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ResearcherID: G-3420-2014

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Employment (2)

University of Rijeka: Rijeka, HR

2024-01 to present | Collaborator (Faculty of Medicine)
Employment
Source: Self-asserted source
Tomáš Etrych

Institute of Macromolecular Chemistry: Prague, CZ

1998 to present | Head of department (Biomedicinal polymeris)
Employment
Source: Self-asserted source
Tomáš Etrych

Works (50)

Targeting Kidney Fibrosis with Polymeric Nanocarriers

Chemistry of Materials
2024-10-08 | Journal article
DOI: 10.1021/acs.chemmater.4c01788
Contributors: Vedangi Kulkarni; Tim Caspers; Diana Moeckel; Susanne Koletnik; Elena Rama; Paraskevi Sotiropoulou; Daniel R. Dietrich; Robert Pola; Lenka Kotrchová; Tomáš Etrych et al.
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Crossref

Step‐By‐Step Standardization of the Bottom‐Up Semi‐Automated Nanocrystallization of Pharmaceuticals: A Quality By Design and Design of Experiments Joint Approach

Small
2024-06 | Journal article
DOI: 10.1002/smll.202306054
Contributors: Luis Castillo Henríquez; Badr Bahloul; Khair Alhareth; Feras Oyoun; Markéta Frejková; Libor Kostka; Tomáš Etrych; Luc Kalshoven; Alain Guillaume; Nathalie Mignet et al.
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Crossref

Highly Effective Synthetic Polymer-Based Blockers of Non-Specific Interactions in Immunochemical Analyses

Polymers
2024-03-10 | Journal article
DOI: 10.3390/polym16060758
Contributors: Vladimír Šubr; Libor Kostka; Jan Plicka; Ondřej Sedláček; Tomáš Etrych
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Crossref

Chemosensitization of tumors via simultaneous delivery of STAT3 inhibitor and doxorubicin through HPMA copolymer-based nanotherapeutics with pH-sensitive activation

Nanomedicine: Nanotechnology, Biology and Medicine
2024-02 | Journal article
DOI: 10.1016/j.nano.2023.102730
Contributors: M. Kovář; V. Šubr; K. Běhalová; M. Studenovský; D. Starenko; J. Kovářová; P. Procházková; T. Etrych; L. Kostka
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Crossref

Hybrid Macromolecular Constructs as a Platform for Spectral Nanoprobes for Advanced Cellular Barcoding in Flow Cytometry

Macromolecular Bioscience
2024-02 | Journal article
DOI: 10.1002/mabi.202300306
Contributors: Júlia Kudláčová; Daniela Kužílková; František Bárta; Naděžda Brdičková; Adéla Vávrová; Libor Kostka; Ondřej Hovorka; Tomáš Kalina; Tomáš Etrych
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Crossref

Biodegradable Covalently Crosslinked Poly[N-(2-Hydroxypropyl) Methacrylamide] Nanogels: Preparation and Physicochemical Properties

Polymers
2024-01-17 | Journal article
DOI: 10.3390/polym16020263
Contributors: Jana Kousalová; Petr Šálek; Ewa Pavlova; Rafał Konefał; Libor Kobera; Jiří Brus; Olga Kočková; Tomáš Etrych
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Crossref

Radiosensitizing molybdenum iodide nanoclusters conjugated with a biocompatible N-(2-hydroxypropyl)methacrylamide copolymer: a step towards radiodynamic therapy

Materials Advances
2023 | Journal article
DOI: 10.1039/D3MA00577A
Contributors: Kaplan Kirakci; Robert Pola; Marina Rodrigues Tavares; Michal Pechar; Tomáš Přibyl; Ivana Křížová; Jaroslav Zelenka; Tomáš Ruml; Tomáš Etrych; Kamil Lang
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Crossref

Adaptable polymerization platform for therapeutics with tunable biodegradability

Acta Biomaterialia
2023-11 | Journal article
DOI: 10.1016/j.actbio.2023.09.004
Contributors: M. Hrochová; L. Kotrchová; M. Frejková; R. Konefał; S. Gao; J. Fang; L. Kostka; T. Etrych
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Crossref

Using surface plasmon resonance, capillary electrophoresis and diffusion-ordered NMR spectroscopy to study drug release kinetics

Communications Chemistry
2023-08-31 | Journal article
DOI: 10.1038/s42004-023-00992-5
Contributors: Alena Libánská; Tomáš Špringer; Lucie Peštová; Kevin Kotalík; Rafał Konefał; Alice Šimonová; Tomáš Křížek; Jiří Homola; Eva Randárová; Tomáš Etrych
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Crossref

