Personal information

Emails & domains

Verified email domains

Activities

Collapse all

Employment (5)

University of Zurich: Zurich, CH

2019 to present | Professor (DMMD)
Employment
Source: Self-asserted source
Raffaella Santoro

University of Zurich: Zurich, CH

2009 to 2019 | Principal Investigator (DMMD)
Employment
Source: Self-asserted source
Raffaella Santoro

ETH Zurich: Zurich, CH

2007 to 2009 | Principal Investigator (BSSE)
Employment
Source: Self-asserted source
Raffaella Santoro

German Cancer Research Center: Heidelberg, DE

1998 to 2007 | Senior postdoc (Mol Biology II)
Employment
Source: Self-asserted source
Raffaella Santoro

Hans Knöll Institute: Jena, DE

1994 to 1997 | Postdoc
Employment
Source: Self-asserted source
Raffaella Santoro

Education and qualifications (3)

University of Zurich: Zurich, CH

2013 | PD/Habilitation/Venia legendi in Biochemistry and Molecular Biology (DMMD)
Education
Source: Self-asserted source
Raffaella Santoro

Sapienza University of Rome: Rome, Lazio, IT

1990 to 1994 | PhD (Dep. Biochemistry)
Education
Source: Self-asserted source
Raffaella Santoro

Sapienza University of Rome: Rome, Lazio, IT

1985 to 1990 | Master in Chemistry (Chemistry)
Education
Source: Self-asserted source
Raffaella Santoro

Funding (4)

Integrative genomic and proteomic analyses to dissect nucleolus functions in aggressive prostate cancer

2023-01 to 2025-12 | Grant
Krebsforschung Schweiz (Bern, CH)
Source: Self-asserted source
Raffaella Santoro

Molecular and functional analysis of the nucleolus in 3D genome organization during early embryo development

2022-08 to 2025-07 | Grant
Swiss National Science Foundation (Bern, CH)
Source: Self-asserted source
Raffaella Santoro

Analysis of the nucleolus and nucleolar chromatin factors in the regulation of genome architecture and function of stem cells

2021-09 to 2024-08 | Grant
Swiss National Science Foundation (Bern, CH)
Source: Self-asserted source
Raffaella Santoro

Analysis of the nucleolus in genome organization and function

2018-09 to 2024-08 | Grant
Horizon 2020 (Brussels, BE)
GRANT_NUMBER:

ERC-AdG-787074-NucleolusChromatin
Source: Self-asserted source
Raffaella Santoro

Works (50 of 66)

Items per page:
Page 1 of 2

LBR and LAP2 mediate heterochromatin tethering to the nuclear periphery to preserve genome homeostasis

2024-12-23 | Preprint | Author
DOI: 10.1101/2024.12.23.628302
Contributors: Renard Lewis; Virginia Sinigiani; Krisztian Koos; Cristiana Bersaglieri; Caroline Ashiono; Raffaella Santoro; Ciaudo; Peter Horvath; Puneet Sharma; Ulrike Kutay
Source: Self-asserted source
Raffaella Santoro

TCF3::HLF Orchestrates an Enhancer-Promoter Network with Activation of MEF2C to Promote Immature HSC gene Expression in Leukemia

2024-11-28 | Preprint
DOI: 10.1101/2024.11.26.625006
Contributors: Valdemar Priebe; Aneta Drakul; Bartimée Galvan; Júlia Aguadé-Gorgorió; Hanna K. A. Mikkola; Beat Bornhauser; Raffaella Santoro; Jean-Pierre Bourquin
Source: Self-asserted source
Raffaella Santoro

NPM1 mediates genome-nucleolus interactions and the establishment of their repressive chromatin states

bioRxiv
2024-07-03 | Preprint | Author
DOI: 10.1101/2024.07.03.601885
Contributors: Shivani Gupta; Cristiana Bersaglieri; Dominik Baer; Mathieu RAINGEVAL; Luana Schaab; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Single-cell dynamics of genome-nucleolus interactions captured by nucleolar laser microdissection (NoLMseq)

bioRxiv
2024-06-19 | Preprint | Author
DOI: 10.1101/2024.06.18.599512
Contributors: Kaivalya Walavalkar; Shivani Gupta; Jelena Kresoja-Rakic; Mathieu Raingeval; Chiara Mungo; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

An RNA-dependent and phase-separated active subnuclear compartment safeguards repressive chromatin domains.

