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Employment (1)

Scripps Research: La Jolla, CA, US

1990 to present | Professor (Chemistry)
Employment
Source: Self-asserted source
K. Barry Sharpless

Education and qualifications (2)

Stanford University: Stanford, CA, US

1963 to 1968 | Ph.D. (Organic Chemistry)
Education
Source: Self-asserted source
K. Barry Sharpless

Dartmouth College: Hanover, New Hampshire, US

1963 | B.A.
Education
Source: Self-asserted source
K. Barry Sharpless

Professional activities (17)

Chinese Academy of Sciences: Beijing, Beijing, CN

2019 to present | Foreign Member
Membership
Source: Self-asserted source
K. Barry Sharpless

Nankai University: Tianjin, CN

2012 | Honorary Professor
Distinction
Source: Self-asserted source
K. Barry Sharpless

University of Florida: Gainesville, FL, US

2011 | Honorary Fellow (Florida Center for Heterocyclic Compounds)
Distinction
Source: Self-asserted source
K. Barry Sharpless

Tianjin University: Tianjin, Tianjin, CN

2010 | Honorary Professor
Distinction
Source: Self-asserted source
K. Barry Sharpless

Kyushu University: Fukouka, JP

2010 | Distinguished University Professor
Distinction
Source: Self-asserted source
K. Barry Sharpless

Nanjing University: Nanjing, Jiangsu, CN

2008 | Honorary Professor
Distinction
Source: Self-asserted source
K. Barry Sharpless

Hong Kong University of Science and Technology: Kowloon, HK

2007 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Shanghai Institute of Organic Chemistry: Shanghai, CN

2004 | Honorary Professor and Member
Distinction
Source: Self-asserted source
K. Barry Sharpless

National Taiwan Normal University: Taipei, TW

2004 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Kitasato University: Tokyo, JP

2002 | Honorary Member
Distinction
Source: Self-asserted source
K. Barry Sharpless

Hong Kong Polytechnic University: Hong Kong, CN

2002 | Distinguished Honorary Professor
Distinction
Source: Self-asserted source
K. Barry Sharpless

Wesleyan University: Middletown, Connecticut, US

1999 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Royal Society of Chemistry: London, GB

1997 | Honorary Fellow
Distinction
Source: Self-asserted source
K. Barry Sharpless

Catholic University of Leuven : Leuven, BE

1996 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Technical University of Munich: Munich, DE

1995 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

KTH Royal Institute of Technology: Stockholm, SE

1995 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Dartmouth College: Hanover, New Hampshire, US

1995 | Honorary Doctorate
Distinction
Source: Self-asserted source
K. Barry Sharpless

Funding (6)

Sulfur(VI) Fluoride Exchange (SuFEx) Click Chemistry in Macromolecule Synthesis and Fabrication

2016-09-01 to 2020-08-31 | Grant
Directorate for Mathematical & Physical Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.5543032
GRANT_NUMBER: 1610987
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

Practical Organic Oxidations in Water (TSE 99-A)

2000-07-01 to 2003-06-30 | Grant
Directorate for Mathematical & Physical Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.3478183
GRANT_NUMBER: 9985553
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

The Reactivity of Metal-Oxo and Metal-Imido Groups

1996-04-01 to 2000-03-31 | Grant
Directorate for Mathematical & Physical Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.3438613
GRANT_NUMBER: 9531152
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

Drug Design Cycle targeting HIV Protease Drug Resistance

1992-09-30 to 2008-08-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2436365
GRANT_NUMBER: P01GM048870
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

New Metal Catalyzed Organic Transformations

1991-11-13 to 1992-09-30 | Grant
Directorate for Mathematical & Physical Sciences (Arlington, US)
URL: https://app.dimensions.ai/details/grant/grant.3411323
GRANT_NUMBER: 9296055
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

NEW ASYMMETRIC PROCESSES FOR USE IN ORGANIC SYNTHESIS

1981-01-01 to 2000-03-31 | Grant
National Institute of General Medical Sciences (Bethesda, US)
URL: https://app.dimensions.ai/details/grant/grant.2635113
GRANT_NUMBER: R37GM028384
Source: Self-asserted source
K. Barry Sharpless via DimensionsWizard

Works (27)

Click Chemistry: The Certainty of Chance (Nobel Lecture)**

Angewandte Chemie
2025-03-20 | Journal article
DOI: 10.1002/ange.202501229
Contributors: K. Barry Sharpless; M. G. Finn; Hartmuth C. Kolb
Source: check_circle
Crossref

Click Chemistry: The Certainty of Chance (Nobel Lecture)**

Angewandte Chemie International Edition
2025-03-20 | Journal article
DOI: 10.1002/anie.202501229
Contributors: K. Barry Sharpless; M. G. Finn; Hartmuth C. Kolb
Source: check_circle
Crossref

