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Uniwersytet Jagielloński w Krakowie: Krakow, Małopolska, PL

2018-09-01 to present | Post-doc (Department of Chemistry)
Employment
Source: Self-asserted source
Jacek Plewka

Works (36)

1,5-disubstituted Tetrazoles as PD-1/PD-L1 Antagonist

RSC Medicinal Chemistry
2024 | Journal article
DOI: 10.1039/d3md00746d
Part of ISSN: 2632-8682
Contributors: Robin van der Straat; Rosalie Draijer; Ewa Surmiak; Roberto Butera; Lenard Land; Katarzyna Magiera-Mularz; Bogdan Musielak; Jacek Plewka; Tad Holak; Alexander Dömling
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Antibody-ligand interactions on a high-capacity staphylococcal protein A resin

Journal of Chromatography A
2024-08 | Journal article
DOI: 10.1016/j.chroma.2024.465102
Contributors: Rupert Tscheliessnig; Goncalo L. Silva; Jacek Plewka; Leo A. Jakob; Helga Lichtenegger; Alois Jungbauer; Ana C. Dias-Cabral
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Crossref

Nonsymmetrically Substituted 1,1′-Biphenyl-Based Small Molecule Inhibitors of the PD-1/PD-L1 Interaction

ACS Medicinal Chemistry Letters
2024-06-13 | Journal article
DOI: 10.1021/acsmedchemlett.4c00042
Contributors: Aleksandra Hec-Gałązka; Urszula Tyrcha; Jan Barczyński; Przemyslaw Bielski; Michał Mikitiuk; Ganna P. Gudz; Radosław Kitel; Bogdan Musielak; Jacek Plewka; Tomasz Sitar et al.
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Crossref

Autoinhibition of suicidal capsid protease from O’nyong’nyong virus

International Journal of Biological Macromolecules
2024-03 | Journal article
DOI: 10.1016/j.ijbiomac.2024.130136
Part of ISSN: 0141-8130
Contributors: Yuliya Chykunova; Jacek Plewka; Piotr Wilk; Marcin Sienczyk; Grzegorz Dubin; Krzysztof Pyrc
Source: Self-asserted source
Jacek Plewka

Despite the odds: formation of the SARS-CoV-2 methylation complex

Nucleic Acids Research
2024-03-18 | Journal article | Author
DOI: 10.1093/nar/gkae165
Part of ISSN: 0305-1048
Part of ISSN: 1362-4962
Contributors: Alex Matsuda; Jacek Plewka; Michał Rawski; André Mourão; Weronika Zajko; Till Siebenmorgen; Leanid Kresik; Kinga Lis; Alisha; Magdalena Pachota et al.
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Solubilizer Tag Effect on PD-L1/Inhibitor Binding Properties for m-Terphenyl Derivatives

ACS Medicinal Chemistry Letters
2024-01-11 | Journal article
DOI: 10.1021/acsmedchemlett.3c00306
Contributors: Ewa Surmiak; Julia Ząber; Jacek Plewka; Grzegorz Wojtanowicz; Justyna Kocik-Krol; Oskar Kruc; Damian Muszak; Ismael Rodríguez; Bogdan Musielak; Monica Viviano et al.
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Crossref

Anti-SARS-CoV-2 activity of cyanopeptolins produced by Nostoc edaphicum CCNP1411

Antiviral Research
2023-10 | Journal article
DOI: 10.1016/j.antiviral.2023.105731
Part of ISSN: 0166-3542
Contributors: Robert Konkel; Aleksandra Milewska; Thuc Nguyen Dan Do; Emilia Barreto Duran; Artur Szczepanski; Jacek Plewka; Ewa Wieczerzak; Sofia Iliakopoulou; Triantafyllos Kaloudis; DIRK JOCHMANS et al.
Source: Self-asserted source
Jacek Plewka

Structural and biological characterization of pAC65, a macrocyclic peptide that blocks PD-L1 with equivalent potency to the FDA-approved antibodies

