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Works (10)

Cancer cells use self-inflicted DNA breaks to evade growth limits imposed by genotoxic stress

Science
2022-04-29 | Journal article
DOI: 10.1126/science.abi6378
Contributors: Brian D. Larsen; Jan Benada; Philip Yuk Kwong Yung; Ryan A. V. Bell; George Pappas; Vaclav Urban; Johanna K. Ahlskog; Tia T. Kuo; Pavel Janscak; Lynn A. Megeney et al.
Source: check_circle
Crossref

WEE1 kinase protects the stability of stalled DNA replication forks by limiting CDK2 activity

Cell Reports
2022-01 | Journal article
DOI: 10.1016/j.celrep.2021.110261
Contributors: Camilla Reiter Elbæk; Valdemaras Petrosius; Jan Benada; Louisa Erichsen; Rune Busk Damgaard; Claus Storgaard Sørensen
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Crossref

Physiological Tolerance to ssDNA Enables Strand Uncoupling during DNA Replication

Cell Reports
2020-02 | Journal article
DOI: 10.1016/j.celrep.2020.01.067
Part of ISSN: 2211-1247
Source: Self-asserted source
Jan Benada

Overcoming Treatment Toxicity through Sequential Therapy.

Cancer cell
2019-06-01 | Journal article
DOI: 10.1016/j.ccell.2019.05.006
PMID: 31185206
Source: Self-asserted source
Jan Benada

ATM/Wip1 activities at chromatin control Plk1 re-activation to determine G2 checkpoint duration.

The EMBO journal
2017-07 | Journal article
DOI: 10.15252/embj.201696082
PMID: 28607002
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Inhibition of WIP1 phosphatase sensitizes breast cancer cells to genotoxic stress and to MDM2 antagonist nutlin-3.

2016-02 | Journal article
DOI: 10.18632/oncotarget.7363
PMID: 26883108
Contributors: Pechackova S; Burdova K; Benada J; Kleiblova P; Jenikova G; Macurek L
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Polo-like kinase 1 inhibits DNA damage response during mitosis.

2015 | Journal article
DOI: 10.4161/15384101.2014.977067
PMID: 25607646
PMC: PMC4613155
Contributors: Benada J; Burdová K; Lidak T; von Morgen P; Macurek L
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Targeting the Checkpoint to Kill Cancer Cells.

2015 | Journal article
DOI: 10.3390/biom5031912
PMID: 26295265
PMC: PMC4598780
Contributors: Benada J; Macurek L
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Gain-of-function mutations of PPM1D/Wip1 impair the p53-dependent G1 checkpoint.

2013-05 | Journal article
DOI: 10.1083/jcb.201210031
PMID: 23649806
PMC: PMC3653305
Contributors: Kleiblova P; Shaltiel IA; Benada J; Ševčík J; Pecháčková S; Pohlreich P; Voest EE; Dundr P; Bartek J; Kleibl Z et al.
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Downregulation of Wip1 phosphatase modulates the cellular threshold of DNA damage signaling in mitosis.

2013-01 | Journal article
DOI: 10.4161/cc.23057
PMID: 23255129
PMC: PMC3575454
Contributors: Macurek L; Benada J; Müllers E; Halim VA; Krejčíková K; Burdová K; Pecháčková S; Hodný Z; Lindqvist A; Medema RH et al.
Source: Self-asserted source
Jan Benada via Europe PubMed Central

Peer review (7 reviews for 5 publications/grants)

Review activity for Biomolecules. (1)
Review activity for Cancers. (2)
Review activity for Genes. (1)
Review activity for International journal of molecular sciences. (1)
Review activity for Journal of experimental & clinical cancer research. (2)
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