Molecular cell
2024-04-02 | Journal article
DOI: 10.1016/j.molcel.2024.03.015
PMID: 38599210
Contributors: Lerra L; Panatta M; Bär D; Zanini I; Tan JY; Pisano A; Mungo C; Baroux C; Panse VG; Marques AC et al.
Source: Self-asserted source
Raffaella Santoro

PRAMEL7 and CUL2 decrease NuRD stability to establish ground-state pluripotency

EMBO Reports
2024-02-08 | Journal article | Author
DOI: 10.1038/s44319-024-00083-z
Part of ISSN: 1469-3178
Contributors: Meneka Rupasinghe; Cristiana Bersaglieri; Deena Leslie Pedrioli; Patrick Pedrioli; Martina Panatta; Michael Hottiger; Cinelli Paolo; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer.

Life science alliance
2023-04-25 | Journal article | Author
DOI: 10.26508/lsa.202301950
PMID: 37184661
PMC: PMC10130768
Contributors: Roganowicz M; Bär D; Cristiana Bersaglieri; Aprigliano R; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Methods for mapping 3D-chromosome architecture around nucleoli.

Current opinion in cell biology
2023-04-01 | Journal article
DOI: 10.1016/j.ceb.2023.102171
PMID: 37230037
Contributors: Bersaglieri C; Santoro R
Source: Self-asserted source
Raffaella Santoro

Image analysis workflows to reveal the spatial organization of cell nuclei and chromosomes.

Nucleus (Austin, Tex.)
2022-12-01 | Journal article | Author
DOI: 10.1080/19491034.2022.2144013
PMID: 36447428
PMC: PMC9754023
Contributors: Ricardo Randall; Claire Jourdain; Anna Nowicka; Kateřina Kaduchová; Michaela Kubová; Mohammad Ayoub; Veit Schubert; Christophe TATOUT; Isabelle Colas; Kalyanikrishna . et al.
Source: Self-asserted source
Raffaella Santoro

PRAMEL7/CUL2 axis regulates NuRD stability to establish ground-state pluripotency in embryonic stem cells

EMBO Reports in press
2022-10-10 | Preprint | Author
DOI: 10.1101/2022.10.10.511527
Contributors: Meneka Rupasinghe; Cristiana Bersaglieri; Deena M Leslie Pedrioli; Patrick G. A. Pedrioli; Michael O. Hottiger; Paolo Cinelli; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Argonaute proteins regulate a specific network of genes through KLF4 in mouse embryonic stem cells.

Stem cell reports
2022-04-21 | Journal article
DOI: 10.1016/j.stemcr.2022.03.014
PMID: 35452597
PMC: PMC9133645
Contributors: Madlen Müller; Schaefer M; Fäh T; Daniel Spies; Hermes V; Ngondo RP; Peña-Hernández R; Santoro R; Ciaudo C
Source: Self-asserted source
Raffaella Santoro

Genome-wide maps of nucleolus interactions reveal distinct layers of repressive chromatin domains.

Nature communications
2022-03-18 | Journal article | Author
DOI: 10.1038/s41467-022-29146-2
PMID: 35304483
PMC: PMC8933459
Contributors: Bersaglieri C; Kresoja-Rakic J; Gupta S; Bär D; Kuzyakiv R; Panatta M; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro
grade
Preferred source (of 2)‎

Introduction to Epigenetics

Springer International Publishing
2021 | Book
DOI: 10.1007/978-3-030-68670-3
ISBN: 9783030686697
ISBN: 9783030686703
Part of ISSN: 2509-6125
Part of ISSN: 2509-6133
Contributors: Renato Paro; Ueli Grossniklaus; Raffaella Santoro; Anton Wutz
Source: Self-asserted source
Raffaella Santoro

Looking for a job in a dynamic and collaborative working place? LncRNAs are recruiting!

