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Optimising IL-2 for Cancer Immunotherapy

Immune Network
2024 | Journal article
Contributors: Jonathan Sprent; Onur Boyman
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Crossref

Persistent complement dysregulation with signs of thromboinflammation in active Long Covid.

Science (New York, N.Y.)
2024-01-19 | Journal article | Author
Contributors: Cervia-Hasler; Brüningk; Tobias Hoch; Fan B; Giulia Muzio; Ryan Conrad Thompson; Laura Ceglarek; Roman Meledin; Patrick Westermann; Marc Emmenegger et al.
Source: Self-asserted source
Onur Boyman

Molecular states during acute COVID-19 reveal distinct etiologies of long-term sequelae

Nature Medicine
2023 | Journal article
EID:

2-s2.0-85143592766

Part of ISSN: 1546170X 10788956
Contributors: Thompson, R.C.; Simons, N.W.; Wilkins, L.; Cheng, E.; Del Valle, D.M.; Hoffman, G.E.; Cervia, C.; Fennessy, B.; Mouskas, K.; Francoeur, N.J. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Tumor Cell–Intrinsic c-Myb Upregulation Stimulates Antitumor Immunity in a Murine Colorectal Cancer Model

Cancer Immunology Research
2023-10-04 | Journal article
Contributors: Merel van Gogh; Jesus F. Glaus Garzon; Dilara Sahin; Lucia Knopfova; Petr Benes; Onur Boyman; Igor Jurisica; Lubor Borsig
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Crossref

A systematic review of interleukin-2-based immunotherapies in clinical trials for cancer and autoimmune diseases

eBioMedicine
2023-04 | Journal article
Contributors: Miro E. Raeber; Dilara Sahin; Ufuk Karakus; Onur Boyman
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Crossref

Comprehensive analysis of human IL‐4 receptor subunits shows compartmentalization in steady state and dupilumab treatment

Allergy
2023-04 | Journal article
Contributors: Lukas E. M. Heeb; Onur Boyman
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Crossref

Human memory B cells show plasticity and adopt multiple fates upon recall response to SARS-CoV-2.

Nature immunology
2023-04-27 | Journal article | Author
Contributors: Yves Zurbuchen; Jan Michler; Patrick Taeschler; Sarah Adamo; Cervia-Hasler; Miro E. Raeber; Ilhan Erkin Acar; Jakob Nilsson; Klaus Warnatz; Soyka MB et al.
Source: Self-asserted source
Onur Boyman

Biased IL-2 signals induce Foxp3-rich pulmonary lymphoid structures and facilitate long-term lung allograft acceptance in mice.

Nature communications
2023-03-13 | Journal article | Author
Contributors: Yamada Y; Tuan T. Nguyen; Daniela Impellizzieri; Katsutaka Mineura; Rintaro Shibuya; Alvaro Gomariz; Martina Haberecker; Jakob Nilsson; Cesar Nombela-Arrieta; Prof. Dr. Dr. Wolfgang Jungraithmayr et al.
Source: Self-asserted source
Onur Boyman

Autoantibodies against chemokines post-SARS-CoV-2 infection correlate with disease course.

Nature immunology
2023-03-06 | Journal article | Author
Contributors: Jonathan Muri; Valentina Cecchinato; Andrea Cavalli; Shanbhag AA; Matkovic M; Biggiogero M; Maida PA; Moritz J; Toscano C; Elaheh Ghovehoud et al.
Source: Self-asserted source
Onur Boyman

Treg-selective IL-2 starvation synergizes with CD40 activation to sustain durable responses in lymphoma models.

