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ResearcherID: A-5495-2009
Scopus Author ID: 8084483900

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Employment (1)

Charles University, First Faculty of Medicine: Prague, CZ

(Institute of Medical Biochemistry and Laboratory Medicine)
Employment
Source: Self-asserted source
Martin Leníček

Education and qualifications (2)

Charles University, First Faculty of Medicine: Prague, CZ

2010 | PhD (Institute of Medical Biochemistry and Laboratory Medicine)
Education
Source: Self-asserted source
Martin Leníček

Charles University, First Faculty of Medicine: Prague, CZ

2003 | MD
Education
Source: Self-asserted source
Martin Leníček

Works (50 of 98)

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Page 1 of 2

Microbially conjugated bile salts found in human bile activate the bile salt receptors TGR5 and FXR

Hepatology Communications
2024-04 | Journal article
DOI: 10.1097/HC9.0000000000000383
Contributors: Ümran Ay; Martin Leníček; Raphael S. Haider; Arno Classen; Hans van Eijk; Kiran V.K. Koelfat; Gregory van der Kroft; Ulf. P. Neumann; Carsten Hoffmann; Carsten Bolm et al.
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Crossref

High Dose Fish Oil Added to Various Lipid Emulsions Normalizes Superoxide Dismutase 1 Activity in Home Parenteral Nutrition Patients

Nutrients
2024-02-08 | Journal article
DOI: 10.3390/nu16040485
Contributors: Stanislav Sevela; Eva Meisnerova; Marek Vecka; Lucie Vavrova; Jana Rychlikova; Martin Lenicek; Libor Vitek; Olga Novakova; Frantisek Novak
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Microbially-conjugated Bile Salts Found in Human Bile Activate the Bile Salt Receptors TGR5 and FXR

2023-09-05 | Preprint
DOI: 10.1101/2023.09.04.556292
Contributors: Ümran Ay; Martin Leníček; Raphael S. Haider; Arno Classen; Hans van Eijk; Kiran V.K. Koelfat; Gregory van der Kroft; Ulf. P. Neumann; Carsten Hoffmann; Carsten Bolm et al.
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Serum concentration of taurochenodeoxycholic acid predicts clinically significant portal hypertension

Liver International
2023-04 | Journal article
DOI: 10.1111/liv.15481
Contributors: Kateřina Žížalová; Barbora Nováková; Marek Vecka; Jaromír Petrtýl; Věra Lánská; Květa Pelinková; Václav Šmíd; Radan Brůha; Libor Vítek; Martin Leníček
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Eggerthella lenta DSM 2243 Alleviates Bile Acid Stress Response in Clostridium ramosum and Anaerostipes caccae by Transformation of Bile Acids

Microorganisms
2022-10-13 | Journal article
DOI: 10.3390/microorganisms10102025
Contributors: Kristian Jensen Pedersen; Sven-Bastiaan Haange; Kateřina Žížalová; Alina Viehof; Thomas Clavel; Martin Leniček; Beatrice Engelmann; Lukas Y. Wick; Frank G. Schaap; Nico Jehmlich et al.
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New Kids on the Block: Bile Salt Conjugates of Microbial Origin

Metabolites
2022-02-13 | Journal article
DOI: 10.3390/metabo12020176
Contributors: Ümran Ay; Martin Leníček; Arno Classen; Steven W. M. Olde Damink; Carsten Bolm; Frank G. Schaap
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Clinically silent LINE 1 insertion in the PNPLA3 gene may impede genotyping of the p.I148M variant

Scientific Reports
2021-12 | Journal article
DOI: 10.1038/s41598-021-00425-0
Part of ISSN: 2045-2322
Source: Self-asserted source
Martin Leníček

Association of Serum Bilirubin and Functional Variants of Heme Oxygenase 1 and Bilirubin UDP-Glucuronosyl Transferase Genes in Czech Adult Patients with Non-Alcoholic Fatty Liver Disease

