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Acclimation of Hairless Spontaneously Hypertensive Rat to Ambient Temperature Attenuates Hypertension-Induced Pro-Arrhythmic Downregulation of Cx43 in the Left Heart Ventricle of Males

Biomolecules
2024-11 | Journal article | Author
DOI: 10.3390/biom14121509
Contributors: Katarína Andelová; Matus Sykora; Veronika Farkasova; Tatiana Stankovicova; Barbara Szeiffova Bacova; Vladimir Knezl; Tamara Egan Benova; Michal Pravenec; Narcis Tribulova
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Multidisciplinary Digital Publishing Institute

Hypolipidemic Effects of Beetroot Juice in SHR-CRP and HHTg Rat Models of Metabolic Syndrome: Analysis of Hepatic Proteome

Metabolites
2023-01 | Journal article | Author
DOI: 10.3390/metabo13020192
Contributors: Jan Šilhavý; Petr Mlejnek; Miroslava Šimáková; Hana Malinska; Irena Markova; Martina Hüttl; Denisa Miklánková; Ludmila Kazdova; Marek Vrbacký; Alena Pecinová et al.
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Multidisciplinary Digital Publishing Institute

Beneficial Effects of Empagliflozin Are Mediated by Reduced Renal Inflammation and Oxidative Stress in Spontaneously Hypertensive Rats Expressing Human C-Reactive Protein

Biomedicines
2022-08 | Journal article | Author
DOI: 10.3390/biomedicines10092066
Contributors: Hana Malinska; Martina Hüttl; Irena Markova; Denisa Miklánková; Silvie Hojná; František Papoušek; Jan Šilhavý; Petr Mlejnek; Josef Zicha; Jaroslav Hrdlička et al.
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Multidisciplinary Digital Publishing Institute

Sodium Accumulation and Blood Capillary Rarefaction in the Skin Predispose Spontaneously Hypertensive Rats to Salt Sensitive Hypertension

Biomedicines
2022-02 | Journal article | Author
DOI: 10.3390/biomedicines10020376
Contributors: Jan Šilhavý; Petr Mlejnek; Miroslava Šimáková; Frantisek Liska; Jan Kubovčiak; Eva Sticová; Michal Pravenec
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Multidisciplinary Digital Publishing Institute

A trans locus causes a ribosomopathy in hypertrophic hearts that affects mRNA translation in a protein length-dependent fashion

Genome Biology
2021 | Journal article
DOI: 10.1186/S13059-021-02397-W
WOSUID: WOS:000669599400002
Contributors: Witte, Franziska; Ruiz-Orera, Jorge; Mattioli, Camilla Ciolli; Blachut, Susanne; Adami, Eleonora; Schulz, Jana Felicitas; Schneider-Lunitz, Valentin; Hummel, Oliver; Patone, Giannino; Mucke, Michael Benedikt et al.
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Excess ischemic tachyarrhythmias trigger protection against myocardial infarction in hypertensive rats

Clinical Science
2021 | Journal article
DOI: 10.1042/CS20210648
WOSUID: WOS:000702536100001
Contributors: Neckar, Jan; Alanova, Petra; Olejnickova, Veronika; Papousek, Frantisek; Hejnova, Lucie; Silhavy, Jan; Behuliak, Michal; Bencze, Michal; Hrdlicka, Jaroslav; Vecka, Marek et al.
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Hepatic Transcriptome Profiling Reveals Lack of <i>Acsm3</i> Expression in Polydactylous Rats with High-Fat Diet-Induced Hypertriglyceridemia and Visceral Fat Accumulation

Nutrients
2021 | Journal article
DOI: 10.3390/NU13051462
WOSUID: WOS:000662434800001
Contributors: Junkova, Kristyna; Mirchi, Lukas F.; Chylikova, Blanka; Janku, Michaela; Silhavy, Jan; Huttl, Martina; Markova, Irena; Miklankova, Denisa; Vcelak, Josef; Malinska, Hana et al.
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High Cysteine Diet Reduces Insulin Resistance in SHR-CRP Rats

