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Scopus Author ID: 55551166400
ResearcherID: C-6096-2019
ResearcherID: C-6096-2019

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Employment (2)

Univerzita Hradec Králové Katedra chemie: Hradec Kralove, Královéhradecký, CZ

Employment
Source: Self-asserted source
Ondrej Benek

University Hospital Hradec Králové: Hradec Králové, CZ

Employment
Source: Self-asserted source
Ondrej Benek

Works (32)

New insights into the 17β-hydroxysteroid dehydrogenase type 10 and amyloid-β 42 derived cytotoxicity relevant to Alzheimer’s disease

2025-02-25 | Preprint
DOI: 10.1101/2025.02.21.639531
Contributors: Aneta Houfková; Monika Schmidt; Ondřej Benek; Ivo Fabrik; Rudolf Andrýs; Lucie Zemanová; Ondřej Soukup; Kamil Musílek
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Neuroprotective Effect of 2-(Benzyloxy)arylureas Is Not Related to CypD Inhibition nor Suppression of mPTP Opening

ACS Medicinal Chemistry Letters
2024-10-10 | Journal article | Author
DOI: 10.1021/acsmedchemlett.4c00353
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Contributors: Annamaria Haleckova; Veronika Syrova; Andrea Joklova; Tereza Vernerova; Jan Hurdalek; Rene Endlicher; Katerina Salamonova; Petra Bubelova; Haka Fajriana Febda Kurnia; Monika Schmidt et al.
Source: Self-asserted source
Ondrej Benek

Exploring the interaction of N-(benzothiazol-2-yl)pyrrolamide DNA gyrase inhibitors with the GyrB ATP-binding site lipophilic floor: A medicinal chemistry and QTAIM study

Bioorganic & Medicinal Chemistry
2024-07 | Journal article
DOI: 10.1016/j.bmc.2024.117798
Contributors: Nace Zidar; Andrej Emanuel Cotman; Wessel Sinnige; Ondrej Benek; Michaela Barančokova; Anamarija Zega; Lucija Peterlin Mašič; Tihomir Tomašič; Janez Ilaš; Sara R. Henderson et al.
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Nanomolar Benzothiazole-Based Inhibitors of 17β-HSD10 with Cellular Bioactivity

ACS Medicinal Chemistry Letters
2023-12-14 | Journal article | Author
DOI: 10.1021/acsmedchemlett.3c00355
Part of ISSN: 1948-5875
Part of ISSN: 1948-5875
Contributors: Michaela Vašková, Michaela Hanzlová; Marketa Sedlacek Miskerikova; Aneta Rotterova; Katarina Chalupova; Katarina Jurkova; Marie Hamsikova; Rudolf Andrys; Annamaria Haleckova; Jana Svobodova; Monika Schmidt et al.
Source: Self-asserted source
Ondrej Benek

Development of submicromolar 17β-HSD10 inhibitors and their in vitro and in vivo evaluation

European Journal of Medicinal Chemistry
2023-10 | Journal article
DOI: 10.1016/j.ejmech.2023.115593
Contributors: Ondrej Benek; Michaela Vaskova; Marketa Miskerikova; Monika Schmidt; Rudolf Andrys; Aneta Rotterova; Adam Skarka; Jana Hatlapatkova; Jana Zdarova Karasova; Matej Medvecky et al.
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Physiologically relevant fluorescent assay for identification of 17β‐hydroxysteroid dehydrogenase type 10 inhibitors

Journal of Neurochemistry
2023-10 | Journal article
DOI: 10.1111/jnc.15917
Contributors: Monika Schmidt; Michaela Vaskova; Aneta Rotterova; Pavlina Fiandova; Marketa Miskerikova; Lucie Zemanova; Ondrej Benek; Kamil Musilek
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Small‐molecule inhibitors of cyclophilin D as potential therapeutics in mitochondria‐related diseases

Medicinal Research Reviews
2022-09 | Journal article
DOI: 10.1002/med.21892
Contributors: Annamaria Haleckova; Ondrej Benek; Lucie Zemanová; Rafael Dolezal; Kamil Musilek
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A novel <i>in vitro</i> method for determining mitochondrial 17β-HSD10 activity: small-molecule inhibitors screening

FEBS Open Bio
2021 | Journal article
WOSUID: WOS:000668898602167
Contributors: Vaskova, M.; Schmidt, M.; Benek, O.; Zemanova, L.; Musilek, K.
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Effects of novel 17β-hydroxysteroid dehydrogenase type 10 inhibitors on mitochondrial respiration

Toxicology Letters
2021-03 | Journal article
DOI: 10.1016/j.toxlet.2020.12.012
Contributors: Zdeněk Fišar; Kamil Musílek; Ondřej Benek; Lukáš Hroch; Lucie Vinklářová; Monika Schmidt; Jana Hroudová; Jiří Raboch
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New dual ATP-competitive inhibitors of bacterial DNA gyrase and topoisomerase IV active against ESKAPE pathogens.

