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SciProfiles: 2553407

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Czech Republic

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Employment (1)

Institute of Microbiology: Prague, CZ

Group leader
Employment
Source: Self-asserted source
David Funda

Professional activities (5)

Society for Mucosal Immunology: Milwaukee, Wisconsin, US

Membership
Source: Self-asserted source
David Funda

Federation Of Clinical Immunology Societies: Milwaukee, WI, US

Membership
Source: Self-asserted source
David Funda

European Association for the Study of Diabetes: Dusseldorf, Nordrhein-Westfalen, DE

Membership
Source: Self-asserted source
David Funda

Czech Immunological Society: Prague, CZ

Membership
Source: Self-asserted source
David Funda

American Diabetes Association: Alexandria, VA, US

Membership
Source: Self-asserted source
David Funda

Funding (6)

Nasal microbiome and molecular immune mechanisms in the prevention and pathogenesis of nasal polyps and chronic rhinitis, relation to olfactory disorders and allergies

2022-01-05 to 2025-12-31 | Grant
Ministry of Health (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.12856565
GRANT_NUMBER: NU22-09-00493
Source: Self-asserted source
David Funda via DimensionsWizard

How does gluten-free diet prevent type 1 diabetes?

2022-01-01 to 2024-12-31 | Grant
Czech Science Foundation (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.12944247
GRANT_NUMBER: GA22-21356S
Source: Self-asserted source
David Funda via DimensionsWizard

Immune mechanisms of gliadin/gluten in pathogenesis and prevention of type 1 diabetes: two immuno-preventive strategies for translation to humans.

2015-01-01 to 2018-12-31 | Grant
Czech Science Foundation (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.6891067
GRANT_NUMBER: GA15-24487S
Source: Self-asserted source
David Funda via DimensionsWizard

Probiotics, gut mucosa parameters and mucosal immunity as immuno-intervention strategy for prevention and/or early cure of type 1 diabetes.

2009-01-01 to 2013-12-31 | Grant
Czech Science Foundation (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.6891435
GRANT_NUMBER: GA310/09/1640
Source: Self-asserted source
David Funda via DimensionsWizard

Mechanisms of dietary gluten and xenobiotics in the prevention and pathogenesis of type 1. diabetes

2006-01-01 to 2008-12-31 | Grant
Czech Science Foundation (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.6891204
GRANT_NUMBER: GA303/06/1329
Source: Self-asserted source
David Funda via DimensionsWizard

Environmental factors, mucosal immunity and regulatory T cells in pathogenesis and prevention of type 1 diabetes (T1D)

2004-01-01 to 2007-12-31 | Grant
Czech Academy of Sciences (Prague, CZ)
URL: https://app.dimensions.ai/details/grant/grant.6891735
GRANT_NUMBER: IAA5020405
Source: Self-asserted source
David Funda via DimensionsWizard

Works (46)

Low-carbohydrate diet in children and young people with type 1 diabetes: A randomized controlled trial with cross-over design.

Diabetes research and clinical practice
2024-09-03 | Journal article
DOI: 10.1016/j.diabres.2024.111844
PMID: 39237039
Contributors: Neuman V; Plachy L; Drnkova L; Pruhova S; Kolouskova S; Obermannova B; Amaratunga SA; Maratova K; Kulich M; Havlik J et al.
Source: Self-asserted source
David Funda

Olfactory event-related potentials (OERPs) and trigeminal event-related potentials (TERPs) - a pilot study in Czech participants with normal sense of smell.

Journal of applied biomedicine
2023-12-07 | Journal article
DOI: 10.32725/jab.2023.020
PMID: 38112455
Contributors: Richard Holy; Janouskova K; Vasina L; Maute E; Kalfert D; Maminak K; Augste E; Hlozek J; Schulz H; Funda D et al.
Source: Self-asserted source
David Funda

Editorial: The gut-pancreas axis in type 1 diabetes - a focus on environmental factors.