Cell
2021-12-01 | Journal article
DOI: 10.1016/j.cell.2021.10.020
PMID: 34890550
Contributors: Santoro R
Source: Self-asserted source
Raffaella Santoro

Epigenetic control of melanoma cell invasiveness by the stem cell factor SALL4.

Nature communications
2021-08-20 | Journal article | Author
DOI: 10.1038/s41467-021-25326-8
PMID: 34417458
PMC: PMC8379183
Contributors: Johanna Diener; Arianna Baggiolini; Mattias Enar Jonasson; Dalcher D; Luigi Lerra; Phil Cheng; Varum S; Häusel J; Salome Stierli; Mathias Treier et al.
Source: Self-asserted source
Raffaella Santoro

BAZ2A-mediated repression via H3K14ac-marked enhancers promotes prostate cancer stem cells.

EMBO reports
2021-08-17 | Journal article | Author
DOI: 10.15252/embr.202153014
PMID: 34403195
PMC: PMC8567280
Contributors: Peña-Hernández R; Rossana Aprigliano; Carina Frommel S; Pietrzak K; Steiger S; Roganowicz M; Luigi Lerra; Bizzarro J; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

BAZ2A-RNA mediated association with TOP2A and KDM1A represses genes implicated in prostate cancer

2021-07-15 | Preprint | Author
DOI: 10.1101/2021.07.15.452487
Contributors: Marcin Roganowicz; Dominik Bär; Cristiana Bersaglieri; Rossana Aprigliano; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

BAZ2A safeguards genome architecture of ground-state pluripotent stem cells.

The EMBO journal
2020-10-14 | Journal article | Author
DOI: 10.15252/embj.2020105606
PMID: 33433018
PMC: PMC7705451
Contributors: Dalcher D; Jennifer Tan; Bersaglieri C; Peña-Hernández R; Vollenweider E; Zeyen S; Schmid MW; Bianchi V; Stefan Butz; Roganowicz M et al.
Source: Self-asserted source
Raffaella Santoro

Regulation and Roles of the Nucleolus in Embryonic Stem Cells: From Ribosome Biogenesis to Genome Organization.

Stem cell reports
2020-09-24 | Journal article
DOI: 10.1016/j.stemcr.2020.08.012
PMID: 32976768
PMC: PMC7724472
Contributors: Gupta S; Santoro R
Source: Self-asserted source
Raffaella Santoro

TIP5 primes prostate luminal cells for the oncogenic transformation mediated by PTEN-loss.

Proceedings of the National Academy of Sciences of the United States of America
2020-02-05 | Journal article | Author
DOI: 10.1073/pnas.1911673117
PMID: 32024754
PMC: PMC7035629
Contributors: Pietrzak K; Kuzyakiv R; Simon R; MARCO BOLIS; Bär D; Aprigliano R; Theurillat JP; Sauter G; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Nucleolus and rRNA Gene Chromatin in Early Embryo Development.

Trends in genetics : TIG
2019-07-18 | Journal article
DOI: 10.1016/j.tig.2019.06.005
PMID: 31327501
PMC: PMC7610737
Contributors: Jelena Kresoja-Rakic; Santoro R
Source: Self-asserted source
Raffaella Santoro

Genome Organization in and around the Nucleolus.

Cells
2019-06-12 | Journal article
DOI: 10.3390/cells8060579
PMID: 31212844
PMC: PMC6628108
Contributors: Bersaglieri C; Santoro R
Source: Self-asserted source
Raffaella Santoro

Oxidative stress in sperm affects the epigenetic reprogramming in early embryonic development.

Epigenetics & chromatin
2018-10-17 | Journal article | Author
DOI: 10.1186/s13072-018-0224-y
PMID: 30333056
PMC: PMC6192351
Contributors: Wyck S; Herrera C; Requena CE; Bittner L; Petra Hajkova; Heinrich Bollwein; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

EZH2-Mediated Primary Cilium Deconstruction Drives Metastatic Melanoma Formation.

