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ResearcherID: C-9340-2017
ResearcherID: C-9340-2017
Scopus Author ID: 56529122500

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Employment (1)

Institute for Clinical and Experimental Medicine: Praha, CZ

2002-03 to present | vice head, Prof. (Centre for Experimental Medicine)
Employment
Source: Self-asserted source
Milan Jirsa

Education and qualifications (2)

Charles University Faculty of Science: Praha, CZ

1986-10 to 1992
Education
Source: Self-asserted source
Milan Jirsa

Charles University Faculty of General Medicine: Praha, CZ

1978-10 to 1984-07 | M.D.
Education
Source: Self-asserted source
Milan Jirsa

Works (50 of 150)

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Page 1 of 3

Impact of mechanical cues on key cell functions and cell-nanoparticle interactions

Discover Nano
2024 | Journal article
DOI: 10.1186/S11671-024-04052-2
WOSUID: WOS:001252598400001
Contributors: Elblova, Petra; Lunova, Mariia; Dejneka, Alexandr; Jirsa, Milan; Lunov, Oleg
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Peptide-coated DNA nanostructures as a platform for control of lysosomal function in cells

Chemical Engineering Journal
2024 | Journal article
DOI: 10.1016/J.CEJ.2024.155633
WOSUID: WOS:001316778900001
Contributors: Elblova, Petra; Lunova, Mariia; Henry, Skylar J. W.; Tu, Xinyi; Cale, Alicia; Dejneka, Alexandr; Havelkova, Jarmila; Petrenko, Yuriy; Jirsa, Milan; Stephanopoulos, Nicholas et al.
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Exome sequencing reveals <i>IFT172</i> variants in patients with non-syndromic cholestatic liver disease

Plos One
2023 | Journal article
DOI: 10.1371/JOURNAL.PONE.0288907
WOSUID: WOS:001035045000049
Contributors: Neroldova, Magdalena; Ciara, Elzbieta; Slatinska, Janka; Frankova, Sona; Liskova, Petra; Kotalova, Radana; Globinovska, Janka; Safarikova, Marketa; Pfeiferova, Lucie; Zunova, Hana et al.
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Iron oxide nanoparticles trigger endoplasmic reticulum damage in steatotic hepatic cells

Nanoscale Advances
2023 | Journal article
DOI: 10.1039/D3NA00071K
WOSUID: WOS:001037449000001
Contributors: Uzhytchak, Mariia; Lunova, Mariia; Smolkova, Barbora; Jirsa, Milan; Dejneka, Alexandr; Lunov, Oleg
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Low Frequency of Cancer-Predisposition Gene Mutations in Liver Transplant Candidates with Hepatocellular Carcinoma

Cancers
2023 | Journal article
DOI: 10.3390/CANCERS15010201
WOSUID: WOS:000908874100001
Contributors: Horackova, Klara; Frankova, Sona; Zemankova, Petra; Nehasil, Petr; Cerna, Marta; Neroldova, Magdalena; Otahalova, Barbora; Kral, Jan; Hovhannisyan, Milena; Stranecky, Viktor et al.
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Lysosomal nanotoxicity: Impact of nanomedicines on lysosomal function

Advanced Drug Delivery Reviews
2023 | Journal article
DOI: 10.1016/J.ADDR.2023.114828
WOSUID: WOS:000989454200001
Contributors: Uzhytchak, Mariia; Smolkova, Barbora; Lunova, Mariia; Frtus, Adam; Jirsa, Milan; Dejneka, Alexandr; Lunov, Oleg
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Mechanical Regulation of Mitochondrial Dynamics and Function in a 3D-Engineered Liver Tumor Microenvironment

ACS Biomaterials Science & Engineering
2023 | Journal article
DOI: 10.1021/ACSBIOMATERIALS.2C01518
WOSUID: WOS:000972147400001
Contributors: Frtus, Adam; Smolkov, Barbora; Uzhytchak, Mariia; Lunova, Mariia; Jirsa, Milan; Petrenko, Yuriy; Dejneka, Alexandr; Lunov, Oleg
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A mutation in the <i>SAA1</i> promoter causes hereditary amyloid A amyloidosis