Molecular Cancer
2023-09-07 | Journal article
DOI: 10.1186/s12943-023-01853-4
Part of ISSN: 1476-4598
Contributors: Ismael Rodriguez; Justyna Kocik-Krol; Lukasz Skalniak; Bogdan Musielak; Aneta Wisniewska; Agnieszka Ciesiołkiewicz; Łukasz Berlicki; Jacek Plewka; Przemyslaw Grudnik; Malgorzata Stec et al.
Source: Self-asserted source
Jacek Plewka

Design, Synthesis, and Antitumor Activity Evaluation of 2-Arylmethoxy-4-(2,2′-dihalogen-substituted biphenyl-3-ylmethoxy) Benzylamine Derivatives as Potent PD-1/PD-L1 Inhibitors

Journal of Medicinal Chemistry
2023-08-10 | Journal article
DOI: 10.1021/acs.jmedchem.3c00731
Contributors: Hua Zhang; Shijia Zhou; Jacek Plewka; Caiyun Wu; Mengyu Zhu; Qimeng Yu; Bogdan Musielak; Xiao Wang; Annoor Awadasseid; Katarzyna Magiera-Mularz et al.
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Design, Synthesis, and Biological Evaluation of 2-Hydroxy-4-phenylthiophene-3-carbonitrile as PD-L1 Antagonist and Its Comparison to Available Small Molecular PD-L1 Inhibitors

Journal of Medicinal Chemistry
2023-07-27 | Journal article
DOI: 10.1021/acs.jmedchem.3c00254
Contributors: Marta A. Ważyńska; Roberto Butera; Marta Requesens; Annechien Plat; Tryfon Zarganes-Tzitzikas; Constantinos G. Neochoritis; Jacek Plewka; Lukasz Skalniak; Justyna Kocik-Krol; Bogdan Musielak et al.
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Crossref

Monocyte subpopulations display disease-specific miRNA signatures depending on the subform of Spondyloarthropathy

Frontiers in Immunology
2023-04-17 | Journal article
DOI: 10.3389/fimmu.2023.1124894
Part of ISSN: 1664-3224
Contributors: Małgorzata Stec; Marcin Czepiel; Marzena Lenart; Agata Piestrzyńska-Kajtoch; Jacek Plewka; Agnieszka Bieniek; Kazimierz Węglarczyk; Rafał Szatanek; Magdalena Rutkowska-Zapała; Zofia Guła et al.
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Computer- and NMR-aided design of small-molecule inhibitors of the Hub1 protein

ChemRxiv
2022 | Journal article
DOI: 10.26434/CHEMRXIV-2022-7859B
WOSUID: PPRN:9430264
Contributors: Surmiak, Ewa; Kubica, Katarzyna; Reyes Romero, Atilio; Plewka, Jacek; Rodriguez, Ismael; Magiera-Mularz, Katarzyna; Domling, Alexander; Holak, Tad A
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Web of Science Researcher Profile Sync

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity

Structure
2022-05 | Journal article
DOI: 10.1016/j.str.2022.04.014
Part of ISSN: 0969-2126
Source: Self-asserted source
Jacek Plewka

Pseudanabaena galeata CCNP1313—Biological Activity and Peptides Production

Toxins
2022-05-06 | Journal article
DOI: 10.3390/toxins14050330
Contributors: Marta Cegłowska; Karolina Szubert; Beata Grygier; Marzena Lenart; Jacek Plewka; Aleksandra Milewska; Kinga Lis; Artur Szczepański; Yuliya Chykunova; Emilia Barreto-Duran et al.
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Crossref
grade
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Novel IL2RG Gene Mutation in One of Dizygotic Twins Causing Profound Changes of Receptor Structure

Frontiers in Pediatrics
2022-04-15 | Journal article
DOI: 10.3389/fped.2022.858166
Part of ISSN: 2296-2360
Source: Self-asserted source
Jacek Plewka

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity

2022-02-18 | Preprint
DOI: 10.1101/2022.02.17.480845
Contributors: Anna Czarna; Jacek Plewka; Leanid Kresik; Alex Matsuda; Abdulkarim Karim; Colin Robinson; Sean O’Byrne; Fraser Cunningham; Irene Georgiou; Magdalena Pachota et al.
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Crossref