Cancer cell
2018-06-28 | Journal article
DOI: 10.1016/j.ccell.2018.06.001
PMID: 30008323
Contributors: Daniel Zingg; Debbache J; Peña-Hernández R; Antunes AT; Schaefer SM; Phil Cheng; Zimmerli D; Haeusel J; Calçada RR; Tuncer E et al.
Source: Self-asserted source
Raffaella Santoro

Pramel7 mediates ground-state pluripotency through proteasomal-epigenetic combined pathways.

Nature cell biology
2017-06-12 | Journal article
DOI: 10.1038/ncb3554
PMID: 28604677
Contributors: Graf U; Casanova EA; Wyck S; Dalcher D; Marco Gatti; Vollenweider E; Okoniewski MJ; Weber FA; Patel SS; Schmid MW et al.
Source: Self-asserted source
Raffaella Santoro

The RNA helicase DHX9 establishes nucleolar heterochromatin, and this activity is required for embryonic stem cell differentiation.

EMBO reports
2017-06-06 | Journal article | Author
DOI: 10.15252/embr.201744330
PMID: 28588071
PMC: PMC5494521
Contributors: Sergio Leone; Bär D; Slabber CF; Dalcher D; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Helicase CHD4 is an epigenetic coregulator of PAX3-FOXO1 in alveolar rhabdomyosarcoma

Journal of Clinical Investigation
2016-10-17 | Journal article
DOI: 10.1172/jci85057
Part of ISSN: 0021-9738
Part of ISSN: 1558-8238
Contributors: Maria Böhm; Marco Wachtel; Joana G. Marques; Natalie Streiff; Dominik Laubscher; Paolo Nanni; Kamel Mamchaoui; Raffaella Santoro; Beat W. Schäfer
Source: Self-asserted source
Raffaella Santoro

Challenges in the analysis of long noncoding RNA functionality

FEBS Letters
2016-08 | Journal article
DOI: 10.1002/1873-3468.12308
Part of ISSN: 0014-5793
Contributors: Sergio Leone; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Identification of cis and trans-acting elements regulating calretinin expression in mesothelioma cells

Oncotarget
2016-04-19 | Journal article
DOI: 10.18632/oncotarget.7114
Part of ISSN: 1949-2553
Contributors: Jelena Kresoja-Rakic; Esra Kapaklikaya; Gabriela Ziltener; Damian Dalcher; Raffaella Santoro; Brock C. Christensen; Kevin C. Johnson; Beat Schwaller; Walter Weder; Rolf A. Stahel et al.
Source: Self-asserted source
Raffaella Santoro

Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma

Genome Biology
2015-12 | Journal article
DOI: 10.1186/s13059-015-0594-4
Part of ISSN: 1474-760X
Contributors: Phil F Cheng; Olga Shakhova; Daniel S Widmer; Ossia M Eichhoff; Daniel Zingg; Sandra C Frommel; Benedetta Belloni; Marieke IG Raaijmakers; Simone M Goldinger; Raffaella Santoro et al.
Source: Self-asserted source
Raffaella Santoro

Antagonistic Cross-Regulation between Sox9 and Sox10 Controls an Anti-tumorigenic Program in Melanoma

PLOS Genetics
2015-01-28 | Journal article
DOI: 10.1371/journal.pgen.1004877
Part of ISSN: 1553-7404
Contributors: Olga Shakhova; Phil Cheng; Pravin J. Mishra; Daniel Zingg; Simon M. Schaefer; Julien Debbache; Jessica Häusel; Claudia Matter; Theresa Guo; Sean Davis et al.
Source: Self-asserted source
Raffaella Santoro

The epigenetic modifier EZH2 controls melanoma growth and metastasis through silencing of distinct tumour suppressors