Journal for immunotherapy of cancer
2023-02-01 | Journal article
Contributors: Kristin Stirm; Leary P; Wüst D; Dominique Stark; Nicole Joller; Ufuk Karakus; Boyman O; Alexandar Tzankov; Anne Müller
Source: Self-asserted source
Onur Boyman

Continuous population-level monitoring of SARS-CoV-2 seroprevalence in a large European metropolitan region.

iScience
2023-01-04 | Journal article | Author
Contributors: Marc Emmenegger; De Cecco E; Lamparter D; Jacquat RPB; Julien Riou; Menges D; Tala Ballouz; Ebner D; Schneider MM; Morales IC et al.
Source: Self-asserted source
Onur Boyman

Immunoglobulin signature predicts risk of post-acute COVID-19 syndrome

Nature Communications
2022 | Journal article
EID:

2-s2.0-85123697980

Part of ISSN: 20411723
Contributors: Cervia, C.; Zurbuchen, Y.; Taeschler, P.; Ballouz, T.; Menges, D.; Hasler, S.; Adamo, S.; Raeber, M.E.; Bächli, E.; Rudiger, A. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Systematic Review of Safety and Efficacy of IL-1-Targeted Biologics in Treating Immune-Mediated Disorders

Frontiers in Immunology
2022 | Journal article
EID:

2-s2.0-85134345241

Part of ISSN: 16643224
Contributors: Arnold, D.D.; Yalamanoglu, A.; Boyman, O.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Systematic Review of Safety and Efficacy of Second- and Third-Generation CD20-Targeting Biologics in Treating Immune-Mediated Disorders

Frontiers in Immunology
2022 | Journal article
EID:

2-s2.0-85124835820

Part of ISSN: 16643224
Contributors: Kaegi, C.; Wuest, B.; Crowley, C.; Boyman, O.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Mechanisms regulating neutrophil responses in immunity, allergy, and autoimmunity

Allergy
2022-12 | Journal article
Contributors: Alaz Özcan; Onur Boyman
Source: check_circle
Crossref

Interleukin-2–based therapies in cancer

Science Translational Medicine
2022-11-09 | Journal article
Contributors: Miro E. Raeber; Dilara Sahin; Onur Boyman
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Crossref

Exposure to avian coronavirus vaccines is associated with increased levels of SARS-CoV-2-cross-reactive antibodies.

Allergy
2022-07-23 | Journal article | Author
Contributors: Özge Ardıçlı; Kamil Tayfun Carlı; Pattraporn Satitsuksanoa; Dreher A; Cusini A; Hutter S; Mirer D; Rückert B; Hulda R. Jonsdottir; Benjamin Weber et al.
Source: Self-asserted source
Onur Boyman

T-cell recovery and evidence of persistent immune activation 12 months after severe COVID-19.

Allergy
2022-06-02 | Journal article | Author
Contributors: Patrick Taeschler; Sarah Adamo; Yun Deng; Cervia-Hasler; Yves Zurbuchen; Stephane Chevrier; Miro E. Raeber; Sara Hasler; esther bachli; Alain Rudiger et al.
Source: Self-asserted source
Onur Boyman

Type 2 immune predisposition results in accelerated neutrophil aging causing susceptibility to bacterial infection

Science Immunology
2022-05-27 | Journal article
Contributors: Cecilie Egholm; Alaz Özcan; Daniel Breu; Onur Boyman
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Crossref

Patients with systemic sclerosis show phenotypic and functional defects in neutrophils

Allergy
2022-04 | Journal article
Contributors: Daniela Impellizzieri; Cecilie Egholm; Alan Valaperti; Oliver Distler; Onur Boyman
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Crossref

Autoantibodies in COVID-19 correlate with antiviral humoral responses and distinct immune signatures.

Allergy
2022-04-08 | Journal article | Author
Contributors: Patrick Taeschler; Cervia-Hasler; Yves Zurbuchen; Sara Hasler; Christian Pou; Ziyang Tan; Sarah Adamo; Miro E. Raeber; esther bachli; Alain Rudiger et al.
Source: Self-asserted source
Onur Boyman

CCR7-guided neutrophil redirection to skin-draining lymph nodes regulates cutaneous inflammation and infection

Science Immunology
2022-02-18 | Journal article
Contributors: A. Özcan; V. Collado-Diaz; C. Egholm; M. Tomura; M. Gunzer; C. Halin; A. G. A. Kolios; O. Boyman
Source: check_circle
Crossref

