Personal information

Neurobiology, single-cell transcriptomics, Human neurons, Brain disorders, Brain Cancer, Parkinson's, Neuronal media, Induced pluripotent stem cells, Electrophysiology
Australia, France, United States

Biography

Professor, Flinder Health and Medical Research Institute, Flinders University
Director of the Laboratory for Human Neurobiology and Stem Cells, South Australian Health and Research Medical Institute (SAHMRI).

The Bardy lab (www.bardylab.com) is located in the South Australian Health and Medical Research Institute (SAHMRI).

​Professor Cedric Bardy is neurobiologist with in-depth expertise in human neural stem cell models and multimodal phenotyping assays (electrophysiology, imaging, and single cell transcriptomic). His research efforts are focused on advancing new stem cell biotechnologies to understand the effect of neurological disorders on brain cells.

Cedric grew up in the South of France before moving to Australia to obtain a PhD in Medicine from the University of Sydney (2008). He pursued his postdoctoral training in Neuroscience in the laboratory of Prof. Pierre-Marie Lledo at the Pasteur Institute in Paris (2008-2010). He then received the prestigious Marie Curie International Fellowship to continue his research in California at the Salk Institute in California under the mentorship of Prof. Fred Gage (2011-2016).

At the end of 2016, he was recruited back to Australia by SAHMRI and Flinders University, where he established a new research program aiming to improve pre-clinical translation in neurology. In January 2021, he was promoted to Associate Professor by Flinders University. He currently leads the Laboratory for Human Neurophysiology and Genetics located at SAHMRI.

Cedric has contributed to pioneering the development of iPSC models to study brain disorders. In particular, he is the inventor of BrainPhys, a neuronal medium broadly used to culture and mature human neurons in vitro, and he co-authored the first iPSC paper of Alzheimer’s published in Nature.

Activities

Employment (6)

Flinders University: N/A, AU

Employment
Source: check_circle
Flinders University PURE

Flinders University: Adelaide, South Australia, AU

2021-01-01 to present | Associate Professor
Employment
Source: Self-asserted source
Cedric Bardy

SAHMRI: Adelaide, South Australia, AU

2016-10-11 to present | Associate Professor (Life long Health- Laboratory for Human Neurophysiology and Genetics)
Employment
Source: Self-asserted source
Cedric Bardy

Flinders University: Adelaide, South Australia, AU

2016-10-11 to 2020-12-31 | Senior Research Fellow / Assist. Prof.
Employment
Source: Self-asserted source
Cedric Bardy

Salk Institute for Biological Studies: La Jolla, CA, US

2011-01-20 to 2016-09-01 | Staff Researcher (Sanford Consortium for Regenerative Medicine )
Employment
Source: Self-asserted source
Cedric Bardy

Institut Pasteur: Paris, Île-de-France, FR

2008 to 2010 | Research Associate (Neuroscience Department)
Employment
Source: Self-asserted source
Cedric Bardy

Education and qualifications (1)

University of Sydney: Sydney, NSW, AU

2004 to 2008 | PhD (School of Medical Sciences)
Education
Source: Self-asserted source
Cedric Bardy

Works (45)

Astrocytes contribute to toll-like receptor 2-mediated neurodegeneration and alpha-synuclein pathology in a human midbrain Parkinson’s model

Translational Neurodegeneration
2024-12 | Journal article | Author
SOURCE-WORK-ID:

0336750e-1c9b-4168-8ede-01206ebe2167

EID:

2-s2.0-85212054546

Contributors: Fiona Weiss; Laura Hughes; Yuhong Fu; Cedric Bardy; Glenda M. Halliday; Nicolas Dzamko
Source: check_circle
Flinders University PURE

Recapitulation of Perturbed Striatal Gene Expression Dynamics of Donors' Brains With Ventral Forebrain Organoids Derived From the Same Individuals With Schizophrenia

The American journal of psychiatry
2024-06 | Journal article | Author
SOURCE-WORK-ID:

