Rastislav Jendželovský (0000-0001-6338-0723)

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Scientific profiling in the field of experimental oncology and molecular cytology, with emphasis on the study of interactions of xenobiotics with transport proteins in cancer cells and mechanisms of chemotherapeutic efficiency enhancement by non-steroidal anti-inflammatory drugs in vitro, with regard to identification and elimination of multiple drug resistance mechanisms.

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Pavol Jozef Šafárik University in Košice: Košice, SK

Assoc. prof. (Department of cellular biology, Institute of Biology and Ecology)

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Rastislav Jendželovský

https://orcid.org/0000-0001-6338-0723

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Pavol Jozef Šafárik University in Košice: Košice, SK

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Czech Society for Analytical Cytometry: Prague, CZ

Works (50 of 52)

Gyrophoric Acid, a Secondary Metabolite of Lichens, Exhibits Antidepressant and Anxiolytic Activity In Vivo in Wistar Rats

Impact of the central atom and halido ligand on the structure, antiproliferative activity and selectivity of half-sandwich Ru(<scp>ii</scp>) and Ir(<scp>iii</scp>) complexes with a 1,3,4-thiadiazole-based ligand

The role of pH on the preparation of citric acid coated cobalt ferrite nanoparticles for biomedical applications

New findings on the action of hypericin in hypoxic cancer cells with a focus on the modulation of side population cells

Atranorin, a Secondary Metabolite of Lichens, Exhibited Anxiolytic/Antidepressant Activity in Wistar Rats

Multifunctional Nanoplatforms as a Novel Effective Approach in Photodynamic Therapy and Chemotherapy, to Overcome Multidrug Resistance in Cancer

Acridine Based N-Acylhydrazone Derivatives as Potential Anticancer Agents: Synthesis, Characterization and ctDNA/HSA Spectroscopic Binding Properties

Synthesis of New Biscoumarin Derivatives, In Vitro Cholinesterase Inhibition, Molecular Modelling and Antiproliferative Effect in A549 Human Lung Carcinoma Cells

Death Receptor 5 (TNFRSF10B) Is Upregulated and TRAIL Resistance Is Reversed in Hypoxia and Normoxia in Colorectal Cancer Cell Lines after Treatment with Skyrin, the Active Metabolite of Hypericum spp.

Tacrine-Coumarin Derivatives as Topoisomerase Inhibitors with Antitumor Effects on A549 Human Lung Carcinoma Cancer Cell Lines

Potentiality, Limitations, and Consequences of Different Experimental Models to Improve Photodynamic Therapy for Cancer Treatment in Relation to Antiangiogenic Mechanism

In vitro study of disodium cromoglicate as a novel effective hydrotrope solvent for hypericin utilisation in photodynamic therapy

Combination of photoactive hypericin and Manumycin A exerts multiple anticancer effects on oxaliplatin-resistant colorectal cells.

Melatonin mitigates hippocampal and cognitive impairments caused by prenatal irradiation

Breast cancer resistance protein is the enemy of hypericin accumulation and toxicity of hypericin-mediated photodynamic therapy

In vitro investigating of anticancer activity of new 7-MEOTA-tacrine heterodimers

Fluorinated 3,6,9-trisubstituted acridine derivatives as DNA interacting agents and topoisomerase inhibitors with A549 antiproliferative activity

Low-dimensional compounds containing bioactive ligands. Part XII: Synthesis, structures, spectra, in vitro antimicrobial and cytotoxic activities of zinc(II) complexes with halogen derivatives of quinolin-8-ol

Novel Insights into the Effect of Hyperforin and Photodynamic Therapy with Hypericin on Chosen Angiogenic Factors in Colorectal Micro-Tumors Created on Chorioallantoic Membrane.

Hypericin affects cancer side populations via competitive inhibition of BCRP

Antitumor effect of the combination of manumycin A and Immodin is associated with antiplatelet activity and increased granulocyte tumor infiltration in a 4T1 breast tumor model

Histone deacetylase inhibitors potentiate photodynamic therapy in colon cancer cells marked by chromatin-mediated epigenetic regulation of CDKN1A

Synthesis, spectral characterization, DNA binding ability and anti-cancer screening of new acridine-based derivatives

Anticancer and immunomodulatory effects of lactobacillus plantarum ls/07, inulin and melatonin in NMU-induced rat model of breast cancer

Drug membrane transporters and CYP3A4 are affected by hypericin, hyperforin or aristoforin in colon adenocarcinoma cells

Hypericin in the light and in the dark: Two sides of the same coin

New spiro tria(thia)zolidine-acridines as topoisomerase inhibitors, DNA binders and cytostatic compounds

Proadifen sensitizes resistant ovarian adenocarcinoma cells to cisplatin

YM155, a small molecule inhibitor of survivin expression, sensitizes cancer cells to hypericin-mediated photodynamic therapy

Downregulation of BCRP and anti-apoptotic proteins by proadifen (SKF-525A) is responsible for the enhanced mitoxantrone accumulation and toxicity in mitoxantrone-resistant human promyelocytic leukemia cells

Inhibition of DNA topoisomerases i and II and growth inhibition of HL-60 cells by novel acridine-based compounds

New nanostructured nickel-polymer nanohybrids with improved surface hydrophobicity and effect on the living cells adhesion

Peroral administration of 5-bromo-2-deoxyuridine in drinking water is not a reliable method for labeling proliferating S-phase cells in rats

Potentiation of hypericin-mediated photodynamic therapy cytotoxicity by MK-886: Focus on ABC transporters, GDF-15 and redox status

Tacrine derivatives as dual topoisomerase I and II catalytic inhibitors

Flow cytometric determination of 5-bromo-2ʹ-deoxyuridine pharmacokinetics in blood serum after intraperitoneal administration to rats and mice

Resveratrol enhances the chemopreventive effect of celecoxib in chemically induced breast cancer in rats

Single pre-treatment with hypericin, a St. John's wort secondary metabolite, attenuates cisplatin- and mitoxantrone-induced cell death in A2780, A2780cis and HL-60 cells

Potency of non-steroidal anti-inflammatory drugs in chemotherapy.

Cellular aspects of photodynamic therapy with hypericin

Procedure for improved cleaning of FACSAria cuvette flow cell

3,6-Bis(3-alkylguanidino)acridines as DNA-intercalating antitumor agents

Inhibition of GSK-3β reverses the pro-apoptotic effect of proadifen (SKF-525A) in HT-29 colon adenocarcinoma cells

Lichen secondary metabolites are responsible for induction of apoptosis in HT-29 and A2780 human cancer cell lines

The pro-apoptotic and anti-invasive effects of hypericin-mediated photodynamic therapy are enhanced by hyperforin or aristoforin in HT-29 colon adenocarcinoma cells

Lower sensitivity of FHC fetal colon epithelial cells to photodynamic therapy compared to HT-29 colon adenocarcinoma cells despite higher intracellular accumulation of hypericin

Targeting HER2 with photodynamic therapy

Variable responses of different human cancer cells to the lichen compounds parietin, atranorin, usnic acid and gyrophoric acid

Degradation of HER2 receptor through hypericin-mediated photodynamic therapy

PUFAs enhance oxidative stress and apoptosis in tumour cells exposed to hypericin-mediated PDT

Peer review (1 review for 1 publication/grant)