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Scopus Author ID: 58537588300
ResearcherID: T-3466-2017
Scopus Author ID: 36477087100

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Employment (1)

Charles University, Faculty of Pharmacy: Hradec Králové, CZ

2015-07-01 to present (Department of Pharmaceutical Botany)
Employment
Source: Self-asserted source
Jakub Chlebek

Works (43)

Amaryllidaceae Alkaloids from <i>Clivia miniata</i> (Lindl.) Bosse (Amaryllidaceae): Isolation, Structural Elucidation, and Biological Activity

Plants
2022-11 | Journal article | Author
DOI: 10.3390/plants11223034
Contributors: Marcela Šafratová; Jana Křoustková; Negar Maafi; Daniela Suchánková; Rudolf Vrabec; Jakub Chlebek; Jiří Kuneš; Lubomír Opletal; Franz Bucar; Lucie Cahlíková
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Interactions of Isoquinoline Alkaloids with Transition Metals Iron and Copper

Molecules
2022-09-29 | Journal article
DOI: 10.3390/molecules27196429
Contributors: Mst Shamima Parvin; Jakub Chlebek; Anna Hošťálková; Maria Carmen Catapano; Zuzana Lomozová; Kateřina Macáková; Přemysl Mladěnka
Source: check_circle
Crossref

Can Isoquinoline Alkaloids Affect Platelet Aggregation in Whole Human Blood?

Toxins
2022-07 | Journal article | Author
DOI: 10.3390/toxins14070491
Contributors: Mst Shamima Parvin; Marcel Hrubša; Jaka Fadraersada; Alejandro Carazo; Jana Karlíčková; Lucie Cahlíková; Jakub Chlebek; Kateřina Macáková; Přemysl Mladěnka
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Alkaloids of <i>Dicranostigma franchetianum</i> (Papaveraceae) and Berberine Derivatives as a New Class of Antimycobacterial Agents

Biomolecules
2022-06 | Journal article | Author
DOI: 10.3390/biom12060844
Contributors: Viriyanata Wijaya; Ondřej Janďourek; Jana Křoustková; Kateřina Breiterová; Jan Korabecny; Kateřina Sobolová; Eliška Kohelová; Anna Hostalkova; Klára Konečná; Marcela Šafratová et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute

Multi-target neuroprotective effects of herbal medicines for Alzheimer's disease

Journal of Ethnopharmacology
2022-05 | Journal article
DOI: 10.1016/j.jep.2022.115107
Contributors: Filipe Fernandes; M. Fátima Barroso; Angela De Simone; Eliška Emriková; Mónica Dias-Teixeira; José Paulo Pereira; Jakub Chlebek; Virgínia Cruz Fernandes; Francisca Rodrigues; Vincenza Andrisano et al.
Source: check_circle
Crossref

In Vitro and In Silico Acetylcholinesterase Inhibitory Activity of Thalictricavine and Canadine and Their Predicted Penetration across the Blood-Brain Barrier

Molecules
2019-04 | Journal article | Author
DOI: 10.3390/molecules24071340
Contributors: Jakub Chlebek; Jan Korabecny; Rafael Doležal; Šárka Štěpánková; Daniel I. Pérez; Anna Hostalkova; Lubomír Opletal; Lucie Cahlíková; Kateřina Macáková; Tomas Kucera et al.
Source: check_circle
Multidisciplinary Digital Publishing Institute
grade
Preferred source (of 2)‎

Cholinesterase and Prolyl Oligopeptidase Inhibitory Activities of Alkaloids from Argemone platyceras (Papaveraceae)

Molecules
2017 | Journal article
DOI: 10.3390/molecules22071181
WOSUID:

WOS:000406621300155
Contributors: Siatka, Tomas; Adamcova, Marketa; Opletal, Lubomir; Cahlikova, Lucie; Jun, Daniel; Hrabinova, Martina; Kunes, Jiri; Chlebek, Jakub
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Application of BACE1 immobilized enzyme reactor for the characterization of multifunctional alkaloids from Corydalis cava (Fumariaceae) as Alzheimer's disease targets