Signature of long-lived memory CD8+ T cells in acute SARS-CoV-2 infection

Nature
2022-02-03 | Journal article
Contributors: Sarah Adamo; Jan Michler; Yves Zurbuchen; Carlo Cervia; Patrick Taeschler; Miro E. Raeber; Simona Baghai Sain; Jakob Nilsson; Andreas E. Moor; Onur Boyman
Source: check_circle
Crossref

A distinct innate immune signature marks progression from mild to severe COVID-19

Cell Reports Medicine
2021 | Journal article
EID:

2-s2.0-85099161330

Part of ISSN: 26663791
Contributors: Chevrier, S.; Zurbuchen, Y.; Cervia, C.; Adamo, S.; Raeber, M.E.; de Souza, N.; Sivapatham, S.; Jacobs, A.; Bachli, E.; Rudiger, A. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

CD122-directed interleukin-2 treatment mechanisms in bladder cancer differ from αPD-L1 and include tissue-selective γδT cell activation

Journal for ImmunoTherapy of Cancer
2021 | Journal article
EID:

2-s2.0-85104101376

Part of ISSN: 20511426
Contributors: Reyes, R.M.; Deng, Y.; Zhang, D.; Ji, N.; Mukherjee, N.; Wheeler, K.; Gupta, H.B.; Padron, A.S.; Kancharla, A.; Zhang, C. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Local delivery of CAR T cells targeting fibroblast activation protein is safe in patients with pleural mesothelioma: first report of FAPME, a phase I clinical trial

Annals of Oncology
2021 | Journal article
EID:

2-s2.0-85097444395

Part of ISSN: 15698041 09237534
Contributors: Hiltbrunner, S.; Britschgi, C.; Schuberth, P.; Bankel, L.; Nguyen-Kim, T.D.L.; Gulati, P.; Weder, W.; Opitz, I.; Lauk, O.; Caviezel, C. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Protein tyrosine phosphatase nonreceptor type 2 controls colorectal cancer development

Journal of Clinical Investigation
2021 | Journal article
EID:

2-s2.0-85098865033

Part of ISSN: 15588238 00219738
Contributors: Katkeviciute, E.; Hering, L.; Montalban-Arques, A.; Busenhart, P.; Schwarzfischer, M.; Manzini, R.; Conde, J.; Atrott, K.; Lang, S.; Rogler, G. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Systemic and mucosal antibody responses specific to SARS-CoV-2 during mild versus severe COVID-19

Journal of Allergy and Clinical Immunology
2021 | Journal article
EID:

2-s2.0-85097465478

Part of ISSN: 10976825 00916749
Contributors: Cervia, C.; Nilsson, J.; Zurbuchen, Y.; Valaperti, A.; Schreiner, J.; Wolfensberger, A.; Raeber, M.E.; Adamo, S.; Weigang, S.; Emmenegger, M. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Systematic review of safety and efficacy of belimumab in treating immune‐mediated disorders

Allergy
2021-09 | Journal article
Contributors: Celine Kaegi; Urs C. Steiner; Benjamin Wuest; Catherine Crowley; Onur Boyman
Source: check_circle
Crossref

Early and Long-Term Effects of Dupilumab Treatment on Circulating T-Cell Functions in Patients with Moderate-to-Severe Atopic Dermatitis

Journal of Investigative Dermatology
2021-08 | Journal article
Contributors: Daphne S. Bakker; Maria M. van der Wal; Lukas E.M. Heeb; Barbara Giovannone; Mindy Asamoah; Eveline M. Delemarre; Julia Drylewicz; Stefan Nierkens; Onur Boyman; Marjolein S. de Bruin-Weller et al.
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Crossref

Commensal Clostridiales strains mediate effective anti-cancer immune response against solid tumors.