Physiological Research
2021 | Journal article
DOI: 10.33549/PHYSIOLRES.934736
WOSUID: WOS:000729810300003
Contributors: Krijt, Jakub; Sokolova, Jitka; Silhavy, Jan; Mlejnek, Petr; Kubovciak, Jan; Liska, Frantisek; Malinska, Hana; Huettl, Martina; Markova, Irena; Krizkova, Michaela et al.
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No evidence of racial disparities in blood pressure salt sensitivity when potassium intake exceeds levels recommended in the US dietary guidelines

American Journal of Physiology-Heart and Circulatory Physiology
2021 | Journal article
DOI: 10.1152/AJPHEART.00980.2020
WOSUID: WOS:000661571000001
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis, Jr.
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Rat PRDM9 shapes recombination landscapes, duration of meiosis, gametogenesis, and age of fertility

BMC Biology
2021 | Journal article
DOI: 10.1186/S12915-021-01017-0
WOSUID: WOS:000645247100001
Contributors: Mihola, Ondrej; Landa, Vladimir; Pratto, Florencia; Brick, Kevin; Kobets, Tatyana; Kusari, Fitore; Gasic, Srdjan; Smagulova, Fatima; Grey, Corinne; Flachs, Petr et al.
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Downregulation of the Glo1 Gene Is Associated with Reduced Adiposity and Ectopic Fat Accumulation in Spontaneously Hypertensive Rats

Antioxidants
2020 | Journal article
DOI: 10.3390/ANTIOX9121179
WOSUID: WOS:000601827500001
Contributors: Silhavy, Jan; Malinska, Hana; Huttl, Martina; Markova, Irena; Oliyarnyk, Olena; Mlejnek, Petr; Simakova, Miroslava; Liska, Frantisek; Kazdova, Ludmila; Moravcova, Radka et al.
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Effect of metformin on the progression of post-ischemic heart failure in transgenic spontaneously hypertensive rats expressing human C-reactive protein

Journal of Molecular and Cellular Cardiology
2020 | Journal article
DOI: 10.1016/J.YJMCC.2019.11.014
WOSUID: WOS:000589265500013
Contributors: Hrdlicka, Jaroslav; Papousek, Frantisek; Silhavy, Jan; Akat, Firat; Pravenec, Michal; Kolar, Frantisek; Neckar, Jan
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Strategies Are Needed to Prevent Salt-Induced Hypertension That Do Not Depend on Reducing Salt Intake

American Journal of Hypertension
2020 | Journal article
DOI: 10.1093/AJH/HPZ173
WOSUID: WOS:000518548300004
Contributors: Kurtz, Theodore W.; Pravenec, Michal; Dicarlo, Stephen E.
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Targeting of the Plzf Gene in the Rat by Transcription Activator-Like Effector Nuclease Results in Caudal Regression Syndrome in Spontaneously Hypertensive Rats (vol 11, e0164206, 2016)

Plos One
2020 | Journal article
DOI: 10.1371/JOURNAL.PONE.0228139
WOSUID: WOS:000534370100086
Contributors: Liska, Frantisek; Peterkova, Renata; Peterka, Miroslav; Landa, Vladimir; Zidek, Vaclav; Mlejnek, Petr; Silhavy, Jan; Simakova, Miroslava; Kren, Vladimi; Starker, Colby G. et al.
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Cardioprotective Regimen of Adaptation to Chronic Hypoxia Diversely Alters Myocardial Gene Expression in SHR and SHR-mt(BN) Conplastic Rat Strains

Frontiers in Endocrinology
2019 | Journal article
DOI: 10.3389/FENDO.2018.00809
WOSUID: WOS:000456247700001
Contributors: Nedvedova, Iveta; Kolar, David; Neckar, Jan; Kalous, Martin; Pravenec, Michel; Silhavil, Jan; Korenkova, Vlasta; Kolar, Frantisek; Zurmanova, Jitka M.
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Changing views on the common physiologic abnormality that mediates salt sensitivity and initiation of salt-induced hypertension: Japanese research underpinning the vasodysfunction theory of salt sensitivity