Frontiers in endocrinology
2023-08-15 | Journal article
DOI: 10.3389/fendo.2023.1270297
PMID: 37654570
PMC: PMC10466039
Contributors: Tina Fløyel; Funda D; Dodero VI; Martin Haupt-Jorgensen
Source: Self-asserted source
David Funda

Reduced phosphatidylcholine level in the intestinal mucus layer of prediabetic NOD mice.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
2023-03-20 | Journal article
DOI: 10.1111/apm.13302
PMID: 36811202
Contributors: Mønsted MØ; Bilgin M; Kuzma M; Pelantová H; Kristina Pedersen; Tomášová P; Anastasiia Nazmutdinova; Šedivá B; Funda D; Castro-Mejía JL et al.
Source: Self-asserted source
David Funda

Protective Effect of Vegan Microbiota on Liver Steatosis Is Conveyed by Dietary Fiber: Implications for Fecal Microbiota Transfer Therapy

Nutrients
2023-01 | Journal article | Author
DOI: 10.3390/nu15020454
Contributors: Nikola Daskova; Marie Heczkova; Istvan Modos; Jaromír Hradecký; Tomas Hudcovic; Marek Kuzma; Helena Pelantová; Irena Buskova; Eva Sticova; David Funda et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Olfactory Evaluation in Clinical Medical Practice

Journal of Clinical Medicine
2022-11 | Journal article | Author
DOI: 10.3390/jcm11226628
Contributors: Květoslav Červený; Karla Janoušková; Kristýna Vaněčková; Šárka Zavázalová; David Funda; Jaromír Astl; Richard Holy
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 3)‎

Engineered human cytokine/antibody fusion proteins expand regulatory T cells and confer autoimmune disease protection.

Cell reports
2022-10-01 | Journal article
DOI: 10.1016/j.celrep.2022.111478
PMID: 36261022
PMC: PMC9631798
Contributors: VanDyke D; Iglesias M; Tomala J; Arabella Young; Smith J; Perry JA; Gebara E; Cross AR; Cheung LS; Dykema AG et al.
Source: Self-asserted source
David Funda

Local Angiotensin-Converting Enzyme 2 Gene Expression in Kidney Allografts Is Not Affected by Renin-Angiotensin-Aldosterone Inhibitors.

Kidney & blood pressure research
2021-03-23 | Journal article
DOI: 10.1159/000513710
PMID: 33756485
PMC: PMC8089425
Source: Self-asserted source
David Funda

Gluten-free diet in children with recent-onset type 1 diabetes: A 12-month intervention trial.

Diabetes, obesity & metabolism
2020-02-08 | Journal article
DOI: 10.1111/dom.13974
PMID: 31984648
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Optimal Tolerogenic Dendritic Cells in Type 1 Diabetes (T1D) Therapy: What Can We Learn From Non-obese Diabetic (NOD) Mouse Models?

Frontiers in immunology
2019-05-14 | Journal article
DOI: 10.3389/fimmu.2019.00967
PMID: 31139178
PMC: PMC6527741
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Human gut microbiota transferred to germ-free NOD mice modulate the progression towards type 1 diabetes regardless of the pace of beta cell function loss in the donor.

Diabetologia
2019-04-25 | Journal article
DOI: 10.1007/s00125-019-4869-2
PMID: 31025045
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Antigen Loading (e.g., Glutamic Acid Decarboxylase 65) of Tolerogenic DCs (tolDCs) Reduces Their Capacity to Prevent Diabetes in the Non-Obese Diabetes (NOD)-Severe Combined Immunodeficiency Model of Adoptive Cotransfer of Diabetes As Well As in NOD Mice.

Frontiers in immunology
2018-02-16 | Journal article
DOI: 10.3389/fimmu.2018.00290
PMID: 29503651
PMC: PMC5820308
Source: Self-asserted source
David Funda

Cell-based Tolerogenic Therapy, Experience from Animal Models of Multiple Sclerosis, Type 1 Diabetes and Rheumatoid Arthritis.

Current pharmaceutical design
2017-01-01 | Journal article
DOI: 10.2174/1381612823666170214120708
PMID: 28201972
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Tolerogenic Dendritic Cells from Poorly Compensated Type 1 Diabetes Patients Have Decreased Ability To Induce Stable Antigen-Specific T Cell Hyporesponsiveness and Generation of Suppressive Regulatory T Cells.

Journal of immunology (Baltimore, Md. : 1950)
2016-12-07 | Journal article
DOI: 10.4049/jimmunol.1600676
PMID: 27927966
Source: Self-asserted source
David Funda

Gluten-Free Diet Only during Pregnancy Efficiently Prevents Diabetes in NOD Mouse Offspring.