Nature Communications
2015-01-22 | Journal article
DOI: 10.1038/ncomms7051
Part of ISSN: 2041-1723
Contributors: Daniel Zingg; Julien Debbache; Simon M. Schaefer; Eylul Tuncer; Sandra C. Frommel; Phil Cheng; Natalia Arenas-Ramirez; Jessica Haeusel; Yudong Zhang; Mario Bonalli et al.
Source: Self-asserted source
Raffaella Santoro

Analysis of Chromatin Composition of Repetitive Sequences: The ChIP-Chop Assay

Methods in Molecular Biology
2014 | Book chapter
DOI: 10.1007/978-1-62703-706-8_25
Part of ISBN: 9781627037051
Part of ISBN: 9781627037068
Part of ISSN: 1064-3745
Part of ISSN: 1940-6029
Contributors: Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells

Molecular Cancer
2014-12 | Journal article
DOI: 10.1186/1476-4598-13-125
Part of ISSN: 1476-4598
Contributors: Samia B Bachmann; Sandra C Frommel; Rosalba Camicia; Hans C Winkler; Raffaella Santoro; Paul O Hassa
Source: Self-asserted source
Raffaella Santoro

BAZ2A (TIP5) is involved in epigenetic alterations in prostate cancer and its overexpression predicts disease recurrence.

Nature genetics
2014-12-08 | Journal article
DOI: 10.1038/ng.3165
PMID: 25485837
Contributors: Gu L; Frommel SC; Oakes CC; Simon R; Grupp K; Gerig CY; Bär D; Mark Robinson; Baer C; Weiss M et al.
Source: Self-asserted source
Raffaella Santoro

lncRNA maturation to initiate heterochromatin formation in the nucleolus is required for exit from pluripotency in ESCs

Cell Stem Cell
2014-12-04 | Journal article | Conceptualization, Funding acquisition, Investigation, Supervision
Contributors: Natasa Savic; Dominik Bär; Sergio Leone; Sandra C. Frommel; Fabienne A. Weber; Eva Vollenweider; Elena Ferrari; Urs Ziegler; Andres Kaech; Olga Shakhova et al.
Source: Self-asserted source
Raffaella Santoro

ARTD2 activity is stimulated by RNA

Nucleic Acids Research
2014-04 | Journal article
DOI: 10.1093/nar/gku131
Part of ISSN: 1362-4962
Part of ISSN: 0305-1048
Contributors: Karolin Léger; Dominik Bär; Nataša Savić; Raffaella Santoro; Michael O. Hottiger
Source: Self-asserted source
Raffaella Santoro

The expanding role of PARPs in the establishment and maintenance of heterochromatin

FEBS Journal
2013-08 | Journal article
DOI: 10.1111/febs.12368
Part of ISSN: 1742-464X
Contributors: Françoise Dantzer; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Formation of nuclear heterochromatin: the nucleolar point of view

Epigenetics
2012-08-18 | Journal article
DOI: 10.4161/epi.21072
Part of ISSN: 1559-2294
Part of ISSN: 1559-2308
Contributors: Claudio Guetg; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Noncoding RNAs link PARP1 to heterochromatin

Cell Cycle
2012-06-15 | Journal article
DOI: 10.4161/cc.20622
Part of ISSN: 1538-4101
Part of ISSN: 1551-4005
Contributors: Claudio Guetg; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Inflammasome-Activated Caspase 7 Cleaves PARP1 to Enhance the Expression of a Subset of NF-κB Target Genes

Molecular Cell
2012-04 | Journal article
DOI: 10.1016/j.molcel.2012.02.016
Part of ISSN: 1097-2765
Contributors: Süheda Erener; Virginie Pétrilli; Ingrid Kassner; Roberta Minotti; Rosa Castillo; Raffaella Santoro; Paul O. Hassa; Jürg Tschopp; Michael O. Hottiger
Source: Self-asserted source
Raffaella Santoro

Inheritance of silent rDNA chromatin is mediated by PARP1 via noncoding RNA.