Kidney International
2022 | Journal article
DOI: 10.1016/J.KINT.2021.09.007
WOSUID: WOS:000746612100019
Contributors: Sikora, Jakub; Kmochova, Tereza; Musalkova, Dita; Pohludka, Michal; Prikryl, Petr; Hartmannova, Hana; Hodanova, Katerina; Treslova, Helena; Noskova, Lenka; Mrazova, Lenka et al.
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The interactions between DNA nanostructures and cells: A critical overview from a cell biology perspective

Acta Biomaterialia
2022 | Journal article
DOI: 10.1016/J.ACTBIO.2022.04.046
WOSUID: WOS:000813339300002
Contributors: Frtus, Adam; Smolkova, Barbora; Uzhytchak, Mariia; Lunova, Mariia; Jirsa, Milan; Henry, Skylar J. W.; Dejneka, Alexandr; Stephanopoulos, Nicholas; Lunov, Oleg
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Alpha-1 Antitrypsin and Hepatocellular Carcinoma in Liver Cirrhosis: SERPINA1 MZ or MS Genotype Carriage Decreases the Risk

International Journal of Molecular Sciences
2021 | Journal article
DOI: 10.3390/IJMS221910560
WOSUID: WOS:000706621800001
Contributors: Rabekova, Zuzana; Frankova, Sona; Jirsa, Milan; Neroldova, Magdalena; Lunova, Mariia; Fabian, Ondrej; Kveton, Martin; Varys, David; Chmelova, Klara; Adamkova, Vera et al.
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Expression of Interferons Lambda 3 and 4 Induces Identical Response in Human Liver Cell Lines Depending Exclusively on Canonical Signaling

International Journal of Molecular Sciences
2021 | Journal article
DOI: 10.3390/IJMS22052560
WOSUID: WOS:000628248000001
Contributors: Lunova, Mariia; Kubovciak, Jan; Smolkova, Barbora; Uzhytchak, Mariia; Michalova, Kyra; Dejneka, Alexandr; Strnad, Pavel; Lunov, Oleg; Jirsa, Milan
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Liver stiffness measured by two-dimensional shear-wave elastography predicts hepatic vein pressure gradient at high values in liver transplant candidates with advanced liver cirrhosis

Plos One
2021 | Journal article
DOI: 10.1371/JOURNAL.PONE.0244934
WOSUID: WOS:000608044300111
Contributors: Frankova, Sona; Lunova, Mariia; Gottfriedova, Halima; Senkerikova, Renata; Neroldova, Magdalena; Kovac, Jozef; Kieslichova, Eva; Lanska, Vera; Urbanek, Petr; Spicak, Julius et al.
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Portal Hypertension Is the Main Driver of Liver Stiffness in Advanced Liver Cirrhosis

Physiological Research
2021 | Journal article
DOI: 10.33549/PHYSIOLRES.934626
WOSUID: WOS:000693412000008
Contributors: Lunova, Mariia; Frankova, Sona; Gottfriedova, Halima; Senkerikova, Renata; Neroldova, Magdalena; Kovac, Jozef; Kieslichova, Eva; Lanska, Vera; Sticova, Eva; Spicak, Julius et al.
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<i>ABCB4</i> disease mimicking morbus Wilson: A potential diagnostic pitfall

Biomedical Papers of the Medical Faculty of the University Palacky, Olomouc, Czechoslovakia
2020 | Journal article
DOI: 10.5507/BP.2019.054
WOSUID: WOS:000528221900015
Contributors: Sticova, Eva; Neroldova, Magdalena; Kotalova, Radana; Subhanova, Iva; Jirsa, Milan
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<i>ABCB4</i> disease: Many faces of one gene deficiency

Annals of Hepatology
2020 | Journal article
DOI: 10.1016/J.AOHEP.2019.09.010
WOSUID: WOS:000518442900003
Contributors: Sticova, Eva; Jirsa, Milan
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Analyzing the mechanisms of iron oxide nanoparticles interactions with cells: A road from failure to success in clinical applications