Cell host & microbe
2021-08-27 | Journal article
Contributors: Ana Montalban-Arques; Katkeviciute E; Busenhart P; Bircher A; Jakob Wirbel; Georg Zeller; Yasser Morsy; Borsig L; Glaus Garzon JF; Müller A et al.
Source: Self-asserted source
Onur Boyman

Profound dysregulation of T cell homeostasis and function in patients with severe COVID-19.

Allergy
2021-06-30 | Journal article | Author
Contributors: Sarah Adamo; Chevrier S; Cervia C; Yves Zurbuchen; Miro E. Raeber; Yang L; Sivapatham S; Jacobs A; Baechli E; Rudiger A et al.
Source: Self-asserted source
Onur Boyman

Biologicals in atopic disease in pregnancy: An EAACI position paper

Allergy
2021-01 | Journal article
Contributors: Birgit Pfaller; Juan José Yepes‐Nuñez; Ioana Agache; Cezmi A. Akdis; Mohammad Alsalamah; Sevim Bavbek; Apostolos Bossios; Onur Boyman; Adam Chaker; Susan Chan et al.
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Crossref

Immune modulation via T regulatory cell enhancement: Disease‐modifying therapies for autoimmunity and their potential for chronic allergic and inflammatory diseases—An EAACI position paper of the Task Force on Immunopharmacology (TIPCO)

Allergy
2021-01 | Journal article
Contributors: Franziska Roth‐Walter; Ian M. Adcock; Cristina Benito‐Villalvilla; Rodolfo Bianchini; Leif Bjermer; Onur Boyman; Gaetano Caramori; Luigi Cari; Kian Fan Chung; Zuzana Diamant et al.
Source: check_circle
Crossref

Erythropoiesis defect observed in STAT3 GOF patients with severe anemia

Journal of Allergy and Clinical Immunology
2020 | Journal article
EID:

2-s2.0-85078157735

Part of ISSN: 10976825 00916749
Contributors: Mauracher, A.A.; Eekels, J.J.M.; Woytschak, J.; van Drogen, A.; Bosch, A.; Prader, S.; Felber, M.; Heeg, M.; Opitz, L.; Trück, J. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Nanoparticle-Coupled Topical Methotrexate Can Normalize Immune Responses and Induce Tissue Remodeling in Psoriasis

Journal of Investigative Dermatology
2020 | Journal article
EID:

2-s2.0-85078762791

Part of ISSN: 15231747 0022202X
Contributors: Özcan, A.; Sahin, D.; Impellizzieri, D.; Nguyen, T.T.; Hafner, J.; Yawalkar, N.; Kurzbach, D.; Tan, G.; Akdis, C.A.; Nilsson, J. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

The AP1 Transcription Factor Fosl2 Promotes Systemic Autoimmunity and Inflammation by Repressing Treg Development

Cell Reports
2020 | Journal article
EID:

2-s2.0-85086922529

Part of ISSN: 22111247
Contributors: Renoux, F.; Stellato, M.; Haftmann, C.; Vogetseder, A.; Huang, R.; Subramaniam, A.; Becker, M.O.; Blyszczuk, P.; Becher, B.; Distler, J.H.W. et al.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

An IL-2-grafted antibody immunotherapy with potent efficacy against metastatic cancer

Nature Communications
2020-12-22 | Journal article
Contributors: Dilara Sahin; Natalia Arenas-Ramirez; Matthias Rath; Ufuk Karakus; Monika Hümbelin; Merel van Gogh; Lubor Borsig; Onur Boyman
Source: check_circle
Crossref

Receptor-gated IL-2 delivery by an anti-human IL-2 antibody activates regulatory T cells in three different species

Science Translational Medicine
2020-12-16 | Journal article
Contributors: Ufuk Karakus; Dilara Sahin; Peer R. E. Mittl; Petra Mooij; Gerrit Koopman; Onur Boyman
Source: check_circle
Crossref

Considerations on biologicals for patients with allergic disease in times of the COVID‐19 pandemic: An EAACI statement

Allergy
2020-11 | Journal article
Contributors: Alessandra Vultaggio; Ioana Agache; Cezmi A. Akdis; Mubeccel Akdis; Sevim Bavbek; Apostolos Bossios; Jean Bousquet; Onur Boyman; Adam M. Chaker; Susan Chan et al.
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Crossref

Clinical Relevance of Anti-TNF Antibody Trough Levels and Anti-Drug Antibodies in Treating Inflammatory Bowel Disease Patients.

