Personal information

Emails & domains

Verified email addresses

Verified email domains

Websites & social links

https://www.maxperutzlabs.ac.at/research/research-groups/slade; www.sladelab.org
University of Vienna profile page

Keywords

transcription regulation, DNA damage, poly(ADP-ribosyl)ation, neuronal differentiation, STING

Countries

Austria

Activities

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Employment (5)

University of Vienna: Wien, AT

Employment
Source: check_circle
University of Vienna - u:cris

Medical University of Vienna: Vienna, AT

2021-09-01 to present | Group leader, Associate Professor (Radiation Oncology, Max Perutz Labs, MedAustron)
Employment
Source: Self-asserted source
Dea Slade

University of Vienna: Vienna, AT

2012-11-01 to 2021-08-31 | Group leader (Biochemistry)
Employment
Source: Self-asserted source
Dea Slade

Paterson Institute for Cancer Research: Manchester, GB

2010-02-01 to 2011-11-30 | Post-doctoral researcher
Employment
Source: Self-asserted source
Dea Slade

Universite´ Paris Descartes: Paris, FR

2009-04-01 to 2010-01-31 | Post-doctoral researcher
Employment
Source: Self-asserted source
Dea Slade

Education and qualifications (3)

Université Pierre et Marie Curie: Paris, Île-de-France, FR

2005-10-01 to 2009-03-26 | PhD
Education
Source: Self-asserted source
Dea Slade

University of Zagreb: Zagreb, Grad Zagreb, HR

2001-10-01 to 2005-09-01 | BSc/MSc (Faculty of Pharmacy and Medicinal Biochemistry)
Education
Source: Self-asserted source
Dea Slade

University of Zagreb: Zagreb, Grad Zagreb, HR

1999-10-01 to 2004-07-01 | BSc/MSc (Faculty of Natural Sciences and Mathematics)
Education
Source: Self-asserted source
Dea Slade

Funding (8)

Co-regulation of transcription by DIDO3 and PHF3 paralogues

2023-12-01 to 2027-05-31 | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.13756863
GRANT_NUMBER: P 36924
Source: Self-asserted source
Dea Slade via DimensionsWizard

Genome Instability

2023-11-27 to present | Grant
FWF Austrian Science Fund (Vienna, AT)
URL: https://app.dimensions.ai/details/grant/grant.13860139
GRANT_NUMBER: DOC 195
Source: Self-asserted source
Dea Slade via DimensionsWizard

PAIR - Pre-clinicAl Ion beam Research

2022-05 to 2026-05 | Grant
FWF Austrian Science Fund (Vienna, AT)
GRANT_NUMBER:

Part of FW774A0101
Source: Self-asserted source
Dea Slade

Structural and functional characterization of SPOC domains

2018-05 to 2022-04 | Grant
Austrian Science Fund (Vienna, AT)
GRANT_NUMBER:

P31546-B28
Source: Self-asserted source
Dea Slade

The regulation of dynamic interactions between PARG and PCNA

2018-05 to 2022-04 | Grant
Austrian Science Fund (Vienna, AT)
GRANT_NUMBER:

P 31112-B28
Source: Self-asserted source
Dea Slade

Applying a new UV laser-based module to monitor protein-protein interactions after DNA damage using time-resolved spectroscopy

2017-12 to 2018-11 | Grant
Vienna Science and Technology Fund (Vienna, AT)
GRANT_NUMBER:

NXT17-017
Source: Self-asserted source
Dea Slade

Integrative Structure Biology

2015-05 to present | Grant
Austrian Science Fund (Vienna, AT)
Part of GRANT_NUMBER:

W 1258
Source: Self-asserted source
Dea Slade

Imaging recruitment of chromatin remodelling proteins to the sites of DNA damage induced by laser microirradiation

2015-02 to 2018-07 | Grant
Vienna Science and Technology Fund (Vienna, AT)
GRANT_NUMBER:

LS14-001
Source: Self-asserted source
Dea Slade

Works (32)

PARP7 as a new target for activating anti-tumor immunity in cancer

EMBO Molecular Medicine
2025-03-24 | Journal article
DOI: 10.1038/s44321-025-00214-6
Contributors: Katerina Popova; Johannes Benedum; Magdalena Engl; Carola Lütgendorf-Caucig; Piero Fossati; Joachim Widder; Klaus Podar; Dea Slade
Source: check_circle
Crossref

STK19 drives transcription-coupled repair by stimulating repair complex stability, RNA Pol II ubiquitylation, and TFIIH recruitment.

