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Scopus Author ID: 7004473765

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Masaryk University: Brno, CZ

2014-11-10 to present | PI (Molecular Medicine)
Employment
Source: Self-asserted source
Liam Keegan

Works (50)

ADAR RNA Modifications, the Epitranscriptome and Innate Immunity.

Trends in biochemical sciences
2021-03-15 | Journal article
DOI: 10.1016/j.tibs.2021.02.002
PMID: 33736931
Source: Self-asserted source
Liam Keegan

The effects of RNA editing in cancer tissue at different stages in carcinogenesis.

RNA biology
2021-02-17 | Journal article
DOI: 10.1080/15476286.2021.1877024
PMID: 33593231
Source: Self-asserted source
Liam Keegan

Adar RNA editing-dependent and -independent effects are required for brain and innate immune functions in Drosophila

Nature Communications
2020 | Journal article
DOI: 10.1038/s41467-020-15435-1
EID:

2-s2.0-85082529398

Part of ISBN:

20411723
Contributors: Deng, P.; Khan, A.; Jacobson, D.; Sambrani, N.; McGurk, L.; Li, X.; Jayasree, A.; Hejatko, J.; Shohat-Ophir, G.; O’Connell, M.A. et al.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Bi-allelic ADARB1 Variants Associated with Microcephaly, Intellectual Disability, and Seizures

American Journal of Human Genetics
2020 | Journal article
DOI: 10.1016/j.ajhg.2020.02.015
EID:

2-s2.0-85082433028

Part of ISBN:

15376605 00029297
Contributors: Tan, T.Y.; Sedmík, J.; Fitzgerald, M.P.; Halevy, R.S.; Keegan, L.P.; Helbig, I.; Basel-Salmon, L.; Cohen, L.; Straussberg, R.; Chung, W.K. et al.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Membrane and synaptic defects leading to neurodegeneration in Adar mutant Drosophila are rescued by increased autophagy

BMC Biology
2020 | Journal article
DOI: 10.1186/s12915-020-0747-0
EID:

2-s2.0-85079361600

Part of ISBN:

17417007
Contributors: Khan, A.; Paro, S.; McGurk, L.; Sambrani, N.; Hogg, M.C.; Brindle, J.; Pennetta, G.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Biallelic variants in <i>ADARB1</i>, encoding a dsRNA-specific adenosine deaminase, cause a severe developmental and epileptic encephalopathy.

Journal of medical genetics
2020-07-27 | Journal article
DOI: 10.1136/jmedgenet-2020-107048
PMID: 32719099
Source: Self-asserted source
Liam Keegan

Activation of innate immunity by mitochondrial dsRNA in mouse cells lacking p53 protein

RNA
2019 | Journal article
DOI: 10.1261/rna.069625.118
EID:

2-s2.0-85066118492

Part of ISBN:

14699001 13558382
Contributors: Wiatrek, D.M.; Candela, M.E.; Sedmík, J.; Oppelt, J.; Keegan, L.P.; O’Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

ADAR RNA editing in innate immune response phasing, in circadian clocks and in sleep

Biochimica et Biophysica Acta - Gene Regulatory Mechanisms
2019 | Journal article
DOI: 10.1016/j.bbagrm.2018.10.011
EID:

2-s2.0-85056316187

Part of ISBN:

18764320 18749399
Contributors: Sinigaglia, K.; Wiatrek, D.; Khan, A.; Michalik, D.; Sambrani, N.; Sedmík, J.; Vukić, D.; O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The evolution of the 9aaTAD domain in Sp2 proteins: inactivation with valines and intron reservoirs

Cellular and Molecular Life Sciences
2019-08-02 | Journal article
DOI: 10.1007/s00018-019-03251-w
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Source: Self-asserted source
Liam Keegan

A to I editing in disease is not fake news

RNA Biology
2017 | Journal article
DOI: 10.1080/15476286.2017.1306173
EID:

2-s2.0-85018681766

Part of ISBN:

15558584 15476286
Contributors: Bajad, P.; Jantsch, M.F.; Keegan, L.; O'Connell, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

ADAR RNA editing below the backbone

RNA
2017 | Journal article
DOI: 10.1261/rna.060921.117
EID:

2-s2.0-85027574125

Part of ISBN:

14699001 13558382
Contributors: Keegan, L.; Khan, A.; Vukic, D.; O'Connell, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

ADAR RNA editing in human disease; more to it than meets the I

Human Genetics
2017 | Journal article
DOI: 10.1007/s00439-017-1837-0
EID:

2-s2.0-85029509992

Part of ISBN:

14321203 03406717
Contributors: Gallo, A.; Vukic, D.; Michalík, D.; O’Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Dynamic landscape and regulation of RNA editing in mammals

