Personal information

Emails & domains

Verified email domains

Websites & social links

Fidock Lab Website

Other IDs

ResearcherID: LGY-4605-2024
Scopus Author ID: 7004002430

Keywords

Plasmodium, malaria, drug resistance, therapeutics, genetics, gene editing, transporters, drug disco

Countries

United States

Activities

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Employment (4)

Columbia University: New York, NY, US

2007-05-01 to present | Professor (Microbiology & Immunology, and Medicine)
Employment
Source: Self-asserted source
David Fidock

Albert Einstein College of Medicine, Yeshiva University: NY, NY, US

2000-01-01 to 2007-04-30 | Associate Professor (Microbiology & Immunology)
Employment
Source: Self-asserted source
David Fidock

Institut Pasteur: Paris, Île-de-France, FR

1992-04-01 to 1999-12-31 | Assistant/Charge de Recherche (Parasitologie)
Employment
Source: Self-asserted source
David Fidock

Biotech Australia: Sydney, New South Wales, AU

1987-02-01 to 1989-03-29 | Research Assistant (Vaccines and Diagnostics)
Employment
Source: Self-asserted source
David Fidock

Education and qualifications (3)

Institut Pasteur: Paris, Île-de-France, FR

1989-07-01 to 1994-11-01 | PhD (Parasitologie)
Education
Source: Self-asserted source
David Fidock

University of Adelaide: Adelaide, SA, AU

1986-02-01 to 1986-12-01 | B. Sciences (Honours) (Genetics)
Education
Source: Self-asserted source
David Fidock

University of Adelaide Faculty of Sciences: Adelaide, SA, AU

1983-02-01 to 1985-12-01 | B. Sc. (Mathematics) (Mathematics)
Education
Source: Self-asserted source
David Fidock

Professional activities (4)

American Society of Tropical Medicine & Hygiene: Washington DC, US

2016-11-01 to 2019-11-30 | Board Member / Councilor
Membership
Source: Self-asserted source
David Fidock

Columbia University Medical Center: New York, NY, US

2017-07-01 | C.S. Hamish Young Professor (Microbiology & Immunology)
Distinction
Source: Self-asserted source
David Fidock

Advance Australia: Sydney, NSW, US

2016-10-21 | Global Australian of the Year in Life Sciences 2016
Distinction
Source: Self-asserted source
David Fidock

American Society of Tropical Medicine and Hygiene: Washington, DC, US

2014-11-01 to 2015-10-31 | Recipient of the Bailey K. Ashford Medal for Outstanding Research in Tropical Medicine
Invited position
Source: Self-asserted source
David Fidock

Works (50 of 235)

Items per page:
Page 1 of 5

Towards next-generation treatment options to combat Plasmodium falciparum malaria

Nature Reviews Microbiology
2025-03 | Journal article
DOI: 10.1038/s41579-024-01099-x
Contributors: John Okombo; David A. Fidock
Source: check_circle
Crossref

Plasmodium falciparum African PfCRT Mutant Isoforms Conducive to Piperaquine Resistance Are Infrequent and Impart a Major Fitness Cost

The Journal of Infectious Diseases
2024-12-11 | Journal article
DOI: 10.1093/infdis/jiae617
Contributors: Laura M Hagenah; Tomas Yeo; Kyra A Schindler; Jin H Jeon; Talia S Bloxham; Jennifer L Small-Saunders; Sachel Mok; David A Fidock
Source: check_circle
Crossref

Author Correction: Antimalarial drug discovery: progress and approaches

Nature Reviews Drug Discovery
2024-11 | Journal article
DOI: 10.1038/s41573-024-01045-9
Contributors: Jair L. Siqueira-Neto; Kathryn J. Wicht; Kelly Chibale; Jeremy N. Burrows; David A. Fidock; Elizabeth A. Winzeler
Source: check_circle
Crossref

tRNA modification reprogramming contributes to artemisinin resistance in Plasmodium falciparum

Nature Microbiology
2024-04-17 | Journal article
DOI: 10.1038/s41564-024-01664-3
Contributors: Jennifer L. Small-Saunders; Ameya Sinha; Talia S. Bloxham; Laura M. Hagenah; Guangxin Sun; Peter R. Preiser; Peter C. Dedon; David A. Fidock
Source: check_circle
Crossref

Drug-induced stress mediates Plasmodium falciparum ring-stage growth arrest and reduces in vitro parasite susceptibility to artemisinin

