Personal information

No personal information available

Activities

Collapse all

Employment (4)

National Institute of Biological Sciences: Beijing, CN

2010-10-01 to present | Director and Investigator
Employment
Source: Self-asserted source
Xiaodong Wang

Howard Hughes Medical Institute - University of Texas Southwestern Medical Center at Dallas: Dallas, TX, US

1997 to 2010 | Investigator
Employment
Source: Self-asserted source
Xiaodong Wang

University of Texas Southwestern Medical Center: TX, TX, US

1996 to 1997 | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Xiaodong Wang

Emory University School of Medicine: Atlanta, GA, US

1995 to 1996 | Assistant Professor (Biochemistry)
Employment
Source: Self-asserted source
Xiaodong Wang

Education and qualifications (2)

University of Texas Southwestern Medical Center: TX, TX, US

1985-09-05 to 1991-03-30 | Ph.D. (Biochemistry)
Education
Source: Self-asserted source
Xiaodong Wang

Beijing Normal University: Beijing, Beijing, CN

1980-09-01 to 1984-06-30 | B.S. (Biology)
Education
Source: Self-asserted source
Xiaodong Wang

Professional activities (5)

European Molecular Biology Organization: Heidelberg, DE

Foreign Associate
Invited position
Source: Self-asserted source
Xiaodong Wang

American Society for Biochemistry and Molecular Biology: Rockville, MD, US

Membership
Source: Self-asserted source
Xiaodong Wang

American Association for Cancer Research: Philadelphia, PA, US

Membership
Source: Self-asserted source
Xiaodong Wang

Chinese Academy of Sciences: Beijing, Beijing, CN

2013 | Foreign associate member
Distinction
Source: Self-asserted source
Xiaodong Wang

National Academy of Sciences: Washington, DC, US

2004-04-30 | member
Distinction
Source: Self-asserted source
Xiaodong Wang

Works (50 of 63)

Items per page:
Page 1 of 2

Mixed Lineage Kinase Domain-like Protein MLKL Breaks Down Myelin following Nerve Injury

Molecular Cell
2018-11 | Journal article
DOI: 10.1016/j.molcel.2018.09.011
Part of ISSN: 1097-2765
Contributors: Zhengxin Ying; Chenjie Pan; Tianyu Shao; Liqing Liu; Lin Li; Dejia Guo; Sitao Zhang; Tianyi Yuan; Ran Cao; Zhaodi Jiang et al.
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

RIP kinases as modulators of inflammation and immunity

Nature Immunology
2018-08 | Journal article
DOI: 10.1038/s41590-018-0188-x
Part of ISSN: 1529-2908
Contributors: Sudan He; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

RIPK1-RIPK3-MLKL-dependent necrosis promotes the aging of mouse male reproductive system

eLife
2017-08 | Journal article
DOI: 10.7554/elife.27692
Part of ISSN: 2050-084X
Contributors: Dianrong Li; Lingjun Meng; Tao Xu; Yaning Su; Xiao Liu; Zhiyuan Zhang; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

A Small Molecule That Protects the Integrity of the Electron Transfer Chain Blocks the Mitochondrial Apoptotic Pathway

Molecular Cell
2016-07 | Journal article
DOI: 10.1016/j.molcel.2016.06.016
Part of ISSN: 1097-2765
Contributors: Xian Jiang; Li Li; Zhengxin Ying; Chenjie Pan; Shaoqiang Huang; Lin Li; Miaomiao Dai; Bo Yan; Ming Li; Hui Jiang et al.
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

RIP3-mediated necrotic cell death accelerates systematic inflammation and mortality

Proceedings of the National Academy of Sciences
2015-08 | Journal article
DOI: 10.1073/pnas.1514730112
Part of ISSN: 0027-8424
Contributors: Lingjun Meng; Wei Jin; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

A cytosolic heat shock protein 90 and cochaperone CDC37 complex is required for RIP3 activation during necroptosis