Antioxidants
2021-12-15 | Journal article
DOI: 10.3390/antiox10122000
Contributors: Jaromír Petrtýl; Karel Dvořák; Jan Stříteský; Martin Leníček; Alena Jirásková; Václav Šmíd; Martin Haluzík; Radan Brůha; Libor Vítek
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Chyme Reinfusion Restores the Regulatory Bile Salt–FGF19 Axis in Patients With Intestinal Failure

Hepatology
2021-11 | Journal article
DOI: 10.1002/hep.32017
Part of ISSN: 0270-9139
Part of ISSN: 1527-3350
Source: Self-asserted source
Martin Leníček

Mathematical recalibration of total bile acids: comparing the incomparable?

Clinical Chemistry and Laboratory Medicine (CCLM)
2021-11-25 | Journal article
DOI: 10.1515/cclm-2021-0793
Contributors: Martin Leníček
Source: check_circle
Crossref

Enzymatic methods may underestimate the total serum bile acid concentration

PLOS ONE
2020-07-24 | Journal article
DOI: 10.1371/journal.pone.0236372
Contributors: Kateřina Žížalová; Pavel Strnad; Marek Vecka; Libor Vítek; Martin Leníček
Source: check_circle
Crossref

Gut microbes take it to the next level? First insights into FXR agonists of microbial origin.

Hepatology (Baltimore, Md.)
2020-07-10 | Journal article
DOI: 10.1002/hep.31455
PMID: 32648608
Source: Self-asserted source
Martin Leníček
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A novel accurate LC-MS/MS method for quantitative determination of Z-lumirubin.

Scientific reports
2020-03-10 | Journal article
DOI: 10.1038/s41598-020-61280-z
PMID: 32157102
PMC: PMC7064611
Source: Self-asserted source
Martin Leníček

Anti-angiogenic effects of the blue-green alga Arthrospira platensis on pancreatic cancer.

Journal of cellular and molecular medicine
2020-01-19 | Journal article
DOI: 10.1111/jcmm.14922
PMID: 31957261
PMC: PMC7028863
Source: Self-asserted source
Martin Leníček

Low circulating concentrations of citrulline and FGF19 predict chronic cholestasis and poor survival in adult patients with chronic intestinal failure: development of a Model for End-Stage Intestinal Failure (MESIF risk score)

The American Journal of Clinical Nutrition
2019-06 | Journal article
DOI: 10.1093/ajcn/nqz036
Contributors: Kiran V K Koelfat; Angelique Huijbers; Frank G Schaap; Sander M J van Kuijk; Martin Lenicek; Maarten R Soeters; Geert J A Wanten; Steven W M Olde Damink
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Gallbladder Dyskinesia Is Associated With an Impaired Postprandial Fibroblast Growth Factor 19 Response in Critically Ill Patients.

Hepatology (Baltimore, Md.)
2019-06-05 | Journal article
DOI: 10.1002/hep.30629
PMID: 30933374
Source: Self-asserted source
Martin Leníček

Hyperbilirubinemia in Gunn Rats is Associated with Decreased Inflammatory Response in LPS-Mediated Systemic Inflammation.

International journal of molecular sciences
2019-05-09 | Journal article
DOI: 10.3390/ijms20092306
PMID: 31075981
PMC: PMC6539717
Source: Self-asserted source
Martin Leníček
grade
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Microbiome and Metabolome Profiles Associated With Different Types of Short Bowel Syndrome: Implications for Treatment.

JPEN. Journal of parenteral and enteral nutrition
2019-04-29 | Journal article
DOI: 10.1002/jpen.1595
PMID: 31032975
Source: Self-asserted source
Martin Leníček

The cholic acid extension study in Zellweger spectrum disorders: Results and implications for therapy.