Nature
2017 | Journal article
DOI: 10.1038/nature24041
EID:

2-s2.0-85031298074

Part of ISBN:

14764687 00280836
Contributors: Tan, M.H.; Li, Q.; Shanmugam, R.; Piskol, R.; Kohler, J.; Young, A.N.; Liu, K.I.; Zhang, R.; Ramaswami, G.; Ariyoshi, K. et al.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

New insights into the biological role of mammalian ADARs; the RNA editing proteins

Biomolecules
2015 | Journal article
DOI: 10.3390/biom5042338
EID:

2-s2.0-85012078057

Part of ISBN:

2218273X
Contributors: Mannion, N.; Arieti, F.; Gallo, A.; Keegan, L.P.; O’Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The Epitranscriptome and Innate Immunity

PLoS Genetics
2015 | Journal article
DOI: 10.1371/journal.pgen.1005687
EID:

2-s2.0-84953219521

Part of ISBN:

15537404 15537390
Contributors: O’Connell, M.A.; Mannion, N.M.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Conflict RNA modification, host-parasite co-evolution, and the origins of DNA and DNA-binding proteins1

Biochemical Society Transactions
2014 | Journal article
DOI: 10.1042/BST20140147
EID:

2-s2.0-84905817625

Part of ISBN:

14708752 03005127
Contributors: McLaughlin, P.J.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The ADAR RNA editing enzyme controls neuronal excitability in Drosophila melanogaster

Nucleic Acids Research
2014 | Journal article
DOI: 10.1093/nar/gkt909
EID:

2-s2.0-84893306964

Part of ISBN:

03051048 13624962
Contributors: Li, X.; Overton, I.M.; Baines, R.A.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The RNA-Editing Enzyme ADAR1 Controls Innate Immune Responses to RNA

Cell Reports
2014 | Journal article
DOI: 10.1016/j.celrep.2014.10.041
EID:

2-s2.0-84912098781

Part of ISBN:

22111247
Contributors: Mannion, N.M.; Greenwood, S.M.; Young, R.; Cox, S.; Brindle, J.; Read, D.; Nellåker, C.; Vesely, C.; Ponting, C.P.; McLaughlin, P.J. et al.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Identifying RNA editing sites using RNA sequencing data alone

Nature Methods
2013 | Journal article
DOI: 10.1038/nmeth.2330
EID:

2-s2.0-84873414540

Part of ISBN:

15487091 15487105
Contributors: Ramaswami, G.; Zhang, R.; Piskol, R.; Keegan, L.P.; Deng, P.; O'Connell, M.A.; Li, J.B.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Mutations in ADAR1 cause Aicardi-Goutières syndrome associated with a type i interferon signature

Nature Genetics
2012 | Journal article
DOI: 10.1038/ng.2414
EID:

2-s2.0-84868207785

Part of ISBN:

10614036 15461718
Contributors: Rice, G.I.; Kasher, P.R.; Forte, G.M.A.; Mannion, N.M.; Greenwood, S.M.; Szynkiewicz, M.; Dickerson, J.E.; Bhaskar, S.S.; Zampini, M.; Briggs, T.A. et al.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Regulation and functions of ADAR in Drosophila

Current Topics in Microbiology and Immunology
2012 | Book
DOI: 10.1007/82_2011_152
EID:

2-s2.0-81855172227

Part of ISBN:

0070217X
Contributors: Paro, S.; Li, X.; O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Functional conservation in human and Drosophila of Metazoan ADAR2 involved in RNA editing: Loss of ADAR1 in insects

Nucleic Acids Research
2011 | Journal article
DOI: 10.1093/nar/gkr423
EID:

2-s2.0-80052460364

Part of ISBN:

03051048 13624962
Contributors: Keegan, L.P.; McGurk, L.; Palavicini, J.P.; Brindle, J.; Paro, S.; Li, X.; Rosenthal, J.J.C.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Laser microdissection and pressure catapulting of single human motor neurons for RNA editing analysis

Methods in Molecular Biology
2011 | Book
DOI: 10.1007/978-1-61779-018-8_4
EID:

2-s2.0-84855475759
Contributors: Sun, H.; Raja, A.; O’Connell, M.A.; Mann, V.; Noble, B.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Pin1 and WWP2 regulate GluR2 Q/R site RNA editing by ADAR2 with opposing effects

EMBO Journal
2011 | Journal article
DOI: 10.1038/emboj.2011.303
EID:

2-s2.0-80054895180

Part of ISBN:

02614189 14602075
Contributors: Marcucci, R.; Brindle, J.; Paro, S.; Casadio, A.; Hempel, S.; Morrice, N.; Bisso, A.; Keegan, L.P.; Del Sal, G.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