Click-chemistry-derived oxime library reveals efficient reactivators of nerve agent-inhibited butyrylcholinesterase suitable for pseudo-catalytic bioscavenging

Archives of Toxicology
2025-03-03 | Journal article
DOI: 10.1007/s00204-025-03985-6
Contributors: Tena Čadež; Nikolina Maček Hrvat; Goran Šinko; Jarosław Kalisiak; Zoran Radić; Valery V. Fokin; Karl Barry Sharpless; Palmer Taylor; Zrinka Kovarik
Source: check_circle
Crossref

Sulfur fluoride exchange

Nature Reviews Methods Primers
2023-08-03 | Journal article
DOI: 10.1038/s43586-023-00241-y
Contributors: Joshua A. Homer; Long Xu; Namitharan Kayambu; Qinheng Zheng; Eun Joung Choi; Byeong Moon Kim; K. Barry Sharpless; Han Zuilhof; Jiajia Dong; John E. Moses
Source: check_circle
Crossref

Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery

Nature Chemistry
2020-10 | Journal article
DOI: 10.1038/s41557-020-0530-4
Contributors: Gabriel J. Brighty; Rachel C. Botham; Suhua Li; Luke Nelson; David E. Mortenson; Gencheng Li; Christophe Morisseau; Hua Wang; Bruce D. Hammock; K. Barry Sharpless et al.
Source: check_circle
Crossref

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Angewandte Chemie International Edition
2020-07-20 | Journal article
DOI: 10.1002/anie.202003219
Contributors: Christopher J. Smedley; Gencheng Li; Andrew S. Barrow; Timothy L. Gialelis; Marie‐Claire Giel; Alessandra Ottonello; Yunfei Cheng; Seiya Kitamura; Dennis W. Wolan; K. Barry Sharpless et al.
Source: check_circle
Crossref

Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Angewandte Chemie
2020-07-20 | Journal article
DOI: 10.1002/ange.202003219
Contributors: Christopher J. Smedley; Gencheng Li; Andrew S. Barrow; Timothy L. Gialelis; Marie‐Claire Giel; Alessandra Ottonello; Yunfei Cheng; Seiya Kitamura; Dennis W. Wolan; K. Barry Sharpless et al.
Source: check_circle
Crossref

Frontispiece: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Angewandte Chemie International Edition
2020-07-20 | Journal article
DOI: 10.1002/anie.202083063
Contributors: Christopher J. Smedley; Gencheng Li; Andrew S. Barrow; Timothy L. Gialelis; Marie‐Claire Giel; Alessandra Ottonello; Yunfei Cheng; Seiya Kitamura; Dennis W. Wolan; K. Barry Sharpless et al.
Source: check_circle
Crossref

Frontispiz: Diversity Oriented Clicking (DOC): Divergent Synthesis of SuFExable Pharmacophores from 2‐Substituted‐Alkynyl‐1‐Sulfonyl Fluoride (SASF) Hubs

Angewandte Chemie
2020-07-20 | Journal article
DOI: 10.1002/ange.202083063
Contributors: Christopher J. Smedley; Gencheng Li; Andrew S. Barrow; Timothy L. Gialelis; Marie‐Claire Giel; Alessandra Ottonello; Yunfei Cheng; Seiya Kitamura; Dennis W. Wolan; K. Barry Sharpless et al.
Source: check_circle
Crossref

Back Cover: Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins (Angew. Chem. Int. Ed. 24/2019)

Angewandte Chemie International Edition
2019-06-11 | Journal article
DOI: 10.1002/anie.201906154
Contributors: Feng Liu; Hua Wang; Suhua Li; Grant A. L. Bare; Xuemin Chen; Chu Wang; John E. Moses; Peng Wu; K. Barry Sharpless
Source: check_circle
Crossref

Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins

Angewandte Chemie
2019-06-11 | Journal article
DOI: 10.1002/ange.201902489
Contributors: Feng Liu; Hua Wang; Suhua Li; Grant A. L. Bare; Xuemin Chen; Chu Wang; John E. Moses; Peng Wu; K. Barry Sharpless
Source: check_circle
Crossref

Rücktitelbild: Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4)‐Derived Connective Hubs for Bioconjugation to DNA and Proteins (Angew. Chem. 24/2019)

Angewandte Chemie
2019-06-11 | Journal article
DOI: 10.1002/ange.201906154
Contributors: Feng Liu; Hua Wang; Suhua Li; Grant A. L. Bare; Xuemin Chen; Chu Wang; John E. Moses; Peng Wu; K. Barry Sharpless
Source: check_circle
Crossref

Biocompatible SuFEx Click Chemistry: Thionyl Tetrafluoride (SOF4 )-Derived Connective Hubs for Bioconjugation to DNA and Proteins.

Angewandte Chemie (International ed. in English)
2019-05-08 | Journal article
DOI: 10.1002/anie.201902489
PMID: 30998840
Source: Self-asserted source
K. Barry Sharpless
grade
Preferred source (of 2)‎

Bacterial glycosyltransferase-mediated cell-surface chemoenzymatic glycan modification.

