro Castro; Jeanluc Bertrand; Gildardo Rivera; Mario Faúndez et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Design and synthesis of novel 1,2,4-triazolo[4,3-b]pyridazine derivatives with anti-cancer activity

Journal of Molecular Structure
2023-11 | Journal article
Contributors: Ab Majeed Ganai; Tabasum Khan Pathan; Sachin Balaso Mohite; Veronika Vojáčková; Eva Řezníčková; Karolína Kozlanská; Vladimír Kryštof; Katya Govender; Sithabile Mokoena; Srinivas Reddy Merugu et al.
Source: check_circle
Crossref

Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7

Biomedicine & Pharmacotherapy
2023-05 | Journal article
Contributors: Markéta Kovalová; Libor Havlíček; Stefan Djukic; Jana Škerlová; Miroslav Peřina; Tomáš Pospíšil; Eva Řezníčková; Pavlína Řezáčová; Radek Jorda; Vladimír Kryštof
Source: check_circle
Crossref

A patent review of cyclin-dependent kinase 7 (CDK7) inhibitors (2018-2022)

Expert Opinion on Therapeutic Patents
2023-02 | Journal article
Contributors: Markéta Kovalová; Joseph Peter Baraka; Václav Mik; Radek Jorda; Lei Luo; Hao Shao; Vladimír Kryštof
Source: check_circle
Crossref

Characterization of new highly selective pyrazolo[4,3-d]pyrimidine inhibitor of CDK7

2023-02-25 | Preprint
Contributors: Markéta Kovalová; Libor Havlíček; Stefan Djukic; Jana Škerlová; Miroslav Peřina; Tomáš Pospíšil; Eva Řezníčková; Pavlína Řezáčová; Radek Jorda; Vladimír Kryštof
Source: check_circle
Crossref

Synthesis and Structural Optimization of 2,7,9-Trisubstituted purin-8-ones as FLT3-ITD Inhibitors

International Journal of Molecular Sciences
2022-12 | Journal article | Author
Contributors: Monika Tomanová; Karolina KOZLANSKA; Radek Jorda; Lukáš Jedinák; Tereza Havlíková; Eva Řezníčková; Miroslav Peřina; Pavel Klener; Alexandra Dolníková; Petr Cankař et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Adamantane-Substituted Purine Nucleosides: Synthesis, Host–Guest Complexes with β-Cyclodextrin and Biological Activity

International Journal of Molecular Sciences
2022-12-01 | Journal article
Contributors: Jana Rudolfová; Vladimír Kryštof; Marek Nečas; Robert Vícha; Michal Rouchal
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Novel Effective Small-Molecule Inhibitors of Protein Kinases Related to Tau Pathology in Alzheimer's Disease

Future Medicinal Chemistry
2022-08 | Journal article
Contributors: Ansgar Opitz; Lisa-Marie Seitz; Vladimir Krystof; Fady Baselious; Max Holzer; Wolfgang Sippl; Andreas Hilgeroth
Source: check_circle
Crossref

Design, Synthesis, In Silico Studies and Inhibitory Activity towards Bcr-Abl, BTK and FLT3-ITD of New 2,6,9-Trisubstituted Purine Derivatives as Potential Agents for the Treatment of Leukaemia

Pharmaceutics
2022-06-17 | Journal article
Contributors: Jeanluc Bertrand; Hana Dostálová; Vladimír Kryštof; Radek Jorda; Thalía Delgado; Alejandro Castro-Alvarez; Jaime Mella; David Cabezas; Mario Faúndez; Christian Espinosa-Bustos et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Synthesis of 4-styrylpyrazoles and Evaluation of their Inhibitory Effects on Cyclin-dependent Kinases

Medicinal Chemistry
2022-05 | Journal article
Contributors: Vladimír Kryštof; Petr Cankař; Daniel Toman; Radek Jorda; Haresh Ajani
Source: check_circle
Crossref

Adamantane-Substituted Purines and Their β-Cyclodextrin Complexes: Synthesis and Biological Activity

International Journal of Molecular Sciences
2021-11 | Journal article | Author
Contributors: Michal Rouchal; Jana Rudolfová; Vladimir Krystof; Veronika Vojáčková; Richard Čmelík; Robert Vícha
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Synthesis and Antiproliferative Activity of 2,4,6,7-Tetrasubstituted-2H-pyrazolo[4,3-c]pyridines

Molecules
2021-11-08 | Journal article
Contributors: Beatričė Razmienė; Eva Řezníčková; Vaida Dambrauskienė; Radek Ostruszka; Martin Kubala; Asta Žukauskaitė; Vladimír Kryštof; Algirdas Šačkus; Eglė Arbačiauskienė
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

How selective are clinical CDK4/6 inhibitors?