Fitoterapia
2016 | Journal article
DOI: 10.1016/j.fitote.2016.01.008
WOSUID:

WOS:000372685400039
Contributors: Chlebek, Jakub; De Simone, Angela; Host'alkova, Anna; Opletal, Lubomir; Perez, Concepcion; Perez, Daniel I.; Havlikova, Lucie; Cahlikova, Lucie; Andrisano, Vincenza
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Cytotoxic potential of naturally occurring isoquinoline alkaloids possessing different structural types

Planta Medica
2016 | Journal article
DOI: 10.1055/s-0036-1596762
WOSUID:

WOS:000411789300586
Contributors: Cahlikova, L.; Doskocil, I.; Chlebek, J.; Host'alkova, A.; Havelek, R.; Safratova, M.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Cytotoxicity of naturally occurring isoquinoline alkaloids of different structural types

Natural Product Communications
2016 | Journal article
EID:

2-s2.0-84989179797
Contributors: Chlebek, J.; Doskočil, I.; Hulcová, D.; Breiterová, K.; Šafratová, M.; Havelek, R.; Habartová, K.; Hoštálková, A.; Volštátová, T.; Cahlíková, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Cytotoxicity of Naturally Occurring Isoquinoline Alkaloids of Different Structural Types

Natural Product Communications
2016 | Journal article
WOSUID:

WOS:000379631600014
Contributors: Chlebek, Jakub; Doskocil, Ivo; Hulcova, Daniela; Breiterova, Katefina; Safratova, Marcela; Havelek, Radim; Habartova, Klara; Host'alkova, Anna; Volstatova, Tereza; Cahlikova, Lucie
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Isolation of Amaryllidaceae alkaloids from Nerine bowdenii W. Watson and their biological activities

Rsc Advances
2016 | Journal article
DOI: 10.1039/c6ra20205e
WOSUID:

WOS:000382539600098
Contributors: Vaneckova, Nina; Host'alkova, Anna; Safratova, Marcela; Kunes, Jiri; Hulcova, Daniela; Hrabinova, Martina; Doskocil, Ivo; Stepankova, Sarka; Opletal, Lubomir; Novakova, Lucie et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Isoquinoline Alkaloids from Fumaria officinalis L. and Their Biological Activities Related to Alzheimer's Disease

Chemistry & Biodiversity
2016 | Journal article
DOI: 10.1002/cbdv.201500033
WOSUID:

WOS:000368578700008
Contributors: Chlebek, Jakub; Novak, Zdenek; Kassemova, Dominika; Safratova, Marcela; Kostelnik, Jan; Maly, Lukas; Locarek, Miroslav; Opletal, Lubomir; Host'alkova, Anna; Hrabinova, Martina et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Multifunctional activity of some isoquinoline alkaloids from Corydalis cava tubers on Alzheimer's disease targets

Planta Medica
2016 | Journal article
DOI: 10.1055/s-0036-1596429
WOSUID:

WOS:000411789300253
Contributors: Chlebek, J.; De Simone, A.; Perez, D. I.; Perez, C.; Havlikova, L.; Host'alkova, A.; Opletal, L.; Cahlikova, L.; Andrisano, V.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Alkaloids from peumus boldus and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase inhibition activity

Natural Product Communications
2015 | Journal article
EID:

2-s2.0-84933513166
Contributors: Hosalkova, A.; Opletal, L.; Kunes, J.; Novak, Z.; Hrabinova, M.; Chlebek, J.; Eegan, L.; Cahlikova, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Alkaloids from Peumus boldus and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Inhibition Activity

Natural Product Communications
2015 | Journal article
WOSUID:

WOS:000353424800010
Contributors: Host'alkova, Anna; Opletal, Lubomir; Kunes, Jiri; Novak, Zdenek; Hrabinova, Martina; Chlebek, Jakub; Cegan, Lukas; Cahlikova, Lucie
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Boldine Alkaloids and Prospects of Their Utilization

Chemicke Listy
2015 | Journal article
WOSUID:

WOS:000368261500005
Contributors: Hostalkova, Anna; Siatka, Tomas; Chlebek, Jakub; Opletal, Lubomir; Drasar, Pavel; Cahlikova, Lucie
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Boldine alkaloids and prospects of their utilization | Boldinové alkaloidy a perspektivy jejich využití

Chemicke Listy
2015 | Journal article
EID:

2-s2.0-84951263241
Contributors: Hošťálková, A.; Siatka, T.; Chlebek, J.; Opletal, L.; Drašar, P.; Cahlíková, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Cytotoxic activities of Amaryllidaceae alkaloids against gastrointestinal cancer cells

Phytochemistry Letters
2015 | Journal article
DOI: 10.1016/j.phytol.2015.08.004
WOSUID:

WOS:000362174600069
Contributors: Doskocil, Ivo; Hostalkova, Anna; Safratova, Marcela; Benesova, Nina; Havlik, Jaroslav; Havelek, Radim; Kunes, Jiri; Kralovec, Karel; Chlebek, Jakub; Cahlikova, Lucie
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Flavones Inhibit the Activity of AKR1B10, a Promising Therapeutic Target for Cancer Treatment

Journal of Natural Products
2015 | Journal article
DOI: 10.1021/acs.jnatprod.5b00616
WOSUID:

WOS:000366005800020
Contributors: Zemanova, Lucie; Hofman, Jakub; Novotna, Eva; Musilek, Kamil; Lundova, Tereza; Havrankova, Jana; Hostalkova, Anna; Chlebek, Jakub; Cahlikova, Lucie; Wsol, Vladimir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

In Vitro Inhibitory Effects of 8-O-Demethylmaritidine and Undulatine on Acetylcholinesterase and Their Predicted Penetration across the Blood-Brain Barrier

Journal of Natural Products
2015 | Journal article
DOI: 10.1021/acs.jnatprod.5b00191
WOSUID:

WOS:000357138300001
Contributors: Cahlikova, Lucie; Perez, Daniel I.; Stepankova, Sarka; Chlebek, Jakub; Safratova, Marcela; Host'alkova, Anna; Opletal, Lubomir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Isoquinoline alkaloids as prolyl oligopeptidase inhibitors

Fitoterapia
2015 | Journal article
DOI: 10.1016/j.fitote.2015.04.004
WOSUID:

WOS:000356738800023
Contributors: Cahlikova, Lucie; Hulova, Lucie; Hrabinova, Martina; Chlebek, Jakub; Host'alkova, Anna; Adamcova, Marketa; Safratova, Marcela; Jun, Daniel; Opletal, Lubomir; Locarek, Miroslav et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Tannins and their Influence on Health

Recent Advances in Medicinal Chemistry
2015 | Book
DOI: 10.1016/B978-0-12-803961-8.50006-3
EID:

2-s2.0-84940913633
Contributors: Macáková, K.; Kolečkář, V.; Cahlíková, L.; Chlebek, J.; Hoštálková, A.; Kuča, K.; Jun, D.; Opletal, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Antimicrobial activity of extracts and isoquinoline alkaloids of selected papaveraceae plants

Natural Product Communications
2014 | Journal article
EID:

2-s2.0-84920387990
Contributors: Opletal, L.; Locárek, M.; Franková, A.; Chlebek, J.; Smid, J.; Hostálková, A.; Safratová, M.; Hulcová, D.; Kloucek, P.; Rozkot, M. et al.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Antimicrobial Activity of Extracts and Isoquinoline Alkaloids of Selected Papaveraceae Plants

