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Loop profile: 299188
Scopus Author ID: 57263627800
SciProfiles: 1767378
ResearcherID: J-6574-2019

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India

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Employment (2)

Aragen Life Sciences: Hyderabad, Telangana, IN

2020 to 2021 | Research Associate (In Vitro Pharmacology)
Employment
Source: Self-asserted source
Rajamanikkam Kamaraj

Dr. Reddy’s Institute of Life Sciences (DRILS): Hyderabad , Telangana, IN

2018 to 2020 | Research Fellow (Center for Innovation in Molecular and Pharmaceutical Sciences (CIMPS))
Employment
Source: Self-asserted source
Rajamanikkam Kamaraj

Education and qualifications (2)

Charles University: Prague, CZ

2021 to present | Ph.D. ( Department of Pharmacology and Toxicology)
Education
Source: Self-asserted source
Rajamanikkam Kamaraj

Kalasalingam University: Madurai, Tamil Nadu, IN

2015 to 2017 | M.Tech (Biotechnology)
Education
Source: Self-asserted source
Rajamanikkam Kamaraj

Professional activities (3)

Gesellschaft Deutscher Chemiker eV: Frankfurt am Main, Hessen, DE

2022 to present
Membership
Source: Self-asserted source
Rajamanikkam Kamaraj

Biophysical Society of Japan: Kyoto , JP

2022 to present
Membership
Source: Self-asserted source
Rajamanikkam Kamaraj

International Chemical Biology Society: Hyderabad, IN

2019-06 to present | Regular Member
Membership
Source: Self-asserted source
Rajamanikkam Kamaraj

Funding (3)

Discovering new chemical modalities to antagonize the pregnane X nuclear receptor (PXR)

2023-04 to 2025 | Grant
Charles University (Prague, CZ)
URL: https://cuni.cz/uken-753.html
GRANT_NUMBER: 200223
Source: Self-asserted source
Rajamanikkam Kamaraj

Thinking outside the ligand-binding pocket: alternative binding sites in the ligand-binding domain of Pregnane X Receptor (PXR) to prevent colon cancer

2022 to 2023 | Grant
4EU+ European University Alliance (Prague, CZ)
URL: https://4euplus.eu/4EU-364.html
GRANT_NUMBER: 170/56/225601
Source: Self-asserted source
Rajamanikkam Kamaraj

Induction of Stem Cells by Activating Wnt Signaling Pathway with Bioactive Molecules Isolated from Tephrosia purpurea

2016 to 2017 | Grant
Tamil Nadu State Council for Science and Technology (Chennai, Tamil Nadu, IN)
URL: https://www.tanscst.nic.in/
GRANT_NUMBER:

MS-16
Source: Self-asserted source
Rajamanikkam Kamaraj

Works (18)

The hypolipidemic effect of MI-883, the combined CAR agonist/ PXR antagonist, in diet-induced hypercholesterolemia model

Nature Communications
2025-02-06 | Journal article | Author
DOI: 10.1038/s41467-025-56642-y
Part of ISSN: 2041-1723
Contributors: Jan Dusek; Ivana Mejdrová; Klára Dohnalová; Tomas Smutny; Karel Chalupsky; Maria Krutakova; Josef Skoda; Azam Rashidian; Ivona Pavkova; Krystof Skach et al.
Source: Self-asserted source
Rajamanikkam Kamaraj

Computational strategies for the design of proteolysis targeting chimera degraders: Artificial intelligence enabled PROTAC design

Annual Reports in Medicinal Chemistry
2024 | Journal article
DOI: 10.1016/BS.ARMC.2024.10.002
Contributors: Rajamanikkam Kamaraj; Radim Nencka; Petr Pavek
Source: check_circle
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Novel antagonists reveal the mechanism of PXR inhibition

Trends in Pharmacological Sciences
2024 | Journal article
DOI: 10.1016/J.TIPS.2024.10.002
WOSUID: WOS:001355556800001
Contributors: Kamaraj, Rajamanikkam; Pavek, Petr
Source: check_circle
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Radiolabeled 15-mer peptide internalization is mediated by megalin (LRP2 receptor) in a CRISPR/Cas9-based <i>LRP2</i> knockout human kidney cell model

EJNMMI Radiopharmacy and Chemistry
2024 | Journal article
DOI: 10.1186/S41181-024-00262-2
WOSUID: WOS:001205507100001
Contributors: Durinova, Anna; Smutna, Lucie; Barta, Pavel; Kamaraj, Rajamanikkam; Smutny, Tomas; Schmierer, Bernhard; Pavek, Petr; Trejtnar, Frantisek
Source: check_circle
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Rifabutin but not rifampicin can partly out-balance P-glycoprotein induction by concurrent P-glycoprotein inhibition through high affinity binding to the inhibitory site

Archives of Toxicology
2024 | Journal article
DOI: 10.1007/S00204-023-03618-W
WOSUID: WOS:001083590000001
Contributors: Phondeth, Lottida; Kamaraj, Rajamanikkam; Nilles, Julie; Weiss, Johanna; Haefeli, Walter E.; Pavek, Petr; Theile, Dirk
Source: check_circle
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Rifampicin and its derivatives: stability, disposition, and affinity towards pregnane X receptor employing 2D and 3D primary human hepatocytes

Biochemical Pharmacology
2024 | Journal article
DOI: 10.1016/J.BCP.2024.116500
WOSUID: WOS:001302787100001
Contributors: Smutny, Tomas; Smutna, Lucie; Lochman, Lukas; Kamaraj, Rajamanikkam; Kucera, Radim; Pavek, Petr
Source: check_circle
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The “specific” P-glycoprotein inhibitor zosuquidar (LY335979) also weakly inhibits human organic cation transporters