Singlet Oxygen In Vivo: It Is All about Intensity—Part 2

Journal of Personalized Medicine
2023-04-30 | Journal article
DOI: 10.3390/jpm13050781
Contributors: Steffen Hackbarth; Shanghui Gao; Vladimír Šubr; Lisheng Lin; Jakob Pohl; Tomáš Etrych; Jun Fang
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Crossref

Polymer-Antimicrobial Peptide Constructs with Tailored Drug-Release Behavior

Pharmaceutics
2023-01 | Journal article | Author
DOI: 10.3390/pharmaceutics15020406
Contributors: Robert Pola; Matěj Vícha; Jiří Trousil; Eliška Grosmanová; Michal Pechar; Anna Rumlerová; Martin Studenovský; Emilie Kučerová; Pavel Ulbrich; Barbora Vokatá et al.
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Multidisciplinary Digital Publishing Institute

Octahedral Molybdenum Cluster-Based Nanomaterials for Potential Photodynamic Therapy

Nanomaterials
2022-09-26 | Journal article
DOI: 10.3390/nano12193350
Contributors: Marina Rodrigues Tavares; Kaplan Kirakci; Nikolay Kotov; Michal Pechar; Kamil Lang; Robert Pola; Tomáš Etrych
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Crossref

The Transmission and Toxicity of Polymer-Bound Doxorubicin-Containing Exosomes Derived from Human Adenocarcinoma Celxdls

Nanomedicine
2022-08 | Journal article
DOI: 10.2217/nnm-2022-0081
Contributors: Kristýna Gunár; Lenka Kotrchová; Marcela Filipová; Tereza Krunclová; Aneta Dydowiczová; Robert Pola; Eva Randárová; Tomáš Etrych; Olga Janoušková
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Crossref

Simultaneous Delivery of Doxorubicin and Protease Inhibitor Derivative to Solid Tumors via Star-Shaped Polymer Nanomedicines Overcomes P-gp- and STAT3-Mediated Chemoresistance

Biomacromolecules
2022-06-13 | Journal article
DOI: 10.1021/acs.biomac.2c00256
Contributors: Libor Kostka; Ladislav Sivák; Vladimír Šubr; Jiřina Kovářová; Milada Šírová; Blanka Říhová; Radislav Sedlacek; Tomáš Etrych; Marek Kovář
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Crossref

HPMA Copolymer Mebendazole Conjugate Allows Systemic Administration and Possesses Antitumour Activity In Vivo

Pharmaceutics
2022-06-04 | Journal article
DOI: 10.3390/pharmaceutics14061201
Contributors: Martin Studenovský; Anna Rumlerová; Jiřina Kovářová; Barbora Dvořáková; Ladislav Sivák; Libor Kostka; Daniel Berdár; Tomáš Etrych; Marek Kovář
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Crossref

Singlet Oxygen In Vivo: It Is All about Intensity

Journal of Personalized Medicine
2022-05-28 | Journal article
DOI: 10.3390/jpm12060891
Contributors: Steffen Hackbarth; Rayhanul Islam; Vladimír Šubr; Tomáš Etrych; Jun Fang
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Crossref

Tumor Stimulus-Responsive Biodegradable Diblock Copolymer Conjugates as Efficient Anti-Cancer Nanomedicines

Journal of Personalized Medicine
2022-04 | Journal article | Author
DOI: 10.3390/jpm12050698
Contributors: Vladimír Šubr; Robert Pola; Shanghui Gao; Rayhanul Islam; Takuma Hirata; Daiki Miyake; Kousuke Koshino; Jian-Rong Zhou; Kazumi Yokomizo; Jun Fang et al.
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Multidisciplinary Digital Publishing Institute

Targeted Drug Delivery and Theranostic Strategies in Malignant Lymphomas

Cancers
2022-01-26 | Journal article
DOI: 10.3390/cancers14030626
Contributors: Tomas Etrych; Alena Braunova; David Zogala; Lukas Lambert; Nicol Renesova; Pavel Klener
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Crossref

The role of the biotin linker in polymer antibody mimetics, iBodies, in biochemical assays

Polymer Chemistry
2021 | Journal article
DOI: 10.1039/D1PY00707F
Contributors: Vladimír Šubr; Tereza Ormsby; Pavel Šácha; Jan Konvalinka; Tomáš Etrych; Libor Kostka
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Crossref

The development of a high-affinity conformation-sensitive antibody mimetic using a biocompatible copolymer carrier (iBody)

