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Scopus Author ID: 7005825932
ResearcherID: A-9227-2013
Loop profile: 46996

Keywords

Cell Biology, Molecular Biology, Trypanosoma

Countries

Brazil

Activities

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Employment (1)

Universidade Federal de Sao Paulo: Sao Paulo, SP, BR

1984-11-30 to present | Professor (Microbiology, Immunology and Parasitology)
Employment
Source: Self-asserted source
Schenkman, S.

Education and qualifications (1)

Universidade de São Paulo: São Paulo, SP, BR

1978-03-01 to 1981-08-24 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
Schenkman, S.

Professional activities (4)

American Society for Cell Biology: Bethesda, MD, US

2014 to present | Member
Membership
Source: Self-asserted source
Schenkman, S.

Brazilian Society of Protozoology: São Paulo, BR

2000 to present | Member
Membership
Source: Self-asserted source
Schenkman, S.

American Society for Microbiology: Washington, DC, US

2000 to present | Member
Membership
Source: Self-asserted source
Schenkman, S.

Brazilian Academy of Sciences: Rio de Janeiro, BR

2009 | Member
Distinction
Source: Self-asserted source
Schenkman, S.

Funding (4)

Acquisition of a 3D Scanning Microscope for the Electronic Microscopy Center of UNIFESP to obtain high resolution images of cells and tissues and three-dimensional reconstruction.

2023-08 to 2026-07 | Grant
Fundação de Amparo à Pesquisa do Estado de São Paulo (Sao Paulo, BR)
GRANT_NUMBER:

2022/11528-5
Source: Self-asserted source
Schenkman, S.

Instituto Paulista de Resistência aos Antimicrobianos (Projeto ARIES)

2023-05 to 2028-04 | Award
Fundação de Amparo à Pesquisa do Estado de São Paulo (Sao Paulo, BR)
Part of GRANT_NUMBER: 21/10599-3
Source: Self-asserted source
Schenkman, S.

Validation of Trypanosoma cruzi dihydroorotate dehydrogenase as a drug target for Chagas´disease

2021-09 to 2025-08 | Award
National Institute of Allergy and Infectious Diseases (Md., Md., US)
Part of GRANT_NUMBER:

R01AI160379
Source: Self-asserted source
Schenkman, S.

Cell signaling during the interaction of Trypanosomes with their host

2016-04 to 2020-03 | Grant
Fundação de Amparo à Pesquisa do Estado de São Paulo (São Paulo, BR)
GRANT_NUMBER: 15/22031-0
Source: Self-asserted source
Schenkman, S.

Works (50 of 181)

Items per page:
Page 1 of 4

Decoding dynamic molecular interactions in cells

Cell Biology International
2025-02 | Journal article
DOI: 10.1002/cbin.12262
Contributors: Mussarat Rafiq; Chengcheng Hu; Xinjiao Gao; Zhikai Wang; Sergio Schenkman; Andreas Merdes; Xing Liu
Source: check_circle
Crossref

Ultra-high throughputin vitrotranslation assay for identification ofTrypanosoma cruzi-specificprotein synthesis inhibitors

2025-02-02 | Preprint
DOI: 10.1101/2025.02.02.636133
Contributors: Camila Colombari Mantovani; Carolina Borsoi Moraes; Guilherme Rodrigo Reis dos Santos; Bertal Huseyin Aktas; Sergio Schenkman
Source: check_circle
Crossref

Genomic tracking the coexistence of mcr and carbapenemase genes in Gram-negative bacteria: A global perspective

International Journal of Antimicrobial Agents
2024-11 | Journal article
DOI: 10.1016/j.ijantimicag.2024.107350
Contributors: Fábio Parra Sellera; Yilu Zhuang; Nilton Lincopan; Eliana Guedes Stehling; Sergio Schenkman; Zhi Ruan; João Pedro Rueda Furlan
Source: check_circle
Crossref

The effect of nutritional and oxidative stress on the metabolome of Trypanosoma cruzi

Molecular Microbiology
2024-11 | Journal article
DOI: 10.1111/mmi.15279
Contributors: Michel Augusto Silva; Mario Augusto Izidoro; Mirella Aricó; Luiz Juliano; Sergio Schenkman
Source: check_circle
Crossref

Trypanosoma cruziVDU deubiquitinase mediates surface protein trafficking and infectivity

2023-04-17 | Preprint
DOI: 10.1101/2023.04.17.537123
Contributors: Normanda Souza-Melo; Nathalia Brito Silva; Amaranta Muniz Malvezzi; Gregory Pedroso dos Santos; Laura Maria Alcântara; Carolina de Lima Alcantara; Narcisa Leal da Cunha e Silva; Martin Zoltner; Mark C. Field; Sergio Schenkman
Source: check_circle
Crossref