85cb75d8-d439-4ba3-8c3c-a8945bf70ba0

EID:

2-s2.0-85195226100

Contributors: Tomoyo Sawada; André R. Barbosa; Bruno Araujo; Alejandra E. McCord; Laura D'Ignazio; Kynon J.M. Benjamin; Bonna Sheehan; Michael Zabolocki; Arthur Feltrin; Ria Arora et al.
Source: check_circle
Flinders University PURE

More than a small adult brain

Brain, Behavior, and Immunity
2024-01 | Journal article | Author
SOURCE-WORK-ID:

0ed4ceab-676d-4596-85e7-7074897c6be4

EID:

2-s2.0-85180010369

Contributors: Maya R. Davies; Zarina Greenberg; Dannis G. van Vuurden; Courtney B. Cross; Andrew C.W. Zannettino; Cedric Bardy; Hannah R. Wardill
Source: check_circle
Flinders University PURE

In vitro modeling of the human dopaminergic system using spatially arranged ventral midbrain–striatum–cortex assembloids

NATURE METHODS
2023-12 | Journal article | Author
SOURCE-WORK-ID:

3f9a4d4f-3b58-49db-9b37-c0ea6987d6c7

EID:

2-s2.0-85178437011

Contributors: Daniel Reumann; Christian Krauditsch; Maria Novatchkova; Edoardo Sozzi; Sakurako Nagumo Wong; Michael Zabolocki; Marthe Priouret; Balint Doleschall; Kaja I. Ritzau-Reid; Marielle Piber et al.
Source: check_circle
Flinders University PURE

Human cerebrospinal fluid affects chemoradiotherapy sensitivities in tumor cells from patients with glioblastoma

Science Advances
2023-10-27 | Journal article | Author
SOURCE-WORK-ID:

281721f9-751d-461d-b7f3-76f587057eeb

EID:

2-s2.0-85175217419

Contributors: Brett William Stringer; Manam Inushi De Silva; Zarina Greenberg; Alejandra Noreña Puerta; Robert Adams; Bridget Milky; Michael Zabolocki; Mark van den Hurk; Lisa M. Ebert; Christine Fairly Bishop et al.
Source: check_circle
Flinders University PURE

Neuronal and tumourigenic boundaries of glioblastoma plasticity

Trends in Cancer
2023-03 | Journal article
Contributors: Manam Inushi De Silva; Brett W. Stringer; Cedric Bardy
Source: check_circle
Crossref
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Druggable transcriptomic pathways revealed in Parkinson’s patient-derived midbrain neurons

npj Parkinson's Disease
2022-10-18 | Journal article | Author
Part of ISSN: 2373-8057
Contributors: Mark van den Hurk; Shong Lau; Maria C. Marchetto; Jerome Mertens; Shani Stern; Olga Corti; Alexis Brice; Beate Winner; Jürgen Winkler; Fred H. Gage et al.
Source: Self-asserted source
Cedric Bardy
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Reduced synaptic activity and dysregulated extracellular matrix pathways in midbrain neurons from Parkinson’s disease patients

npj Parkinson's Disease
2022-08-10 | Journal article | Author
SOURCE-WORK-ID:

759abc21-2947-469c-9c39-a894fcbe816a

EID:

2-s2.0-85135853844

Contributors: Shani Stern; Shong Lau; Andreea Manole; Idan Rosh; Menachem Mendel Percia; Ran Ben Ezer; Maxim N. Shokhirev; Fan Qiu; Simon Schafer; Abed Al Fatah Mansour et al.
Source: check_circle
Flinders University PURE

Long-term adherence of human brain cells in vitro is enhanced by charged amine-based plasma polymer coatings

Stem Cell Reports
2022-03-08 | Journal article | Author
SOURCE-WORK-ID:

129e7c6d-5620-470a-8496-baf3c52049ce

EID:

