Personal information

Websites & social links

Baranello's group
Laura Baranello

Other IDs

Scopus Author ID: 16238025100

Keywords

DNA Topology, Topoisomerase, Transcription regulation, Chromatin biology, Anti-cancer therapy

Countries

Sweden

Activities

Collapse all

Employment (3)

Karolinska Institutet: Stockholm, STOCKHOLMS LAN, SE

2022-07-01 to present | Principal Investigator - Associate Professor (Cell and Molecular Biology)
Employment
Source: Self-asserted source
Laura Baranello

Karolinska Institutet: Stockholm, SE

2018-07-01 to 2022-06-30 | Assistant Professor (Cell and Molecular Biology)
Employment
Source: Self-asserted source
Laura Baranello

Karolinska Institutet: Stockholm, SE

2017-05-01 to 2018-06-30 | Marie Curie Researcher (Cell and Molecular Biology)
Employment
Source: Self-asserted source
Laura Baranello

Education and qualifications (2)

University of Bologna: Bologna, IT

2007-01-01 to 2010-04-29 | Doctoral Degree in Cellular, Molecular and Industrial Biology (Biochemistry)
Education
Source: Self-asserted source
Laura Baranello

University of Bologna : Bologna, IT

2000-10-01 to 2006-03-24 | Degree in Medical Biotechnology (Master and Bachelor Degrees integrated)
Education
Source: Self-asserted source
Laura Baranello

Professional activities (2)

National Institutes of Health: Bethesda, Maryland, US

2017-03-20 to present | Visiting Researcher (Laboratory of Pathology)
Invited position
Source: Self-asserted source
Laura Baranello

AcademiaNet - Expert Database of Outstanding Women Academics: Heidelberg, DE

2017 to present (Cell and Molecular Biology)
Membership
Source: Self-asserted source
Laura Baranello

Funding (7)

Inhibition av topoisomeras-reglering för att hämma tumörtillväxt

2022-01 to 2024-12 | Grant
Swedish Research Council (Stockholm, SE)
Source: Self-asserted source
Laura Baranello

Targeting Topoisomerase Regulation of Oncogenic Growth

2022-01 to 2024-12 | Grant
Swedish Cancer Society (Stockholm, SE)
Source: Self-asserted source
Laura Baranello

EMBO Workshop “DNA Topology in genomic transactions”

2020 to 2021 | Grant
EMBO (Heidelberg, DE)
Source: Self-asserted source
Laura Baranello

Funktionell karaktärisering av topoisomeras reglerande interaktioner, för riktad anticancer-terapi

2018-01-01 to present | Grant
Swedish Cancer Society (Stockholm, SE)
URL: https://app.dimensions.ai/details/grant/grant.8469133
GRANT_NUMBER: 180608
Source: Self-asserted source
Laura Baranello via DimensionsWizard

Molecular characterization and pharmacological targeting of Topoisomerase regulatory interactions to kill cancer cells

2017-07 to 2023-06 | Grant
Knut och Alice Wallenbergs Stiftelse (Stockholm, SE)
Source: Self-asserted source
Laura Baranello

Molecular characterization and pharmacological targeting of Topoisomerase regulatory interactions to kill cancer cells

2017-01-01 to 2020-12-31 | Grant
Swedish Research Council (Stockholm, SE)
URL: https://app.dimensions.ai/details/grant/grant.7106876
GRANT_NUMBER: 2016-02610_VR
Source: Self-asserted source
Laura Baranello via DimensionsWizard

Molecular characterization and pharmacological targeting of Topoisomerase interactions to kill cancer cells

2016-08-01 to 2019-12-30 | Grant
VINNOVA (Stockholm, SE)
URL: https://app.dimensions.ai/details/grant/grant.7124799
GRANT_NUMBER: 2016-02055_VINNOVA
Source: Self-asserted source
Laura Baranello via DimensionsWizard

Works (32)