Proceedings of the National Academy of Sciences
2015-04-07 | Journal article
DOI: 10.1073/pnas.1505244112
Part of ISSN: 0027-8424
Contributors: Dianrong Li; Tao Xu; Yang Cao; Huayi Wang; Lin Li; She Chen; Xiaodong Wang; Zhirong Shen
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

A new kind of cell suicide: mechanisms and functions of programmed necrosis

Trends in Biochemical Sciences
2014 | Journal article
DOI: 10.1016/j.tibs.2014.10.003
Part of ISSN: 0968-0004
Contributors: Liming Sun; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Activation of mitochondrial protease OMA1 by Bax and Bak promotes cytochrome c release during apoptosis

Proceedings of the National Academy of Sciences
2014-10-01 | Journal article
DOI: 10.1073/pnas.1417253111
Part of ISSN: 0027-8424
Contributors: X. Jiang; H. Jiang; Z. Shen; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Mixed Lineage Kinase Domain-like Protein MLKL Causes Necrotic Membrane Disruption upon Phosphorylation by RIP3

Molecular Cell
2014-04 | Journal article
DOI: 10.1016/j.molcel.2014.03.003
Part of ISSN: 1097-2765
Contributors: Huayi Wang; Liming Sun; Lijing Su; Josep Rizo; Lei Liu; Li-Feng Wang; Fu-Sheng Wang; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Small-molecule activation of the TRAIL receptor DR5 in human cancer cells

Nature Chemical Biology
2012 | Journal article
DOI: 10.1038/nchembio.1153
Part of ISSN: 1552-4450
Contributors: Gelin Wang; Xiaoming Wang; Hong Yu; Shuguang Wei; Noelle Williams; Daniel L Holmes; Randal Halfmann; Jacinth Naidoo; Lai Wang; Lin Li et al.
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Mixed Lineage Kinase Domain-like Protein Mediates Necrosis Signaling Downstream of RIP3 Kinase

Cell
2012-01 | Journal article
DOI: 10.1016/j.cell.2011.11.031
Part of ISSN: 0092-8674
Contributors: Liming Sun; Huayi Wang; Zhigao Wang; Sudan He; She Chen; Daohong Liao; Lai Wang; Jiacong Yan; Weilong Liu; Xiaoguang Lei et al.
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

The Mitochondrial Phosphatase PGAM5 Functions at the Convergence Point of Multiple Necrotic Death Pathways

Cell
2012-01 | Journal article
DOI: 10.1016/j.cell.2011.11.030
Part of ISSN: 0092-8674
Contributors: Zhigao Wang; Hui Jiang; She Chen; Fenghe Du; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Toll-like receptors activate programmed necrosis in macrophages through a receptor-interacting kinase-3-mediated pathway

Proceedings of the National Academy of Sciences
2011-11 | Journal article
DOI: 10.1073/pnas.1116302108
Part of ISSN: 0027-8424
Contributors: S. He; Y. Liang; F. Shao; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Upregulation of human autophagy-initiation kinase ULK1 by tumor suppressor p53 contributes to DNA-damage-induced cell death

Cell Death & Differentiation
2011-04-08 | Journal article
DOI: 10.1038/cdd.2011.33
Part of ISSN: 1350-9047
Contributors: W Gao; Z Shen; L Shang; X Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Nutrient starvation elicits an acute autophagic response mediated by Ulk1 dephosphorylation and its subsequent dissociation from AMPK

Proceedings of the National Academy of Sciences
2011-03-07 | Journal article
DOI: 10.1073/pnas.1100844108
Part of ISSN: 0027-8424
Contributors: L. Shang; S. Chen; F. Du; S. Li; L. Zhao; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

The ER UDPase ENTPD5 Promotes Protein N-Glycosylation, the Warburg Effect, and Proliferation in the PTEN Pathway