Journal of Biological Chemistry
2021-11 | Journal article
DOI: 10.1016/j.jbc.2021.101342
Contributors: Kristyna Blažková; Jana Beranová; Martin Hradilek; Libor Kostka; Vladimír Šubr; Tomáš Etrych; Pavel Šácha; Jan Konvalinka
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Crossref

Polymer‐Based Drug‐Free Therapeutics for Anticancer, Anti‐Inflammatory, and Antibacterial Treatment

Macromolecular Bioscience
2021-08 | Journal article
DOI: 10.1002/mabi.202100135
Contributors: Marina Rodrigues Tavares; Michal Pechar; Petr Chytil; Tomáš Etrych
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Crossref

HPMA-Based Polymer Conjugates for Repurposed Drug Mebendazole and Other Imidazole-Based Therapeutics

Polymers
2021-07-30 | Journal article
DOI: 10.3390/polym13152530
Contributors: Martin Studenovský; Anna Rumlerová; Libor Kostka; Tomáš Etrych
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Crossref

Unraveling the role of Intralipid in suppressing off-target delivery and augmenting the therapeutic effects of anticancer nanomedicines

Acta Biomaterialia
2021-05 | Journal article
DOI: 10.1016/j.actbio.2021.03.044
Contributors: Rayhanul Islam; Shanghui Gao; Waliul Islam; Vladimír Šubr; Jian-Rong Zhou; Kazumi Yokomizo; Tomáš Etrych; Hiroshi Maeda; Jun Fang
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Crossref

HPMA Copolymer-Based Nanomedicines in Controlled Drug Delivery

Journal of Personalized Medicine
2021-02-10 | Journal article
DOI: 10.3390/jpm11020115
Contributors: Petr Chytil; Libor Kostka; Tomáš Etrych
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Crossref

HPMA-Based Copolymers Carrying STAT3 Inhibitor Cucurbitacin-D as Stimulus-Sensitive Nanomedicines for Oncotherapy

Pharmaceutics
2021-01-28 | Journal article
DOI: 10.3390/pharmaceutics13020179
Contributors: Marina R. Tavares; Klára Hrabánková; Rafał Konefał; Martin Kaňa; Blanka Říhová; Tomáš Etrych; Milada Šírová; Petr Chytil
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Crossref

Graft copolymers with tunable amphiphilicity tailored for efficient dual drug delivery via encapsulation and pH-sensitive drug conjugation

Polymer Chemistry
2020 | Journal article
DOI: 10.1039/D0PY00609B
Contributors: Markéta Bláhová; Eva Randárová; Rafal Konefał; Benjamin Nottelet; Tomáš Etrych
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Crossref

Overcoming resistance to rituximab in relapsed non-Hodgkin lymphomas by antibody-polymer drug conjugates actively targeted by anti-CD38 daratumumab

Journal of Controlled Release
2020-12 | Journal article
DOI: 10.1016/j.jconrel.2020.08.042
Contributors: Ondřej Lidický; Pavel Klener; Daniela Machová; Petra Vočková; Eva Pokorná; Karel Helman; Cory Mavis; Olga Janoušková; Tomáš Etrych
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Crossref

Structure-to-Efficacy Relationship of HPMA-Based Nanomedicines: The Tumor Spheroid Penetration Study

Pharmaceutics
2020-12-20 | Journal article
DOI: 10.3390/pharmaceutics12121242
Contributors: Júlia Kudláčová; Lenka Kotrchová; Libor Kostka; Eva Randárová; Marcela Filipová; Olga Janoušková; Jun Fang; Tomáš Etrych
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Crossref

HPMA copolymer-antibody constructs in neoplastic treatment: an overview of therapeutics, targeted diagnostics, and drug-free systems

Journal of Controlled Release
2020-09 | Journal article
DOI: 10.1016/j.jconrel.2020.06.040
Contributors: Eva Randárová; Júlia Kudláčová; Tomáš Etrych
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Crossref

Intratumoral Distribution and pH-Dependent Drug Release of High Molecular Weight HPMA Copolymer Drug Conjugates Strongly Depend on Specific Tumor Substructure and Microenvironment

International Journal of Molecular Sciences
2020-08-21 | Journal article
DOI: 10.3390/ijms21176029
Contributors: Anne-Kathrin Noack; Henrike Lucas; Petr Chytil; Tomáš Etrych; Karsten Mäder; Thomas Mueller
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Crossref

Glycopolymers for Efficient Inhibition of Galectin-3: In Vitro Proof of Efficacy Using Suppression of T Lymphocyte Apoptosis and Tumor Cell Migration