Development and characterization of a multimeric recombinant protein based on the spike protein receptor binding domain of SARS-CoV-2 that can neutralize virus infection

2023-02-15 | Preprint
DOI: 10.1101/2023.02.15.528632
Contributors: Veronica Aparecida de Lima; Rodrigo da Silva Ferreira; Maria Luiza Vilela Oliva; Robert Andreata-Santos; Luiz Mario Ramos Janini; Juliana Terzi Maricato; Milena Apetito Akamatsu; Paulo Lee Ho; Sergio Schenkman
Source: check_circle
Crossref

Stress Induces Release of Extracellular Vesicles by Trypanosoma cruzi Trypomastigotes

Journal of Immunology Research
2021-09-23 | Journal article
DOI: 10.1155/2021/2939693
Contributors: Camilla Ioshida Vasconcelos; A Cronemberger-Andrade; Normanda Souza-Melo; Juliana Terzi Maricato; Patrícia Xander; Wagner Luiz Batista; Rodrigo Pedro Soares; Sergio Schenkman; Ana Claudia Torrecilhas; Ilaria Roato
Source: check_circle
Crossref

Mitochondrial sirtuin TcSir2rp3 affects TcSODA activity and oxidative stress response in Trypanosoma cruzi

2021-09-06 | Other
DOI: 10.1101/2021.09.06.458705
Contributors: Leila dos Santos Moura; Vinícius Santana Nunes; Antoniel A. S. Gomes; Ana Caroline de Castro Nascimento Sousa; Marcos R. M. Fontes; Sergio Schenkman; Nilmar S. Moretti
Source: check_circle
Crossref

Cyclophilin 19 secreted in the host cell cytosol by Trypanosoma cruzi promotes ROS production required for parasite growth

Cellular Microbiology
2021-04-09 | Journal article
DOI: 10.1111/cmi.13295
Contributors: Gregory Pedroso Santos; Fernanda Midori Abukawa; Normanda Souza‐Melo; Laura Maria Alcântara; Paula Bittencourt‐Cunha; Carolina Borsoi Moraes; Bijay Kumar Jha; Bradford S. McGwire; Nilmar Silvio Moretti; Sergio Schenkman
Source: check_circle
Crossref

EIF2α phosphorylation is regulated in intracellular amastigotes for the generation of infective Trypanosoma cruzi trypomastigote forms

Cellular Microbiology
2020-11-28 | Journal article
DOI: 10.1111/cmi.13243
Contributors: Fabricio Castro Machado; Paula Bittencourt‐Cunha; Amaranta Muniz Malvezzi; Mirella Arico; Santiago Radio; Pablo Smircich; Martin Zoltner; Mark C. Field; Sergio Schenkman
Source: check_circle
Crossref

Novel structural CYP51 mutation in Trypanosoma cruzi associated with multidrug resistance to CYP51 inhibitors and reduced infectivity.

International journal for parasitology. Drugs and drug resistance
2020-06-13 | Journal article
DOI: 10.1016/j.ijpddr.2020.06.001
PMID: 32688218
PMC: PMC7369355
Source: Self-asserted source
Schenkman, S.

Identification of Inhibitors to <i>Trypanosoma cruzi</i> Sirtuins Based on Compounds Developed to Human Enzymes

International Journal of Molecular Sciences
2020-05 | Journal article | Author
DOI: 10.3390/ijms21103659
Contributors: Tanira Bastos; Milena Botelho Pereira Soares; Caio Haddad Franco; Laura Maria Alcântara; Lorenzo Antonini; Manuela Sabatino; Nicola Mautone; Lucio Holanda Freitas-Junior; Moraes, C. B.; Rino Ragno et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Effect of lysine acetylation on the regulation of Trypanosoma brucei glycosomal aldolase activity.

The Biochemical journal
2020-04-24 | Journal article
DOI: 10.1042/bcj20200142
PMID: 32329788
Source: Self-asserted source
Schenkman, S.

GCN2-Like Kinase Modulates Stress Granule Formation During Nutritional Stress in Trypanosoma cruzi.

Frontiers in cellular and infection microbiology
2020-04-16 | Journal article
DOI: 10.3389/fcimb.2020.00149
PMID: 32373547
PMC: PMC7176912
Source: Self-asserted source
Schenkman, S.

Trimethylation of histone H3K76 by Dot1B enhances cell cycle progression after mitosis in Trypanosoma cruzi.

