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cardiovascular diseases, regenerative medicine, heart injury models, cardiac fibrosis, new therapies

Biography

Diana S Nascimento (DSN) is an Assistant Researcher at Instituto de Ciências Biomédicas Abel Salazar (ICBAS, Universidade do Porto, Porto) and at Instituto de Investigação e Invovação em Saúde (i3S, Universidade do Porto, Porto). The main goal of DS Nascimento research is the development of more efficient bioengineered therapies for cardiovascular disorders, with special emphasis on driving cardiac regeneration and/or inhibiting the formation of fibrosis in patients with heart failure. In the past hears, her main findings were published in prestigious international journals, namely Biomaterials, Nature Communications, Nature Aging, PLOS Biology, Stem Cell Reports, Circulation Research and Cardiovascular Research.
In parallel to these scientific activities, DSN has also been engaged in pedagogic activities and, from 2013, she is an assistant professor at the Integrated Master of Bioengineering ICBAS and, since 2011, collaborates in several post-graduate programmes.
Overall, DSN has made significant contributions in the cardiovascular field, with 45 publications (IF=257, h-index=23, 2103 citations), 3 book chapters, 2 patents, and 1 software. She has also demonstrated remarkable skills in project management (>5M€, as PI or co-PI and as project partner), industry collaboration, supervision (4 post-docs, 7 PhDs, and 16 MSc students), science communication/dissemination (invited lecturer in 30 meetings), and was recognized with 6 national/international awards (co-authored >19 prizes). DS Nascimento has been appointed member staff of the Bioimaging Centre for Biomaterials and Regenerative Therapies of i3S is member of the governing board of the Portuguese Society for Stem Cells and Cellular Therapy (SPCE-TC) (2015-2019 and 2024 to present).

Activities

Employment (7)

I3S/INEB: Porto, PT

2015-07-02 to present | Assistant Investigator
Employment
Source: Self-asserted source
DS Nascimento

Instituto de Ciências Biomédicas Abel Salazar: Porto, PT

2013-09-01 to present | Assistant Researcher/Professor
Employment
Source: Self-asserted source
DS Nascimento

Staff Member of the Bioimaging Centre for Biomaterials and Regenerative Therapies (b.IMAGE): Porto, PT

2012 to present | Staff Member
Employment
Source: Self-asserted source
DS Nascimento

INEB: Porto, PT

2013-06-01 to 2015-06-31 | Postdoctoral research assistant
Employment
Source: Self-asserted source
DS Nascimento

INEB: Porto, PT

2008-05-01 to 2013-05-31 | PostDoc Fellow
Employment
Source: Self-asserted source
DS Nascimento

Instituto Politécnico do Porto: Porto, Porto, PT

2007-09-01 to 2009-07-30 | Invited Assistent Porfessor (School of Health Technologies of Porto)
Employment
Source: Self-asserted source
DS Nascimento

Keck Graduate Institute of Applied Life Sciences: Claremont, CA, US

2008-11-01 to 2009-01-31 | Visiting PostDoc researcher
Employment
Source: Self-asserted source
DS Nascimento

Education and qualifications (2)

University of Aberdeen: Aberdeen, Aberdeen, GB

2003-09-01 to 2008-04 | PhD (Zoology)
Education
Source: Self-asserted source
DS Nascimento

Faculdade de Ciências da Universidade do Porto : Porto, PT

1998 to 2003 | BSc
Education
Source: Self-asserted source
DS Nascimento

Funding (28)

SAPHIRE - S100A9-Associated Pharmacological Inhibition for Therapeutic HFpEF Exploitation

2024-10-01 to 2025-06-30 | Grant
Novo Nordisk A/S (Gentofte, DK)
GRANT_NUMBER:

SAPHIRE

Source: check_circle
CIÊNCIAVITAE

Are extracellular vesicles EV the missing link between aging and HFpEF?

2023-03-12 to 2025-03-31 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2022.08730.PTDC

Source: check_circle
CIÊNCIAVITAE

Peroxidasin as a Novel Target in Chronic Kidney Disease Diagnosis and Treatment

2023-01-01 to 2025-12-31 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2022.04524.PTDC

Source: check_circle
CIÊNCIAVITAE

CD24: a guardian of cardiac renewal potential?

2023-01-01 to 2025-02-28 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

2022.09110.PTDC

Source: check_circle
CIÊNCIAVITAE

Harnessing endothelial plasticity for therapeutic vascularization of ischemic tissues: a bioengineering approach

2021-03-29 to 2025-01-28 | Grant
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BTM-ORG/5154/2020

Source: check_circle
CIÊNCIAVITAE

Institute for Research and Innovation in Health

2021-01-01 to 2025-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

LA/P/0070/2020

Source: check_circle
CIÊNCIAVITAE

Assistant researcher contract

2019-12-02 to 2025-12-01 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

CEECINST/00091/2018/CP1500/CT0010

Source: check_circle
CIÊNCIAVITAE

Institute for Research and Innovation in Health Sciences

2019-01-01 to 2019-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

UID/BIM/04293/2019

Source: check_circle
CIÊNCIAVITAE

Assistant researcher contract

2018-11-01 to 2019-12-01 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

DL 57/2016/CP1360/CT0002

Source: check_circle
CIÊNCIAVITAE

Scar(less) - Positive impact of fibroblasts on cardiac regeneration

2018-07-26 to 2022-04-25 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/MED-OUT/30985/2017

Source: check_circle
CIÊNCIAVITAE

In vivo amelioration of AGE-associated haLlmarkS by tranScriptional modulation

2018-07-26 to 2021-07-25 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/BIA-CEL/31120/2017

Source: check_circle
CIÊNCIAVITAE

AGELess - In vivo amelioration of AGE-associated haLlmarkS by tranScriptional modulation.