Inflammatory intestinal diseases
2020-11-20 | Journal article
Contributors: Ilana Reinhold; Blümel S; Schreiner J; Boyman O; Bögeholz J; Cheetham M; Rogler G; Biedermann L; Michael Scharl
Source: Self-asserted source
Onur Boyman

Interleukin-2 signals converge in a lymphoid–dendritic cell pathway that promotes anticancer immunity

Science Translational Medicine
2020-09-16 | Journal article
Contributors: Miro E. Raeber; Rodney A. Rosalia; Dominic Schmid; Ufuk Karakus; Onur Boyman
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Crossref

Establishment of a scalable microfluidic assay for characterization of population‐based neutrophil chemotaxis

Allergy
2020-06 | Journal article
Contributors: Fulvio Grigolato; Cecilie Egholm; Daniela Impellizzieri; Paolo Arosio; Onur Boyman
Source: check_circle
Crossref

Chemical Synthesis of Interleukin‐2 and Disulfide Stabilizing Analogues

Angewandte Chemie International Edition
2020-05-25 | Journal article
Contributors: Claudia E. Murar; Mamiko Ninomiya; Satomi Shimura; Ufuk Karakus; Onur Boyman; Jeffrey W. Bode
Source: check_circle
Crossref

Evolution and function of interleukin-4 receptor signaling in adaptive immunity and neutrophils

Genes & Immunity
2020-05-06 | Journal article
Contributors: Lukas E. M. Heeb; Cecilie Egholm; Onur Boyman
Source: check_circle
Crossref

Systematic Review of Safety and Efficacy of Atacicept in Treating Immune-Mediated Disorders.

Frontiers in immunology
2020-03-24 | Journal article
Contributors: Kaegi C; Steiner UC; Wuest B; Crowley C; Boyman O
Source: Self-asserted source
Onur Boyman

Rapid expansion of Treg cells protects from collateral colitis following a viral trigger.

Nature communications
2020-03-23 | Journal article | Author
Contributors: Schorer M; Lambert K; Rakebrandt N; Felix Rost; Kung-Chi Kao; Yermanos A; Roman Spörri; Oderbolz J; Miro E. Raeber; Christian Wolfgang Keller et al.
Source: Self-asserted source
Onur Boyman

Apremilast in treatment-refractory recurrent aphthous stomatitis

New England Journal of Medicine
2019 | Journal article
EID:

2-s2.0-85074958203

Contributors: Kolios, A.G.A.; Yawalkar, N.; Feusi, A.; Köndig, T.; Boyman, O.; Nilsson, J.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

Group A Streptococcal DNase Sda1 Impairs Plasmacytoid Dendritic Cells’ Type 1 Interferon Response

Journal of Investigative Dermatology
2019 | Journal article
EID:

2-s2.0-85061797338

Contributors: Keller, N.; Woytschak, J.; Heeb, L.E.M.; Marques Maggio, E.; Mairpady Shambat, S.; Snäll, J.; Hyldegaard, O.; Boyman, O.; Norrby-Teglund, A.; Zinkernagel, A.S.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier

IL-4 receptor engagement in human neutrophils impairs their migration and extracellular trap formation

Journal of Allergy and Clinical Immunology
2019 | Journal article
EID:

2-s2.0-85062700108

Contributors: Impellizzieri, D.; Ridder, F.; Raeber, M.E.; Egholm, C.; Woytschak, J.; Kolios, A.G.A.; Legler, D.F.; Boyman, O.
Source: Self-asserted source
Onur Boyman via Scopus - Elsevier
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