Microbiology Spectrum
2024-04-02 | Journal article
DOI: 10.1128/spectrum.03500-23
Contributors: Lucien Platon; Didier Leroy; David A. Fidock; Didier Ménard; Anat Florentin
Source: check_circle
Crossref

Antimalarial drug discovery: progress and approaches

Nature Reviews Drug Discovery
2023-10 | Journal article
DOI: 10.1038/s41573-023-00772-9
Contributors: Jair L. Siqueira-Neto; Kathryn J. Wicht; Kelly Chibale; Jeremy N. Burrows; David A. Fidock; Elizabeth A. Winzeler
Source: check_circle
Crossref

Keystone Malaria Symposium 2022: a vibrant discussion of progress made and challenges ahead from drug discovery to treatment

Trends in Parasitology
2022-09 | Journal article
DOI: 10.1016/j.pt.2022.06.005
Contributors: Mariko Kanai; Laura M. Hagenah; Elizabeth A. Ashley; Kelly Chibale; David A. Fidock
Source: check_circle
Crossref

The RTS,S vaccine—a chance to regain the upper hand against malaria?

Cell
2022-03 | Journal article
DOI: 10.1016/j.cell.2022.01.028
Contributors: Photini Sinnis; David A. Fidock
Source: check_circle
Crossref

Comparative Analysis of Plasmodium falciparum Genotyping via SNP Detection, Microsatellite Profiling, and Whole-Genome Sequencing

Antimicrobial Agents and Chemotherapy
2022-01-18 | Journal article
DOI: 10.1128/AAC.01163-21
Contributors: Mariko Kanai; Tomas Yeo; Victor Asua; Philip J. Rosenthal; David A. Fidock; Sachel Mok
Source: check_circle
Crossref

The Plasmodium falciparum protein PfMRP1 functions as an influx ABC transporter

2022-01-13 | Preprint
DOI: 10.21203/rs.3.rs-1210682/v1
Contributors: Miguel Silva; Carla Calçada; Nuno Osório; Vitória Baptista; Vandana Thathy; Miguel Teixeira; Adam Reid; Pedro Ferreira; David Fidock; Maria Veiga
Source: check_circle
Crossref

Assessing risks of Plasmodium falciparum resistance to select next-generation antimalarials

Trends in Parasitology
2021-08 | Journal article
DOI: 10.1016/j.pt.2021.04.006
Contributors: Maëlle Duffey; Benjamin Blasco; Jeremy N. Burrows; Timothy N.C. Wells; David A. Fidock; Didier Leroy
Source: check_circle
Crossref

Malaria parasite beats the heat

Nature Microbiology
2021-08-16 | Journal article
DOI: 10.1038/s41564-021-00953-5
Contributors: Vandana Thathy; David A. Fidock
Source: check_circle
Crossref

Hemozoin Promotes Lung Inflammation via Host Epithelial Activation

mBio
2021-02-23 | Journal article
DOI: 10.1128/mBio.02399-20
Contributors: Shivang S. Shah; David A. Fidock; Alice S. Prince; Jennifer M. Bomberger
Source: check_circle
Crossref

Plasmodium berghei K13 Mutations Mediate In Vivo Artemisinin Resistance That Is Reversed by Proteasome Inhibition

mBio
2020-12-22 | Journal article
DOI: 10.1128/mBio.02312-20
Contributors: Nelson V. Simwela; Barbara H. Stokes; Dana Aghabi; Matt Bogyo; David A. Fidock; Andrew P. Waters; Louis H. Miller
Source: check_circle
Crossref

Genetic screens reveal a central role for heme metabolism in artemisinin susceptibility

Nature Communications
2020-09-23 | Journal article
DOI: 10.1038/s41467-020-18624-0
Contributors: Clare R. Harding; Saima M. Sidik; Boryana Petrova; Nina F. Gnädig; John Okombo; Alice L. Herneisen; Kurt E. Ward; Benedikt M. Markus; Elizabeth A. Boydston; David A. Fidock et al.
Source: check_circle
Crossref

Turning the tide: targeting PfCRT to combat drug-resistant P. falciparum?

Nature Reviews Microbiology
2020-05 | Journal article
DOI: 10.1038/s41579-020-0353-8
Contributors: Jennifer L. Small-Saunders; Laura M. Hagenah; David A. Fidock
Source: check_circle
Crossref

Insights into the intracellular localization, protein associations and artemisinin resistance properties of Plasmodium falciparum K13.

PLoS pathogens
2020-04-20 | Journal article
DOI: 10.1371/journal.ppat.1008482
PMID: 32310999
Source: Self-asserted source
David Fidock

Pan-active imidazolopiperazine antimalarials target the Plasmodium falciparum intracellular secretory pathway.