Journal of Controlled Release
2020 | Journal article
DOI: 10.1016/J.JCONREL.2020.08.036
WOSUID: WOS:000600791600005
Contributors: Frtus, Adam; Smolkova, Barbora; Uzhytchak, Mariia; Lunova, Mariia; Jirsa, Milan; Kubinova, Sarka; Dejneka, Alexandr; Lunov, Oleg
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Donor <i>PNPLA3</i> and <i>TM6SF2</i> Variant Alleles Confer Additive Risks for Graft Steatosis After Liver Transplantation

Transplantation
2020 | Journal article
DOI: 10.1097/TP.0000000000002876
WOSUID: WOS:000528038200030
Contributors: Mikova, Irena; Neroldova, Magdalena; Hubacek, Jaroslav A.; Dlouha, Dana; Jirsa, Milan; Honsova, Eva; Sticova, Eva; Lanska, Vera; Spicak, Julius; Trunecka, Pavel
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Hepatic Tumor Cell Morphology Plasticity under Physical Constraints in 3D Cultures Driven by YAP-mTOR Axis

Pharmaceuticals
2020 | Journal article
DOI: 10.3390/PH13120430
WOSUID: WOS:000602349300001
Contributors: Frtus, Adam; Smolkova, Barbora; Uzhytchak, Mariia; Lunova, Mariia; Jirsa, Milan; Hof, Martin; Jurkiewicz, Piotr; Lozinsky, Vladimir, I; Wolfova, Lucie; Petrenko, Yuriy et al.
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Iron Oxide Nanoparticle-Induced Autophagic Flux Is Regulated by Interplay between p53-mTOR Axis and Bcl-2 Signaling in Hepatic Cells

Cells
2020 | Journal article
DOI: 10.3390/CELLS9041015
WOSUID: WOS:000535559500226
Contributors: Uzhytchak, Mariia; Smolkova, Barbora; Lunova, Mariia; Jirsa, Milan; Frtus, Adam; Kubinova, Sarka; Dejneka, Alexandr; Lunov, Oleg
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Light-induced modulation of the mitochondrial respiratory chain activity: possibilities and limitations

Cellular and Molecular Life Sciences
2020 | Journal article
DOI: 10.1007/S00018-019-03321-Z
WOSUID: WOS:000488923000001
Contributors: Lunova, Mariia; Smolkova, Barbora; Uzhytchak, Mariia; Janouskova, Klara Zofie; Jirsa, Milan; Egorova, Daria; Kulikov, Andrei; Kubinova, Sarka; Dejneka, Alexandr; Lunov, Oleg
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Progressive lysosomal membrane permeabilization induced by iron oxide nanoparticles drives hepatic cell autophagy and apoptosis

Nano Convergence
2020 | Journal article
DOI: 10.1186/S40580-020-00228-5
WOSUID: WOS:000533789500001
Contributors: Levada, Kateryna; Pshenichnikov, Stanislav; Omelyanchik, Alexander; Rodionova, Valeria; Nikitin, Aleksey; Savchenko, Alexander; Schetinin, Igor; Zhukov, Dmitry; Abakumov, Maxim; Majouga, Alexander et al.
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The first Turkish family with Rotor syndrome diagnosed at the molecular level

Turk Pediatri Arsivi - Turkish Archives of Pediatrics
2020 | Journal article
DOI: 10.14744/TURKPEDIATRIARS.2019.55798
WOSUID: WOS:000600407000014
Contributors: Gumus, Evren; Karaca, Meryem; Deveci, Ugur; Jirsa, Milan
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Transcript, protein, metabolite and cellular studies in skin fibroblasts demonstrate variable pathogenic impacts of <i>NPC1</i> mutations

Orphanet Journal of Rare Diseases
2020 | Journal article
DOI: 10.1186/S13023-020-01360-5
WOSUID: WOS:000524598800003
Contributors: Musalkova, Dita; Majer, Filip; Kuchar, Ladislav; Luksan, Ondrej; Asfaw, Befekadu; Vlaskova, Hana; Storkanova, Gabriela; Reboun, Martin; Poupetova, Helena; Jahnova, Helena et al.
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<i>IL28B</i> rs12979860 T allele protects against CMV disease in liver transplant recipients in the post-prophylaxis and late period