Journal of inherited metabolic disease
2019-02-21 | Journal article
DOI: 10.1002/jimd.12042
PMID: 30793331
Source: Self-asserted source
Martin Leníček

Prolonged fibroblast growth factor 19 response in patients with primary sclerosing cholangitis after an oral chenodeoxycholic acid challenge

Hepatology International
2017 | Journal article
DOI: 10.1007/s12072-016-9769-7
WOSUID:

WOS:000392290900014
Contributors: Zweers, Serge J.; de Vries, Elisabeth M.; Lenicek, Martin; Tolenaars, Dagmar; de Waart, D. Rudi; Koelfat, Kiran V. K.; Groen, Albert K.; Damink, Steven W. M. Olde; Beuers, Ulrich; Ponsioen, Cyriel et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
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Iron depletion induces hepatic secretion of biliary lipids and glutathione in rats.

Biochimica et biophysica acta. Molecular and cell biology of lipids
2017-09-06 | Journal article
DOI: 10.1016/j.bbalip.2017.09.003
PMID: 28888833
Source: Self-asserted source
Martin Leníček

Cholic acid therapy in Zellweger spectrum disorders

Journal of Inherited Metabolic Disease
2016 | Journal article
DOI: 10.1007/s10545-016-9962-9
WOSUID:

WOS:000386383500010
Contributors: Berendse, Kevin; Klouwer, Femke C. C.; Koot, Bart G. P.; Kemper, Elles M.; Ferdinandusse, Sacha; Koelfat, Kiran V. K.; Lenicek, Martin; Schaap, Frank G.; Waterham, Hans R.; Vaz, Frederic M. et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
grade
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Comparison of simple extraction procedures in liquid chromatography-mass spectrometry based determination of serum 7 alpha-hydroxy-4-cholesten-3-one, a surrogate marker of bile acid synthesis

Journal of Chromatography B-Analytical Technologies in the Biomedical and Life Sciences
2016 | Journal article
DOI: 10.1016/j.jchromb.2016.08.046
WOSUID:

WOS:000385322600039
Contributors: Lenicek, Martin; Vecka, Marek; Zizalova, Katerina; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID
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Diurnal variation in cholesterol 7 alpha-hydroxylase activity is determined by the-203A > C polymorphism of the CYP7A1 gene

Croatian Medical Journal
2016 | Journal article
DOI: 10.3325/cmj.2016.57.111
WOSUID:

WOS:000377053400004
Contributors: Vlachova, Miluse; Blahova, Tereza; Lanska, Vera; Lenicek, Martin; Pit'ha, Jan; Vitek, Libor; Kovar, Jan
Source: Self-asserted source
Martin Leníček via ResearcherID
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Osteopontin: A non-invasive parameter of portal hypertension and prognostic marker of cirrhosis

World Journal of Gastroenterology
2016 | Journal article
DOI: 10.3748/wjg.v22.i12.3441
WOSUID:

WOS:000372573800015
Contributors: Bruha, Radan; Jachymova, Marie; Petrtyl, Jaromir; Dvorak, Karel; Lenicek, Martin; Urbanek, Petr; Svestka, Tomislav; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID
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The effect of colesevelam treatment on bile acid and lipid metabolism and glycemic control in healthy men

Physiological Research
2016 | Journal article
EID:

2-s2.0-85011805091
Contributors: Blahová, T.; Peterková, L.; Leníček, M.; Vlachová, M.; Zemánková, K.; Adámková, V.; Vítek, L.; Kovář, J.
Source: Self-asserted source
Martin Leníček via Scopus - Elsevier

Parenteral nutrition dysregulates bile salt homeostasis in a rat model of parenteral nutrition-associated liver disease.

