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UCL IRIS Profile

Keywords

Genetics, Genomics, Inherited eye diseases

Countries

United Kingdom

Activities

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Employment (1)

University College London: London, England, GB

Employment
Source: check_circle
University College London

Education and qualifications (2)

Newcastle University: Newcastle upon Tyne, Tyne and Wear, GB

1993 | PhD Molecular Biology
Qualification
Source: Self-asserted source
Alison Hardcastle

UEL: London, GB

1988 | BSC (Hons) Biophysics
Qualification
Source: Self-asserted source
Alison Hardcastle

Professional activities (11)

Retina UK: London, GB

2021-08-01 to present | Medical Advisory Board
Service
Source: Self-asserted source
Alison Hardcastle

International Centre for Translational Eye Research: Warsaw, PL

2019 to present | Scientific advisory committee
Service
Source: Self-asserted source
Alison Hardcastle

Fight for Sight: London, GB

2018 to present | Grant Assessment Panel
Service
Source: Self-asserted source
Alison Hardcastle

UK Biobank : London, GB

2017 to present | Eye and Vision Consortium
Membership
Source: Self-asserted source
Alison Hardcastle

Genomics England Clinical Interpretation Partnership : London, GB

2015 to present | Rare Disease, Hearing and Sight domain and Paediatric domain
Membership
Source: Self-asserted source
Alison Hardcastle

University of London: London, GB

2019 | Personal Chair, Sembal Professor of Experimental Ophthalmology (UCL Institute of Ophthalmology)
Distinction
Source: Self-asserted source
Alison Hardcastle

UCL Institute of Ophthalmlogy: London, GB

2016 | Deputy Director
Distinction
Source: Self-asserted source
Alison Hardcastle

RP Fighting Blindess: London, GB

2016 | Jessie Mole Medal for contribution to research
Distinction
Source: Self-asserted source
Alison Hardcastle

Annals of Human Genetics: London, GB

2013 to 2016 | Senior Editor
Service
Source: Self-asserted source
Alison Hardcastle

Alberta Vision Science Congress: Alberta, CA

2007 | Keynote Lecture
Distinction
Source: Self-asserted source
Alison Hardcastle

ARVO Foundation for Eye Research: Md., Md., US

2004 to 2007 | Program organising committee, Chair in 2007
Invited position
Source: Self-asserted source
Alison Hardcastle

Funding (24)

Variants, genes and perturbed molecular pathways associated with keratoconus

2021-11 to 2024-10 | Grant
Moorfields Eye Charity (London, GB)
Source: Self-asserted source
Alison Hardcastle

Seahorse bioanalyser to assess mitochondrial function and metabolism in eye cells and eye disease

2021-10 to present | Grant
Moorfields Eye Charity (London, GB)
Source: Self-asserted source
Alison Hardcastle

Investigation of LW/MW cone opsin disease and therapy in retinal organoids

2021-10 to 2024-09 | Grant
Fight for Sight UK (London, GB)
Source: Self-asserted source
Alison Hardcastle

The UK Inherited Retinal Disease Consortium (UK IRDC)

2020 to 2023 | Award
Retina UK (Buckingham, GB)
Source: Self-asserted source
Alison Hardcastle

Exploring the molecular mechanism of a new cause of autosomal dominant retinitis pigmentosa and potential therapies

2019 to 2022 | Award
Fight for Sight UK (London, GB)
Source: Self-asserted source
Alison Hardcastle

Assessment of genotype-phenotype relationship for blue cone monochromacy

2019 to 2021 | Award
Blue Cone Monochromacy families foundation (Jupiter, Florida, US)
Source: Self-asserted source
Alison Hardcastle

Investigating genetic causes and transcriptional dysregulation events associated with posterior polymorphous corneal dystrophy (PPCD)

2018-10-01 to 2021-09-30 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527681
GRANT_NUMBER:

R180021A
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Investigation of the underlying cause of retinal dystrophies caused by IFT140 mutations

2018-10-01 to 2019-09-30 | Grant
Fight for Sight (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527911
GRANT_NUMBER:

2029/2030
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Understanding the mechanisms of cone opsin mediated disease to develop new therapies

2018-05-31 to 2021-05-30 | Grant
Medical Research Council (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.7748702
GRANT_NUMBER: MR/R012121/1
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Oligonucleotide suppression of mis-splicing of the cone opsin genes as a potential therapeutic for X-linked cone dysfunction

2018-02-01 to 2019-07-31 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527679
GRANT_NUMBER:

R180003A
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Development and utilisation of an ex-vivo patient-derived cell model to investigate Fuchs corneal endothelial dystrophy (FECD) disease aetiology and test potential therapies

2018 to 2021 | Award
National Eye Research Centre (Bristol, GB)
Source: Self-asserted source
Alison Hardcastle

Towards a therapy for Fuch’s Corneal Dystrophy caused by expanded repeats of the TCF4 gene

2018 to 2020 | Award
ProQR Industrial Research Collaboration (Leiden, NL)
Source: Self-asserted source
Alison Hardcastle

Development of iPSC derived corneal cell models of dominant corneal dystrophies

2017-10-01 to 2020-09-30 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527676
GRANT_NUMBER:

R170035A
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Genetic classification of corneal dystrophies and development of iPSC derived models of disease

2017-10-01 to 2020-09-30 | Grant
Fight for Sight (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527860
GRANT_NUMBER:

5035/5036
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

A genome-wide association study of keratoconus

2016-10-01 to 2018-09-30 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527754
GRANT_NUMBER:

R170002A
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Gene discovery for corneal dystrophies

2016-10-01 to 2018-03-31 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527710
GRANT_NUMBER:

R170022A
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Aberrant RNA processing in Retinal Dystrophies: understanding mechanisms and developing therapies

2016 to 2019 | Award
RP Fighting Blindness (Retina UK) (Buckingham, GB)
Source: Self-asserted source
Alison Hardcastle

Towards a therapy for Fuch’s Corneal Dystrophy caused by expanded repeats of the TCF4 gene

2015-11 to 2018-09 | Award
ProQR Industrial Research Collaboration (Leiden, NL)
Source: Self-asserted source
Alison Hardcastle

Probing RP2 mechanisms of disease using patient iPS cells

2015-02-01 to 2020-08-31 | Grant
Moorfields Eye Charity (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.8527693
GRANT_NUMBER:

R150022A/B
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

The UK RP Genome Project

2015 to 2018 | Award
RP Fighting Blindness (Retina UK) (Buckingham, GB)
Source: Self-asserted source
Alison Hardcastle

Identification of genetic risk factors for glaucoma and pectinate ligament dysplasia in multiple breeds of dog and development of DNA tests to reduce disease prevalence

2014 to 2019 | Award
Dogs Trust (London, GB)
Source: Self-asserted source
Alison Hardcastle

Investigating the function of the Nance-Horan Syndrome protein; a new protein family with homology to the Wiskott-Aldrich Syndrome protein (WASp) family.

2005-10-01 to 2009-03-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3630635
GRANT_NUMBER:

077477/Z/05/Z
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

Functional characterisation of Nyctalopin; probing the development of retinal architecture.

2002-05-01 to 2005-07-31 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3627218
GRANT_NUMBER:

066580/Z/01/Z
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard

X-linked progressive cone dystrophies; Identification of the genes causing COD1 and COD2.

2002-04-01 to 2005-04-30 | Grant
Wellcome Trust (London, GB)
URL: https://app.dimensions.ai/details/grant/grant.3629482
GRANT_NUMBER:

065454/Z/01/Z
Source: Self-asserted source
Alison Hardcastle via DimensionsWizard
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