Molecular cell
2024-11-14 | Journal article
DOI: 10.1016/j.molcel.2024.10.030
PMID: 39547223
Contributors: Ramadhin AR; Lee SH; Zhou D; Salmazo A; Gonzalo-Hansen C; van Sluis M; Blom CMA; Janssens RC; Raams A; Dekkers D et al.
Source: Self-asserted source
Dea Slade

Cytosolic nucleic acid sensors and interferon beta-1 activation drive radiation-induced anti-tumour immune effects in human pancreatic cancer cells.

Frontiers in immunology
2024-09-20 | Journal article
DOI: 10.3389/fimmu.2024.1286942
PMID: 39372406
PMC: PMC11449851
Contributors: Kerschbaum-Gruber S; Kleinwächter A; Popova K; Kneringer A; Lisa-Marie Appel; Stasny K; Röhrer A; Dias AB; Benedum J; Walch L et al.
Source: Self-asserted source
Dea Slade

FIP200 Phosphorylation Regulates Late Steps in Mitophagy.

Journal of molecular biology
2024-05-29 | Journal article
DOI: 10.1016/j.jmb.2024.168631
PMID: 38821350
Contributors: Eickhorst C; Riccardo Babic; Jorrell Rush-Kittle; Lucya L; Imam FL; Sánchez-Martín P; David Hollenstein; Jonas Benjamin Michaelis; Münch C; Chris Meisinger et al.
Source: Self-asserted source
Dea Slade

The interplay between autophagy and cGAS-STING signaling and its implications for cancer.

Frontiers in immunology
2024-04-10 | Journal article
DOI: 10.3389/fimmu.2024.1356369
PMID: 38660307
PMC: PMC11039819
Contributors: Schmid M; Fischer P; Engl M; Widder J; Kerschbaum-Gruber S; Slade D
Source: Self-asserted source
Dea Slade

Brillouin light scattering anisotropy microscopy for imaging the viscoelastic anisotropy in living cells

Nature Photonics
2024-03 | Journal article | Author
DOI: 10.1038/s41566-023-01368-w
SOURCE-WORK-ID:

2f2a9446-0b4e-4023-adb4-247c6d935b20

EID:

2-s2.0-85182452976
Contributors: Hamid Keshmiri; Domagoj Cikes; Marketa Samalova; Lukas Schindler; Lisa Marie Appel; Michal Urbanek; Ivan Yudushkin; Dea Slade; Wolfgang J. Weninger; Alexis Peaucelle et al.
Source: check_circle
University of Vienna - u:cris
grade
Preferred source (of 2)‎

The SPOC proteins DIDO3 and PHF3 co-regulate gene expression and neuronal differentiation.

Nature communications
2023-11-30 | Journal article | Author
DOI: 10.1038/s41467-023-43724-y
PMID: 38036524
PMC: PMC10689479
Contributors: Johannes Benedum; Vedran Franke; Lisa-Marie Appel; Walch L; Melania Bruno; Schneeweiss R; Gruber J; Oberndorfer H; Frank E; Strobl X et al.
Source: Self-asserted source
Dea Slade

Leveraging homologous recombination repair deficiency in sarcoma

EMBO Molecular Medicine
2023-04-11 | Journal article
DOI: 10.15252/emmm.202317453
Contributors: Dea Slade; Joanna I Loizou
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

SPOC domain proteins in health and disease

Genes & Development
2023-03-01 | Journal article
DOI: 10.1101/gad.350314.122
Part of ISSN: 0890-9369
Part of ISSN: 1549-5477
Contributors: Lisa-Marie Appel; Johannes Benedum; Magdalena Engl; Sebastian Platzer; Alexander Schleiffer; Xué Strobl; Dea Slade
Source: Self-asserted source
Dea Slade
grade
Preferred source (of 2)‎

The SPOC domain is a phosphoserine binding module that bridges transcription machinery with co- and post-transcriptional regulators.

Nature communications
2023-01-11 | Journal article | Author
DOI: 10.1038/s41467-023-35853-1
PMID: 36631525
PMC: PMC9834408
Contributors: Lisa-Marie Appel; Vedran Franke; Johannes Benedum; Irina Grishkovskaya; Strobl X; Anton Polyansky; Gregor Ammann; Sebastian W. Platzer; Andrea Neudolt; Wunder A et al.
Source: Self-asserted source
Dea Slade
grade
Preferred source (of 2)‎

Analysis of Golgi Protein Acetylation Using In Vitro Assays and Parallel Reaction Monitoring Mass Spectrometry.