2018-06 to 2021-06 | Grant
Fundação para a Ciência e a Tecnologia (Lisbon, PT)
GRANT_NUMBER:

POCI-01-0145-FEDER-031120, co-principal investigator

Source: check_circle
CIÊNCIAVITAE

NEw Targets in DIAstolic heart failure

2016-12 to 2019-11 | Award
Ministério da Ciência, Tecnologia e Ensino Superior (Lisboa, PT)
GRANT_NUMBER:

POCI-01-0145-FEDER-016385

Source: Self-asserted source
DS Nascimento
grade
Preferred source (of 2)‎

microRNAs como biomarcadores/alvos terapêuticos para identificar/reverter a fibrose cardíaca

2016-01 to 2017-06 | Grant
INFARMED (Lisbon, PT)
Source: Self-asserted source
DS Nascimento

Structured Programme on Bioengineering Therapies for Infectious Diseases and Tissue Regeneration

2016 to 2019 | Grant
Comissao de Coordenacao e Desenvolvimento Regional do Norte (Porto, PT)
GRANT_NUMBER:

NORTE-01-0145-FEDER-000012

Source: check_circle
CIÊNCIAVITAE

PERI-TARGETS - microRNAs as therapeutic targets to revert cardiac fibrosis

2016 to 2018 | Grant
Infarmed Autoridade Nacional do Medicamento e Produtos de Saúde IP (Lisboa, PT)
GRANT_NUMBER:

FIS-FIS-2015-01_CCV_20150630-157

Source: check_circle
CIÊNCIAVITAE

Assessment of the role of human UC-derived ECBio cells-transplantation into the myocardial-infarcted C57BL/6 mouse heart

2014 to present | Contract
ECBio (Amadora, PT)
Source: Self-asserted source
DS Nascimento

CARDIOSTEM- Engineered cardiac tissues and stem cell-based therapies for cardiovascular applications.

2014 to present | Grant
MIT Portugal (Lisbon, PT)
GRANT_NUMBER:

MITP-TB/ECE/0013/2013

Source: Self-asserted source
DS Nascimento
grade
Preferred source (of 2)‎

Industrial contract between ECBio - R&D in Biotechnology and INEB

2014 to 2016 | Contract
Instituto Nacional de Engenharia Biomédica (Porto, PT)
GRANT_NUMBER:

Lisboa-01-0202-FEDER-030196 - CO-PRINCIPAL INVESTIGATOR

Source: check_circle
CIÊNCIAVITAE

MatriCard - Dissecção e Reconstrução de Matriz Extracelular: Nicho de Regeneração Cardíaca

2012 to 2015 | Grant
Fundação Portuguesa para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

PTDC/SAU-ORG/118297/2010

Source: check_circle
CIÊNCIAVITAE
grade
Preferred source (of 2)‎

Project on Biomedical Engineering for Regenerative Therapies and Cancer

2012 to 2015 | Grant
Comissao de Coordenacao e Desenvolvimento Regional do Norte (Porto, PT)
GRANT_NUMBER:

NORTE-07-0124-FEDER-000005

Source: check_circle
CIÊNCIAVITAE

Assessment of the role of human umbilical cord tissue-derived mesenchymal stromal/stem cells (UCX®) transplantation into the myocardial-infarcted murine heart

2012 to 2013 | Contract
ECBio (Amadora, PT)
Source: Self-asserted source
DS Nascimento

Projecto Estratégico - LA 2 - 2011-2012

2011-01-01 to 2012-12-31 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PEst-C/SAU/LA0002/2011

Source: check_circle
CIÊNCIAVITAE

Industrial contract between ECBio - R&D in Biotechnology and INEB

2011 to 2012 | Contract
ECBio SA (Amadora, PT)
GRANT_NUMBER:

-

Source: check_circle
CIÊNCIAVITAE

Creating tools for studying sea bass (Dicentrarchus labrax) immunity

2007-10-01 to 2011-06-30 | Contract
Fundação para a Ciência e a Tecnologia (Lisboa, PT)
GRANT_NUMBER:

PTDC/CVT/69086/2006

Source: check_circle
CIÊNCIAVITAE

Towards the establishment of cell-based therapy for repairing cardiac-injury: characterization, purification and functional analysis of potential therapeutic-beneficial cell-subsets

2007 to 2011 | Grant
Fundação Portuguesa para a Ciência e Tecnologia (Lisbon, PT)
GRANT_NUMBER:

PTDC/SAU-OSM/68473/2006

Source: Self-asserted source
DS Nascimento
grade
Preferred source (of 2)‎

Production of important markers for monitoring the immune response in sea bass (Dicentrarchus labrax)

2003 to 2006 | Grant
FCT (Porto, PT)
Source: Self-asserted source
DS Nascimento

Production of important markers for monitoring the immune response in sea bass (Dicentrarchus labrax)

2003 to 2006 | Grant
Fundação para a Ciência e a Tecnologia (Lisbon, PT)
GRANT_NUMBER:

POCTI/CVT/44925/2002

Source: check_circle
CIÊNCIAVITAE

Peer review (2 reviews for 2 publications/grants)

Review activity for Advanced science. (1)
Review activity for PloS one. (1)