2-s2.0-85125627976

Contributors: Bridget Milky; Michael Zabolocki; Sameer A. Al-Bataineh; Mark van den Hurk; Zarina Greenberg; Lucy Turner; Paris Mazzachi; Amber Williams; Imanthi Illeperuma; Robert Adams et al.
Source: check_circle
Flinders University PURE

Modeling the Human Brain With ex vivo Slices and in vitro Organoids for Translational Neuroscience

Frontiers in Neuroscience
2022-02-24 | Journal article | Author
SOURCE-WORK-ID:

d1a8d9f6-a79f-4d0c-b8a5-01eff140d58d

EID:

2-s2.0-85126255012

Contributors: Giovanna O. Nogueira; Patricia P. Garcez; Cedric Bardy; Mark O. Cunningham; Adriano Sebollela
Source: check_circle
Flinders University PURE

Retromer regulates the lysosomal clearance of MAPT/tau

Autophagy
2021-09-02 | Journal article
Contributors: Julian M. Carosi; Leanne K. Hein; Mark van den Hurk; Robert Adams; Bridget Milky; Sanjna Singh; Cedric Bardy; Donna Denton; Sharad Kumar; Timothy J. Sargeant
Source: check_circle
Crossref
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Patch-seq: Past, Present, and Future

The Journal of Neuroscience
2021-02-03 | Journal article
Contributors: Marcela Lipovsek; Cedric Bardy; Cathryn R. Cadwell; Kristen Hadley; Dmitry Kobak; Shreejoy J. Tripathy
Source: check_circle
Crossref
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Personalized psychiatry with human iPSCs and neuronal reprogramming

Personalized Psychiatry
2020 | Book chapter | Author
SOURCE-WORK-ID:

cf0652c0-546c-47f1-ad8a-0f33f374f299

EID:

2-s2.0-85081938132

Part of ISBN: 9780128131763
Part of ISBN: 9780128131770
Contributors: Cedric Bardy; Zarina Greenberg; Seth W. Perry; Julio Licinio
Source: check_circle
Flinders University PURE

BrainPhys neuronal medium optimized for imaging and optogenetics in vitro

Nature Communications
2020-11-03 | Journal article | Author
SOURCE-WORK-ID:

9e0f7f97-3a25-43bc-acc7-35b00c9596bf

EID:

2-s2.0-85094950684

Contributors: Michael Zabolocki; Kasandra McCormack; Mark van den Hurk; Bridget Milky; Andrew P. Shoubridge; Robert Adams; Jenne Tran; Anita Mahadevan-Jansen; Philipp Reineck; Jacob Thomas et al.
Source: check_circle
Flinders University PURE

The prohibitin-binding compound fluorizoline affects multiple components of the translational machinery and inhibits protein synthesis.

The Journal of biological chemistry
2020-05-19 | Journal article
Source: Self-asserted source
Cedric Bardy
grade
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Genetic predispositions of Parkinson’s disease revealed in patient-derived brain cells

npj Parkinson's Disease
2020-04-24 | Journal article
Contributors: Jenne Tran; Helena Anastacio; Cedric Bardy
Source: check_circle
Crossref
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Endothelial, pericyte and tumor cell expression in glioblastoma identifies fibroblast activation protein (FAP) as an excellent target for immunotherapy

Clinical & Translational Immunology
2020-01 | Journal article
Part of ISSN: 2050-0068
Part of ISSN: 2050-0068
Source: Self-asserted source
Cedric Bardy
grade
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Single-cell multimodal transcriptomics to study neuronal diversity in human stem cell-derived brain tissue and organoid models

Journal of Neuroscience Methods
2019-09 | Journal article
Contributors: Mark van den Hurk; Cedric Bardy
Source: check_circle
Crossref
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Corrigendum

Frontiers in Molecular Neuroscience
2019-06-11 | Other | Author
SOURCE-WORK-ID:

79062f51-acf4-404e-9fa8-4160e78ae8d3

EID:

2-s2.0-85069448800

Contributors: Mark van den Hurk; Jennifer A. Erwin; Gene W. Yeo; Fred H. Gage; Cedric Bardy
Source: check_circle
Flinders University PURE

Efficient Generation of CA3 Neurons from Human Pluripotent Stem Cells Enables Modeling of Hippocampal Connectivity In Vitro

Cell Stem Cell
2018 | Journal article
Source: Self-asserted source
Cedric Bardy
grade
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Patch-Seq Protocol to Analyze the Electrophysiology, Morphology and Transcriptome of Whole Single Neurons Derived From Human Pluripotent Stem Cells

Frontiers in Molecular Neuroscience
2018 | Journal article
Source: Self-asserted source
Cedric Bardy
grade
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Review: Synthetic scaffolds to control the biochemical, mechanical, and geometrical environment of stem cell-derived brain organoids

APL Bioengineering
2018 | Journal article
Source: Self-asserted source
Cedric Bardy
grade
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Survival of syngeneic and allogeneic iPSC–derived neural precursors after spinal grafting in minipigs

Science Translational Medicine
2018-05-09 | Journal article
Contributors: Jan Strnadel; Cassiano Carromeu; Cedric Bardy; Michael Navarro; Oleksandr Platoshyn; Andreas N. Glud; Silvia Marsala; Jozef Kafka; Atsushi Miyanohara; Tomohisa Kato, Jr. et al.
Source: check_circle
Crossref
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A human neurodevelopmental model for Williams syndrome

Nature
2016 | Journal article
EID:

2-s2.0-84983372661

Contributors: Chailangkarn, T.; Trujillo, C.A.; Freitas, B.C.; Hrvoj-Mihic, B.; Herai, R.H.; Yu, D.X.; Brown, T.T.; Marchetto, M.C.; Bardy, C.; McHenry, L. et al.
Source: Self-asserted source
Cedric Bardy via Scopus - Elsevier
grade
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Predicting the functional states of human iPSC-derived neurons with single-cell RNA-seq and electrophysiology

Molecular Psychiatry
2016-11 | Journal article
Contributors: C Bardy; M van den Hurk; B Kakaradov; J A Erwin; B N Jaeger; R V Hernandez; T Eames; A A Paucar; M Gorris; C Marchand et al.
Source: check_circle
Crossref
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A human neurodevelopmental model for Williams syndrome.

2016-08 | Journal article
Contributors: Chailangkarn T; Trujillo CA; Freitas BC; Hrvoj-Mihic B; Herai RH; Yu DX; Brown TT; Marchetto MC; Bardy C; McHenry L et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central

Transcriptional and epigenetic mechanisms of cellular reprogramming to induced pluripotency.

2016-08 | Journal article
Contributors: van den Hurk M; Kenis G; Bardy C; van den Hove DL; Gage FH; Steinbusch HW; Rutten BP
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
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Evaluating cell reprogramming, differentiation and conversion technologies in neuroscience.

2016-05 | Journal article
Contributors: Mertens J; Marchetto MC; Bardy C; Gage FH
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Alleviation of neuronal energy deficiency by mTOR inhibition as a treatment for mitochondria-related neurodegeneration

eLife
2016-03-23 | Journal article
Contributors: Xinde Zheng; Leah Boyer; Mingji Jin; Yongsung Kim; Weiwei Fan; Cedric Bardy; Travis Berggren; Ronald M Evans; Fred H Gage; Tony Hunter
Source: check_circle
Crossref
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Generation of functional human serotonergic neurons from fibroblasts.

2016-01 | Journal article
Contributors: Vadodaria KC; Mertens J; Paquola A; Bardy C; Li X; Jappelli R; Fung L; Marchetto MC; Hamm M; Gorris M et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
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The different moods of human serotonergic neurons.