Natural Product Communications
2014 | Journal article
WOSUID:

WOS:000346892700011
Contributors: Opletal, Lubomir; Locarek, Miroslav; Frankova, Adela; Chlebek, Jakub; Smid, Jakub; Host'alkova, Anna; Safratova, Marcela; Hulcova, Daniela; Kloucek, Pavel; Rozkot, Miroslav et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Isoquinoline alkaloids as a novel type of AKR1C3 inhibitors

Journal of Steroid Biochemistry and Molecular Biology
2014 | Journal article
DOI: 10.1016/j.jsbmb.2014.04.005
WOSUID:

WOS:000341465500027
Contributors: Skarydova, Lucie; Hofman, Jakub; Chlebek, Jakub; Havrankova, Jana; Kosanova, Katerina; Skarka, Adam; Hostalkova, Anna; Plucha, Tomas; Cahlikova, Lucie; Wsol, Vladimir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Natural compounds (Small molecules) as potential and real drugs of Alzheimer's disease: A critical review

Studies in Natural Products Chemistry
2014 | Book
DOI: 10.1016/B978-0-444-63281-400006-9
EID:

2-s2.0-84897690011
Contributors: Cahlíková, L.; Macáková, K.; Benešová, N.; Chlebek, J.; Hošťálková, A.; Opletal, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Natural Products as Potential Human Ether-A-Go-Go-Related Gene Channel Inhibitors - Screening of Plant-Derived Alkaloids

Planta Medica
2014 | Journal article
DOI: 10.1055/s-0034-1368590
WOSUID:

WOS:000338039800020
Contributors: Schramm, Anja; Saxena, Priyanka; Chlebek, Jakub; Cahlikova, Lucie; Baburin, Igor; Hering, Steffen; Hamburger, Matthias
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Alkaloids from chlidanthus fragrans and their acetylcholinesterase, butyrylcholinesterase and prolyl oligopeptidase activities

Natural Product Communications
2013 | Journal article
EID:

2-s2.0-84887468975
Contributors: Cahlíková, L.; Kulhánková, A.; Benešová, N.; Chlebek, J.; Macáková, K.; Opletal, L.; Hrabinová, M.; Jun, D.; Kuča, K.; Novák, Z. et al.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Alkaloids from Chlidanthus fragrans and their Acetylcholinesterase, Butyrylcholinesterase and Prolyl Oligopeptidase Activities

Natural Product Communications
2013 | Journal article
WOSUID:

WOS:000326859300010
Contributors: Cahlikova, Lucie; Hrabinova, Martina; Kulhankova, Andrea; Benesova, Nina; Chlebek, Jakub; Jun, Daniel; Novak, Zdenek; Macakova, Katerina; Kunes, Jiri; Kuca, Kamil et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Isolation and cholinesterase inhibitory activity of Narcissus extracts and amaryllidaceae alkaloid

Natural Product Communications
2013 | Journal article
EID:

2-s2.0-84886433196
Contributors: Cahlíková, L.; Ločárek, M.; Benešová, N.; Kučera, R.; Chlebek, J.; Novák, Z.; Opletal, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Isolation and Cholinesterase Inhibitory Activity of Narcissus Extracts and Amaryllidaceae Alkaloid

Natural Product Communications
2013 | Journal article
WOSUID:

WOS:000319855300027
Contributors: Cahlikova, Lucie; Locarek, Miroslav; Benesova, Nina; Kucera, Radim; Chlebek, Jakub; Novak, Zdenek; Opletal, Lubomir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Corylucinine, a new alkaloid from Corydalis cava (fumariaceae), and its cholinesterase activity

Natural Product Communications
2012 | Journal article
EID:

2-s2.0-84864704369
Contributors: Novák, Z.; Chlebek, J.; Opletal, L.; Jiroš, P.; Macáková, K.; Kuneš, J.; Cahlíková, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Corylucinine, a new Alkaloid from Corydalis cava (Fumariaceae), and its Cholinesterase Activity