European journal of medicinal chemistry
2021-01-22 | Journal article
DOI: 10.1016/j.ejmech.2021.113200
PMID: 33524686
Source: Self-asserted source
Ondrej Benek

Discovery of novel berberine derivatives with balanced cholinesterase and prolyl oligopeptidase inhibition profile

European Journal of Medicinal Chemistry
2020 | Journal article
DOI: 10.1016/J.EJMECH.2020.112593
WOSUID: WOS:000568867400025
Contributors: Sobolova, Katerina; Hrabinova, Martina; Hepnarova, Vendula; Kucera, Tomas; Kobrlova, Tereza; Benkova, Marketa; Janockova, Jana; Dolezal, Rafael; Prchal, Lukas; Benek, Ondrej et al.
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Exploring the Chemical Space of Benzothiazole-Based DNA Gyrase B Inhibitors

ACS Medicinal Chemistry Letters
2020-12-10 | Journal article
DOI: 10.1021/acsmedchemlett.0c00416
Contributors: Žiga Skok; Michaela Barančoková; Ondřej Benek; Cristina Durante Cruz; Päivi Tammela; Tihomir Tomašič; Nace Zidar; Lucija Peterlin Mašič; Anamarija Zega; Clare E. M. Stevenson et al.
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Friend or enemy? Review of 17β‐HSD10 and its role in human health or disease

Journal of Neurochemistry
2020-11 | Journal article
DOI: 10.1111/jnc.15027
Contributors: Lucie Vinklarova; Monika Schmidt; Ondrej Benek; Kamil Kuca; Frank Gunn‐Moore; Kamil Musilek
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A Perspective on Multi-target Drugs for Alzheimer’s Disease

Trends in Pharmacological Sciences
2020-07 | Journal article
DOI: 10.1016/j.tips.2020.04.008
Part of ISSN: 0165-6147
Source: Self-asserted source
Ondrej Benek

SEARCHING FOR NEW ANTIMICROBIAL AGENTS BY TARGETING BACTERIAL NAD METABOLISM: EVALUATION OF FRENTIZOLE DERIVATIVES SELECTED BY MOLECULAR DOCKING

Military Medical Science Letters
2020-06-05 | Journal article
DOI: 10.31482/mmsl.2020.005
Contributors: Michaela Hympanova; Tomas Kucera; Ondrej Benek; Jan Korabecny; Jan Marek
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RNase T1 Refolding Assay for Determining Mitochondrial Cyclophilin D Activity - A Novel in vitro Method Applicable in Drug Research and Discovery

Biochemistry
2020-04-10 | Journal article
DOI: 10.1021/acs.biochem.9b01025
Part of ISSN: 0006-2960
Contributors: Lucie Zemanová; Michaela Vaskova; Monika Schmidt; Jana Roubalova; Annamaria Haleckova; Ondrej Benek; Kamil Musilek
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search

Benzothiazolyl Ureas are Low Micromolar and Uncompetitive Inhibitors of 17β-HSD10 with Implications to Alzheimer’s Disease Treatment

International Journal of Molecular Sciences
2020-03-17 | Journal article
DOI: 10.3390/ijms21062059
Contributors: Monika Schmidt; Ondrej Benek; Lucie Vinklarova; Martina Hrabinova; Lucie Zemanova; Matej Chribek; Vendula Kralova; Lukas Hroch; Rafael Dolezal; Antonin Lycka et al.
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Novel 17β-HSD10 inhibitors as small molecules for neurodegenerative disorders or cancer

FEBS Open Bio
2019 | Journal article
WOSUID: WOS:000486972404125
Contributors: Vinklarova, L.; Schmidt, M.; Benek, O.; Zemanova, L.; Musilek, K.
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A Systematic Review on Donepezil-based Derivatives as Potential Cholinesterase Inhibitors for Alzheimer’s Disease

Current Medicinal Chemistry
2019-10 | Journal article
DOI: 10.2174/0929867325666180517094023
Part of ISSN: 0929-8673
Contributors: Jan Korabecny; Katarina Spilovska; Eva Mezeiova; Ondrej Benek; Radomir Juza; Daniel Kaping; Ondrej Soukup
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search
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Novel Benzothiazole-based Ureas as 17β-HSD10 Inhibitors, A Potential Alzheimer’s Disease Treatment

Molecules
2019-07 | Journal article
DOI: 10.3390/molecules24152757
Part of ISSN: 1420-3049
Contributors: Aitken; Benek; McKelvie; Hughes; Hroch; Schmidt; Major; Vinklarova; Kuca; Smith et al.
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search
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Rational design of novel TLR4 ligands by in silico screening and their functional and structural characterization in vitro