Control of protein synthesis through mRNA pseudouridylation by dyskerin

Science Advances
2023-07-28 | Journal article
DOI: 10.1126/sciadv.adg1805
Contributors: Chiara Pederiva; Davide M. Trevisan; Dimitra Peirasmaki; Shan Chen; Sharon A. Savage; Ola Larsson; Jernej Ule; Laura Baranello; Federico Agostini; Marianne Farnebo
Source: check_circle
Crossref

NEDDylated Cullin 3 mediates the adaptive response to topoisomerase 1 inhibitors

Science Advances
2022-12-09 | Journal article
DOI: 10.1126/sciadv.abq0648
Contributors: Alice Meroni; Jan Grosser; Sumedha Agashe; Natasha Ramakrishnan; Jessica Jackson; Priyanka Verma; Laura Baranello; Alessandro Vindigni
Source: check_circle
Crossref

TOP1 CAD-seq: A protocol to map catalytically engaged topoisomerase 1 in human cells

STAR Protocols
2022-09 | Journal article
DOI: 10.1016/j.xpro.2022.101581
Part of ISSN: 2666-1667
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

MYCMI-7 - a small MYC-binding compound that inhibits MYC:MAX interaction and tumor cell growth in a MYC-dependent manner

Cancer Research Communications
2022-02 | Journal article
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

MYC assembles and stimulates topoisomerases 1 and 2 in a “topoisome”

Molecular Cell
2022-01 | Journal article
DOI: 10.1016/j.molcel.2021.11.016
Part of ISSN: 1097-2765
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

Topoisomerase 1 activity during mitotic transcription favors the transition from mitosis to G1

Molecular Cell
2021-12 | Journal article
DOI: 10.1016/j.molcel.2021.10.015
Part of ISSN: 1097-2765
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

The Epstein-Barr virus deubiquitinating enzyme BPLF1 regulates the activity of topoisomerase II during productive infection

PLOS Pathogens
2021-09-20 | Journal article
DOI: 10.1371/journal.ppat.1009954
Contributors: Jinlin Li; Paul M. Lieberman; Noemi Nagy; Jiangnan Liu; Soham Gupta; Teresa Frisan; Thomas Hennig; Donald P. Cameron; Laura Baranello; Maria G. Masucci
Source: check_circle
Crossref

Deficiency of Polη in Saccharomyces cerevisiae reveals the impact of transcription on damage-induced cohesion

PLOS Genetics
2021-09-09 | Journal article
DOI: 10.1371/journal.pgen.1009763
Part of ISSN: 1553-7404
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

Cyclin A2 localises in the cytoplasm at the S/G2 transition to activate PLK1

Life Science Alliance
2021-03 | Journal article
DOI: 10.26508/lsa.202000980
Contributors: Helena Silva Cascales; Kamila Burdova; Anna Middleton; Vladislav Kuzin; Erik Müllers; Henriette Stoy; Laura Baranello; Libor Macurek; Arne Lindqvist
Source: check_circle
Crossref

Analysis of Myc Chromatin Binding by Calibrated ChIP-Seq Approach

The Myc Gene
2021-01 | Book chapter
DOI: 10.1007/978-1-0716-1476-1_8
Part of ISBN: 9781071614754
Part of ISBN: 9781071614761
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Contributors: Laura Baranello
Source: Self-asserted source
Laura Baranello

MYC protein stability is negatively regulated by BRD4.

Proceedings of the National Academy of Sciences of the United States of America
2020-06-01 | Journal article
DOI: 10.1073/pnas.1919507117
PMID: 32482868
PMC: PMC7306749
Source: Self-asserted source
Laura Baranello

Spatial Chromosome Folding and Active Transcription Drive DNA Fragility and Formation of Oncogenic MLL Translocations.

Molecular cell
2019-06-12 | Journal article
DOI: 10.1016/j.molcel.2019.05.015
PMID: 31202576
Source: Self-asserted source
Laura Baranello

The Energetics and Physiological Impact of Cohesin Extrusion.