Nature communications
2020-04-14 | Journal article
DOI: 10.1038/s41467-020-15440-4
PMID: 32286267
Source: Self-asserted source
David Fidock

A phase 1, placebo controlled, randomised, single ascending dose study and a volunteer infection study to characterize the safety, pharmacokinetics and antimalarial activity of the Plasmodium phosphatidylinositol 4-kinase inhibitor MMV390048.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2020-04-02 | Journal article
DOI: 10.1093/cid/ciaa368
PMID: 32239164
Source: Self-asserted source
David Fidock

Preclinical Antimalarial Combination Study of M5717, a Plasmodium falciparum Elongation Factor 2 Inhibitor, and Pyronaridine, a Hemozoin Formation Inhibitor.

Antimicrobial agents and chemotherapy
2020-03-24 | Journal article
DOI: 10.1128/aac.02181-19
PMID: 32041711
Source: Self-asserted source
David Fidock
grade
Preferred source (of 2)‎

Structure-Based Screening of Plasmodium berghei Glutathione S-Transferase Identifies CB-27 as a Novel Antiplasmodial Compound.

Frontiers in pharmacology
2020-03-17 | Journal article
DOI: 10.3389/fphar.2020.00246
PMID: 32256353
PMC: PMC7090221
Source: Self-asserted source
David Fidock

Probing the Open Global Health Chemical Diversity Library for Multistage-Active Starting Points for Next-Generation Antimalarials.

ACS infectious diseases
2020-03-04 | Journal article
DOI: 10.1021/acsinfecdis.9b00482
PMID: 32078764
PMC: PMC7155171
Source: Self-asserted source
David Fidock

The Antimalarial Natural Product Salinipostin A Identifies Essential α/β Serine Hydrolases Involved in Lipid Metabolism in P. falciparum Parasites.

Cell chemical biology
2020-01-23 | Journal article
DOI: 10.1016/j.chembiol.2020.01.001
PMID: 31978322
Source: Self-asserted source
David Fidock

Comparative 3D genome organization in apicomplexan parasites

Proceedings of the National Academy of Sciences of the United States of America
2019 | Journal article
DOI: 10.1073/pnas.1810815116
EID:

2-s2.0-85061860877
Contributors: Bunnik, E.M.; Venkat, A.; Shao, J.; McGovern, K.E.; Batugedara, G.; Worth, D.; Prudhomme, J.; Lapp, S.A.; Andolina, C.; Ross, L.S. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Identification and Mechanistic Understanding of Dihydroorotate Dehydrogenase Point Mutations in Plasmodium falciparum that Confer in Vitro Resistance to the Clinical Candidate DSM265

ACS Infectious Diseases
2019 | Journal article
DOI: 10.1021/acsinfecdis.8b00211
EID:

2-s2.0-85056694127
Contributors: White, J.; Dhingra, S.K.; Deng, X.; El Mazouni, F.; Lee, M.C.S.; Afanador, G.A.; Lawong, A.; Tomchick, D.R.; Ng, C.L.; Bath, J. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Combining Stage Specificity and Metabolomic Profiling to Advance Antimalarial Drug Discovery.

Cell chemical biology
2019-12-05 | Journal article
DOI: 10.1016/j.chembiol.2019.11.009
PMID: 31813848
PMC: PMC7031696
Source: Self-asserted source
David Fidock

Structure and drug resistance of the Plasmodium falciparum transporter PfCRT.

Nature
2019-11-27 | Journal article
DOI: 10.1038/s41586-019-1795-x
PMID: 31776516
Source: Self-asserted source
David Fidock

Plasmodium falciparum resistance to piperaquine driven by PfCRT.

The Lancet. Infectious diseases
2019-11-01 | Journal article
DOI: 10.1016/s1473-3099(19)30543-2
PMID: 31657776
Source: Self-asserted source
David Fidock

Blocking Plasmodium Development in Mosquitoes: A Powerful New Approach for Expanding Malaria Control Efforts.

The American journal of tropical medicine and hygiene
2019-10-01 | Journal article
DOI: 10.4269/ajtmh.19-0318
PMID: 31264564
PMC: PMC6779223
Source: Self-asserted source
David Fidock

Generation of Transmission-Competent Human Malaria Parasites with Chromosomally-Integrated Fluorescent Reporters.

