David VAUZOUR (0000-0001-5952-8756)

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My initial work focused on the cellular and molecular mechanisms underlying neuronal death in Parkinson’s and Alzheimer’s disease. My recent interests concern how food bioactives influence brain health through their interactions with specific cellular signaling pathways pivotal in protection against neurotoxins, in preventing neuroinflammation and in controlling memory, learning and neuro-cognitive performance. I am also interested in the gut-brain axis connection

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University of East Anglia: Norwich, Norfolk, GB

2023-01-01 to present | Associate Professor (Norwich Medical School)

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David VAUZOUR

https://orcid.org/0000-0001-5952-8756

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Biography

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Employment (3)

University of East Anglia: Norwich, Norfolk, GB

University of East Anglia: Norwich, Norfolk, GB

University of Reading: Reading, Reading, GB

Education and qualifications (4)

University of Bordeaux: Bordeaux, FR

University of Montpellier: Montpellier, Languedoc-Roussillon, FR

University of Bordeaux: Bordeaux, FR

University of Bordeaux: Bordeaux, FR

Professional activities (2)

ILSI Europe aisbl: Brussels, Brussels, BE

ILSI Europe aisbl: Brussels, Brussels, BE

Funding (4)

Enhancing cognition through the menopausal transition in at-risk 'APOE4' carriers by fatty acid and hormonal modulation.

The gut-sleep-brain axis: Targeting the gut microbiota and sleep quality by individualized non-pharmaceutical approaches to promote healthy ageing

APOE genotype, brain n-3 fatty acid status and cognition

Enhanced cognition through dietary modulation of neuroinflammation in high risk APOE4 carriers

Works (50 of 165)

(Poly)phenols and brain health – beyond their antioxidant capacity

Oral microbiome and nitric oxide biomarkers in older people with mild cognitive impairment and APOE4 genotype

Refined diet consumption increases neuroinflammatory signalling through bile acid dysmetabolism

Dietary (Poly)phenols and the Gut–Brain Axis in Ageing

Circulatory dietary and gut-derived metabolites predict preclinical Alzheimer’s disease

Do microbes play a role in Alzheimer's disease?

Reply to M. Plourde and M. Stiffel

Unravelling phenolic metabotypes in the frame of the COMBAT study, a randomized, controlled trial with cranberry supplementation

A combined DHA-rich fish oil and cocoa flavanols intervention does not improve cognition or brain structure in older adults with memory complaints: results from the CANN randomized, controlled parallel-design study

Personality, dietary identity, mental and sleep health in vegans and vegetarians: A preliminary cross‐sectional study

The Influence of APOE Genotype, DHA, and Flavanol Intervention on Brain DHA and Lipidomics Profile in Aged Transgenic Mice

Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice

Data from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice

Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice

Supplementary Table S1, Figures S1-S8 from A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice

Natural Products and Neuroprotection 3.0

(-)-Epicatechin mitigates anxiety-related behavior in a mouse model of high fat diet-induced obesity

Cerebrovascular damage caused by the gut microbe-derived uraemic toxin<i>p</i>-cresol sulfate is prevented by blockade of the epidermal growth factor receptor

Saffron extract (Safr'Inside™) improves anxiety related behaviour in a mouse model of low-grade inflammation through the modulation of the microbiota and gut derived metabolites.

Wholegrain fermentation affects gut microbiota composition, phenolic acid metabolism and pancreatic beta cell function in a rodent model of type 2 diabetes.

Multi-nutrient interventions and cognitive ageing: are we barking up the right tree?

The EAT-Lancet reference diet and cognitive function across the life course.

A Ketogenic Diet in Combination with Gemcitabine Increases Survival in Pancreatic Cancer KPC Mice

Editorial: Polyphenols' action on the brain.

Microbial-derived metabolites as a risk factor of age-related cognitive decline and dementia

Chronic Consumption of Cranberries (<i>Vaccinium macrocarpon</i>) for 12 Weeks Improves Episodic Memory and Regional Brain Perfusion in Healthy Older Adults: A Randomised, Placebo-Controlled, Parallel-Groups Feasibility Study.

Systematic analysis of nutrigenomic effects of polyphenols related to cardiometabolic health in humans - Evidence from untargeted mRNA and miRNA studies.

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr&rsquo;Inside<sup>TM</sup>) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain.

DHA-Enriched Fish Oil Ameliorates Deficits in Cognition Associated with Menopause and the APOE4 Genotype in Rodents

The microbiota-gut-brain axis: pathways to better brain health. Perspectives on what we know, what we need to investigate and how to put knowledge into practice.

The microRNA-455 Null Mouse Has Memory Deficit and Increased Anxiety, Targeting Key Genes Involved in Alzheimer&rsquo;s Disease

The role of the mucin-glycan foraging <i>Ruminococcus gnavus</i> in the communication between the gut and the brain.

Regulation of blood-brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide.

Differential Influence of Soluble Dietary Fibres on Intestinal and Hepatic Carbohydrate Response

Molecular Determinants of the Cardiometabolic Improvements of Dietary Flavanols Identified by an Integrative Analysis of Nutrigenomic Data from a Systematic Review of Animal Studies

Systematic Bioinformatic Analyses of Nutrigenomic Modifications by Polyphenols Associated with Cardiometabolic Health in Humans—Evidence from Targeted Nutrigenomic Studies

Anthocyanins Promote Learning through Modulation of Synaptic Plasticity Related Proteins in an Animal Model of Ageing

Acute Effects of Polyphenols on Human Attentional Processes: A Systematic Review and Meta-Analysis.

APOE4 genotype exacerbates the impact of menopause on cognition and synaptic plasticity in APOE‐TR mice

Therapeutic Opportunities for Food Supplements in Neurodegenerative Disease and Depression.

Citrus Polyphenols in Brain Health and Disease: Current Perspectives

Regulation of blood–brain barrier integrity and cognition by the microbiome-associated methylamines trimethylamine-N-oxide and trimethylamine

Nutrition and the ageing brain: Moving towards clinical applications

Faecal microbiota transplant from aged donor mice affects spatial learning and memory via modulating hippocampal synaptic plasticity- and neurotransmission-related proteins in young recipients.

The Effect of Long-Term Aronia melanocarpa Extract Supplementation on Cognitive Performance, Mood, and Vascular Function: A Randomized Controlled Trial in Healthy, Middle-Aged Individuals

(-)-Epicatechin Prevents High Fat Diet-Induced Bile-Associated Intestinal Permeabilization Both In Vivo and In Vitro.

The role of diet in preventing and reducing cognitive decline.

Effects of Saffron Extract Supplementation on Mood, Well-Being, and Response to a Psychosocial Stressor in Healthy Adults: A Randomized, Double-Blind, Parallel Group, Clinical Trial.

Inorganic nitrate and nitrite supplementation fails to improve skeletal muscle mitochondrial efficiency in mice and humans.

Circulating Human Serum Metabolites Derived from the Intake of a Saffron Extract (Safr’Inside<sup>TM</sup>) Protect Neurons from Oxidative Stress: Consideration for Depressive Disorders

The microRNA-455 Null Mouse Has Memory Deficit and Increased Anxiety, Targeting Key Genes Involved in Alzheimer’s Disease