Biomacromolecules
2020-08-10 | Journal article
DOI: 10.1021/acs.biomac.0c00515
Contributors: Marcela Filipová; Pavla Bojarová; Marina Rodrigues Tavares; Ladislav Bumba; Lothar Elling; Petr Chytil; Kristýna Gunár; Vladimír Křen; Tomáš Etrych; Olga Janoušková
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Crossref

Polymer Nanomedicines with Ph-Sensitive Release of Dexamethasone for the Localized Treatment of Inflammation

Pharmaceutics
2020-07 | Journal article | Author
DOI: 10.3390/pharmaceutics12080700
Contributors: Alena Libánská; Eva Randárová; Franck Lager; Gilles Renault; Daniel Scherman; Tomáš Etrych
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Multidisciplinary Digital Publishing Institute

Polymer nanomedicines based on micelle-forming amphiphilic or water-soluble polymer-doxorubicin conjugates: Comparative study of in vitro and in vivo properties related to the polymer carrier structure, composition, and hydrodynamic properties

Journal of Controlled Release
2020-05 | Journal article
DOI: 10.1016/j.jconrel.2020.03.002
Contributors: Alena Braunová; Petr Chytil; Richard Laga; Milada Šírová; Daniela Machová; Jozef Parnica; Blanka Říhová; Olga Janoušková; Tomáš Etrych
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Crossref

Highly effective anti-tumor nanomedicines based on HPMA copolymer conjugates with pirarubicin prepared by controlled RAFT polymerization

Acta Biomaterialia
2020-04 | Journal article
DOI: 10.1016/j.actbio.2020.02.011
Contributors: Eva Randárová; Hideaki Nakamura; Rayhanul Islam; Martin Studenovský; Haratake Mamoru; Jun Fang; Petr Chytil; Tomáš Etrych
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Crossref

High-Affinity N-(2-Hydroxypropyl)methacrylamide Copolymers with Tailored N-Acetyllactosamine Presentation Discriminate between Galectins

Biomacromolecules
2020-02-10 | Journal article
DOI: 10.1021/acs.biomac.9b01370
Contributors: Marina Rodrigues Tavares; Markéta Bláhová; Lieselotte Sedláková; Lothar Elling; Helena Pelantová; Rafał Konefał; Tomáš Etrych; Vladimír Křen; Pavla Bojarová; Petr Chytil
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Crossref

Targeted Polymer-Based Probes for Fluorescence Guided Visualization and Potential Surgery of EGFR-Positive Head-and-Neck Tumors

Pharmaceutics
2020-01 | Journal article | Author
DOI: 10.3390/pharmaceutics12010031
Contributors: Robert Pola; Eliška Böhmová; Marcela Filipová; Michal Pechar; Jan Pankrác; David Větvička; Tomas Olejar; Martina Kabešová; Pavla Poučková; Luděk Šefc et al.
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Multidisciplinary Digital Publishing Institute

Molecular Mechanisms of the Interactions of N-(2-Hydroxypropyl)methacrylamide Copolymers Designed for Cancer Therapy with Blood Plasma Proteins

Pharmaceutics
2020-01-28 | Journal article
DOI: 10.3390/pharmaceutics12020106
Contributors: Larisa Janisova; Andrey Gruzinov; Olga V. Zaborova; Nadiia Velychkivska; Ondřej Vaněk; Petr Chytil; Tomáš Etrych; Olga Janoušková; Xiaohan Zhang; Clement Blanchet et al.
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Crossref

Polymer Cancerostatics Containing Cell-Penetrating Peptides: Internalization Efficacy Depends on Peptide Type and Spacer Length

Pharmaceutics
2020-01-10 | Journal article
DOI: 10.3390/pharmaceutics12010059
Contributors: Eliška Böhmová; Robert Pola; Michal Pechar; Jozef Parnica; Daniela Machová; Olga Janoušková; Tomáš Etrych
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Crossref

Singlet oxygen phosphorescence detection in vivo identifies PDT-induced anoxia in solid tumors

Photochemical & Photobiological Sciences
2019 | Journal article
DOI: 10.1039/C8PP00570B
Contributors: Steffen Hackbarth; Waliul Islam; Jun Fang; Vladimír Šubr; Beate Röder; Tomáš Etrych; Hiroshi Maeda
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Crossref

Tris-(Nitrilotriacetic Acid)-Decorated Polymer Conjugates as Tools for Immobilization and Visualization of His-Tagged Proteins

Catalysts
2019-12-01 | Journal article
DOI: 10.3390/catal9121011
Contributors: Jana Beranová; Tomáš Knedlík; Adéla Šimková; Vladimír Šubr; Libor Kostka; Tomáš Etrych; Pavel Šácha; Jan Konvalinka
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Crossref