Molecular cell
2012-03-08 | Journal article
DOI: 10.1016/j.molcel.2012.01.024
PMID: 22405650
Contributors: Guetg C; Scheifele F; Rosenthal F; Michael Hottiger; Santoro R
Source: Self-asserted source
Raffaella Santoro

The Epigenetics of the Nucleolus: Structure and Function of Active and Silent Ribosomal RNA Genes

The Nucleolus
2011 | Book chapter
DOI: 10.1007/978-1-4614-0514-6_4
Part of ISBN: 9781461405139
Part of ISBN: 9781461405146
Contributors: Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

Nuclear envelope alterations generate an aging-like epigenetic pattern in mice deficient in Zmpste24 metalloprotease

Aging Cell
2010-12 | Journal article
DOI: 10.1111/j.1474-9726.2010.00621.x
Part of ISSN: 1474-9718
Contributors: Fernando G. Osorio; Ignacio Varela; Ester Lara; Xose S. Puente; Jesús Espada; Raffaella Santoro; José M. P. Freije; Mario F. Fraga; Carlos López-Otín
Source: Self-asserted source
Raffaella Santoro

The NoRC complex mediates the heterochromatin formation and stability of silent rRNA genes and centromeric repeats.

The EMBO journal
2010-02-18 | Journal article
DOI: 10.1038/emboj.2010.17
PMID: 20168299
PMC: PMC2905252
Contributors: Guetg C; Philipp Lienemann; Sirri V; Grummt I; Hernandez-Verdun D; Michael Hottiger; Fussenegger M; Santoro R
Source: Self-asserted source
Raffaella Santoro

Intergenic transcripts originating from a subclass of ribosomal DNA repeats silence ribosomal RNA genes in trans

EMBO reports
2010-01 | Journal article
DOI: 10.1038/embor.2009.254
Part of ISSN: 1469-221X
Part of ISSN: 1469-3178
Contributors: Raffaella Santoro; Kerstin‐Maike Schmitz; Juan Sandoval; Ingrid Grummt
Source: Self-asserted source
Raffaella Santoro

Epigenetic Engineering of Ribosomal RNA Genes Enhances Protein Production

PLoS ONE
2009-08-14 | Journal article
DOI: 10.1371/journal.pone.0006653
Part of ISSN: 1932-6203
Contributors: Raffaella Santoro; Philipp Lienemann; Martin Fussenegger
Source: Self-asserted source
Raffaella Santoro

Epigenetic disruption of ribosomal RNA genes and nucleolar architecture in DNA methyltransferase 1 (Dnmt1) deficient cells

Nucleic Acids Research
2007-03-11 | Journal article
DOI: 10.1093/nar/gkm118
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: J. Espada; E. Ballestar; R. Santoro; M. F. Fraga; A. Villar-Garea; A. Nemeth; L. Lopez-Serra; S. Ropero; A. Aranda; H. Orozco et al.
Source: Self-asserted source
Raffaella Santoro

Intergenic Transcripts Regulate the Epigenetic State of rRNA Genes

Molecular Cell
2006-05 | Journal article
DOI: 10.1016/j.molcel.2006.03.028
Part of ISSN: 1097-2765
Contributors: Christine Mayer; Kerstin-Maike Schmitz; Junwei Li; Ingrid Grummt; Raffaella Santoro
Source: Self-asserted source
Raffaella Santoro

The silence of the ribosomal RNA genes

Cellular and Molecular Life Sciences
2005-09 | Journal article
DOI: 10.1007/s00018-005-5110-7
Part of ISSN: 1420-682X
Part of ISSN: 1420-9071
Contributors: R. Santoro
Source: Self-asserted source
Raffaella Santoro
Items per page:
Page 1 of 2

Peer review (9 reviews for 8 publications/grants)

Review activity for Cell research (1)
Review activity for EMBO journal. (1)
Review activity for Mammalian genome. (1)
Review activity for Nature (1)
Review activity for Nature cell biology (2)
Review activity for Nature structural & molecular biology. (1)
Review activity for Science. (1)
Review activity for The Journal of cell biology. (1)
How many people are using ORCID?