Hypertension Research
2019 | Journal article
DOI: 10.1038/S41440-018-0122-5
WOSUID: WOS:000455031100001
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis
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Ethnicity-Specific Skeletal Muscle Transcriptional Signatures and Their Relevance to Insulin Resistance in Singapore

The Journal of Clinical Endocrinology & Metabolism
2019 | Journal article
DOI: 10.1210/JC.2018-00309
WOSUID: WOS:000462864100032
Contributors: Tan, Amelia Li Min; Langley, Sarah R.; Tan, Chee Fan; Chai, Jin Fang; Khoo, Chin Meng; Leow, Melvin Khee-Shing; Khoo, Eric Yin Hao; Moreno-Moral, Aida; Pravenec, Michal; Rotival, Maxime et al.
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Small Amounts of Inorganic Nitrate or Beetroot Provide Substantial Protection From Salt-Induced Increases in Blood Pressure

Hypertension
2019 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.118.12234
WOSUID: WOS:000469352400023
Contributors: Morris, R. Curtis, Jr.; Morris, R. Curtis, Jr.; Pravenec, Michal; Pravenec, Michal; Silhavy, Jan; Silhavy, Jan; DiCarlo, Stephen E.; DiCarlo, Stephen E.; Kurtz, Theodore W.; Kurtz, Theodore W.
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Transgenic overexpression of glutathione <i>S</i>-transferase μ-type 1 reduces hypertension and oxidative stress in the stroke-prone spontaneously hypertensive rat

Journal of Hypertension
2019 | Journal article
DOI: 10.1097/HJH.0000000000001960
WOSUID: WOS:000473104200015
Contributors: Olson, Erin; Pravenec, Michal; Landa, Vladimir; Koh-Tan, H. H. Caline; Dominiczak, Anna F.; McBride, Martin W.; Graham, Delyth
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VERY SMALL AMOUNTS OF INORGANIC NITRATE OR BEETROOT PROVIDE SUBSTANTIAL PROTECTION FROM SALT-INDUCED INCREASES IN BLOOD PRESSURE

Journal of Hypertension
2019 | Journal article
DOI: 10.1097/01.HJH.0000571608.64585.83
WOSUID: WOS:000481429700340
Contributors: Silhavy, J.; Morris, R. C., Jr.; Pravenec, M.; Dicarlo, S. E.; Mlejnek, P.; Simakova, M.; Kurtz, T. W.
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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-11551-9
WOSUID: WOS:000480234600007
Contributors: Chen, Huimei; Moreno-Moral, Aida; Pesce, Francesco; Devapragash, Nithya; Mancini, Massimilano; Heng, Ee Ling; Rotival, Maxime; Srivastava, Prashant K.; Harmston, Nathan; Shkura, Kirill et al.
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WWP2 regulates pathological cardiac fibrosis by modulating SMAD2 signaling (vol 10, 3616, 2019)

Nature Communications
2019 | Journal article
DOI: 10.1038/S41467-019-12060-5
WOSUID: WOS:000484780000003
Contributors: Chen, Huimei; Moreno-Moral, Aida; Pesce, Francesco; Devapragash, Nithya; Mancini, Massimiliano; Heng, Ee Ling; Rotival, Maxime; Srivastava, Prashant K.; Harmston, Nathan; Shkura, Kirill et al.
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Acute Toxic Effects of Telmisartan in Spontaneously Hypertensive Rats Fed a High Fructose Diet

Physiological Research
2018 | Journal article
DOI: 10.33549/PHYSIOLRES.933951
WOSUID: WOS:000453554300002
Contributors: Silhavy, J.; Mlejnek, P.; Simakova, M.; Vaneckova, I; Behuliak, M.; Kuda, O.; Sticova, E.; Jirsa, M.; Pravenec, M.
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Cardiac ischemic tolerance of spontaneously hypertensive rats with increased expression of C-reactive protein