Scientific reports
2019-09-11 | Journal article
DOI: 10.1038/s41598-019-49348-x
PMID: 31511546
PMC: PMC6739413
Source: Self-asserted source
David Fidock

Accelerated evolution and spread of multidrug-resistant Plasmodium falciparum takes down the latest first-line antimalarial drug in southeast Asia.

The Lancet. Infectious diseases
2019-07-22 | Journal article
DOI: 10.1016/S1473-3099(19)30394-9
PMID: 31345711
PMC: PMC6754981
Source: Self-asserted source
David Fidock

Elucidating Mechanisms of Drug-Resistant Plasmodium falciparum.

Cell host & microbe
2019-07-01 | Journal article
DOI: 10.1016/j.chom.2019.06.001
PMID: 31295423
Source: Self-asserted source
David Fidock

Pyronaridine-Artesunate Shows Promise as an Effective and Well-Tolerated Treatment for Artemisinin-Resistant Plasmodium falciparum Malaria.

Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
2019-06-28 | Journal article
DOI: 10.1093/cid/ciz583
PMID: 31251323
Source: Self-asserted source
David Fidock

Covalent Plasmodium falciparum-selective proteasome inhibitors exhibit a low propensity for generating resistance in vitro and synergize with multiple antimalarial agents

PLOS Pathogens
2019-06-06 | Journal article
DOI: 10.1371/journal.ppat.1007722
Contributors: Barbara H. Stokes; Michael J. Blackman; Euna Yoo; James M. Murithi; Madeline R. Luth; Pavel Afanasyev; Paula C. A. da Fonseca; Elizabeth A. Winzeler; Caroline L. Ng; Matthew Bogyo et al.
Source: check_circle
Crossref

Structure-Guided Identification of Resistance Breaking Antimalarial N‑Myristoyltransferase Inhibitors.

Cell chemical biology
2019-05-09 | Journal article
DOI: 10.1016/j.chembiol.2019.03.015
PMID: 31080074
PMC: PMC6658617
Source: Self-asserted source
David Fidock

Cyclization-blocked proguanil as a strategy to improve the antimalarial activity of atovaquone.

Communications biology
2019-05-03 | Journal article
DOI: 10.1038/s42003-019-0397-3
PMID: 31069275
PMC: PMC6499835
Source: Self-asserted source
David Fidock

Global Spread of Mutant PfCRT and Its Pleiotropic Impact on Plasmodium falciparum Multidrug Resistance and Fitness

mBio
2019-04-30 | Journal article
DOI: 10.1128/mBio.02731-18
Contributors: Satish K. Dhingra; Stanislaw J. Gabryszewski; Jennifer L. Small-Saunders; Tomas Yeo; Philipp P. Henrich; Sachel Mok; David A. Fidock; Louis H. Miller
Source: check_circle
Crossref

Plasmodium falciparum In Vitro Drug Resistance Selections and Gene Editing.

Methods in molecular biology (Clifton, N.J.)
2019-01-01 | Journal article
DOI: 10.1007/978-1-4939-9550-9_9
PMID: 31267498
PMC: PMC6756925
Source: Self-asserted source
David Fidock

A Breathprint for Malaria: New Opportunities for Noninterventional Diagnostics and Mosquito Traps?

Journal of Infectious Diseases
2018 | Journal article
DOI: 10.1093/infdis/jiy073
EID:

2-s2.0-85046263413
Contributors: Fidock, D.A.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Antimalarial activity of single-dose DSM265, a novel plasmodium dihydroorotate dehydrogenase inhibitor, in patients with uncomplicated Plasmodium falciparum or Plasmodium vivax malaria infection: a proof-of-concept, open-label, phase 2a study

The Lancet Infectious Diseases
2018 | Journal article
DOI: 10.1016/S1473-3099(18)30309-8
EID:

2-s2.0-85048309311
Contributors: Llanos-Cuentas, A.; Casapia, M.; Chuquiyauri, R.; Hinojosa, J.-C.; Kerr, N.; Rosario, M.; Toovey, S.; Arch, R.H.; Phillips, M.A.; Rozenberg, F.D. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Changes in genome organization of parasite-specific gene families during the Plasmodium transmission stages

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-04295-5
EID:

2-s2.0-85047179219
Contributors: Bunnik, E.M.; Cook, K.B.; Varoquaux, N.; Batugedara, G.; Prudhomme, J.; Cort, A.; Shi, L.; Andolina, C.; Ross, L.S.; Brady, D. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Defining the Determinants of Specificity of Plasmodium Proteasome Inhibitors

Journal of the American Chemical Society
2018 | Journal article
DOI: 10.1021/jacs.8b06656
EID:

2-s2.0-85052306165
Contributors: Yoo, E.; Stokes, B.H.; De Jong, H.; Vanaerschot, M.; Kumar, T.R.S.; Lawrence, N.; Njoroge, M.; Garcia, A.; Van Der Westhuyzen, R.; Momper, J.D. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Emerging Southeast Asian PfCRT mutations confer Plasmodium falciparum resistance to the first-line antimalarial piperaquine

Nature Communications
2018 | Journal article
DOI: 10.1038/s41467-018-05652-0
EID:

2-s2.0-85051627566
Contributors: Ross, L.S.; Dhingra, S.K.; Mok, S.; Yeo, T.; Wicht, K.J.; Kümpornsin, K.; Takala-Harrison, S.; Witkowski, B.; Fairhurst, R.M.; Ariey, F. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Erratum: UCT943, a next-generation plasmodium falciparum PI4K inhibitor preclinical candidate for the treatment of malaria (Antimicrobial Agents and Chemotherapy (2018) 62:9 (e00012-18) DOI: 10.1128/AAC.00012-18)

Antimicrobial Agents and Chemotherapy
2018 | Journal article
DOI: 10.1128/AAC.01941-18
EID:

2-s2.0-85055602859
Contributors: Brunschwig, C.; Lawrence, N.; Taylor, D.; Abay, E.; Njoroge, M.; Basarab, G.S.; Le Manach, C.; Paquet, T.; Cabrera, D.G.; Nchinda, A.T. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Evidence for Regulation of Hemoglobin Metabolism and Intracellular Ionic Flux by the Plasmodium falciparum Chloroquine Resistance Transporter

Scientific Reports
2018 | Journal article
DOI: 10.1038/s41598-018-31715-9
EID:

2-s2.0-85053277076
Contributors: Lee, A.H.; Dhingra, S.K.; Lewis, I.A.; Singh, M.K.; Siriwardana, A.; Dalal, S.; Rubiano, K.; Klein, M.S.; Baska, K.S.; Krishna, S. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Mapping the malaria parasite druggable genome by using in vitro evolution and chemogenomics

Science
2018 | Journal article
DOI: 10.1126/science.aan4472
EID:

2-s2.0-85040443759
Contributors: Cowell, A.N.; Istvan, E.S.; Lukens, A.K.; Gomez-Lorenzo, M.G.; Vanaerschot, M.; Sakata-Kato, T.; Flannery, E.L.; Magistrado, P.; Owen, E.; Abraham, M. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Stable Integration and Comparison of hGrx1-roGFP2 and sfroGFP2 Redox Probes in the Malaria Parasite Plasmodium falciparum

ACS Infectious Diseases
2018 | Journal article
DOI: 10.1021/acsinfecdis.8b00140
EID:

2-s2.0-85053193005
Contributors: Schuh, A.K.; Rahbari, M.; Heimsch, K.C.; Mohring, F.; Gabryszewski, S.J.; Weder, S.; Buchholz, K.; Rahlfs, S.; Fidock, D.A.; Becker, K.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Uct943, a next-generation plasmodium falciparum pi4k inhibitor preclinical candidate for the treatment of malaria

Antimicrobial Agents and Chemotherapy
2018 | Journal article
DOI: 10.1128/AAC.00012-18
EID:

2-s2.0-85052242696
Contributors: Brunschwig, C.; Lawrence, N.; Taylor, D.; Abay, E.; Njoroge, M.; Basarab, G.S.; Le Manach, C.; Paquet, T.; Cabrera, D.G.; Nchinda, A.T. et al.
Source: Self-asserted source
David Fidock via Scopus - Elsevier

Open-source discovery of chemical leads for next-generation chemoprotective antimalarials.

Science (New York, N.Y.)
2018-12-01 | Journal article
DOI: 10.1126/science.aat9446
PMID: 30523084
PMC: PMC6516198
Source: Self-asserted source
David Fidock
grade
Preferred source (of 2)‎

Artemisinin resistance phenotypes and K13 inheritance in a Plasmodium falciparum cross and Aotus model.

Proceedings of the National Academy of Sciences of the United States of America
2018-11-19 | Journal article
DOI: 10.1073/pnas.1813386115
PMID: 30455312
PMC: PMC6298093
Source: Self-asserted source
David Fidock
grade
Preferred source (of 2)‎
Items per page:
Page 1 of 5

Peer review (3 reviews for 3 publications/grants)

Review activity for F1000Research. (1)
Review activity for Nature (1)
Review activity for Wellcome open research. (1)
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