RNA Editing by Mammalian ADARs

Advances in Genetics
2011 | Book
DOI: 10.1016/B978-0-12-380860-8.00003-3
EID:

2-s2.0-79551648715

Part of ISBN:

00652660
Contributors: Hogg, M.; Paro, S.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Human BLCAP transcript: New editing events in normal and cancerous tissues

International Journal of Cancer
2010 | Journal article
DOI: 10.1002/ijc.25022
EID:

2-s2.0-77953412786

Part of ISBN:

00207136 10970215
Contributors: Galeano, F.; Leroy, A.; Rossetti, C.; Gromova, I.; Gautier, P.; Keegan, L.P.; Massimi, L.; Di Rocco, C.; O'Connell, M.A.; Gallo, A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The effect of RNA editing and ADARs on miRNA biogenesis and function

Advances in Experimental Medicine and Biology
2010 | Book
DOI: 10.1007/978-1-4419-7823-3_8
EID:

2-s2.0-79958287315

Part of ISBN:

00652598
Contributors: Heale, B.S.E.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

ADARs have effects beyond RNA editing

Cell Cycle
2009 | Journal article
DOI: 10.4161/cc.8.24.10214
EID:

2-s2.0-74849101768

Part of ISBN:

15514005 15384101
Contributors: Heale, B.S.E.; Keegan, L.P.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Editing independent effects of ADARs on the miRNA/siRNA pathways

EMBO Journal
2009 | Journal article
DOI: 10.1038/emboj.2009.244
EID:

2-s2.0-70350336432

Part of ISBN:

02614189 14602075
Contributors: Heale, B.S.E.; Keegan, L.P.; McGurk, L.; Michlewski, G.; Brindle, J.; Stanton, C.M.; Caceres, J.F.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Evidence for ADAR-induced hypermutation of the Drosophila sigma virus (Rhabdoviridae)

BMC Genetics
2009 | Journal article
DOI: 10.1186/1471-2156-10-75
EID:

2-s2.0-71949124275

Part of ISBN:

14712156
Contributors: Carpenter, J.A.; Keegan, L.P.; Wilfert, L.; O'Connell, M.A.; Jiggins, F.M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Purification and Assay of ADAR Activity

Methods in Enzymology
2007 | Book
DOI: 10.1016/S0076-6879(07)24014-5
EID:

2-s2.0-34548562454
Contributors: Keegan, L.P.; Rosenthal, J.J.; Roberson, L.M.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Three-dimensional imaging of Drosophila melanogaster

PLoS ONE
2007 | Journal article
DOI: 10.1371/journal.pone.0000834
EID:

2-s2.0-41049093625

Part of ISBN:

19326203
Contributors: McGurk, L.; Morrison, H.; Keegan, L.P.; Sharpe, J.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Drosha versus ADAR: Wrangling over pri-miRNA

Nature Structural and Molecular Biology
2006 | Journal article
DOI: 10.1038/nsmb0106-3
EID:

2-s2.0-30044434746

Part of ISBN:

15459993 15459985
Contributors: O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

SUMO-1 modification alters ADAR1 editing activity

Molecular Biology of the Cell
2005 | Journal article
DOI: 10.1091/mbc.E05-06-0536
EID:

2-s2.0-27644479211

Part of ISBN:

10591524
Contributors: Desterro, J.M.P.; Keegan, L.P.; Jaffray, E.; Hay, R.T.; O'Connell, M.A.; Carmo-Fonseca, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Tuning of RNA editing by ADAR is required in Drosophila

EMBO Journal
2005 | Journal article
DOI: 10.1038/sj.emboj.7600691
EID:

2-s2.0-21844472772

Part of ISBN:

02614189
Contributors: Keegan, L.P.; Brindle, J.; Gallo, A.; Leroy, A.; Reenan, R.A.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Adenosine deaminases acting on RNA (ADARs): RNA-editing enzymes

Genome Biology
2004 | Journal article
DOI: 10.1186/gb-2004-5-2-209
EID:

2-s2.0-10744223020

Part of ISBN:

14656906
Contributors: Keegan, L.P.; Leroy, A.; Sproul, D.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Purification and assay of recombinant ADAR proteins expressed in the yeast Pichia pastoris or in Escherichia coli.