The FASEB Journal
2018 | Journal article
DOI: 10.1093/CVR/CVY060.061
WOSUID: WOS:000405986504443
Contributors: Neckar, Jan; Papousek, Frantisek; Silhavy, Jan; Pravenec, Michal; Kolar, Frantisek
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Changes in the activity of some metabolic enzymes in the heart of SHR rat incurred by transgenic expression of CD36

Journal of Physiology and Biochemistry
2018 | Journal article
DOI: 10.1007/S13105-018-0641-1
WOSUID: WOS:000440827500011
Contributors: Manakov, Dmitry; Kolar, David; Zurmanova, Jitka; Pravenec, Michal; Novotny, Jiri
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Dissecting the Role of <i>Folr1</i> and <i>Folh1</i> Genes in the Pathogenesis of Metabolic Syndrome in Spontaneously Hypertensive Rats

Physiological Research
2018 | Journal article
DOI: 10.33549/PHYSIOLRES.933932
WOSUID: WOS:000442016100014
Contributors: Silhavy, J.; Krijt, J.; Sokolova, J.; Zidek, V; Mlejnek, P.; Simakova, M.; Skop, V; Trnovska, J.; Oliyarnyk, O.; Markova, I et al.
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Functional foods for augmenting nitric oxide activity and reducing the risk for salt-induced hypertension and cardiovascular disease in Japan

Journal of Cardiology
2018 | Journal article
DOI: 10.1016/J.JJCC.2018.02.003
WOSUID: WOS:000442063100006
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis
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Genetically Determined Folate Deficiency Is Associated With Abnormal Hepatic Folate Profiles in the Spontaneously Hypertensive Rat

Physiological Research
2018 | Journal article
DOI: 10.33549/PHYSIOLRES.933897
WOSUID: WOS:000439466000006
Contributors: Pravenec, M.; Leung, K-Y; Zidek, V; Mlejnek, P.; Simakova, M.; Silhavy, J.; Kozich, V; Greene, N. D. E.
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Mechanisms of salt sensitivity of blood pressure: an unbiased approach to skinning a cat Reply

Journal of Hypertension
2018 | Journal article
DOI: 10.1097/HJH.0000000000001637
WOSUID: WOS:000429317500034
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis, Jr.
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Mitochondrial genome modulates myocardial Akt/Glut/HK salvage pathway in spontaneously hypertensive rats adapted to chronic hypoxia

Physiological Genomics
2018 | Journal article
DOI: 10.1152/PHYSIOLGENOMICS.00040.2017
WOSUID: WOS:000440973800006
Contributors: Nedvedova, Iveta; Kolar, David; Elsnicova, Barbara; Hornikova, Daniela; Novotny, Jiri; Kalous, Martin; Pravenec, Michal; Neckar, Jan; Kolar, Frantisek; Zurmanova, Jitka M.
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PREDICTING THE PATHWAYS FROM THE GENOME TO PHENOTYPE USING A SYSTEMS GENETIC APPROACH

Alcoholism: Clinical and Experimental Research
2018 | Journal article
WOSUID: WOS:000443221502011
Contributors: Tabakoff, B.; Saba, L. M.; Yu, Y.; Mahaffey, S.; Lusk, R.; Pravenec, M.; Vanderlinden, L. A.; Hoffman, P. L.
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Systems genetic analysis of brown adipose tissue function

Physiological Genomics
2018 | Journal article
DOI: 10.1152/PHYSIOLGENOMICS.00091.2017
WOSUID: WOS:000425922500005
Contributors: Pravenec, Michal; Saba, Laura M.; Zidek, Vaclav; Landa, Vladimir; Mlejnek, Petr; Silhavy, Jan; Simakova, Miroslava; Strnad, Hynek; Trnovska, Jaroslava; Skop, Vojtech et al.
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Systems Genetics Approaches in Rat Identify Novel Genes and Gene Networks Associated With Cardiac Conduction