Medicinal Research Reviews
2021-05 | Journal article
Contributors: Denisa Hendrychová; Radek Jorda; Vladimír Kryštof
Source: check_circle
Crossref

CDK9 activity is critical for maintaining MDM4 overexpression in tumor cells

Cell Death & Disease
2020-09-15 | Journal article
Contributors: Monika Štětková; Kateřina Growková; Petr Fojtík; Barbora Valčíková; Veronika Palušová; Amandine Verlande; Radek Jorda; Vladimír Kryštof; Václav Hejret; Panagiotis Alexiou et al.
Source: check_circle
Crossref

Novel modified leucine and phenylalanine dipeptides modulate viability and attachment of cancer cells

European Journal of Medicinal Chemistry
2020-02 | Journal article
Contributors: Radek Jorda; Pratibha Magar; Denisa Hendrychová; Karel Pauk; Michal Dibus; Eliška Pilařová; Aleš Imramovský; Vladimír Kryštof
Source: check_circle
Crossref

Solid-phase synthesis for thalidomide-based proteolysis-targeting chimeras (PROTAC)

Chemical Communications
2019 | Journal article
Contributors: S. Krajcovicova; R. Jorda; D. Hendrychova; V. Krystof; M. Soural
Source: check_circle
Crossref

3-Hydrazinoisatin-based benzenesulfonamides as novel carbonic anhydrase inhibitors endowed with anticancer activity: Synthesis, in vitro biological evaluation and in silico insights

European Journal of Medicinal Chemistry
2019-12 | Journal article
Contributors: Mahmoud F. Abo-Ashour; Wagdy M. Eldehna; Alessio Nocentini; Alessandro Bonardi; Silvia Bua; Hany S. Ibrahim; Mahmoud M. Elaasser; Vladimír Kryštof; Radek Jorda; Paola Gratteri et al.
Source: check_circle
Crossref

Promising 2,6,9-Trisubstituted Purine Derivatives for Anticancer Compounds: Synthesis, 3D-QSAR, and Preliminary Biological Assays

International Journal of Molecular Sciences
2019-12-25 | Journal article
Contributors: Cristian O. Salas; Ana Maria Zarate; Vladimir Kryštof; Jaime Mella; Mario Faundez; Jose Brea; María Isabel Loza; Ivan Brito; Denisa Hendrychová; Radek Jorda et al.
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Activity of 2,6,9-trisubstituted purines as potent PDGFRα kinase inhibitors with antileukaemic activity

European Journal of Medicinal Chemistry
2019-11 | Journal article
Contributors: Eva Řezníčková; Tomáš Gucký; Veronika Kováčová; Haresh Ajani; Radek Jorda; Vladimír Kryštof
Source: check_circle
Crossref

6-Substituted purines as ROCK inhibitors with anti-metastatic activity

Bioorganic Chemistry
2019-09 | Journal article
Part of ISSN: 0045-2068
Source: Self-asserted source
Vladimir Krystof

3,5,7-Substituted Pyrazolo[4,3-d]pyrimidine Inhibitors of Cyclin-Dependent Kinases and Their Evaluation in Lymphoma Models

Journal of Medicinal Chemistry
2019-05-09 | Journal article
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Vladimir Krystof

Dose and drug changes in chronic lymphocytic leukemia cell response in�vitro: A comparison of standard therapy regimens with two novel cyclin‑dependent kinase inhibitors

Molecular Medicine Reports
2019-03-05 | Journal article
Part of ISSN: 1791-2997
Part of ISSN: 1791-3004
Source: Self-asserted source
Vladimir Krystof

Constituents of Mediterranean Spices Counteracting Vascular Smooth Muscle Cell Proliferation: Identification and Characterization of Rosmarinic Acid Methyl Ester as a Novel Inhibitor

Molecular Nutrition and Food Research
2018 | Journal article
Source: Self-asserted source
Vladimir Krystof