Methods in molecular biology (Clifton, N.J.)
2023-01-01 | Journal article
DOI: 10.1007/978-1-0716-2639-9_43
PMID: 36512247
Contributors: Slade D; Hartl M
Source: Self-asserted source
Dea Slade

PHF3 regulates neuronal gene expression through the Pol II CTD reader domain SPOC

Nature Communications
2021-10-19 | Journal article
DOI: 10.1038/s41467-021-26360-2
SOURCE-WORK-ID:

fcc0e2d7-c4ec-4d16-baf7-2cfced95ce11

EID:

2-s2.0-85117730956

PMID: 34667177
WOSUID:

000709050300001
Contributors: Lisa Marie Appel; Vedran Franke; Melania Bruno; Irina Grishkovskaya; Aiste Kasiliauskaite; Tanja Kaufmann; Ursula E. Schoeberl; Martin G. Puchinger; Sebastian Kostrhon; Carmen Ebenwaldner et al.
Source: check_circle
University of Vienna - u:cris

Direct measurement of protein–protein interactions by FLIM-FRET at UV laser-induced DNA damage sites in living cells

Nucleic Acids Research
2020-12-02 | Journal article
DOI: 10.1093/nar/gkaa859
Contributors: Tanja Kaufmann; Sébastien Herbert; Benjamin Hackl; Johanna Maria Besold; Christopher Schramek; Josef Gotzmann; Kareem Elsayad; Dea Slade
Source: check_circle
Crossref
grade
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Cep97 Is Required for Centriole Structural Integrity and Cilia Formation in Drosophila

Current Biology
2020-08 | Journal article
DOI: 10.1016/j.cub.2020.05.078
Contributors: Jeroen Dobbelaere; Marketa Schmidt Cernohorska; Martina Huranova; Dea Slade; Alexander Dammermann
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

Tuning drug binding.

Science (New York, N.Y.)
2020-04 | Journal article
DOI: 10.1126/science.abb1462
PMID: 32241937
Contributors: Slade D; Eustermann S
Source: Self-asserted source
Dea Slade via Europe PubMed Central
grade
Preferred source (of 2)‎

PARP and PARG inhibitors in cancer treatment

Genes & Development
2020-03-01 | Journal article
DOI: 10.1101/gad.334516.119
Contributors: Dea Slade
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

SIRT2 deacetylates GRASP55 to facilitate post-mitotic Golgi assembly

Journal of Cell Science
2019-11-01 | Journal article
SOURCE-WORK-ID:

b5bb47df-fee7-442c-8406-f8fe023987d9
Contributors: Xiaoyan Zhang; Andreas Brachner; Eva Kukolj; Dea Slade; Yanzhuang Wang
Source: check_circle
University of Vienna - u:cris

Mitotic functions of poly(ADP-ribose) polymerases.

Biochemical pharmacology
2019-03 | Journal article
DOI: 10.1016/j.bcp.2019.03.028
PMID: 30910692
Contributors: Slade D
Source: Self-asserted source
Dea Slade via Europe PubMed Central
grade
Preferred source (of 3)‎

Simultaneous dual-channel imaging to quantify interdependent protein recruitment to laser-induced DNA damage sites.

Nucleus (Austin, Tex.)
2018-09 | Journal article
DOI: 10.1080/19491034.2018.1516485
PMID: 30205747
Contributors: Garbrecht J; Hornegger H; Herbert S; Kaufmann T; Gotzmann J; Elsayad K; Slade D
Source: Self-asserted source
Dea Slade via Europe PubMed Central
grade
Preferred source (of 3)‎

Maneuvers on PCNA Rings during DNA Replication and Repair

Genes
2018-08-17 | Journal article
DOI: 10.3390/genes9080416
Contributors: Dea Slade
Source: check_circle
Crossref
grade
Preferred source (of 3)‎

A histone-mimicking interdomain linker in a multidomain protein modulates multivalent histone binding

Journal of Biological Chemistry
2017-10 | Journal article
DOI: 10.1074/jbc.M117.801464
Contributors: Sebastian Kostrhon; Georg Kontaxis; Tanja Kaufmann; Erika Schirghuber; Stefan Kubicek; Robert Konrat; Dea Slade
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

PARP inhibition causes premature loss of cohesion in cancer cells.

