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Lab Webpage

Keywords

CRISPR, RNA

Countries

United States

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Employment (2)

Yale University: New Haven, US

2024-07-01 to present | Professor (Molecular Biophysics and Biochemistry)
Employment
Source: Self-asserted source
Ailong Ke

Cornell University: Ithaca, New York, US

2005-08-01 to present | Professor (Department of Molecular Biology and Genetics)
Employment
Source: Self-asserted source
Ailong Ke

Education and qualifications (1)

Johns Hopkins Medicine: Baltimore, MD, US

1996-08-20 to 2002-04-08 | PHD (Department of Biophysics and Biophysical Chemistry)
Education
Source: Self-asserted source
Ailong Ke

Professional activities (1)

RNA Society: Bethesda, Maryland, US

2019-07-12 | RNA society Mid-Career Award
Distinction
Source: Self-asserted source
Ailong Ke

Works (14)

Assessing and engineering the IscB–ωRNA system for programmed genome editing

Nature Chemical Biology
2024-12 | Journal article
DOI: 10.1038/s41589-024-01669-3
Contributors: Hao Yan; Xiaoqing Tan; Siyuan Zou; Yihong Sun; Ailong Ke; Weixin Tang
Source: check_circle
Crossref

Exploiting activation and inactivation mechanisms in type I-C CRISPR-Cas3 for genome-editing applications

Molecular Cell
2024-02 | Journal article
DOI: 10.1016/j.molcel.2023.12.034
Contributors: Chunyi Hu; Mason T. Myers; Xufei Zhou; Zhonggang Hou; Macy L. Lozen; Ki Hyun Nam; Yan Zhang; Ailong Ke
Source: check_circle
Crossref

Allosteric control of type I-A CRISPR-Cas3 complexes and establishment as effective nucleic acid detection and human genome editing tools

Molecular Cell
2022-08 | Journal article
DOI: 10.1016/j.molcel.2022.06.007
Contributors: Chunyi Hu; Dongchun Ni; Ki Hyun Nam; Sonali Majumdar; Justin McLean; Henning Stahlberg; Michael P. Terns; Ailong Ke
Source: check_circle
Crossref

Structural basis for RNA-guided DNA cleavage by IscB-ωRNA and mechanistic comparison with Cas9

Science
2022-06-24 | Journal article
DOI: 10.1126/science.abq7220
Contributors: Gabriel Schuler; Chunyi Hu; Ailong Ke
Source: check_circle
Crossref

tRNA Fusion to Streamline RNA Structure Determination: Case Studies in Probing Aminoacyl-tRNA Sensing Mechanisms by the T-Box Riboswitch

Crystals
2022-05-13 | Journal article
DOI: 10.3390/cryst12050694
Contributors: Jason C. Grigg; Ian R. Price; Ailong Ke
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Mechanism for Cas4-assisted directional spacer acquisition in CRISPR–Cas

Nature
2021-10-21 | Journal article
DOI: 10.1038/s41586-021-03951-z
Contributors: Chunyi Hu; Cristóbal Almendros; Ki Hyun Nam; Ana Rita Costa; Jochem N. A. Vink; Anna C. Haagsma; Saket R. Bagde; Stan J. J. Brouns; Ailong Ke
Source: check_circle
Crossref

Structural basis for target site selection in RNA-guided DNA transposition systems

Science
2021-08-13 | Journal article
DOI: 10.1126/science.abi8976
Contributors: Jung-Un Park; Amy Wei-Lun Tsai; Eshan Mehrotra; Michael T. Petassi; Shan-Chi Hsieh; Ailong Ke; Joseph E. Peters; Elizabeth H. Kellogg
Source: check_circle
Crossref

Structural basis for target-site selection in RNA-guided DNA transposition systems

2021-05-25 | Other
DOI: 10.1101/2021.05.25.445634
Contributors: Jung-Un Park; Amy Tsai; Eshan Mehrotra; Michael T. Petassi; Shan-Chi Hsieh; Ailong Ke; Joseph E. Peters; Elizabeth H. Kellogg
Source: check_circle
Crossref

Real-time observation of CRISPR spacer acquisition by Cas1–Cas2 integrase

Nature Structural & Molecular Biology
2020-05-04 | Journal article
DOI: 10.1038/s41594-020-0415-7
Contributors: Jagat B. Budhathoki; Yibei Xiao; Gabriel Schuler; Chunyi Hu; Alexander Cheng; Fran Ding; Ailong Ke
Source: check_circle
Crossref

Structural basis for tRNA decoding and aminoacylation sensing by T-box riboregulators

Nature Structural & Molecular Biology
2019-12-18 | Journal article
DOI: 10.1038/s41594-019-0327-6
Contributors: Robert A. Battaglia; Jason C. Grigg; Ailong Ke
Source: check_circle
Crossref

ATP/ADP modulates gp16–pRNA conformational change in the Phi29 DNA packaging motor

Nucleic Acids Research
2019-10-10 | Journal article
DOI: 10.1093/nar/gkz692
Contributors: Rujie Cai; Ian R Price; Fang Ding; Feifei Wu; Ting Chen; Yunlong Zhang; Guangfeng Liu; Paul J Jardine; Changrui Lu; Ailong Ke
Source: check_circle
Crossref

Local-to-global signal transduction at the core of a Mn2+ sensing riboswitch

Nature Communications
2019-09-20 | Journal article
DOI: 10.1038/s41467-019-12230-5
Contributors: Krishna C. Suddala; Ian R. Price; Shiba S. Dandpat; Michal Janeček; Petra Kührová; Jiří Šponer; Pavel Banáš; Ailong Ke; Nils G. Walter
Source: check_circle
Crossref

Local-to-global signal transduction at the core of the Mn2+ sensing riboswitch

2019-02-18 | Other
DOI: 10.1101/553354
Contributors: Krishna C Suddala; Ian R Price; Michal Janeček; Petra Kührová; Shiba Dandpat; Jiří Šponer; Pavel Banáš; Ailong Ke; Nils G Walter
Source: check_circle
Crossref

Structure basis for RNA-guided DNA degradation by Cascade and Cas3

Science
2018-07-06 | Journal article
DOI: 10.1126/science.aat0839
Contributors: Yibei Xiao; Min Luo; Adam E. Dolan; Maofu Liao; Ailong Ke
Source: check_circle
Crossref
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