Abigail Saffron Tucker (0000-0001-8871-6094)

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Biography

Abigail Tucker obtained her DPhil from Oxford University in 1996 in the lab of Prof Jonathan Slack. She then worked as a post-doctoral fellow at Guy’s Hospital, London, in the labs of Prof Paul Sharpe and Prof Andrew Lumsden. Here she started her interest in embryonic development of the head. She set up her own lab as a Wellcome Trust Research Career Development fellow in 1999 in the MRC centre for Developmental Neurobiology at King’s. In 2002 she moved to her current position as Lecturer in the department of Craniofacial Development within the Dental Institute at King’s College London and was promoted to Senior Lecturer in 2007, to Reader in 2012 and to full Professor in 2015.

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King's College London: London, GB

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Abigail Saffron Tucker

https://orcid.org/0000-0001-8871-6094

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Employment (2)

King's College London: London, GB

King's College London: London, London, GB

Education and qualifications (3)

King's College London: London, London, GB

Oxford University: Oxford, GB

University of Oxford: Oxford, Oxfordshire, GB

Professional activities (5)

Royal Society of Biology: London, GB

Higher Education Academy: York, North Yorkshire, GB

Genetics Society: London, GB

Anatomical Society: London, GB

British society Developmental Biology: London, GB

Funding (17)

Cellular and sub-cellular sampling using laser capture microdissection to understand disease mechanisms

Understanding and enhancing repair of the tympanic membrane

Analysis of the tissue and temporal specific role of Eya1 in ear development and its contribution to hearing loss

Fate decisions in the dental placode: an investigation into the signaling factors that determine cell fate decisions in the early oral cavity

An investigation of the development of the stapes, annular ligament and otosclerosis

Investigating the etiology of cholesteatoma

High resolution microCT

Newton001: Salivary gland development and regeneration

Analysis of the impact of ossicular defects on hearing

Consequences of the dual origin of the middle ear epithelium on function.

A new mouse model for investigating xerostomia

Evolution of mammals: a comparative study of the developing middle ear

Cause of Otitis media in a new mouse model

Middle ear cavitation and mesenchymal clearance: links with deafness and otitis media

A multiuser confocal laser scanning microscope for live and 3-D imaging of craniofacial cellular dynamics

Genetics and morphology of the middle ear ossicles in the developing mouse embryo

The role of the rhombencephalic neural crest in patterning of the branchial arches. (Supplement to existing award).

Works (50 of 211)

FSP1/S100A4-Expressing Stem/Progenitor Cells Are Essential for Temporomandibular Joint Growth and Homeostasis

Divergent patterns of cranial suture fusion in marsupial and placental mammals

Sprouty2/4 deficiency disrupts AER integrity and ZPA cell migration impacting chondrogenesis of the mouse forelimb

Tracking Cell Layer Contribution During Repair of the Tympanic Membrane

Postnatal dentition changes in the Cuban false chameleons: adaptation to a dietary shift

Metalloproteinases are involved in the regulation of prenatal tooth morphogenesis

Divergent patterns of cranial suture fusion in marsupial and placental mammals

CACNA1S mutation-associated dental anomalies

Tracking cell layer contribution during repair of the tympanic membrane

Spatiotemporal monitoring of hard tissue development reveals unknown features of tooth and bone development

Tracking Cell Layer Contribution During Repair of the Tympanic Membrane

Pedomorphosis in the ancestry of marsupial mammals

Wnt signaling from Gli1-expressing apical stem/progenitor cells is essential for the coordination of tooth root development

Molecular profiling of the vestibular lamina highlights a key role for Hedgehog signalling

Genetic Variants in Protein Tyrosine Phosphatase Non-Receptor Type 23 Are Responsible for Mesiodens Formation

Getting out of a mammalian egg: the egg tooth and caruncle of the echidna

Nuclear Receptor Nr5a2 Promotes Diverse Connective Tissue Fates in the Jaw

Mechanisms driving vestibular lamina formation and opening in the mouse

A conserved tooth resorption mechanism in modern and fossil snakes

Evolution and development of the mammalian jaw joint: Making a novel structure

Eda controls the size of the enamel knot during incisor development

Salivary Gland Development in Culture

Identification and characterisation of spontaneous mutations causing deafness from a targeted knockout programme

Mutations in LRP6 highlight the role of WNT signaling in oral exostoses and dental anomalies

The interconnected relationships between middle ear bulla size, cavitation defects and chronic otitis media revealed in a syndromic mouse model

Mechanisms driving vestibular lamina formation and opening in the mouse

Endothelial cells during craniofacial development

Expanding genotypic and phenotypic spectrums of LTBP3 variants in dental anomalies and short stature syndrome

A mesenchymal to epithelial switch in Fgf10 expression specifies an evolutionary-conserved population of ionocytes in salivary glands

Getting out of a mammalian egg: the egg tooth and caruncle of the echidna

Editorial

Comparing development and regeneration in the submandibular gland highlights distinct mechanisms

Characteristics of aquaporin 1, 3, and 5 expression during early murine salivary gland development

The intertwined evolution and development of sutures and cranial morphology

Craniofacial transitions: the role of EMT and MET during head development

B.BerkovitzR. P.ShellisThe Teeth of Mammalian Vertebrates. Elsevier, published 17th August 2018. Hardcover ISBN:9780128028186. eBook ISBN:9780128028193.

Inhibition of Aurora Kinase B activity disrupts development and differentiation of salivary glands.