Cell
2018-04-26 | Journal article
DOI: 10.1016/j.cell.2018.03.072
PMID: 29706548
PMC: PMC6065110
Source: Self-asserted source
Laura Baranello

DNA Supercoiling, Topoisomerases, and Cohesin: Partners in Regulating Chromatin Architecture?

International Journal of Molecular Sciences
2018-03 | Journal article
DOI: 10.3390/ijms19030884
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Mapping DNA Breaks by Next-Generation Sequencing.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7306-4_13
PMID: 29043624
Source: Self-asserted source
Laura Baranello

The Use of Psoralen Photobinding to Study Transcription-Induced Supercoiling.

Methods in molecular biology (Clifton, N.J.)
2018-01-01 | Journal article
DOI: 10.1007/978-1-4939-7459-7_7
PMID: 29177736
PMC: PMC7433354
Source: Self-asserted source
Laura Baranello
grade
Preferred source (of 2)‎

Permanganate/S1 Nuclease Footprinting Reveals Non-B DNA Structures with Regulatory Potential across a Mammalian Genome

Cell Syst
2017 | Journal article
DOI: 10.1016/j.cels.2017.01.013
SOURCE-WORK-ID:

135617223

PMID: 28237796
Contributors: Kouzine, F; Wojtowicz, D; Baranello, L; Yamane, A; Nelson, S; Resch, W; Kieffer-Kwon, KR; Benham, CJ; Casellas, R; Przytycka, TM et al.
Source: check_circle
Karolinska Institutet

Global Inhibition with Specific Activation: How p53 and MYC Redistribute the Transcriptome in the DNA Double-Strand Break Response.

Molecular cell
2017-08-31 | Journal article
DOI: 10.1016/j.molcel.2017.07.028
PMID: 28867293
PMC: PMC5657607
Source: Self-asserted source
Laura Baranello

Myc Regulates Chromatin Decompaction and Nuclear Architecture during B Cell Activation.

Molecular cell
2017-08-10 | Journal article
DOI: 10.1016/j.molcel.2017.07.013
PMID: 28803781
PMC: PMC5854204
Source: Self-asserted source
Laura Baranello

ChIP bias as a function of cross-linking time

Chromosome Res.
2016 | Journal article
DOI: 10.1007/s10577-015-9509-1
SOURCE-WORK-ID:

133503295

PMID: 26685864
Contributors: Baranello, L; Kouzine, F; Sanford, S; Levens, D
Source: check_circle
Karolinska Institutet

GTF2E2 Mutations Destabilize the General Transcription Factor Complex TFIIE in Individuals with DNA Repair-Proficient Trichothiodystrophy

Am. J. Hum. Genet.
2016 | Journal article
DOI: 10.1016/j.ajhg.2016.02.008
SOURCE-WORK-ID:

133363887

PMID: 26996949
Contributors: Kuschal, C; Botta, E; Orioli, D; Digiovanna, JJ; Seneca, S; Keymolen, K; Tamura, D; Heller, E; Khan, SG; Caligiuri, G et al.
Source: check_circle
Karolinska Institutet

RNA Polymerase II Regulates Topoisomerase 1 Activity to Favor Efficient Transcription

Cell
2016 | Journal article
DOI: 10.1016/j.cell.2016.02.036
SOURCE-WORK-ID:

133365760

PMID: 27058666
Contributors: Baranello, L; Wojtowicz, D; Cui, KR; Devaiah, BN; Chung, HJ; Chan-Salis, KY; Guha, R; Wilson, K; Zhang, XH; Zhang, HL et al.
Source: check_circle
Karolinska Institutet

Controlling gene expression by DNA mechanics: emerging insights and challenges.