Naunyn-Schmiedeberg's Archives of Pharmacology
2024-12-24 | Journal article
DOI: 10.1007/s00210-024-03743-y
Part of ISSN: 0028-1298
Part of ISSN: 1432-1912
Contributors: Gzona Bajraktari-Sylejmani; Rajamanikkam Kamaraj; Dirk Theile; Petr Pávek; Johanna Weiss
Source: Self-asserted source
Rajamanikkam Kamaraj

Targeted Protein Degradation (TPD) for Immunotherapy: Understanding Proteolysis Targeting Chimera-Driven Ubiquitin-Proteasome Interactions

Bioconjugate Chemistry
2024-08-21 | Journal article
DOI: 10.1021/acs.bioconjchem.4c00253
Contributors: Rajamanikkam Kamaraj; Subhrojyoti Ghosh; Souvadra Das; Shinjini Sen; Priyanka Kumar; Madhurima Majumdar; Renesa Dasgupta; Sampurna Mukherjee; Shrimanti Das; Indrilla Ghose et al.
Source: check_circle
Crossref

2-Substituted quinazolines: Partial agonistic and antagonistic ligands of the constitutive androstane receptor (CAR)

European Journal of Medicinal Chemistry
2023 | Journal article
DOI: 10.1016/J.EJMECH.2023.115631
WOSUID: WOS:001045022900001
Contributors: Brozova, Zuzana Rania; Dusek, Jan; Palsa, Norbert; Maixnerova, Jana; Kamaraj, Rajamanikkam; Smutna, Lucie; Matous, Petr; Braeuning, Albert; Pavek, Petr; Kunes, Jiri et al.
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Gene Expression Profiling of 1α,25(OH)<sub>2</sub>D<sub>3</sub> Treatment in 2D/3D Human Hepatocyte Models Reveals <i>CYP3A4</i> Induction but Minor Changes in Other Xenobiotic-Metabolizing Genes

Molecular Nutrition and Food Research
2022 | Journal article
DOI: 10.1002/MNFR.202200070
WOSUID: WOS:000762216200001
Contributors: Pavek, Petr; Dusek, Jan; Smutny, Tomas; Lochman, Lukas; Kucera, Radim; Skoda, Josef; Smutna, Lucie; Kamaraj, Rajamanikkam; Soucek, Pavel; Vrzal, Radim et al.
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Preparation, In Vitro Affinity, and In Vivo Biodistribution of Receptor-Specific 68Ga-Labeled Peptides Targeting Vascular Endothelial Growth Factor Receptors

Bioconjugate Chemistry
2022-10-19 | Journal article
DOI: 10.1021/acs.bioconjchem.2c00272
Contributors: Pavel Barta; Rajamanikkam Kamaraj; Monika Kucharova; Zbynek Novy; Milos Petrik; Katerina Bendova; Marian Hajduch; Petr Pavek; Frantisek Trejtnar
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Crossref

Allosteric Antagonism of the Pregnane X Receptor (PXR): Current-State-of-the-Art and Prediction of Novel Allosteric Sites

Cells
2022-09-24 | Journal article
DOI: 10.3390/cells11192974
Contributors: Rajamanikkam Kamaraj; Martin Drastik; Jana Maixnerova; Petr Pavek
Source: check_circle
Crossref
grade
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Dietary phytochemicals as modulators of human pregnane X receptor

Critical Reviews in Food Science and Nutrition
2021 | Journal article
DOI: 10.1080/10408398.2021.1995322
EID:

2-s2.0-85118220729

Part of ISSN: 15497852 10408398
Contributors: Zhang, J.; Pavek, P.; Kamaraj, R.; Ren, L.; Zhang, T.
Source: Self-asserted source
Rajamanikkam Kamaraj via Scopus - Elsevier
grade
Preferred source (of 2)‎

A review on pharmacological activities and synergistic effect of quercetin with small molecule agents

Phytomedicine
2021-11 | Journal article
DOI: 10.1016/j.phymed.2021.153736
Part of ISSN: 0944-7113
Source: Self-asserted source
Rajamanikkam Kamaraj
grade
Preferred source (of 3)‎

Amberlyst-15 catalysed synthesis of novel indole derivatives under ultrasound irradiation: Their evaluation as serotonin 5-HT2C receptor agonists

Bioorganic Chemistry
2021-11 | Journal article
DOI: 10.1016/j.bioorg.2021.105380
Part of ISSN: 0045-2068
Source: Self-asserted source
Rajamanikkam Kamaraj
grade
Preferred source (of 3)‎

Coelomic Fluid of Earthworm, Eudrilus Eugeniae, Inhibits the Growth of Fungal Hyphae, in Vitro

International Journal of Engineering and Advanced Technology
2019-12-30 | Journal article
DOI: 10.35940/ijeat.a1146.1291s419
Part of ISSN: 2249-8958
Source: Self-asserted source
Rajamanikkam Kamaraj
grade
Preferred source (of 2)‎

Earthworm, an in Vivo System to Screen Proliferative and Antimitotic Compounds

International Journal of Innovative Technology and Exploring Engineering
2019-12-30 | Journal article
DOI: 10.35940/ijitee.b1164.1292s219
Part of ISSN: 2278-3075
Source: Self-asserted source
Rajamanikkam Kamaraj
grade
Preferred source (of 2)‎

Earthworm, a novel in vivo system to validate antimitotic compounds

TURKISH JOURNAL OF ZOOLOGY
2019-03-01 | Journal article
DOI: 10.3906/zoo-1806-36
Contributors: Kamaraj RAJAMANIKKAM; Subramanian ELAIYA RAJA; Senthamarai Kannan BALAJI; Ganapathy NADANA RAJAVADIVU; Sudhakar SIVASUBRAMANIAM; Karuppaiah PALANICHELVAM
Source: check_circle
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