Biochimica et biophysica acta. Molecular cell research
2020-03-06 | Journal article
DOI: 10.1016/j.bbamcr.2020.118694
PMID: 32151656
Source: Self-asserted source
Schenkman, S.

Trypanosoma cruzi.

Trends in parasitology
2019-11-07 | Journal article
DOI: 10.1016/j.pt.2019.10.002
PMID: 31708398
Source: Self-asserted source
Schenkman, S.

Galactosyl and sialyl clusters: synthesis and evaluation against T. cruzi parasite

Pure and Applied Chemistry
2019-07-26 | Journal article
DOI: 10.1515/pac-2019-0216
Part of ISSN: 1365-3075
Part of ISSN: 0033-4545
Source: Self-asserted source
Schenkman, S.

Deregulation of Ikaros expression in B‐1 cells: New insights in the malignant transformation to chronic lymphocytic leukemia

Journal of Leukocyte Biology
2019-07-12 | Journal article
DOI: 10.1002/jlb.ma1118-454r
Part of ISSN: 0741-5400
Part of ISSN: 1938-3673
Source: Self-asserted source
Schenkman, S.

Chemical Constituents of Anacardium occidentale as Inhibitors of Trypanosoma cruzi Sirtuins

Molecules
2019-04-03 | Journal article
DOI: 10.3390/molecules24071299
Part of ISSN: 1420-3049
Source: Self-asserted source
Schenkman, S.

Proteomic analysis reveals different composition of extracellular vesicles released by two Trypanosoma cruzi strains associated with their distinct interaction with host cells

Journal of Extracellular Vesicles
2018-12 | Journal article
DOI: 10.1080/20013078.2018.1463779
Contributors: Kleber Silva Ribeiro; Camilla Ioshida Vasconcellos; Rodrigo Pedro Soares; Maria Tays Mendes; Cameron C. Ellis; Marcela Aguilera‐Flores; Igor Correia de Almeida; Sergio Schenkman; Leo Kei Iwai; Ana Claudia Torrecilhas
Source: check_circle
Crossref

The in vivo and in vitro roles of Trypanosoma cruzi Rad51 in the repair of DNA double strand breaks and oxidative lesions

PLOS Neglected Tropical Diseases
2018-11-13 | Journal article
DOI: 10.1371/journal.pntd.0006875
Part of ISSN: 1935-2735
Source: Self-asserted source
Schenkman, S.

Overexpression of eukaryotic initiation factor 5A (eIF5A) affects susceptibility to benznidazole in Trypanosoma cruzi populations

Memórias do Instituto Oswaldo Cruz
2018-07-26 | Journal article
DOI: 10.1590/0074-02760180162
Part of ISSN: 1678-8060
Part of ISSN: 0074-0276
Source: Self-asserted source
Schenkman, S.

Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation

Scientific Reports
2018-03-20 | Journal article
DOI: 10.1038/s41598-018-23259-9
Contributors: Fabricio Castro Machado; Caio Haddad Franco; Jose Vitorino dos Santos Neto; Karina Luiza Dias-Teixeira; Carolina Borsoi Moraes; Ulisses Gazos Lopes; Bertal Huseyin Aktas; Sergio Schenkman
Source: check_circle
Crossref

Comparative Proteomic Analysis of Lysine Acetylation in Trypanosomes

Journal of Proteome Research
2018-01-05 | Journal article
DOI: 10.1021/acs.jproteome.7b00603
Contributors: Nilmar Silvio Moretti; Igor Cestari; Atashi Anupama; Ken Stuart; Sergio Schenkman
Source: check_circle
Crossref

Highlights of the São Paulo ISEV workshop on extracellular vesicles in cross-kingdom communication

Journal of Extracellular Vesicles
2017-12 | Journal article
DOI: 10.1080/20013078.2017.1407213
Part of ISSN: 2001-3078
Source: Self-asserted source
Schenkman, S.

Comparative transcriptome profiling of virulent and non-virulent Trypanosoma cruzi underlines the role of surface proteins during infection

PLOS Pathogens
2017-12-14 | Journal article
DOI: 10.1371/journal.ppat.1006767
Contributors: A. Trey Belew; Martin Taylor; Caroline Junqueira; Gabriela F. Rodrigues-Luiz; Bruna M. Valente; Antonio Edson R. Oliveira; Rafael B. Polidoro; Luciana W. Zuccherato; Daniella C. Bartholomeu; Sergio Schenkman et al.
Source: check_circle
Crossref

Catalase expression impairs oxidative stress-mediated signalling in Trypanosoma cruzi

Parasitology
2017-09 | Journal article
DOI: 10.1017/s0031182017001044
Part of ISSN: 0031-1820
Part of ISSN: 1469-8161
Source: Self-asserted source
Schenkman, S.