Methods in molecular biology (Clifton, N.J.)
2004 | Journal article
EID:

2-s2.0-3142720737

Part of ISBN:

10643745
Contributors: Ring, G.M.; O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

An ADAR that edits transcripts encoding ion channel subunits functions as a dimer

EMBO Journal
2003 | Journal article
DOI: 10.1093/emboj/cdg327
EID:

2-s2.0-0037587631

Part of ISBN:

02614189
Contributors: Gallo, A.; Keegan, L.P.; Ring, G.M.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Dynamic association of RNA-editing enzymes with the nucleolus

Journal of Cell Science
2003 | Journal article
DOI: 10.1242/jcs.00371
EID:

2-s2.0-0038664237

Part of ISBN:

00219533
Contributors: Desterro, J.M.P.; Keegan, L.P.; Lafarga, M.; Berciano, M.T.; O'Connell, M.; Carmo-Fonseca, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Micro-processing events in mRNAs identified by DHPLC analysis

Nucleic Acids Research
2002 | Journal article
EID:

2-s2.0-0037106538

Part of ISBN:

03051048
Contributors: Gallo, A.; Thomson, E.; Brindle, J.; O'Connell, M.A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Report on the 17 <sup>th</sup> European Drosophila research conference

BioEssays
2002 | Journal article
DOI: 10.1002/bies.10048
EID:

2-s2.0-0036007424

Part of ISBN:

02659247
Contributors: Bownes, M.; Charlesworth, B.; Davis, I.; Finnegan, D.; Heck, M.; Jarman, A.; Keegan, L.; Ohkura, H.; Rabouille, C.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The many roles of an RNA editor

Nature Reviews Genetics
2001 | Journal article
DOI: 10.1038/35098584
EID:

2-s2.0-0035512727

Part of ISBN:

14710056
Contributors: Keegan, L.P.; Gallo, A.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

A-to-I pre-mRNA editing in Drosophila is primarily involved in adult nervous system function and integrity

Cell
2000 | Journal article
DOI: 10.1016/S0092-8674(00)00049-0
EID:

2-s2.0-0034682706

Part of ISBN:

00928674
Contributors: Palladino, M.J.; Keegan, L.P.; O'Connell, M.A.; Reenan, R.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

dADAR, a Drosophila double-stranded RNA-specific adenosine deaminase is highly developmentally regulated and is itself a target for RNA editing

RNA
2000 | Journal article
DOI: 10.1017/S1355838200000248
EID:

2-s2.0-0033943052

Part of ISBN:

13558382
Contributors: Palladino, M.J.; Keegan, L.P.; O'Connell, M.A.; Reenan, R.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Survival is impossible without an editor

Science
2000 | Journal article
DOI: 10.1126/science.290.5497.1707
EID:

2-s2.0-0034535218

Part of ISBN:

00368075
Contributors: Keegan, L.P.; Gallo, A.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

The properties of a tRNA-specific adenosine deaminase from Drosophila melanogaster support an evolutionary link between pre-mRNA editing and tRNA modification

Molecular and Cellular Biology
2000 | Journal article
DOI: 10.1128/MCB.20.3.825-833.2000
EID:

2-s2.0-0033982815

Part of ISBN:

02707306
Contributors: Keegan, L.P.; Gerber, A.P.; Brindle, J.; Leemans, R.; Gallo, A.; Keller, W.; O'Connell, M.A.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Purification of Native and Recombinant Double-Stranded RNA-Specific Adenosine Deaminases

Methods
1998 | Journal article
DOI: 10.1006/meth.1998.0605
EID:

2-s2.0-0031666401

Part of ISBN:

10462023 10959130
Contributors: O'Connell, M.A.; Gerber, A.; Keegan, L.P.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

A sequence conserved in vertebrate Hox gene introns functions as an enhancer regulated by posterior homeotic genes in Drosophila imaginal discs

Mechanisms of Development
1997 | Journal article
DOI: 10.1016/S0925-4773(97)00038-5
EID:

2-s2.0-0030982227

Part of ISBN:

09254773
Contributors: Keegan, L.P.; Haerry, T.E.; Crotty, D.A.; Packer, A.I.; Wolgemuth, D.J.; Gehring, W.J.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Separation of DNA binding from the transcription-activating function of a eukaryotic regulatory protein

Science
1986 | Journal article
DOI: 10.1126/science.3080805
EID:

2-s2.0-0022622235

Part of ISBN:

00368075
Contributors: Keegan, L.; Gill, G.; Ptashne, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Amino terminus of the yeast GAL4 gene product is sufficient for nuclear localization

Proceedings of the National Academy of Sciences of the United States of America
1984 | Journal article
DOI: 10.1073/pnas.81.19.5951
EID:

2-s2.0-0000976047

Part of ISBN:

00278424
Contributors: Silver, P.A.; Keegan, L.P.; Ptashne, M.
Source: Self-asserted source
Liam Keegan via Scopus - Elsevier

Peer review (3 reviews for 3 publications/grants)

Review activity for Cell reports. (1)
Review activity for Journal of proteome research. (1)
Review activity for Nature communications (1)
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