2016-01 | Journal article
Contributors: Vadodaria KC; Mertens J; Paquola A; Bardy C; Li X; Jappelli R; Fung L; Marchetto MC; Hamm M; Gorris M et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Correction for Bardy et al., Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro

Proceedings of the National Academy of Sciences of the United States of America
2015-06-23 | Other | Author
SOURCE-WORK-ID:

2f4ff966-a16c-4de8-90e5-9b11f48e01b8

EID:

2-s2.0-84934951811

Contributors: Cedric Bardy; M. van den Hurk; T. Eames; C Marchand; M Hernandez; M. Kellog; M. Gorris; B. Galet; V. Palomares; J Brown et al.
Source: check_circle
Flinders University PURE

Neuronal medium that supports basic synaptic functions and activity of human neurons in vitro.

2015-05 | Journal article
Contributors: Bardy C; van den Hurk M; Eames T; Marchand C; Hernandez RV; Kellogg M; Gorris M; Galet B; Palomares V; Brown J et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Cord blood-derived neuronal cells by ectopic expression of Sox2 and c-Myc.

2012-07 | Journal article
Contributors: Giorgetti A; Marchetto MC; Li M; Yu D; Fazzina R; Mu Y; Adamo A; Paramonov I; Cardoso JC; Monasterio MB et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Activation of adult-born neurons facilitates learning and memory.

2012-06 | Journal article
Contributors: Alonso M; Lepousez G; Sebastien W; Bardy C; Gabellec MM; Torquet N; Lledo PM
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Probing sporadic and familial Alzheimer's disease using induced pluripotent stem cells.

2012-02 | Journal article
Contributors: Israel MA; Yuan SH; Bardy C; Reyna SM; Mu Y; Herrera C; Hefferan MP; Van Gorp S; Nazor KL; Boscolo FS et al.
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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What happens to olfaction without adult neurogenesis?

2010 | Journal article
Contributors: Bardy C; Pallotto M
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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How, when, and where new inhibitory neurons release neurotransmitters in the adult olfactory bulb.

2010-12 | Journal article
Contributors: Bardy C; Alonso M; Bouthour W; Lledo PM
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Influence of 'feedback' signals on spatial integration in receptive fields of cat area 17 neurons.

2010-04 | Journal article
Contributors: Wang C; Huang JY; Bardy C; FitzGibbon T; Dreher B
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Contrast dependence of center and surround integration in primary visual cortex of the cat.

2009 | Journal article
Contributors: Wang C; Bardy C; Huang JY; FitzGibbon T; Dreher B
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Early synapse formation in developing interneurons of the adult olfactory bulb.

2009-12 | Journal article
Contributors: Panzanelli P; Bardy C; Nissant A; Pallotto M; Sassoè-Pognetto M; Lledo PM; Fritschy JM
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Adult neurogenesis promotes synaptic plasticity in the olfactory bulb.

2009-06 | Journal article
Contributors: Nissant A; Bardy C; Katagiri H; Murray K; Lledo PM
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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'Top-down' influences of ipsilateral or contralateral postero-temporal visual cortices on the extra-classical receptive fields of neurons in cat's striate cortex.

2009-01 | Journal article
Contributors: Bardy C; Huang JY; Wang C; Fitzgibbon T; Dreher B
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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'Simplification' of responses of complex cells in cat striate cortex: suppressive surrounds and 'feedback' inactivation.

2006-08 | Journal article
Contributors: Bardy C; Huang JY; Wang C; FitzGibbon T; Dreher B
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Modulatory effect of substance P to the brain stem locomotor command in lampreys.

2005-04 | Journal article
Contributors: Brocard F; Bardy C; Dubuc R
Source: Self-asserted source
Cedric Bardy via Europe PubMed Central
grade
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Peer review (14 reviews for 8 publications/grants)

Review activity for Advanced science. (2)
Review activity for BMC biology. (1)
Review activity for Brain, behavior, and immunity. (1)
Review activity for Developmental cell. (2)
Review activity for Nature communications (3)
Review activity for Nature neuroscience. (3)
Review activity for NPJ Parkinson's disease. (1)
Review activity for Signal transduction and targeted therapy. (1)