Cell
2010-11 | Journal article
DOI: 10.1016/j.cell.2010.10.010
Part of ISSN: 0092-8674
Contributors: Min Fang; Zhirong Shen; Song Huang; Liping Zhao; She Chen; Tak W. Mak; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Overcoming cancer cell resistance to Smac mimetic induced apoptosis by modulating cIAP-2 expression

Proceedings of the National Academy of Sciences
2010-06 | Journal article
DOI: 10.1073/pnas.1005667107
Part of ISSN: 0027-8424
Contributors: S. L. Petersen; M. Peyton; J. D. Minna; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Receptor Interacting Protein Kinase-3 Determines Cellular Necrotic Response to TNF-α

Cell
2009-06 | Journal article
DOI: 10.1016/j.cell.2009.05.021
Part of ISSN: 0092-8674
Contributors: Sudan He; Lai Wang; Lin Miao; Tao Wang; Fenghe Du; Liping Zhao; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

PHAPI, CAS, and Hsp70 Promote Apoptosome Formation by Preventing Apaf-1 Aggregation and Enhancing Nucleotide Exchange on Apaf-1

Molecular Cell
2008 | Journal article
DOI: 10.1016/j.molcel.2008.12.018
Part of ISSN: 1097-2765
Contributors: Hyun-Eui Kim; Xuejun Jiang; Fenghe Du; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

TNF-α Induces Two Distinct Caspase-8 Activation Pathways

Cell
2008-05 | Journal article
DOI: 10.1016/j.cell.2008.03.036
Part of ISSN: 0092-8674
Contributors: Lai Wang; Fenghe Du; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Autocrine TNFα Signaling Renders Human Cancer Cells Susceptible to Smac-Mimetic-Induced Apoptosis

Cancer Cell
2007-11 | Journal article
DOI: 10.1016/j.ccr.2007.08.029
Part of ISSN: 1535-6108
Contributors: Sean L. Petersen; Lai Wang; Asligul Yalcin-Chin; Lin Li; Michael Peyton; John Minna; Patrick Harran; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Diazonamide toxins reveal an unexpected function for ornithine  -amino transferase in mitotic cell division

Proceedings of the National Academy of Sciences
2007-02-07 | Journal article
DOI: 10.1073/pnas.0610832104
Part of ISSN: 0027-8424
Contributors: G. Wang; L. Shang; A. W. G. Burgett; P. G. Harran; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Argonaute2 Cleaves the Anti-Guide Strand of siRNA during RISC Activation

Cell
2005-11 | Journal article
DOI: 10.1016/j.cell.2005.10.020
Part of ISSN: 0092-8674
Contributors: Tim A. Rand; Sean Petersen; Fenghe Du; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Formation of apoptosome is initiated by cytochrome c-induced dATP hydrolysis and subsequent nucleotide exchange on Apaf-1

Proceedings of the National Academy of Sciences
2005-10 | Journal article
DOI: 10.1073/pnas.0507900102
Part of ISSN: 0027-8424
Contributors: H.-E. Kim; F. Du; M. Fang; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Mule/ARF-BP1, a BH3-Only E3 Ubiquitin Ligase, Catalyzes the Polyubiquitination of Mcl-1 and Regulates Apoptosis

Cell
2005-07 | Journal article
DOI: 10.1016/j.cell.2005.06.009
Part of ISSN: 0092-8674
Contributors: Qing Zhong; Wenhua Gao; Fenghe Du; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Specific Ablation of the Apoptotic Functions of Cytochrome c Reveals a Differential Requirement for Cytochrome c and Apaf-1 in Apoptosis

Cell
2005-05 | Journal article
DOI: 10.1016/j.cell.2005.03.016
Part of ISSN: 0092-8674
Contributors: Zhenyue Hao; Gordon S. Duncan; Chia-Che Chang; Andrew Elia; Min Fang; Andrew Wakeham; Hitoshi Okada; Thomas Calzascia; YingJu Jang; Annick You-Ten et al.
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Biochemical identification of Argonaute 2 as the sole protein required for RNA-induced silencing complex activity