Despite the odds: formation of the SARS-CoV-2 methylation complex

2022-01-26 | Preprint
DOI: 10.1101/2022.01.25.477673
Contributors: Alex Matsuda; Jacek Plewka; Yuliya Chykunova; Alisha N. Jones; Magdalena Pachota; Michał Rawski; André Mourão; Abdulkarim Karim; Leanid Kresik; Kinga Lis et al.
Source: check_circle
Crossref

A computationally designed β-amino acid-containing miniprotein

Chemical Communications
2021 | Journal article
DOI: 10.1039/d1cc02192c
Part of ISSN: 1359-7345
Part of ISSN: 1364-548X
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Terphenyl-based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein-Protein Interaction

ChemRxiv
2021 | Journal article
DOI: 10.26434/CHEMRXIV.13849442.V1
WOSUID: PPRN:9282786
Contributors: Muszak, Damian; Surmiak, Ewa; Plewka, Jacek; Magiera-Mularz, Katarzyna; Kocik, Justyna; Musielak, Bogdan; Sala, Dominik; Kitel, Radoslaw; Stec, Malgorzata; Siedlar, Maciej et al.
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Web of Science Researcher Profile Sync

A fragment-based approach identifies an allosteric pocket that impacts malate dehydrogenase activity

Communications Biology
2021-12 | Journal article
DOI: 10.1038/s42003-021-02442-1
Part of ISSN: 2399-3642
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

PD-L1 Inhibitors: Different Classes, Activities, and Mechanisms of Action

International Journal of Molecular Sciences
2021-10-30 | Journal article
DOI: 10.3390/ijms222111797
Contributors: Ewa Surmiak; Katarzyna Magiera-Mularz; Bogdan Musielak; Damian Muszak; Justyna Kocik-Krol; Radoslaw Kitel; Jacek Plewka; Tad A. Holak; Lukasz Skalniak
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Crossref
grade
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Terphenyl-Based Small-Molecule Inhibitors of Programmed Cell Death-1/Programmed Death-Ligand 1 Protein–Protein Interaction

Journal of Medicinal Chemistry
2021-08-12 | Journal article
DOI: 10.1021/acs.jmedchem.1c00957
Contributors: Damian Muszak; Ewa Surmiak; Jacek Plewka; Katarzyna Magiera-Mularz; Justyna Kocik-Krol; Bogdan Musielak; Dominik Sala; Radoslaw Kitel; Malgorzata Stec; Kazimierz Weglarczyk et al.
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Design, Synthesis, and Biological Evaluation of Imidazopyridines as PD-1/PD-L1 Antagonists

ACS Medicinal Chemistry Letters
2021-05-13 | Journal article
DOI: 10.1021/acsmedchemlett.1c00033
Contributors: Roberto Butera; Marta Ważyńska; Katarzyna Magiera-Mularz; Jacek Plewka; Bogdan Musielak; Ewa Surmiak; Dominik Sala; Radoslaw Kitel; Marco de Bruyn; Hans W. Nijman et al.
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Crossref

Human and mouse PD-L1: similar molecular structure, but different druggability profiles

iScience
2021-01 | Journal article
DOI: 10.1016/j.isci.2020.101960
Part of ISSN: 2589-0042
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Macrocyclic Peptide Inhibitor of PD‐1/PD‐L1 Immune Checkpoint

Advanced Therapeutics
2020-11-18 | Journal article
DOI: 10.1002/adtp.202000195
Part of ISSN: 2366-3987
Part of ISSN: 2366-3987
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 2)‎

Di-bromo-Based Small-Molecule Inhibitors of the PD-1/PD-L1 Immune Checkpoint

Journal of Medicinal Chemistry
2020-10-08 | Journal article
DOI: 10.1021/acs.jmedchem.0c01260
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 3)‎

Competition NMR for Detection of Hit/Lead Inhibitors of Protein–Protein Interactions

Molecules
2020-07-01 | Journal article
DOI: 10.3390/molecules25133017
Contributors: Bogdan Musielak; Weronika Janczyk; Ismael Rodriguez; Jacek Plewka; Dominik Sala; Katarzyna Magiera-Mularz; Tad Holak
Source: check_circle
Crossref
grade
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Competition NMR for Detection of Hit/Lead Inhibitors of Protein-Protein Interactions