European Journal of Medicinal Chemistry
2018-02 | Journal article
DOI: 10.1016/j.ejmech.2017.12.074
Contributors: Jan Honegr; David Malinak; Rafael Dolezal; Ondrej Soukup; Marketa Benkova; Lukas Hroch; Ondrej Benek; Jana Janockova; Kamil Kuca; Roman Prymula
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1-(Benzo[d]thiazol-2-yl)-3-phenylureas as dual inhibitors of casein kinase 1 and ABAD enzymes for treatment of neurodegenerative disorders

Journal of Enzyme Inhibition and Medicinal Chemistry
2018-01-01 | Journal article
DOI: 10.1080/14756366.2018.1445736
Contributors: Ondrej Benek; Lukas Hroch; Laura Aitken; Frank Gunn-Moore; Lucie Vinklarova; Kamil Kuca; Daniel I. Perez; Concepcion Perez; Ana Martinez; Zdenek Fisar et al.
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6-Benzothiazolyl Ureas, Thioureas and Guanidines are Potent Inhibitors of ABAD/17β-HSD10 and Potential Drugs for Alzheimer"s Disease Treatment: Design, Synthesis and in vitro Evaluation

Medicinal Chemistry
2017-05-05 | Journal article
DOI: 10.2174/1573406413666170109142725
Part of ISSN: 1573-4064
Contributors: Ondrej Benek; Lukas Hroch; Laura Aitken; Rafael Dolezal; Patrick Guest; Marketa Benkova; Ondrej Soukup; Karel Musil; Kamil Kuca; Terry K. Smith et al.
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search
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Design, synthesis and in vitro evaluation of benzothiazole-based ureas as potential ABAD/17β-HSD10 modulators for Alzheimer's disease treatment

Bioorganic and Medicinal Chemistry Letters
2016 | Journal article
DOI: 10.1016/j.bmcl.2016.05.087
Source: Self-asserted source
Ondrej Benek
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Design, Synthesis and in vitro Evaluation of Indolotacrine Analogues as Multitarget-Directed Ligands for the Treatment of Alzheimer's Disease

ChemMedChem
2016 | Journal article
DOI: 10.1002/cmdc.201500383
Source: Self-asserted source
Ondrej Benek
grade
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Novel caffeine derivatives with antiproliferative activity

RSC Advances
2016 | Journal article
DOI: 10.1039/c5ra22889a
Source: Self-asserted source
Ondrej Benek
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Synthesis and evaluation of frentizole-based indolyl thiourea analogues as MAO/ABAD inhibitors for Alzheimer's disease treatment.

2016-12 | Journal article
DOI: 10.1016/j.bmc.2016.12.029
PMID: 28082069
Contributors: Hroch L; Guest P; Benek O; Soukup O; Janockova J; Dolezal R; Kuca K; Aitken L; Smith TK; Gunn-Moore F et al.
Source: Self-asserted source
Ondrej Benek via Europe PubMed Central
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A Direct Interaction Between Mitochondrial Proteins and Amyloid-&#946; Peptide and its Significance for the Progression and Treatment of Alzheimer&#8217;s Disease

Current Medicinal Chemistry
2015-02 | Journal article
DOI: 10.2174/0929867322666150114163051
Part of ISSN: 0929-8673
Contributors: O. Benek; L. Aitken; L. Hroch; K. Kuca; F. Gunn-Moore; K. Musilek
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search
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Benzothiazoles - Scaffold of Interest for CNS Targeted Drugs

Current Medicinal Chemistry
2015-01 | Journal article
DOI: 10.2174/0929867322666141212120631
Part of ISSN: 0929-8673
Contributors: Lukas Hroch; Laura Aitken; Ondrej Benek; Martin Dolezal; Kamil Kuca; Frank Gunn-Moore; Kamil Musilek
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search
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Preparation, In Vitro Screening and Molecular Modelling of Monoquaternary Compounds Related to the Selective Acetylcholinesterase Inhibitor BW284c51

Medicinal Chemistry
2014 | Journal article
DOI: 10.2174/1573406410666140428153110
Part of ISSN: 1573-4064
Contributors: Ondrej Benek; Kamil Musilek; Anna Horova; Vlastimil Dohnal; Rafael Dolezal; Kamil Kuca
Source: Self-asserted source
Ondrej Benek via Crossref Metadata Search

[Mitochondrial enzyme ABAD and its role in the development and treatment of Alzheimer's disease]. [Mitochondriáilní enzym ABAD a jeho role v rozvoji a lécbe Alzheimerovy nemoci.]

Ceská a Slovenská farmacie : casopis Ceské farmaceutické spolecnosti a Slovenské farmaceutické spolecnosti
2012 | Journal article
Source: Self-asserted source
Ondrej Benek

Tacrine and its derivatives in the therapy of Alzheimer's disease [Takrin a jeho deriváty v terapii Alzheimerovy choroby]

Ceska a Slovenska Farmacie
2012 | Journal article
Source: Self-asserted source
Ondrej Benek
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