Discovery of N2-(4-Amino-cyclohexyl)-9-cyclopentyl- N6-(4-morpholin-4-ylmethyl-phenyl)- 9H-purine-2,6-diamine as a Potent FLT3 Kinase Inhibitor for Acute Myeloid Leukemia with FLT3 Mutations

Journal of Medicinal Chemistry
2018 | Journal article
Source: Self-asserted source
Vladimir Krystof

Imidazo[1,2-c]pyrimidin-5(6H)-one as a novel core of cyclin-dependent kinase 2 inhibitors: Synthesis, activity measurement, docking, and quantum mechanical scoring

Journal of Molecular Recognition
2018 | Journal article
Source: Self-asserted source
Vladimir Krystof

LC-MS/MS method for determination of cyclin-dependent kinase inhibitors, BP-14 and BP-20, and its application in pharmacokinetic study in rat

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences
2018 | Journal article
Source: Self-asserted source
Vladimir Krystof

Selective inhibition reveals cyclin-dependent kinase 2 as another kinase that phosphorylates the androgen receptor at serine 81

Biochimica et Biophysica Acta - Molecular Cell Research
2018 | Journal article
Source: Self-asserted source
Vladimir Krystof

How Selective Are Pharmacological Inhibitors of Cell-Cycle-Regulating Cyclin-Dependent Kinases?

Journal of Medicinal Chemistry
2018-10-25 | Journal article
Contributors: Radek Jorda; Denisa Hendrychová; Jiří Voller; Eva Řezníčková; Tomáš Gucký; Vladimír Kryštof
Source: check_circle
Crossref

Synthesis, Bacteriostatic and Anticancer Activity of Novel Phenanthridines Structurally Similar to Benzo[<i>c</i>]phenanthridine Alkaloids

Molecules
2018-08 | Journal article | Author
Contributors: Pavel Lasák; Kamil Motyka; Vladimir Krystof; Jakub Stýskala
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Synthesis and anti-mitotic activity of 2,4- or 2,6-disubstituted- and 2,4,6-trisubstituted-2H-pyrazolo[4,3-c]pyridines

European Journal of Medicinal Chemistry
2018-04 | Journal article
Contributors: Vaida Milišiūnaitė; Eglė Arbačiauskienė; Eva Řezníčková; Radek Jorda; Veronika Malínková; Asta Žukauskaitė; Wolfgang Holzer; Algirdas Šačkus; Vladimír Kryštof
Source: check_circle
Crossref

Synthesis, anticancer evaluation, and molecular docking studies of some novel 4,6-disubstituted pyrazolo[3,4- d ]pyrimidines as cyclin dependent kinase 2 (CDK2) inhibitors

Bioorganic Chemistry
2018-03 | Journal article
Contributors: Srinivasulu Cherukupalli; Balakumar Chandrasekaran; Vladimir Krystof; Rajeshwar Reddy Aleti; Nisar Sayyad; Srinivas Reddy Merugu; Narva Deshwar Kushwaha; Rajshekhar Karpoormath
Source: check_circle
Crossref

ALK5 kinase inhibitory activity and synthesis of 2,3,4-substituted 5,5-dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles

European Journal of Medicinal Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof
grade
Preferred source (of 2)‎

Biological Evaluation of Dipyrromethanes in Cancer Cell Lines: Antiproliferative and Pro-apoptotic Properties

ChemMedChem
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof
grade
Preferred source (of 2)‎

Explicit treatment of active-site waters enhances quantum mechanical/implicit solvent scoring: Inhibition of CDK2 by new pyrazolo[1,5-a]pyrimidines

European Journal of Medicinal Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof

Exploitation of new structurally diverse d-glucuronamide-containing: N -glycosyl compounds: Synthesis and anticancer potential

Organic and Biomolecular Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof
grade
Preferred source (of 2)‎

Semisynthetic esters of 17-hydroxycativic acid with in Vitro cytotoxic activity against leukemia cell lines

Biological and Pharmaceutical Bulletin
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof

Structural Basis of the Interaction of Cyclin-Dependent Kinase 2 with Roscovitine and Its Analogues Having Bioisosteric Central Heterocycles

ChemPhysChem
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof

Synthesis and antiproliferative activities of novel O-benzyl salicylamide derivatives

Letters in Drug Design and Discovery
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof

Synthesis and antiproliferative evaluation of novel azido nucleosides and their phosphoramidate derivatives