Characterization and role of the 3-methylglutaconyl coenzyme A hidratase in Trypanosoma brucei

Molecular and Biochemical Parasitology
2017-06 | Journal article
DOI: 10.1016/j.molbiopara.2017.03.007
Part of ISSN: 0166-6851
Source: Self-asserted source
Schenkman, S.

Beta-adrenergic antagonist propranolol inhibits mammalian cell lysosome spreading and invasion by Trypanosoma cruzi metacyclic forms

Microbes and Infection
2017-04 | Journal article
DOI: 10.1016/j.micinf.2017.01.004
Part of ISSN: 1286-4579
Source: Self-asserted source
Schenkman, S.

Effect of ionizing radiation exposure on Trypanosoma cruzi ubiquitin-proteasome system

Molecular and Biochemical Parasitology
2017-03 | Journal article
DOI: 10.1016/j.molbiopara.2017.01.005
Part of ISSN: 0166-6851
Source: Self-asserted source
Schenkman, S.

Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity

PLOS Pathogens
2017-03-02 | Journal article
DOI: 10.1371/journal.ppat.1006170
Contributors: Michael P. Rout; Laura J. Knoll; Samson O. Obado; Sergio Schenkman; Mark C. Field
Source: check_circle
Crossref

Frontiers in Parasitology

[]
2017-02-15 | Book
Part of DOI: 10.2174/97816810840531170101
Part of ISBN: 9781681084053
Source: Self-asserted source
Schenkman, S.

Reduction of Tubulin Expression inAngomonas deaneiby RNAi Modifies the Ultrastructure of the Trypanosomatid Protozoan and Impairs Division of Its Endosymbiotic Bacterium

Journal of Eukaryotic Microbiology
2016-11 | Journal article
DOI: 10.1111/jeu.12326
Part of ISSN: 1066-5234
Source: Self-asserted source
Schenkman, S.

Characterization of TcCYC6 from Trypanosoma cruzi, a gene with homology to mitotic cyclins

Parasitology International
2016-06 | Journal article
DOI: 10.1016/j.parint.2015.12.007
Part of ISSN: 1383-5769
Source: Self-asserted source
Schenkman, S.

Chromatin Proteomics Reveals Variable Histone Modifications during the Life Cycle of Trypanosoma cruzi

Journal of Proteome Research
2016-06-03 | Journal article
DOI: 10.1021/acs.jproteome.6b00208
Part of ISSN: 1535-3893
Part of ISSN: 1535-3907
Source: Self-asserted source
Schenkman, S.
grade
Preferred source (of 2)‎

Chemogenetic Characterization of Inositol Phosphate Metabolic Pathway Reveals Druggable Enzymes for Targeting Kinetoplastid Parasites

Cell Chemical Biology
2016-05 | Journal article
DOI: 10.1016/j.chembiol.2016.03.015
Part of ISSN: 2451-9456
Source: Self-asserted source
Schenkman, S.

Phosphorylation of eIF2α on Threonine 169 is not required for Trypanosoma brucei cell cycle arrest during differentiation

Molecular and Biochemical Parasitology
2016-01 | Journal article
DOI: 10.1016/j.molbiopara.2016.03.004
Part of ISSN: 0166-6851
Source: Self-asserted source
Schenkman, S.

Expression of non-acetylatable lysines 10 and 14 of histone H4 impairs transcription and replication in Trypanosoma cruzi

Molecular and Biochemical Parasitology
2015-11 | Journal article
DOI: 10.1016/j.molbiopara.2015.11.001
Contributors: Thiago Cesar Prata Ramos; Vinicius Santana Nunes; Sheila Cristina Nardelli; Bruno dos Santos Pascoalino; Nilmar Silvio Moretti; Antonio Augusto Rocha; Leonardo da Silva Augusto; Sergio Schenkman
Source: check_circle
Crossref

Ikaros could be a key factor in the maintenance of “B-side” of B-1 cells

Immunobiology
2015-11 | Journal article
DOI: 10.1016/j.imbio.2015.06.010
Part of ISSN: 0171-2985
Source: Self-asserted source
Schenkman, S.

Click chemistry oligomerisation of azido-alkyne-functionalised galactose accesses triazole-linked linear oligomers and macrocycles that inhibit Trypanosoma cruzi macrophage invasion

Tetrahedron
2015-09 | Journal article
DOI: 10.1016/j.tet.2015.04.085
Part of ISSN: 0040-4020
Source: Self-asserted source
Schenkman, S.