Transplant Infectious Disease
2019 | Journal article
DOI: 10.1111/TID.13124
WOSUID: WOS:000481577000023
Contributors: Chmelova, Klara; Frankova, Sona; Jirsa, Milan; Neroldova, Magdalena; Sticova, Eva; Merta, Dusan; Senkerikova, Renata; Trunecka, Pavel; Spicak, Julius; Sperl, Jan
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<i>PNPLA3</i> rs738409 G allele carriers with genotype 1b HCV cirrhosis have lower viral load but develop liver failure at younger age

Plos One
2019 | Journal article
DOI: 10.1371/JOURNAL.PONE.0222609
WOSUID: WOS:000532231400033
Contributors: Senkerikova, Renata; Frankova, Sona; Jirsa, Milan; Kreidlova, Miluse; Merta, Dusan; Neroldova, Magdalena; Chmelova, Klara; Spicak, Julius; Sperl, Jan
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Dubin-Johnson syndrome in Tunisia: Spectrum of a rare disease

La Presse Médicale
2019 | Journal article
DOI: 10.1016/J.LPM.2018.09.020
WOSUID: WOS:000458896600015
Contributors: Guirat, Naouel; Abdelhedi, Fatma; Tfifha, Miniar; Charfi, Afifa; Sticova, Eva; Jirsa, Milan
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Functional evaluation of variants of unknown significance in the BRCA2 gene identified in genetic testing

Cancer Biology & Therapy
2019 | Journal article
DOI: 10.1080/15384047.2018.1550566
WOSUID: WOS:000465170300006
Contributors: Heczkova, Marie; Machackova, Eva; Macinga, Peter; Gallmeier, Eike; Cahova, Monika; Spicak, Julius; Jirsa, Milan; Foretova, Lenka; Hucl, Tomas
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Non-Thermal Plasma, as a New Physicochemical Source, to Induce Redox Imbalance and Subsequent Cell Death in Liver Cancer Cell Lines

Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology
2019 | Journal article
DOI: 10.33594/000000009
EID:

2-s2.0-85061973909
Contributors: Smolková, B.; Lunova, M.; Lynnyk, A.; Uzhytchak, M.; Churpita, O.; Jirsa, M.; Kubinová, Š.; Lunov, O.; Dejneka, A.
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Remote Actuation of Apoptosis in Liver Cancer Cells via Magneto-Mechanical Modulation of Iron Oxide Nanoparticles

Cancers
2019 | Journal article
DOI: 10.3390/CANCERS11121873
WOSUID: WOS:000507382100052
Contributors: Lunov, Oleg; Uzhytchak, Mariia; Smolkova, Barbora; Lunova, Mariia; Jirsa, Milan; Dempsey, Nora M.; Dias, Andre L.; Bonfim, Marlio; Hof, Martin; Jurkiewicz, Piotr et al.
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Targeting the mTOR Signaling Pathway Utilizing Nanoparticles: A Critical Overview

Cancers
2019 | Journal article
DOI: 10.3390/CANCERS11010082
WOSUID: WOS:000457233300002
Contributors: Lunova, Mariia; Smolkova, Barbora; Lynnyk, Anna; Uzhytchak, Mariia; Jirsa, Milan; Kubinova, Sarka; Dejneka, Alexandr; Lunov, Oleg
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Acute Toxic Effects of Telmisartan in Spontaneously Hypertensive Rats Fed a High Fructose Diet

Physiological Research
2018 | Journal article
DOI: 10.33549/PHYSIOLRES.933951
WOSUID: WOS:000453554300002
Contributors: Silhavy, J.; Mlejnek, P.; Simakova, M.; Vaneckova, I; Behuliak, M.; Kuda, O.; Sticova, E.; Jirsa, M.; Pravenec, M.
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Aldehyde dehydrogenase 2 polymorphism affects the outcome of methanol poisoning in exposed humans

Clinical Genetics
2018 | Journal article
DOI: 10.1111/CGE.13411
WOSUID: WOS:000446554800006
Contributors: Hubacek, J. A.; Jirsa, M.; Bobak, M.; Pelclova, D.; Zakharov, S.
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Donor <i>PNPLA3</i> rs738409 genotype is a risk factor for graft steatosis. A post-transplant biopsy-based study