Journal of the American Heart Association
2018 | Journal article
DOI: 10.1161/JAHA.118.009243
WOSUID: WOS:000452823800010
Contributors: Adriaens, Michiel E.; Lodder, Elisabeth M.; Moreno-Moral, Aida; Silhavy, Jan; Heinig, Matthias; Glinge, Charlotte; Belterman, Charly; Wolswinkel, Rianne; Petretto, Enrico; Pravenec, Michal et al.
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Testing Computer Models Predicting Human Responses to a High-Salt Diet: Implications for Understanding Mechanisms of Salt-Sensitive Hypertension

Hypertension
2018 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.118.11552
WOSUID: WOS:000449404600025
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Jezek, Filip; Silar, Jan; Kofranek, Jiri; Morris, R. Curtis, Jr.
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THE EXPRESSION OF CONNEXIN 37 GENE IN THE AORTA OF RAT MODELS OF DYSLIPIDEMIA, HYPERTENSION AND DICARBONYL STRESS

Atherosclerosis
2018 | Journal article
DOI: 10.1016/J.ATHEROSCLEROSIS.2018.06.560
WOSUID: WOS:000442512600572
Contributors: Markova, I.; Pitha, J.; Pravenec, M.
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The pivotal role of renal vasodysfunction in salt sensitivity and the initiation of salt-induced hypertension

Current Opinion in Nephrology and Hypertension
2018 | Journal article
DOI: 10.1097/MNH.0000000000000394
WOSUID: WOS:000429661000005
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis, Jr.
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A SYSTEMS GENETIC APPROACH FOR ELUCIDATING THE GENETICS OF DIFFERENTIAL ACETATE EXPOSURE

Alcoholism: Clinical and Experimental Research
2017 | Journal article
WOSUID: WOS:000402419601288
Contributors: Lusk, R.; Vanderlinden, L.; Pravenec, M.; Saba, L. M.; Hoffman, P. L.; Tabakoff, B.
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An Appraisal of Methods Recently Recommended for Testing Salt Sensitivity of Blood Pressure

Journal of the American Heart Association
2017 | Journal article
DOI: 10.1161/JAHA.117.005653
WOSUID: WOS:000404098500059
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis, Jr.
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AUTOCRINE EFFECTS OF TRANSGENIC RESISTIN ON BROWN ADIPOSE TISSUE GLUCOSE AND LIPID METABOLISM

Atherosclerosis
2017 | Journal article
DOI: 10.1016/J.ATHEROSCLEROSIS.2017.06.235
WOSUID: WOS:000407634000202
Contributors: Trnovska, Jaroslava; Pravenec, Michal; Silhavy, Jan; Strnad, Hynek; Eigner, Sebastian; Henke, Katerina Eigner; Skop, Vojtech; Malinska, Hana; Kazdova, Ludmila; Drahota, Zdenek et al.
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Connexin 50 Mutation Lowers Blood Pressure in Spontaneously Hypertensive Rat

Physiological Research
2017 | Journal article
DOI: 10.33549/PHYSIOLRES.933432
WOSUID: WOS:000398620000002
Contributors: Seda, O.; Liska, F.; Pravenec, M.; Vernerova, Z.; Kazdova, L.; Krenova, D.; Zidek, V.; Sedova, L.; Krupkova, M.; Kren, V.
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DISSECTING A GENETIC LINK BETWEEK GLUCOSE METABOLISM IN BROWN ADIPOSE TISSUE AND ALCOHOL CLEARANCE

Alcoholism: Clinical and Experimental Research
2017 | Journal article
WOSUID: WOS:000402419601287
Contributors: Smith, H. S.; Saba, L. M.; Vanderlinden, L.; Pravenec, M.; Hoffman, P. L.; Tabakoff, B.
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Downregulation of <i>Plzf</i> Gene Ameliorates Metabolic and Cardiac Traits in the Spontaneously Hypertensive Rat

Hypertension
2017 | Journal article
DOI: 10.1161/HYPERTENSIONAHA.116.08798
WOSUID: WOS:000400993600069
Contributors: Liska, Frantisek; Landa, Vladimir; Zidek, Vaclav; Mlejnek, Petr; Silhavy, Jan; Simakova, Miroslava; Strnad, Hynek; Trnovska, Jaroslava; Skop, Vojtech; Kazdova, Ludmila et al.
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Genetic, physiological and comparative genomic studies of hypertension and insulin resistance in the spontaneously hypertensive rat