Journal of diabetes research
2016-08-25 | Journal article
DOI: 10.1155/2016/3047574
PMID: 27642610
PMC: PMC5014974
Source: Self-asserted source
David Funda

Dietary gluten and the development of type 1 diabetes.

Diabetologia
2014-05-29 | Journal article
DOI: 10.1007/s00125-014-3265-1
PMID: 24871322
PMC: PMC4119241
Source: Self-asserted source
David Funda

Prevention or early cure of type 1 diabetes by intranasal administration of gliadin in NOD mice.

PloS one
2014-04-11 | Journal article
DOI: 10.1371/journal.pone.0094530
PMID: 24728138
PMC: PMC3984166
Source: Self-asserted source
David Funda

Pepsin digest of wheat gliadin fraction increases production of IL-1β via TLR4/MyD88/TRIF/MAPK/NF-κB signaling pathway and an NLRP3 inflammasome activation.

PloS one
2013-04-29 | Journal article
DOI: 10.1371/journal.pone.0062426
PMID: 23658628
PMC: PMC3639175
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Dietary gluten alters the balance of pro-inflammatory and anti-inflammatory cytokines in T cells of BALB/c mice.

Immunology
2013-01-01 | Journal article
DOI: 10.1111/imm.12007
PMID: 22913724
Source: Self-asserted source
David Funda

Increased expression of chemokine receptors CCR1 and CCR3 in nasal polyps: molecular basis for recruitment of the granulocyte infiltrate.

Folia microbiologica
2012-10-11 | Journal article
DOI: 10.1007/s12223-012-0194-6
PMID: 23054685
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Impact of dietary gluten on regulatory T cells and Th17 cells in BALB/c mice.

PloS one
2012-03-13 | Journal article
DOI: 10.1371/journal.pone.0033315
PMID: 22428018
PMC: PMC3302844
Source: Self-asserted source
David Funda

The role of gut microbiota (commensal bacteria) and the mucosal barrier in the pathogenesis of inflammatory and autoimmune diseases and cancer: contribution of germ-free and gnotobiotic animal models of human diseases.

Cellular & molecular immunology
2011-01-31 | Journal article
DOI: 10.1038/cmi.2010.67
PMID: 21278760
PMC: PMC4003137
Source: Self-asserted source
David Funda

A subset of human pancreatic beta cells express functional CD14 receptors: a signaling pathway for beta cell-related glycolipids, sulfatide and β-galactosylceramide.

Diabetes/metabolism research and reviews
2010-10-14 | Journal article
DOI: 10.1002/dmrr.1134
PMID: 20949640
Source: Self-asserted source
David Funda

Expression of IGF-1R and iNOS in nasal polyps; epithelial cell homeostasis and innate immune mechanisms in pathogenesis of nasal polyposis.

Folia microbiologica
2008-01-01 | Journal article
DOI: 10.1007/s12223-008-0089-8
PMID: 19381485
Source: Self-asserted source
David Funda

Gluten-free but also gluten-enriched (gluten+) diet prevent diabetes in NOD mice; the gluten enigma in type 1 diabetes.

Diabetes/metabolism research and reviews
2008-01-01 | Journal article
DOI: 10.1002/dmrr.748
PMID: 17607660
Source: Self-asserted source
David Funda

TCR gamma delta intraepithelial lymphocytes are required for self-tolerance.

Journal of immunology (Baltimore, Md. : 1950)
2006-06-01 | Journal article
DOI: 10.4049/jimmunol.176.11.6553
PMID: 16709812
Source: Self-asserted source
David Funda

Diabetes preventive gluten-free diet decreases the number of caecal bacteria in non-obese diabetic mice.

Diabetes/metabolism research and reviews
2006-05-01 | Journal article
DOI: 10.1002/dmrr.609
PMID: 16355418
Source: Self-asserted source
David Funda

TCR-mediated activation promotes GITR upregulation in T cells and resistance to glucocorticoid-induced death.

International immunology
2004-07-19 | Journal article
DOI: 10.1093/intimm/dxh134
PMID: 15262900
Source: Self-asserted source
David Funda

Commensal bacteria (normal microflora), mucosal immunity and chronic inflammatory and autoimmune diseases.

Immunology letters
2004-05-01 | Journal article
DOI: 10.1016/j.imlet.2004.02.005
PMID: 15158604
Source: Self-asserted source
David Funda

Vaccination studies in type 1 diabetes.