Proceedings of the National Academy of Sciences
2004-09 | Journal article
DOI: 10.1073/pnas.0405913101
Part of ISSN: 0027-8424
Contributors: T. A. Rand; K. Ginalski; N. V. Grishin; X. Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

A Small Molecule Smac Mimic Potentiates TRAIL- and TNF -Mediated Cell Death

Science
2004-09-03 | Journal article
DOI: 10.1126/science.1098231
Part of ISSN: 0036-8075
Contributors: L. Li
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Cytochrome C-Mediated Apoptosis

Annual Review of Biochemistry
2004-06 | Journal article
DOI: 10.1146/annurev.biochem.73.011303.073706
Part of ISSN: 0066-4154
Contributors: Xuejun Jiang; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Mitochondrial activation of apoptosis

Cell
2004-01 | Journal article
DOI: 10.1016/s0092-8674(04)00031-5
Part of ISSN: 0092-8674
Contributors: Peng Li; Deepak Nijhawan; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

R2D2, a Bridge Between the Initiation and Effector Steps of the Drosophila RNAi Pathway

Science
2003-09 | Journal article
DOI: 10.1126/science.1088710
Part of ISSN: 0036-8075
Contributors: Q. Liu
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Elimination of Mcl-1 is required for the initiation of apoptosis following ultraviolet irradiation

Genes & Development
2003-06 | Journal article
DOI: 10.1101/gad.1093903
Part of ISSN: 0890-9369
Contributors: D. Nijhawan
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Distinctive Roles of PHAP Proteins and Prothymosin-alpha in a Death Regulatory Pathway

Science
2003-01-10 | Journal article
DOI: 10.1126/science.1076807
Part of ISSN: 0036-8075
Contributors: X. Jiang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Three-Dimensional Structure of the Apoptosome

Molecular Cell
2002-02 | Journal article
DOI: 10.1016/s1097-2765(02)00442-2
Part of ISSN: 1097-2765
Contributors: Devrim Acehan; Xuejun Jiang; David Gene Morgan; John E Heuser; Xiaodong Wang; Christopher W Akey
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Apaf-1 deficiency and neural tube closure defects are found in fog mice

Proceedings of the National Academy of Sciences
2001-08 | Journal article
DOI: 10.1073/pnas.171283198
Part of ISSN: 0027-8424
Contributors: N. Honarpour; S. L. Gilbert; B. T. Lahn; X. Wang; J. Herz
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Endonuclease G is an apoptotic DNase when released from mitochondria

Nature
2001-07 | Journal article
DOI: 10.1038/35083620
Part of ISSN: 0028-0836
Contributors: Lily Y. Li; Xu Luo; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Mitochondrial endonuclease G is important for apoptosis in C. elegans

Nature
2001-07 | Journal article
DOI: 10.1038/35083608
Part of ISSN: 0028-0836
Contributors: Jay Parrish; Lily Li; Kristina Klotz; Duncan Ledwich; Xiaodong Wang; Ding Xue
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

A Mutational Epitope for CytochromecBinding to the Apoptosis Protease Activation Factor-1

Journal of Biological Chemistry
2000 | Journal article
DOI: 10.1074/jbc.m009773200
Part of ISSN: 0021-9258
Contributors: Tianning Yu; Xiaodong Wang; Cherie Purring-Koch; Yen Wei; George L. McLendon
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

In Vitro Assays for Caspase-3 Activation and DNA Fragmentation

Apoptosis
2000 | Other
DOI: 10.1016/s0076-6879(00)22017-x
Part of ISBN: 9780121822231
Part of ISSN: 0076-6879
Contributors: Xuesong Liu; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Structural basis of IAP recognition by Smac/DIABLO