Oncotarget
2017-10 | Journal article
DOI: 10.18632/oncotarget.21879
PMID: 29262611
PMC: PMC5732777
Contributors: Kukolj E; Kaufmann T; Dick AE; Zeillinger R; Gerlich DW; Slade D
Source: Self-asserted source
Dea Slade via Europe PubMed Central
grade
Preferred source (of 2)‎

A novel non-canonical PIP-box mediates PARG interaction with PCNA

Nucleic Acids Research
2017-07 | Journal article
DOI: 10.1093/nar/gkx604
Part of ISSN: 0305-1048
Contributors: Tanja Kaufmann; Irina Grishkovskaya; Anton A. Polyansky; Sebastian Kostrhon; Eva Kukolj; Karin M. Olek; Sebastien Herbert; Etienne Beltzung; Karl Mechtler; Thomas Peterbauer et al.
Source: Self-asserted source
Dea Slade via Crossref Metadata Search
grade
Preferred source (of 2)‎

SIRT2 regulates nuclear envelope reassembly through ANKLE2 deacetylation

Journal of Cell Science
2016-11 | Journal article
DOI: 10.1242/jcs.192633
Part of ISSN: 0021-9533
Contributors: Tanja Kaufmann; Eva Kukolj; Andreas Brachner; Etienne Beltzung; Melania Bruno; Sebastian Kostrhon; Susanne Opravil; Otto Hudecz; Karl Mechtler; Graham Warren et al.
Source: Self-asserted source
Dea Slade via Crossref Metadata Search
grade
Preferred source (of 2)‎

The structure and catalytic mechanism of a poly(ADP-ribose) glycohydrolase

Nature
2011-09 | Journal article
DOI: 10.1038/nature10404
Part of ISSN: 0028-0836
Contributors: Dea Slade; Mark S. Dunstan; Eva Barkauskaite; Ria Weston; Pierre Lafite; Neil Dixon; Marijan Ahel; David Leys; Ivan Ahel
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Oxidative Stress Resistance in Deinococcus radiodurans

Microbiology and Molecular Biology Reviews
2011-03-01 | Journal article
DOI: 10.1128/mmbr.00015-10
Part of ISSN: 1092-2172
Contributors: D. Slade; M. Radman
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Identification of Macrodomain Proteins as NovelO-Acetyl-ADP-ribose Deacetylases

Journal of Biological Chemistry
2011-01 | Journal article
DOI: 10.1074/jbc.m110.206771
Part of ISSN: 0021-9258
Contributors: Dawei Chen; Melanie Vollmar; Marianna N. Rossi; Claire Phillips; Rolf Kraehenbuehl; Dea Slade; Pawan V. Mehrotra; Frank von Delft; Susan K. Crosthwaite; Opher Gileadi et al.
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

RecA protein assures fidelity of DNA repair and genome stability in Deinococcus radiodurans

DNA Repair
2010-11 | Journal article
DOI: 10.1016/j.dnarep.2010.08.003
Part of ISSN: 1568-7864
Contributors: Jelena Repar; Svjetlana Cvjetan; Dea Slade; Miroslav Radman; Davor Zahradka; Ksenija Zahradka
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Recombination and Replication in DNA Repair of Heavily Irradiated Deinococcus radiodurans

Cell
2009-03 | Journal article
DOI: 10.1016/j.cell.2009.01.018
Part of ISSN: 0092-8674
Contributors: Dea Slade; Ariel B. Lindner; Gregory Paul; Miroslav Radman
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Involvement of Escherichia coli DNA Polymerase IV in Tolerance of Cytotoxic Alkylating DNA Lesions in Vivo

Genetics
2007-05-04 | Journal article
DOI: 10.1534/genetics.107.072405
Part of ISSN: 0016-6731
Contributors: I. Bjedov; C. N. Dasgupta; D. Slade; S. Le Blastier; M. Selva; I. Matic
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Reassembly of shattered chromosomes in Deinococcus radiodurans

Nature
2006-09 | Journal article
DOI: 10.1038/nature05160
Part of ISSN: 0028-0836
Contributors: Ksenija Zahradka; Dea Slade; Adriana Bailone; Suzanne Sommer; Dietrich Averbeck; Mirjana Petranovic; Ariel B. Lindner; Miroslav Radman
Source: Self-asserted source
Dea Slade via Crossref Metadata Search

Selective inhibition of divergent seryl-tRNA synthetases by serine analogues

FEBS Letters
2005-07 | Journal article
DOI: 10.1016/j.febslet.2005.06.073
Part of ISSN: 0014-5793
Contributors: Dragana Ahel; Dea Slade; Marko Mocibob; Dieter Söll; Ivana Weygand-Durasevic
Source: Self-asserted source
Dea Slade via Crossref Metadata Search
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