Pure and Applied Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof
grade
Preferred source (of 2)‎

Synthesis and antiproteasomal activity of novel O-benzyl salicylamide-based inhibitors built from leucine and phenylalanine

European Journal of Medicinal Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof
grade
Preferred source (of 2)‎

Trisubstituted purine inhibitors of PDGFRα and their antileukemic activity in the human eosinophilic cell line EOL-1

Bioorganic and Medicinal Chemistry
2017 | Journal article
Source: Self-asserted source
Vladimir Krystof

A Stepwise Approach for the Synthesis of Folic Acid Conjugates with Protein Kinase Inhibitors

The Journal of Organic Chemistry
2017-12-15 | Journal article
Contributors: Soňa Krajčovičová; Tomáš Gucký; Denisa Hendrychová; Vladimír Kryštof; Miroslav Soural
Source: check_circle
Crossref

Anti-angiogenic effects of novel cyclin-dependent kinase inhibitors with a pyrazolo[4,3-d]pyrimidine scaffold

British Journal of Pharmacology
2016 | Journal article
EID:

2-s2.0-84981268360

Contributors: Zhang, S.; Ulrich, M.; Gromnicka, A.; Havlíček, L.; Kryštof, V.; Jorda, R.; Strnad, M.; Vollmar, A.M.; Zahler, S.
Source: Self-asserted source
Vladimir Krystof via Scopus - Elsevier

Application of Pd-Catalyzed Cross-Coupling Reactions in the Synthesis of 5,5-Dimethyl-5,6-dihydro-4H-pyrrolo[1,2-b]pyrazoles that Inhibit ALK5 Kinase

Journal of Organic Chemistry
2016 | Journal article
EID:

2-s2.0-85000996070

Contributors: Tenora, L.; Galeta, J.; Řezníčková, E.; Kryštof, V.; Potáček, M.
Source: Self-asserted source
Vladimir Krystof via Scopus - Elsevier

Design, synthesis and antitrypanosomal activities of 2,6-disubstituted-4,5,7-trifluorobenzothiophenes

European Journal of Medicinal Chemistry
2016 | Journal article
WOSUID:

WOS:000369191800029

Contributors: Bhambra, Avninder S.; Edgar, Mark; Elsegood, Mark R. J.; Li, Yuqi; Weaver, George W.; Arroo, Randolph R. J.; Yardley, Vanessa; Burrell-Saward, Hollie; Krystof, Vladimir
Source: Self-asserted source
Vladimir Krystof via ResearcherID

Discovery of nitroaryl urea derivatives with antiproliferative properties

Journal of enzyme inhibition and medicinal chemistry
2016 | Journal article
WOSUID:

MEDLINE:26114307

Contributors: Wrobel, Tomasz M.; Kielbus, Michal; Kaczor, Agnieszka A.; Krystof, Vladimir; Karczmarzyk, Zbigniew; Wysocki, Waldemar; Fruzinski, Andrzej; Krol, Sylwia K.; Grabarska, Aneta; Stepulak, Andrzej et al.
Source: Self-asserted source
Vladimir Krystof via ResearcherID

Effects of BP-14, a novel cyclin-dependent kinase inhibitor, on anaplastic thyroid cancer cells

Oncology Reports
2016 | Journal article
WOSUID:

WOS:000371947700060

Contributors: Allegri, Lorenzo; Baldan, Federica; Mio, Catia; Puppin, Cinzia; Russo, Diego; Krystof, Vladimir; Damante, Giuseppe
Source: Self-asserted source
Vladimir Krystof via ResearcherID
Items per page:
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Peer review (33 reviews for 15 publications/grants)

Review activity for ACS medicinal chemistry letters. (5)
Review activity for ACS omega. (1)
Review activity for Advances in Medical Sciences. (1)
Review activity for Apoptosis (1)
Review activity for Applied sciences. (1)
Review activity for Bioorganic & medicinal chemistry letters. (1)
Review activity for Bioorganic chemistry. (2)
Review activity for ChemistrySelect (1)
Review activity for ChemMedChem. (1)
Review activity for European journal of medicinal chemistry. (1)
Review activity for Journal of herbal medicine. (1)
Review activity for Journal of medicinal chemistry. (13)
Review activity for Journal of molecular structure. (1)
Review activity for Life. (2)
Review activity for Toxicology in vitro. (1)