Digestive and Liver Disease
2018 | Journal article
DOI: 10.1016/J.DLD.2017.12.030
WOSUID: WOS:000429911700011
Contributors: Trunecka, Pavel; Mikova, Irena; Dlouha, Dana; Hubacek, Jaroslav A.; Honsova, Eva; Kolesar, Libor; Lanska, Vera; Frankova, Sona; Sperl, Jan; Jirsa, Milan et al.
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Manipulating the mitochondria activity in human hepatic cell line Huh7 by low-power laser irradiation

Biomedical Optics Express
2018 | Journal article
DOI: 10.1364/BOE.9.001283
WOSUID: WOS:000426743300028
Contributors: Lynnyk, Anna; Lunova, Mariia; Jirsa, Milan; Egorova, Daria; Kulikov, Andrei; Kubinova, Sarka; Lunov, Oleg; Dejneka, Alexandr
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New Insights in Genetic Cholestasis: From Molecular Mechanisms to Clinical Implications

Canadian Journal of Gastroenterology and Hepatology
2018 | Journal article
DOI: 10.1155/2018/2313675
WOSUID: WOS:000440933900001
Contributors: Sticova, Eva; Jirsa, Milan; Pawlowska, Joanna
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Variable X-chromosome inactivation and enlargement of pericentral glutamine synthetase zones in the liver of heterozygous females with OTC deficiency

Virchows Archiv
2018 | Journal article
DOI: 10.1007/S00428-018-2345-X
WOSUID: WOS:000435410300017
Contributors: Musalkova, Dita; Sticova, Eva; Reboun, Martin; Sokolova, Jitka; Krijt, Jakub; Honzikova, Jitka; Gurka, Jiri; Neroldova, Magdalena; Honzik, Tomas; Zeman, Jiri et al.
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Chemically different non-thermal plasmas target distinct cell death pathways

Scientific Reports
2017 | Journal article
DOI: 10.1038/S41598-017-00689-5
WOSUID: WOS:000398162400011
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Cytotoxic bilirubin metabolites overlooked so far

Journal of Hepatology
2017 | Journal article
DOI: 10.1016/J.JHEP.2017.04.025
WOSUID: WOS:000405497200003
Contributors: Jirsa, Milan
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Hepcidin knockout mice spontaneously develop chronic pancreatitis owing to cytoplasmic iron overload in acinar cells

The Journal of Pathology
2017 | Journal article
DOI: 10.1002/PATH.4822
WOSUID: WOS:000392844000011
Contributors: Lunova, Mariia; Schwarz, Peggy; Nuraldeen, Renwar; Levada, Kateryna; Kuscuoglu, Deniz; Stuetzle, Michael; Vujic Spasic, Maja; Haybaeck, Johannes; Ruchala, Piotr; Jirsa, Milan et al.
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Nanoparticle core stability and surface functionalization drive the mTOR signaling pathway in hepatocellular cell lines

Scientific Reports
2017 | Journal article
DOI: 10.1038/S41598-017-16447-6
WOSUID: WOS:000416118900015
Contributors: Lunova, Mariia; Prokhorov, Andrey; Jirsa, Milan; Hof, Martin; Olzynska, Agnieszka; Jurkiewicz, Piotr; Kubinova, Sarka; Lunov, Oleg; Dejneka, Alexandr
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The use of pulsed magnetic fields to increase the uptake of iron oxide nanoparticles by living cells

Applied Physics Letters
2017 | Journal article
DOI: 10.1063/1.5007797
WOSUID: WOS:000418098900051
Contributors: Uzhytchak, M.; Lynnyk, A.; Zablotskii, V.; Dempsey, N. M.; Dias, A. L.; Bonfim, M.; Lunova, M.; Jirsa, M.; Kubinova, S.; Lunov, O. et al.
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HGSNAT has a TATA-less promoter with multiple starts of transcription