Nature communications
2019-04-17 | Journal article
DOI: 10.1038/s41467-019-09608-w
PMID: 30996301
PMC: PMC6470217
Source: Self-asserted source
K. Barry Sharpless

Counteracting tabun inhibition by reactivation by pyridinium aldoximes that interact with active center gorge mutants of acetylcholinesterase.

Toxicology and applied pharmacology
2019-04-09 | Journal article
DOI: 10.1016/j.taap.2019.04.007
PMID: 30978400
Source: Self-asserted source
K. Barry Sharpless

Bifluoride Ion Mediated SuFEx Trifluoromethylation of Sulfonyl Fluorides and Iminosulfur Oxydifluorides.

Angewandte Chemie (International ed. in English)
2019-02-27 | Journal article
DOI: 10.1002/anie.201813761
PMID: 30740848
Source: Self-asserted source
K. Barry Sharpless

Reversal of Tabun Toxicity Enabled by a Triazole-Annulated Oxime Library-Reactivators of Acetylcholinesterase.

Chemistry (Weinheim an der Bergstrasse, Germany)
2019-02-14 | Journal article
DOI: 10.1002/chem.201805051
PMID: 30458057
Source: Self-asserted source
K. Barry Sharpless

Pharmacology, Pharmacokinetics, and Tissue Disposition of Zwitterionic Hydroxyiminoacetamido Alkylamines as Reactivating Antidotes for Organophosphate Exposure.

The Journal of pharmacology and experimental therapeutics
2018-09-06 | Journal article
DOI: 10.1124/jpet.118.249383
PMID: 30190337
PMC: PMC6223194
Source: Self-asserted source
K. Barry Sharpless

Quantitative and Orthogonal Formation and Reactivity of SuFEx Platforms.

Chemistry (Weinheim an der Bergstrasse, Germany)
2018-06-27 | Journal article
DOI: 10.1002/chem.201802356
PMID: 29949211
PMC: PMC6099289
Source: Self-asserted source
K. Barry Sharpless

SuFEx Click Chemistry Enabled Late-Stage Drug Functionalization.

Journal of the American Chemical Society
2018-02-16 | Journal article
DOI: 10.1021/jacs.7b12788
PMID: 29451783
PMC: PMC6192542
Source: Self-asserted source
K. Barry Sharpless

SuFEx Chemistry of Thionyl Tetrafluoride (SOF4 ) with Organolithium Nucleophiles: Synthesis of Sulfonimidoyl Fluorides, Sulfoximines, Sulfonimidamides, and Sulfonimidates.

Angewandte Chemie (International ed. in English)
2018-01-16 | Journal article
DOI: 10.1002/anie.201712145
PMID: 29314580
PMC: PMC6005182
Source: Self-asserted source
K. Barry Sharpless

"Inverse Drug Discovery" Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates.

Journal of the American Chemical Society
2017-12-21 | Journal article
DOI: 10.1021/jacs.7b08366
PMID: 29265822
PMC: PMC5762408
Source: Self-asserted source
K. Barry Sharpless

Bifluoride-catalysed sulfur(VI) fluoride exchange reaction for the synthesis of polysulfates and polysulfonates.

Nature chemistry
2017-06-19 | Journal article
DOI: 10.1038/nchem.2796
PMID: 29064495
PMC: PMC5972039
Source: Self-asserted source
K. Barry Sharpless

Palladium-Catalyzed Fluorosulfonylvinylation of Organic Iodides.

Angewandte Chemie (International ed. in English)
2017-03-29 | Journal article
DOI: 10.1002/anie.201701162
PMID: 28370917
PMC: PMC5653204
Source: Self-asserted source
K. Barry Sharpless

Multidimensional SuFEx Click Chemistry: Sequential Sulfur(VI) Fluoride Exchange Connections of Diverse Modules Launched From An SOF4 Hub.

Angewandte Chemie (International ed. in English)
2017-02-06 | Journal article
DOI: 10.1002/anie.201611048
PMID: 28165188
PMC: PMC5434761
Source: Self-asserted source
K. Barry Sharpless

Ethenesulfonyl Fluoride (ESF): An On-Water Procedure for the Kilogram-Scale Preparation.

The Journal of organic chemistry
2016-11-03 | Journal article
DOI: 10.1021/acs.joc.6b01423
PMID: 27764941
Source: Self-asserted source
K. Barry Sharpless

A Heck-Matsuda Process for the Synthesis of β-Arylethenesulfonyl Fluorides: Selectively Addressable Bis-electrophiles for SuFEx Click Chemistry.

Angewandte Chemie (International ed. in English)
2016-10-10 | Journal article
DOI: 10.1002/anie.201608807
PMID: 27723200
PMC: PMC5102157
Source: Self-asserted source
K. Barry Sharpless
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