Nature
2000 | Journal article
DOI: 10.1038/35050012
Part of ISSN: 0028-0836
Contributors: Geng Wu; Jijie Chai; Tomeka L. Suber; Jia-Wei Wu; Chunying Du; Xiaodong Wang; Yigong Shi
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Cardiolipin provides specificity for targeting of tBid to mitochondria

Nature Cell Biology
2000-10 | Journal article
DOI: 10.1038/35036395
Part of ISSN: 1465-7392
Contributors: Michael Lutter; Min Fang; Xu Luo; Masahiro Nishijima; Xiao-song Xie; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

CytochromecPromotes Caspase-9 Activation by Inducing Nucleotide Binding to Apaf-1

Journal of Biological Chemistry
2000-08-11 | Journal article
DOI: 10.1074/jbc.c000405200
Part of ISSN: 0021-9258
Contributors: Xuejun Jiang; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Smac, a Mitochondrial Protein that Promotes Cytochrome c–Dependent Caspase Activation by Eliminating IAP Inhibition

Cell
2000-07 | Journal article
DOI: 10.1016/s0092-8674(00)00008-8
Part of ISSN: 0092-8674
Contributors: Chunying Du; Min Fang; Yucheng Li; Lily Li; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

DFF45/ICAD Can Be Directly Processed by Granzyme B during the Induction of Apoptosis

Immunity
2000-06 | Journal article
DOI: 10.1016/s1074-7613(00)80213-7
Part of ISSN: 1074-7613
Contributors: Dori A Thomas; Chunying Du; Ming Xu; Xiaodong Wang; Timothy J Ley
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Cytochrome c Deficiency Causes Embryonic Lethality and Attenuates Stress-Induced Apoptosis

Cell
2000-05 | Journal article
DOI: 10.1016/s0092-8674(00)80849-1
Part of ISSN: 0092-8674
Contributors: Kang Li; Yucheng Li; John M Shelton; James A Richardson; Erika Spencer; Zhijian J Chen; Xiaodong Wang; R.Sanders Williams
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Apoptosis in Neural Development and Disease

Annual Review of Neuroscience
2000-03 | Journal article
DOI: 10.1146/annurev.neuro.23.1.73
Part of ISSN: 0147-006X
Contributors: Deepak Nijhawan; Narimon Honarpour; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Biochemical Pathways of Caspase Activation During Apoptosis

Annual Review of Cell and Developmental Biology
1999-11 | Journal article
DOI: 10.1146/annurev.cellbio.15.1.269
Part of ISSN: 1081-0706
Contributors: Imawati Budihardjo; Holt Oliver; Michael Lutter; Xu Luo; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Activation of the Apoptotic Endonuclease DFF40 (Caspase-activated DNase or Nuclease)

Journal of Biological Chemistry
1999-05 | Journal article
DOI: 10.1074/jbc.274.20.13836
Part of ISSN: 0021-9258
Contributors: Xuesong Liu; Hua Zou; Piotr Widlak; William Garrard; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

An APAF-1·CytochromecMultimeric Complex Is a Functional Apoptosome That Activates Procaspase-9

Journal of Biological Chemistry
1999-04 | Journal article
DOI: 10.1074/jbc.274.17.11549
Part of ISSN: 0021-9258
Contributors: Hua Zou; Yuchen Li; Xuesong Liu; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search

Bid, a Bcl2 Interacting Protein, Mediates Cytochrome c Release from Mitochondria in Response to Activation of Cell Surface Death Receptors

Cell
1998-08 | Journal article
DOI: 10.1016/s0092-8674(00)81589-5
Part of ISSN: 0092-8674
Contributors: Xu Luo; Imawati Budihardjo; Hua Zou; Clive Slaughter; Xiaodong Wang
Source: Self-asserted source
Xiaodong Wang via Crossref Metadata Search
Items per page:
Page 1 of 2
How many people are using ORCID?