Characterization of Trypanosoma cruzi Sirtuins as Possible Drug Targets for Chagas Disease

Antimicrobial Agents and Chemotherapy
2015-08 | Journal article
DOI: 10.1128/aac.04694-14
Part of ISSN: 0066-4804
Part of ISSN: 1098-6596
Source: Self-asserted source
Schenkman, S.

Endosymbiosis in trypanosomatid protozoa: the bacterium division is controlled during the host cell cycle

Frontiers in Microbiology
2015-06-02 | Journal article
DOI: 10.3389/fmicb.2015.00520
Part of ISSN: 1664-302X
Source: Self-asserted source
Schenkman, S.

Iron superoxide dismutases in eukaryotic pathogens: new insights from Apicomplexa andTrypanosomastructures

Acta Crystallographica Section F Structural Biology Communications
2015-05-01 | Journal article
DOI: 10.1107/s2053230x15004185
Part of ISSN: 2053-230X
Source: Self-asserted source
Schenkman, S.

A Membrane-bound eIF2 Alpha Kinase Located in Endosomes Is Regulated by Heme and Controls Differentiation and ROS Levels in Trypanosoma cruzi

PLOS Pathogens
2015-02-06 | Journal article
DOI: 10.1371/journal.ppat.1004618
Part of ISSN: 1553-7374
Source: Self-asserted source
Schenkman, S.

Characterization of two different Asf1 histone chaperones with distinct cellular localizations and functions in Trypanosoma brucei

2014 | Journal article
DOI: 10.1093/nar/gkt1267
EID:

2-s2.0-84899005555
Contributors: Pascoalino, B.; Dindar, G.; Vieira-Da-Rocha, J.P.; Machado, C.R.; Janzen, C.J.; Schenkman, S.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier

Genome of the Avirulent Human-Infective Trypanosome—Trypanosoma rangeli

2014 | Journal article
DOI: 10.1371/journal.pntd.0003176
EID:

2-s2.0-84907584660
Contributors: Stoco, P.H.; Wagner, G.; Talavera-Lopez, C.; Gerber, A.; Zaha, A.; Thompson, C.E.; Bartholomeu, D.C.; Lückemeyer, D.D.; Bahia, D.; Loreto, E. et al.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier

Nitroheterocyclic compounds are more efficacious than CYP51 inhibitors against Trypanosoma cruzi: Implications for Chagas disease drug discovery and development

2014 | Journal article
DOI: 10.1038/srep04703
EID:

2-s2.0-84898824975
Contributors: Moraes, C.B.; Giardini, M.A.; Kim, H.; Franco, C.H.; Araujo-Junior, A.M.; Schenkman, S.; Chatelain, E.; Freitas-Junior, L.H.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier

ORC1/CDC6 and MCM7 distinct associate with chromatin through Trypanosoma cruzi life cycle

2014 | Journal article
DOI: 10.1016/j.molbiopara.2014.03.004
EID:

2-s2.0-84897359217
Contributors: Calderano, S.; Godoy, P.; Soares, D.; Sant'Anna, O.A.; Schenkman, S.; Elias, M.C.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier

Stress induces changes in the phosphorylation of Trypanosoma cruzi RNA polymerase II, affecting its association with chromatin and RNA processing

2014 | Journal article
DOI: 10.1128/EC.00066-14
EID:

2-s2.0-84903614546
Contributors: Rocha, A.A.; Moretti, N.S.; Schenkman, S.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier

Structural characterization of the cell division cycle in Strigomonas culicis, an endosymbiont-bearing trypanosomatid

2014 | Journal article
DOI: 10.1017/S1431927613013925
EID:

2-s2.0-84896491474
Contributors: Brum, F.L.; Catta-Preta, C.M.C.; De Souza, W.; Schenkman, S.; Elias, M.C.; Motta, M.C.M.
Source: Self-asserted source
Schenkman, S. via Scopus - Elsevier
Items per page:
Page 1 of 4

Peer review (19 reviews for 12 publications/grants)

Review activity for ACS infectious diseases. (1)
Review activity for Biochimica et biophysica acta. (1)
Review activity for Computational and Structural Biotechnology Journal (1)
Review activity for Journal of proteome research. (1)
Review activity for Molecular and biochemical parasitology. (1)
Review activity for Nature communications (1)
Review activity for Parasitology research. (1)
Review activity for PLOS genetics. (1)
Review activity for PLoS neglected tropical diseases (2)
Review activity for PloS one. (3)
Review activity for PLOS pathogens : (5)
Review activity for Scientific data. (1)
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