Biophysical reviews
2016-11-14 | Journal article
DOI: 10.1007/s12551-016-0243-5
PMID: 28510218
PMC: PMC5418512
Source: Self-asserted source
Laura Baranello
grade
Preferred source (of 2)‎

CTCF and cohesin cooperate to organize the 3D structure of the mammalian genome

Proc. Natl. Acad. Sci. U. S. A.
2014 | Journal article
DOI: 10.1073/pnas.1321957111
SOURCE-WORK-ID:

128133610

PMID: 24398527
Contributors: Baranello, L; Kouzine, F; Levens, D
Source: check_circle
Karolinska Institutet

DNA break mapping reveals topoisomerase II activity genome-wide

Int J Mol Sci
2014 | Journal article
DOI: 10.3390/ijms150713111
SOURCE-WORK-ID:

129536515

PMID: 25056547
Contributors: Baranello, L; Kouzine, F; Wojtowicz, D; Cui, K; Przytycka, TM; Zhao, K; Levens, D
Source: check_circle
Karolinska Institutet

DNA topology and transcription

Nucleus
2014 | Journal article
DOI: 10.4161/nucl.28909
SOURCE-WORK-ID:

129703820

PMID: 24755522
Contributors: Kouzine, F; Levens, D; Baranello, L
Source: check_circle
Karolinska Institutet

DNA topoisomerases beyond the standard role

Transcription
2013 | Journal article
SOURCE-WORK-ID:

224135702

PMID: 24135702
Contributors: Baranello, L; Kouzine, F; Levens, D
Source: check_circle
Karolinska Institutet

Transcription-dependent dynamic supercoiling is a short-range genomic force

Nat. Struct. Mol. Biol.
2013 | Journal article
DOI: 10.1038/nsmb.2517
SOURCE-WORK-ID:

126340011

PMID: 23416947
Contributors: Kouzine, F; Gupta, A; Baranello, L; Wojtowicz, D; Ben-Aissa, K; Liu, J; Przytycka, TM; Levens, D
Source: check_circle
Karolinska Institutet

The importance of being supercoiled: how DNA mechanics regulate dynamic processes

Biochim. Biophys. Acta
2012 | Journal article
DOI: 10.1016/j.bbagrm.2011.12.007
SOURCE-WORK-ID:

124902620

PMID: 22233557
Contributors: Baranello, L; Levens, D; Gupta, A; Kouzine, F
Source: check_circle
Karolinska Institutet

Dissecting the transcriptional functions of human DNA topoisomerase I by selective inhibitors: implications for physiological and therapeutic modulation of enzyme activity

Biochim. Biophys. Acta
2010 | Journal article
DOI: 10.1016/j.bbcan.2010.06.003
SOURCE-WORK-ID:

121831544

PMID: 20600630
Contributors: Capranico, G; Marinello, J; Baranello, L
Source: check_circle
Karolinska Institutet

DNA topoisomerase I inhibition by camptothecin induces escape of RNA polymerase II from promoter-proximal pause site, antisense transcription and histone acetylation at the human HIF-1 alpha gene locus

Nucleic Acids Res.
2010 | Journal article
DOI: 10.1093/nar/gkp817
SOURCE-WORK-ID:

119830535

PMID: 19854946
Contributors: Baranello, L; Bertozzi, D; Fogli, MV; Pommier, Y; Capranico, G
Source: check_circle
Karolinska Institutet

Induction of a novel long antisense RNA from the human HIF-1\#945; locus may contribute to HIF-1\#945; regulation and inhibition by camptothecins in cancer cells.

Cancer Res.
2009 | Conference abstract
SOURCE-WORK-ID:

133406324
Contributors: Baranello, L; Bertozzi, D; Pommier, Y; Capranico, G
Source: check_circle
Karolinska Institutet

Peer review (7 reviews for 5 publications/grants)

Review activity for EMBO journal. (1)
Review activity for Molecular cell. (1)
Review activity for Nature communications (1)
Review activity for Nature reviews. (1)
Review activity for Nature structural & molecular biology. (3)
How many people are using ORCID?