Lancet (London, England)
2002-08-01 | Journal article
DOI: 10.1016/s0140-6736(02)09646-0
PMID: 12241742
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎

Mucosal immunity: its role in defense and allergy.

International archives of allergy and immunology
2002-06-01 | Journal article
DOI: 10.1159/000059397
PMID: 12065907
Source: Self-asserted source
David Funda

CD14 is expressed and released as soluble CD14 by human intestinal epithelial cells in vitro: lipopolysaccharide activation of epithelial cells revisited.

Infection and immunity
2001-06-01 | Journal article
DOI: 10.1128/iai.69.6.3772-3781.2001
PMID: 11349042
PMC: PMC98389
Source: Self-asserted source
David Funda

Gluten-free diet prevents diabetes in NOD mice.

Diabetes/metabolism research and reviews
1999-09-01 | Journal article
DOI: 10.1002/(sici)1520-7560(199909/10)15:5<323::aid-dmrr53>3.0.co;2-p
PMID: 10585617
Source: Self-asserted source
David Funda

Effect of intrathymic administration of mycobacterial heat shock protein 65 and peptide p277 on the development of diabetes in NOD mice: caution required in vaccination studies.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
1998-10-01 | Journal article
DOI: 10.1111/j.1699-0463.1998.tb00253.x
PMID: 9833705
Source: Self-asserted source
David Funda

Autoimmunity, immunodeficiency and mucosal infections: chronic intestinal inflammation as a sensitive indicator of immunoregulatory defects in response to normal luminal microflora.

Folia microbiologica
1998-01-01 | Journal article
DOI: 10.1007/bf02820817
PMID: 9821323
Source: Self-asserted source
David Funda

Brush border enzyme activities in the small intestine after long-term gliadin feeding in animal models of human coeliac disease.

Folia microbiologica
1998-01-01 | Journal article
DOI: 10.1007/bf02820803
PMID: 9821309
Source: Self-asserted source
David Funda

Differences in thermoregulation between immunocompetent and immunodeficient hairless mice exposed to mild cold.

Folia microbiologica
1998-01-01 | Journal article
DOI: 10.1007/bf02820799
PMID: 9821305
Source: Self-asserted source
David Funda

Enhancement by mild cold stress of the antibody forming capacity in euthymic and athymic hairless mice.

Folia microbiologica
1998-01-01 | Journal article
DOI: 10.1007/bf02820811
PMID: 9821317
Source: Self-asserted source
David Funda

Shifts of lymphoid and phagocytic cell populations during mild cold acclimation in hairless mice.

Folia microbiologica
1998-01-01 | Journal article
DOI: 10.1007/bf02820797
PMID: 9821303
Source: Self-asserted source
David Funda

Autoimmune reactions induced by gliadin feeding in germ-free AVN rats and athymic nude mice. Animal models for celiac disease.

Annals of the New York Academy of Sciences
1997-04-01 | Journal article
DOI: 10.1111/j.1749-6632.1997.tb52115.x
PMID: 9186710
Source: Self-asserted source
David Funda

Essential fatty acid deficiency and bone fragility in rats.

Folia biologica
1996-01-01 | Journal article
PMID: 8997644
Source: Self-asserted source
David Funda

Age-related changes in T gamma delta cells of NOD mice.

Immunology letters
1995-03-01 | Journal article
DOI: 10.1016/0165-2478(95)00003-n
PMID: 7558171
Source: Self-asserted source
David Funda

The gut as a lymphoepithelial organ: the role of intestinal epithelial cells in mucosal immunity.

Folia microbiologica
1995-01-01 | Journal article
DOI: 10.1007/bf02814746
PMID: 8763152
Source: Self-asserted source
David Funda

Hairlessness does not influence growth retardation in nude mice. Computer image analysis study.

Folia biologica
1994-01-01 | Journal article
PMID: 7805935
Source: Self-asserted source
David Funda

Development of the cellular response in the mouse omentum after intraperitoneal immunization.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
1993-12-01 | Journal article
DOI: 10.1111/j.1699-0463.1993.tb00205.x
PMID: 8110451
Source: Self-asserted source
David Funda

Ossification in nude mice. 2. A histological, histochemical and immunohistochemical study.

APMIS : acta pathologica, microbiologica, et immunologica Scandinavica
1991-11-01 | Journal article
PMID: 1793459
Source: Self-asserted source
David Funda
grade
Preferred source (of 2)‎
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