Micelle-Forming Block Copolymers Tailored for Inhibition of P-gp-Mediated Multidrug Resistance: Structure to Activity Relationship

Pharmaceutics
2019-11-05 | Journal article
DOI: 10.3390/pharmaceutics11110579
Contributors: Alena Braunová; Martin Kaňa; Júlia Kudláčová; Libor Kostka; Jan Bouček; Jan Betka; Milada Šírová; Tomáš Etrych
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Crossref

Fluorescence Imaging as a Tool in Preclinical Evaluation of Polymer-Based Nano-DDS Systems Intended for Cancer Treatment

Pharmaceutics
2019-09-12 | Journal article
DOI: 10.3390/pharmaceutics11090471
Contributors: Tomáš Etrych; Olga Janoušková; Petr Chytil
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Crossref

Superior Penetration and Cytotoxicity of HPMA Copolymer Conjugates of Pirarubicin in Tumor Cell Spheroid

Molecular Pharmaceutics
2019-08-05 | Journal article
DOI: 10.1021/acs.molpharmaceut.9b00248
Contributors: Hideaki Nakamura; Eva Koziolová; Petr Chytil; Tomáš Etrych; Mamoru Haratake; Hiroshi Maeda
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Crossref

Inhibitor–Polymer Conjugates as a Versatile Tool for Detection and Visualization of Cancer-Associated Carbonic Anhydrase Isoforms

ACS Omega
2019-04-30 | Journal article
DOI: 10.1021/acsomega.9b00596
Contributors: Klára Pospíšilová; Tomáš Knedlík; Pavel Šácha; Libor Kostka; Jiří Schimer; Jiří Brynda; Vlastimil Král; Petr Cígler; Václav Navrátil; Tomáš Etrych et al.
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Crossref

Polymer Cancerostatics Targeted by Recombinant Antibody Fragments to GD2-Positive Tumor Cells

Biomacromolecules
2019-01-14 | Journal article
DOI: 10.1021/acs.biomac.8b01616
Contributors: Robert Pola; Vlastimil Král; Sergey K. Filippov; Leonid Kaberov; Tomáš Etrych; Irena Sieglová; Juraj Sedláček; Milan Fábry; Michal Pechar
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Crossref

Interaction of spin-labeled HPMA-based nanoparticles with human blood plasma proteins – the introduction of protein-corona-free polymer nanomedicine

Nanoscale
2018 | Journal article
DOI: 10.1039/C7NR09355A
Contributors: Damir Klepac; Hana Kostková; Svetlana Petrova; Petr Chytil; Tomáš Etrych; Sami Kereïche; Ivan Raška; David A. Weitz; Sergey K. Filippov
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Crossref

Effective doxorubicin-based nano-therapeutics for simultaneous malignant lymphoma treatment and lymphoma growth imaging

Journal of Controlled Release
2018-11 | Journal article
DOI: 10.1016/j.jconrel.2018.09.018
Contributors: Tomáš Etrych; Lenka Daumová; Eva Pokorná; Diana Tušková; Ondřej Lidický; Věra Kolářová; Jan Pankrác; Luděk Šefc; Petr Chytil; Pavel Klener
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Crossref

N-(2-Hydroxypropyl)methacrylamide-Based Linear, Diblock, and Starlike Polymer Drug Carriers: Advanced Process for Their Simple Production

Biomacromolecules
2018-10-08 | Journal article
DOI: 10.1021/acs.biomac.8b00973
Contributors: Eva Koziolová; Libor Kostka; Lenka Kotrchová; Vladimír Šubr; Rafal Konefal; Benjamin Nottelet; Tomáš Etrych
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Crossref

Bloodstream Stability Predetermines the Antitumor Efficacy of Micellar Polymer–Doxorubicin Drug Conjugates with pH-Triggered Drug Release

Molecular Pharmaceutics
2018-09-04 | Journal article
DOI: 10.1021/acs.molpharmaceut.8b00156
Contributors: Petr Chytil; Milada Šírová; Júlia Kudláčová; Blanka Říhová; Karel Ulbrich; Tomáš Etrych
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Crossref

Inhibitor–GCPII Interaction: Selective and Robust System for Targeting Cancer Cells with Structurally Diverse Nanoparticles

Molecular Pharmaceutics
2018-08-06 | Journal article
DOI: 10.1021/acs.molpharmaceut.7b00889
Contributors: Jitka Neburkova; Frantisek Sedlak; Jirina Zackova Suchanova; Libor Kostka; Pavel Sacha; Vladimir Subr; Tomas Etrych; Petr Simon; Jitka Barinkova; Robin Krystufek et al.
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Crossref
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