Clinical nutrition (Edinburgh, Scotland)
2016-09-24 | Journal article
DOI: 10.1016/j.clnu.2016.09.012
PMID: 28029505
Source: Self-asserted source
Martin Leníček
grade
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Enhanced and Prolonged FGF19 Response in Primary Sclerosing Cholangitis after a CDCA Challenge

Hepatology
2015 | Journal article
WOSUID:

WOS:000368375401487
Contributors: Zweers, Serge; de Vries, Elisabeth M.; Lenicek, Martin; Tolenaars, Dagmar; de Waart, Dirk R.; Koelfat, Kiran V.; Groen, Albert; Damink, Steven Olde; Beuers, Ulrich; Ponsioen, Cyriel Y. et al.
Source: Self-asserted source
Martin Leníček via ResearcherID

Osteopontin is a new prognostic marker of liver cirrhosis

Hepatology
2015 | Journal article
WOSUID:

WOS:000368375403279
Contributors: Bruha, Radan; Jachymova, Marie; Petrtyl, Jaromir; Dvorak, Karel; Lenicek, Martin; Urbanek, Petr; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID

PREDICTIVE VALUE OF ANTI-C REACTIVE PROTEIN ANTIBODIES IN LUPUS NEPHRITIS

Nephrology Dialysis Transplantation
2015 | Journal article
WOSUID:

WOS:000361215102001
Contributors: Pesickova, Satu Sinikka; Lenicek, Martin; Rysava, Romana; Vitek, Libor; Zavada, Jakub; Tesar, Vladimir
Source: Self-asserted source
Martin Leníček via ResearcherID

Prognostic value of anti-CRP antibodies in lupus nephritis in long-term follow-up

Arthritis Research & Therapy
2015 | Journal article
DOI: 10.1186/s13075-015-0879-8
WOSUID:

WOS:000367347900001
Contributors: Pesickova, Satu Sinikka; Rysava, Romana; Lenicek, Martin; Vitek, Libor; Potlukova, Eliska; Hruskova, Zdenka; Jancova, Eva; Honsova, Eva; Zavada, Jakub; Trendelenburg, Marten et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
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Protective effect of heme oxygenase induction in ethinylestradiol-induced cholestasis

Journal of Cellular and Molecular Medicine
2015 | Journal article
DOI: 10.1111/jcmm.12401
WOSUID:

WOS:000353991100003
Contributors: Muchova, Lucie; Vanova, Katerina; Suk, Jakub; Micuda, Stanislav; Dolezelova, Eva; Fuksa, Leos; Cerny, Dalibor; Farghali, Hassan; Zelenkova, Miroslava; Lenicek, Martin et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
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The effect of heme oxygenase on ganglioside redistribution within hepatocytes in experimental estrogen-induced cholestasis

Physiological Research
2014 | Journal article
EID:

2-s2.0-84904576449
Contributors: Petr, T.; Šmíd, V.; Kǔcerová, V.; Váňová, K.; Leníček, M.; Vítek, L.; Šmíd, F.; Muchová, L.
Source: Self-asserted source
Martin Leníček via Scopus - Elsevier

The Effect of Heme Oxygenase on Ganglioside Redistribution Within Hepatocytes in Experimental Estrogen-Induced Cholestasis

Physiological Research
2014 | Journal article
WOSUID:

WOS:000339879900009
Contributors: Petr, T.; Smid, V.; Kucerova, V.; Vanova, K.; Lenicek, M.; Vitek, L.; Smid, F.; Muchova, L.
Source: Self-asserted source
Martin Leníček via ResearcherID

The Relationship Between Serum Bilirubin and Crohn's Disease

Inflammatory Bowel Diseases
2014 | Journal article
DOI: 10.1097/01.MIB.0000440817.84251.98
WOSUID:

WOS:000335650700007
Contributors: Lenicek, Martin; Duricova, Dana; Hradsky, Ondrej; Dusatkova, Petra; Jiraskova, Alena; Lukas, Milan; Nachtigal, Petr; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID
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Use of Non-Invasive Parameters of Non-Alcoholic Steatohepatitis and Liver Fibrosis in Daily Practice - An Exploratory Case-Control Study

Plos One
2014 | Journal article
DOI: 10.1371/journal.pone.0111551
WOSUID:

WOS:000343943100077
Contributors: Dvorak, Karel; Stritesky, Jan; Petrtyl, Jaromir; Vitek, Libor; Sroubkova, Renata; Lenicek, Martin; Smid, Vaclav; Haluzik, Martin; Bruha, Radan
Source: Self-asserted source
Martin Leníček via ResearcherID
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Cholestatic effect of epigallocatechin gallate in rats is mediated via decreased expression of Mrp2

Toxicology
2013 | Journal article
DOI: 10.1016/j.tox.2012.10.018
WOSUID:

WOS:000314856800002
Contributors: Hirsova, Petra; Karlasova, Gabriela; Dolezelova, Eva; Cermanova, Jolana; Zagorova, Marie; Kadova, Zuzana; Hroch, Milos; Sispera, Ludek; Tomsik, Pavel; Lenicek, Martin et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
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Expression of Biliverdin Reductase A in Peripheral Blood Leukocytes Is Associated with Treatment Response in HCV-Infected Patients

Plos One
2013 | Journal article
DOI: 10.1371/journal.pone.0057555
WOSUID:

WOS:000316251100011
Contributors: Subhanova, Iva; Muchova, Lucie; Lenicek, Martin; Vreman, Hendrik J.; Luksan, Ondrej; Kubickova, Kristyna; Kreidlova, Miluse; Zima, Tomas; Vitek, Libor; Urbanek, Petr
Source: Self-asserted source
Martin Leníček via ResearcherID
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Functional variants of eNOS and iNOS genes have no relationship to the portal hypertension in patients with liver cirrhosis

Scandinavian Journal of Gastroenterology
2013 | Journal article
DOI: 10.3109/00365521.2013.773459
WOSUID:

WOS:000317933300012
Contributors: Petrtyl, Jaromir; Dvorak, Karel; Jachymova, Marie; Vitek, Libor; Lenicek, Martin; Urbanek, Petr; Linhart, Ales; Jansa, Pavel; Bruha, Radan
Source: Self-asserted source
Martin Leníček via ResearcherID
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Protective role of nuclear factor erythroid 2-related factor 2 (Nrf2)-mediated upregulation of liver Mrp3 transporter in ethinylestradiol-induced cholestasis in rats

Hepatology
2013 | Journal article
WOSUID:

WOS:000330252201380
Contributors: Muchova, Lucie; Vanova, Katerina; Suk, Jakub; Petr, Tomas; Smid, Vaclav; Lenicek, Martin; Micuda, Stanislav; Cerny, Dalibor; Farghali, Hassan; Wong, Ronald J. et al.
Source: Self-asserted source
Martin Leníček via ResearcherID

Biliverdin reductase A expression in peripheral blood mononuclear cells is associated with treatment response to antiviral therapy in chronic hepatitis C patients

Hepatology
2012 | Journal article
WOSUID:

WOS:000310955602420
Contributors: Subhanova, Iva; Vitek, Libor; Muchova, Lucie; Lenicek, Martin; Luksan, Ondrej; Zima, Tomas; Urbanek, Petr
Source: Self-asserted source
Martin Leníček via ResearcherID

-203A/C POLYMORPHISM OF CHOLESTEROL 7 alpha-HYDROXYLASE (CYP7A1) GENE AFFECTS CYP7A1 ACTIVITY AFTER SHORT-TERM TREATMENT WITH CHOLESTYRAMINE

Atherosclerosis Supplements
2011 | Journal article
WOSUID:

WOS:000300159000045
Contributors: Kovar, J.; Zimolova, M.; Lenicek, M.; Vitek, L.; Jirsa, M.; Poledne, R.
Source: Self-asserted source
Martin Leníček via ResearcherID

Bile Acid Malabsorption in Inflammatory Bowel Disease: Assessment by Serum Markers

Inflammatory Bowel Diseases
2011 | Journal article
DOI: 10.1002/ibd.21502
WOSUID:

WOS:000290442400030
Contributors: Lenicek, Martin; Duricova, Dana; Komarek, Viktor; Gabrysova, Bronislava; Lukas, Milan; Smerhovsky, Zdenek; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID
grade
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Bile acids decrease intracellular bilirubin levels in the cholestatic liver: implications for bile acid-mediated oxidative stress

Journal of Cellular and Molecular Medicine
2011 | Journal article
DOI: 10.1111/j.1582-4934.2010.01098.x
WOSUID:

WOS:000291045800015
Contributors: Muchova, Lucie; Vanova, Katerina; Zelenka, Jaroslav; Lenicek, Martin; Petr, Tomas; Vejrazka, Martin; Sticova, Eva; Vreman, Hendrik Jan; Wong, Ronald James; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID
grade
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Determination of Beta-Defensin Genomic Copy Number in Different Populations: A Comparison of Three Methods

Plos One
2011 | Journal article
DOI: 10.1371/journal.pone.0016768
WOSUID:

WOS:000287656600019
Contributors: Fode, Peder; Jespersgaard, Cathrine; Hardwick, Robert J.; Bogle, Helen; Theisen, Michael; Dodoo, Daniel; Lenicek, Martin; Vitek, Libor; Vieira, Ana; Freitas, Joao et al.
Source: Self-asserted source
Martin Leníček via ResearcherID
grade
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GENETIC POLYMORPHISMS OF ENOS AND INOS HAVE NO RELATION TO THE SEVERITY OF PORTAL HYPERTENSION IN CONTAST TO THE INFLAMMATORY PARAMETERS

Hepatology
2011 | Journal article
WOSUID:

WOS:000295578004332
Contributors: Bruha, Radan; Dvorak, Karel; Jachymova, Marie; Urbanek, Petr; Petrtyl, Jaromir; Lenicek, Martin; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Annals of Hepatology
2011 | Journal article
EID:

2-s2.0-80052719924
Contributors: Urbánek, P.; Leníček, M.; Muchová, L.; Subhanová, I.; Dušek, L.; Kaspříková, N.; Hrabal, P.; Brůha, R.; Vítek, L.
Source: Self-asserted source
Martin Leníček via Scopus - Elsevier

No association of promoter variations of HMOX1 and UGT1A1 genes with liver injury in chronic hepatitis C

Annals of Hepatology
2011 | Journal article
WOSUID:

WOS:000296672600005
Contributors: Urbanek, Petr; Lenicek, Martin; Muchova, Lucie; Subhanova, Iva; Dusek, Ladislav; Kasprikova, Nikola; Hrabal, Petr; Bruha, Radan; Vitek, Libor
Source: Self-asserted source
Martin Leníček via ResearcherID

PROTECTIVE EFFECTS OF HEME OXYGENASE-1 IN ETHINYLESTRADIOL-INDUCED CHOLESTASIS IN RATS

Hepatology
2011 | Journal article
WOSUID:

WOS:000295578003105
Contributors: Muchova, Lucie; Vanova, Katerina; Petr, Tomas; Smid, Vaclav; Lenicek, Martin; Micuda, Stanislav; Brcakova, Eva; Fuksa, Leos; Cerny, Dalibor; Farghali, Hassan et al.
Source: Self-asserted source
Martin Leníček via ResearcherID

Serum concentration of hyaluronic acid correlates with the degree of fibrosis and portal hypertension | Sérové hodnoty hyaluronové kyseliny souvisejí se stupněm jaterní fibrózy i portální hypertenzí

Ceska a Slovenska Gastroenterologie a Hepatologie
2011 | Journal article
EID:

2-s2.0-83455233722
Contributors: Brůha, R.; Zima, T.; Pelinková, K.; Urbánek, P.; Leníček, M.; Subhanová, I.; Dvořák, K.; Petrtýl, J.; Stříteský, J.; Benáková, H. et al.
Source: Self-asserted source
Martin Leníček via Scopus - Elsevier
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Peer review (2 reviews for 1 publication/grant)

Review activity for PloS one. (2)
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