Natural Product Communications
2012 | Journal article
WOSUID:

WOS:000306764200012
Contributors: Novak, Zdenek; Chlebek, Jakub; Opletal, Lubomir; Jiros, Pavel; Macakova, Katerina; Kunes, Jiri; Cahlikova, Lucie
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Proanthocyanidins and Their Antioxidation Activity

Chemicke Listy
2012 | Journal article
WOSUID:

WOS:000300592500006
Contributors: Koleckar, Vit; Rehakova, Zuzana; Brojerova, Eliska; Kuca, Kamil; Jun, Daniel; Macakova, Katerina; Opletal, Lubomir; Drasar, Pavel; Jahodar, Ludek; Chilebek, Jakub et al.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Proanthocyanidins and their antioxidation activity | Proanthocyanidiny a jejich antioxidační aktivita

Chemicke Listy
2012 | Journal article
EID:

2-s2.0-84858146886
Contributors: Kolečkář, V.; Řeháková, Z.; Brojerová, E.; Kuča, K.; Jun, D.; Macáková, K.; Opletal, L.; Drašar, P.; Jahodář, L.; Chlebek, J. et al.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Corydalis cava (Fumariaceae)

Natural Product Communications
2011 | Journal article
EID:

2-s2.0-79955862259
Contributors: Chlebek, J.; Macáková, K.; Cahlíková, L.; Kurfürst, M.; Kuneš, J.; Opletal, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Corydalis cava (Fumariaceae)

Natural Product Communications
2011 | Journal article
WOSUID:

WOS:000290506200011
Contributors: Chlebek, Jakub; Macakova, Katerina; Cahlikova, Lucie; Kurfuerst, Milan; Kunes, Jiri; Opletal, Lubomir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Anticholinesterase and free-radical scavenging activity of Corydalis cava alkaloids

Planta Medica
2011 | Journal article
WOSUID:

WOS:000294139000629
Contributors: Chlebek, J.; Macakova, K.; Cahlikova, L.; Opletal, L.; Kunes, J.; Kurfuerst, M.
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Ecdysterone and its activity on some degenerative diseases

Natural Product Communications
2011 | Journal article
EID:

2-s2.0-79955845773
Contributors: Cahlíková, L.; Macáková, K.; Chlebek, J.; Hošt'álková, A.; Kulhánková, A.; Opletal, L.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Ecdysterone and its Activity on some Degenerative Diseases

Natural Product Communications
2011 | Journal article
WOSUID:

WOS:000290506200031
Contributors: Cahlikova, Lucie; Macakova, Katerina; Chlebek, Jakub; Host'alkova, Anna; Kulhankova, Andrea; Opletal, Lubomir
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Acetylcholinesterase and butyrylcholinesterase inhibitory compounds from Eschscholzia californica (Papaveraceae)

Natural Product Communications
2010 | Journal article
EID:

2-s2.0-77956638262
Contributors: Cahlíková, L.; Macáková, K.; Kuneš, J.; Kurfürst, M.; Opletal, L.; Cvačka, J.; Chlebek, J.; Blunden, G.
Source: Self-asserted source
Jakub Chlebek via Scopus - Elsevier

Acetylcholinesterase and Butyrylcholinesterase Inhibitory Compounds from Eschscholzia californica (Papaveraceae)

Natural Product Communications
2010 | Journal article
WOSUID:

WOS:000280117300010
Contributors: Cahlikova, Lucie; Macakova, Katerina; Kunes, Jiri; Kurfuerst, Milan; Opletal, Lubomir; Cvacka, Josef; Chlebek, Jakub; Blunden, Gerald
Source: Self-asserted source
Jakub Chlebek via ResearcherID

Peer review (2 reviews for 2 publications/grants)

Review activity for Fitoterapia. (1)
Review activity for Journal of natural products. (1)
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