2020-06-13 | Preprint
DOI: 10.1101/2020.06.12.148379
Contributors: Bogdan Musielak; Weronika Janczyk; Ismael Rodriguez; Jacek Plewka; Dominik Sala; Katarzyna Magiera-Mularz; Tad A. Holak
Source: check_circle
Crossref

A bacteriophage mimic of the bacterial nucleoid-associated protein Fis

Biochemical Journal
2020-04-17 | Journal article
DOI: 10.1042/bcj20200146
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 3)‎

Multicomponent Peptide Stapling as a Diversity-Driven Tool for the Development of Inhibitors of Protein-Protein Interactions

Angewandte Chemie International Edition
2020-01-15 | Journal article
DOI: 10.1002/anie.201916257
Part of ISSN: 1433-7851
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 3)‎

Antibody Binding Heterogeneity of Protein A Resins

Biotechnology Journal
2019-08 | Journal article
DOI: 10.1002/biot.201800632
Part of ISSN: 1860-6768
Part of ISSN: 1860-7314
Source: Self-asserted source
Jacek Plewka
grade
Preferred source (of 3)‎

CA-170 – A Potent Small-Molecule PD-L1 Inhibitor or Not?

Molecules
2019-08-01 | Journal article
DOI: 10.3390/molecules24152804
Contributors: Bogdan Musielak; Justyna Kocik; Lukasz Skalniak; Katarzyna Magiera-Mularz; Dominik Sala; Miroslawa Czub; Malgorzata Stec; Maciej Siedlar; Tad A. Holak; Jacek Plewka
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Crossref
grade
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The pearl necklace model in protein A chromatography: Molecular mechanisms at the resin interface

Biotechnology and Bioengineering
2019-01 | Journal article
DOI: 10.1002/bit.26843
Contributors: Goncalo L. Silva; Jacek Plewka; Helga Lichtenegger; Ana C. Dias‐Cabral; Alois Jungbauer; Rupert Tscheließnig
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Crossref
grade
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Antibody adsorption in protein‐A affinity chromatography – in situ measurement of nanoscale structure by small‐angle X‐ray scattering

Journal of Separation Science
2018-11 | Journal article
DOI: 10.1002/jssc.201800776
Contributors: Jacek Plewka; Gonçalo L. Silva; Rupert Tscheließnig; Harald Rennhofer; Cristina Dias‐Cabral; Alois Jungbauer; Helga C. Lichtenegger
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grade
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Viscoelasticity and structure of blood clots generated in-vitro by rheometry: A comparison between human, horse, rat, and camel.

Clinical hemorheology and microcirculation
2018-04 | Journal article
DOI: 10.3233/ch-189203
PMID: 29710696
Contributors: Dibiasi C; Plewka J; Ploszczanski L; Glanz V; Lichtenegger H; Windberger U
Source: Self-asserted source
Jacek Plewka via Europe PubMed Central
grade
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TRIM5α SPRY/coiled-coil interactions optimize avid retroviral capsid recognition

PLOS Pathogens
2017-10-17 | Journal article
DOI: 10.1371/journal.ppat.1006686
Contributors: Marcin D. Roganowicz; Félix A. Rey; Sevnur Komurlu; Santanu Mukherjee; Jacek Plewka; Steven L. Alam; Katarzyna A. Skorupka; Yueping Wan; Damian Dawidowski; David S. Cafiso et al.
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grade
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Peer review (29 reviews for 13 publications/grants)

Review activity for ACS chemical biology. (2)
Review activity for ACS omega. (1)
Review activity for Advanced nanoBiomed research. (4)
Review activity for Biomedicine & pharmacotherapy. (2)
Review activity for ChemBioChem. (3)
Review activity for ChemMedChem. (5)
Review activity for International journal of molecular sciences. (1)
Review activity for Journal of biotechnology. (2)
Review activity for Journal of medicinal chemistry. (1)
Review activity for Molecules. (1)
Review activity for New journal of chemistry. (1)
Review activity for Oncoimmunology. (4)
Review activity for Pharmaceutics. (2)
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