Disease Models & Mechanisms
2017 | Journal article
DOI: 10.1242/DMM.026716
WOSUID: WOS:000395717100009
Contributors: Coan, Philip M.; Hummel, Oliver; Diaz, Ana Garcia; Barrier, Marjorie; Alfazema, Neza; Norsworthy, Penny J.; Pravenec, Michal; Petretto, Enrico; Huebner, Norbert; Aitman, Timothy J.
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Mutant <i>Wars2</i> Gene in Spontaneously Hypertensive Rats Impairs Brown Adipose Tissue Function and Predisposes to Visceral Obesity

Physiological Research
2017 | Journal article
DOI: 10.33549/PHYSIOLRES.933811
WOSUID: WOS:000419545200002
Contributors: Pravenec, M.; Zidek, V.; Landa, V.; Mlejnek, P.; Silhavy, J.; Simakova, M.; Trnovska, J.; Skop, V.; Markova, I.; Malinska, H. et al.
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Salsalate ameliorates metabolic disturbances by reducing inflammation in spontaneously hypertensive rats expressing human C-reactive protein and by activating brown adipose tissue in nontransgenic controls

Plos One
2017 | Journal article
DOI: 10.1371/JOURNAL.PONE.0179063
WOSUID: WOS:000402875700044
Contributors: Trnovska, Jaroslava; Silhavy, Jans; Kuda, Ondrej; Landa, Vladimir; Zidek, Vaclav; Mlejnek, Petr; Slimakova, Miroslava; Strnad, Hynek; Skop, Vojtech; Oliyarnyk, Olena et al.
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Selective replacement of mitochondrial DNA increases the cardioprotective effect of chronic continuous hypoxia in spontaneously hypertensive rats

Clinical Science
2017 | Journal article
DOI: 10.1042/CS20170083
WOSUID: WOS:000399576600007
Contributors: Neckar, Jan; Svatonova, Anna; Weissova, Romana; Drahota, Zdenek; Zajickova, Pavlina; Brabcova, Iveta; Kolar, David; Alanova, Petra; Vasinova, Jana; Silhavy, Jan et al.
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The American Heart Association Scientific Statement on salt sensitivity of blood pressure: Prompting consideration of alternative conceptual frameworks for the pathogenesis of salt sensitivity?

Journal of Hypertension
2017 | Journal article
DOI: 10.1097/HJH.0000000000001458
WOSUID: WOS:000411899000016
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Morris, R. Curtis, Jr.
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<i>Wars2</i> is a determinant of angiogenesis

Nature Communications
2016 | Journal article
DOI: 10.1038/NCOMMS12061
WOSUID: WOS:000380304400001
Contributors: Wang, Mao; Sips, Patrick; Khin, Ester; Rotival, Maxime; Sun, Ximing; Ahmed, Rizwan; Widjaja, Anissa Anindya; Schafer, Sebastian; Yusoff, Permeen; Choksi, Pervinder Kaur et al.
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Alterations in the cardiac proteome of the spontaneously hypertensive rat induced by transgenic expression of CD36

Journal of Proteomics
2016 | Journal article
DOI: 10.1016/J.JPROT.2016.04.041
WOSUID: WOS:000383931000018
Contributors: Manakov, Dmitry; Ujcikova, Hana; Pravenec, Michal; Novotny, Jiri
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An alternative hypothesis to the widely held view that renal excretion of sodium accounts for resistance to salt-induced hypertension

Kidney International
2016 | Journal article
DOI: 10.1016/J.KINT.2016.05.032
WOSUID: WOS:000386547100012
Contributors: Kurtz, Theodore W.; DiCarlo, Stephen E.; Pravenec, Michal; Schmidlin, Olga; Tanaka, Masae; Morris, R. Curtis, Jr.
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