Gene
2016 | Journal article
DOI: 10.1016/J.GENE.2016.07.051
WOSUID: WOS:000383304600006
Contributors: Richtrova, Eva; Mrazova, Lenka S.; Musalkova, Dita; Luksan, Ondrej; Stolnaya, Larisa; Minks, Jakub; Lukas, Jan; Dvorakova, Lenka; Jirsa, Milan; Hrebicek, Martin
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Large Copy-Number Variations in Patients With Statin-Associated Myopathy Affecting Statin Myopathy-Related Loci

Physiological Research
2016 | Journal article
WOSUID:

WOS:000391198200012
Contributors: Stranecky, V.; Neroldova, M.; Hodanova, K.; Hartmannova, H.; Piherova, L.; Zemankova, P.; Pristoupilova, A.; Vrablik, M.; Adamkova, V.; Kmoch, S. et al.
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Modulation of collective cell behaviour by geometrical constraints

Integrative Biology
2016 | Journal article
DOI: 10.1039/C6IB00125D
WOSUID: WOS:000387979900001
Contributors: Lunova, Mariia; Zablotskii, Vitalii; Dempsey, Nora M.; Devillers, Thibaut; Jirsa, Milan; Sykova, Eva; Kubinova, Sarka; Lunov, Oleg; Dejneka, Alexandr
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Prevalence and Risk Factors of Steatosis After Liver Transplantation and Patient Outcomes

Liver Transplantation
2016 | Journal article
DOI: 10.1002/LT.24393
WOSUID: WOS:000375155700010
Contributors: Hejlova, Irena; Honsova, Eva; Sticova, Eva; Lanska, Vera; Hucl, Tomas; Spicak, Julius; Jirsa, Milan; Trunecka, Pavel
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Rare variants in known and novel candidate genes predisposing to statin-associated myopathy

Pharmacogenomics
2016 | Journal article
DOI: 10.2217/PGS-2016-0071
WOSUID: WOS:000382319300004
Contributors: Neroldova, Magdalena; Stranecky, Viktor; Hodanova, Katerina; Hartmannova, Hana; Piherova, Lenka; Pristoupilova, Anna; Mrazova, Lenka; Vrablik, Michal; Adamkova, Vera; Hubacek, Jaroslav A. et al.
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Successful Treatment of Iron-Overload Cardiomyopathy in Hereditary Hemochromatosis With Deferoxamine and Deferiprone

Canadian Journal of Cardiology
2016 | Journal article
DOI: 10.1016/J.CJCA.2016.07.589
WOSUID: WOS:000389529800035
Contributors: Tauchenova, Lydie; Krizova, Barbora; Kubanek, Milos; Frankova, Sona; Melenovsky, Vojtech; Tintera, Jaroslav; Kautznerova, Dana; Maluskova, Jana; Jirsa, Milan; Kautzner, Josef
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Alagille Syndrome Mimicking Biliary Atresia in Early Infancy

Plos One
2015 | Journal article
DOI: 10.1371/JOURNAL.PONE.0143939
WOSUID: WOS:000365889800091
Contributors: Dedic, Tomas; Jirsa, Milan; Keil, Radan; Rygl, Michal; Snajdauf, Jiri; Kotalova, Radana
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Complicated diagnostics of primary sclerosing cholangitis in a patient with recurrent episodes of acute bacterial cholangitis | Svízelná dia gnostika primární sklerozující cholangitidy u pa cienta s rekurentními epizodami akutní bakteriální cholangitidy

Gastroenterologia y Hepatologia
2015 | Journal article
DOI: 10.14735/amgh2015368
EID:

2-s2.0-84940775987
Contributors: Douda, L.; Keil, R.; Lochmannová, J.; Drábek, J.; Fabián, O.; Hornofová, L.; Honsová, E.; Jirsa, M.
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Milan Jirsa via Scopus - Elsevier

Down-regulation of OATP1B proteins correlates with hyperbilirubinemia in advanced cholestasis

International Journal of Clinical and Experimental Pathology
2015 | Journal article
WOSUID: WOS:000358370300107
Contributors: Sticova, Eva; Lodererova, Alena; van de Steeg, Evita; Frankova, Sona; Kollar, Marek; Lanska, Vera; Kotalova, Radana; Dedic, Tomas; Schinkel, Alfred H.; Jirsa, Milan
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