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Czech Republic, Canada

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Employment (3)

Czech Academy of Sciences, Institute of Organic Chemistry and Biochemistry: Prague, CZ

(Drug discovery group)
Employment
Source: Self-asserted source
Ales Machara

Charles University in Prague: Prague, Prague, CZ

2012-01-01 to 2016-12-31 (Organic Chemistry)
Employment
Source: Self-asserted source
Ales Machara

Brock University: Saint Catharines, Ontario, CA

2009-01-01 to 2010-12-31 | post doc (Chemistry)
Employment
Source: Self-asserted source
Ales Machara

Education and qualifications (2)

University of Chemistry and Technology, Prague: Prague, Prague, CZ

2008-12 | Ph.D. (Organic Chemistry)
Education
Source: Self-asserted source
Ales Machara

University of Chemistry and Technology, Prague: Prague, Prague, CZ

2004 | Ms. (Organic Chemistry)
Education
Source: Self-asserted source
Ales Machara

Professional activities (1)

American Society of Pharmacognosy: Northbrook, Illinois, US

2018 | Jack L. Beal Award
Distinction
Source: Self-asserted source
Ales Machara

Works (50 of 55)

Items per page:
Page 1 of 2

Design, synthesis, and activity evaluation of C-8 arylated luteolin derivatives as influenza endonuclease inhibitors

Bioorganic & Medicinal Chemistry Letters
2025-06 | Journal article
DOI: 10.1016/j.bmcl.2025.130178
Part of ISSN: 0960-894X
Contributors: Artem Tsalyy; Michal Kráľ; Róbert Reiberger; Pavel Majer; Jan Konvalinka; Milan Kožíšek; Aleš Machara
Source: Self-asserted source
Ales Machara

Small-molecule activators of NRF1 transcriptional activity prevent protein aggregation

Biomedicine & Pharmacotherapy
2025-02 | Journal article
DOI: 10.1016/j.biopha.2025.117864
Contributors: Jindrich Sedlacek; Zuzana Smahelova; Michael Adamek; Dominika Subova; Lucie Svobodova; Alena Kadlecova; Pavel Majer; Ales Machara; Klara Grantz Saskova
Source: check_circle
Crossref

The evaluation of DNA-linked inhibitor antibody and AlphaScreen assays for high-throughput screening of compounds targeting the cap-binding domain in influenza a polymerase

European Journal of Pharmaceutical Sciences
2025-02 | Journal article
DOI: 10.1016/j.ejps.2024.106990
Part of ISSN: 0928-0987
Contributors: Kateřina Čermáková; Jiří Gregor; Michal Kráľ; Elena Karlukova; Václav Navrátil; Róbert Reiberger; Carlos Berenguer Albiñana; Vít Bechynský; Pavel Majer; Jan Konvalinka et al.
Source: Self-asserted source
Ales Machara

DSSBU: A novel mass spectrometry-cleavable analogue of the BS3 cross-linker

Journal of Proteomics
2025-01 | Journal article
DOI: 10.1016/j.jprot.2024.105330
Part of ISSN: 1874-3919
Contributors: Banerjee Swati; Sýs Jakub; Machara Aleš; Junková Petra; Hubálek Martin
Source: Self-asserted source
Ales Machara

4-Amino-2,6- bis(fenylmethylen)cyklohexanony a jejich použití

2024-11-27 | Patent | Investigation
PAT:

CZ 310214
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

3’‐Dehydroxypurpurogallin‐4‐carboxamides as Influenza A Endonuclease Inhibitors: Synthesis, SAR Analysis, and Structural Characterization of Protein Complex

ChemMedChem
2024-10-14 | Journal article
DOI: 10.1002/cmdc.202400577
Part of ISSN: 1860-7179
Part of ISSN: 1860-7187
Contributors: Ales Machara; Michal Kral; Tomáš Kotačka; Robert Reiberger; Gabriela Panýrková; Kateřina Radilová; Zuzana Osifová; Miroslav Flieger; Jan Konvalinka; Pavel Majer et al.
Source: Self-asserted source
Ales Machara

Female melon fruit flies, Zeugodacus cucurbitae, are attracted to a synthetic chemical blend based on male epicuticular components

Journal of Pest Science
2023-11-20 | Journal article
DOI: 10.1007/s10340-023-01707-4
Part of ISSN: 1612-4758
Part of ISSN: 1612-4766
Contributors: Vincent Jacob; Gaëlle Ramiaranjatovo; Emma Persyn; Aleš Machara; Pavlína Kyjaková; Toulassi Atiama-Nurbel; Antonio Pompeiano; Giovanni Benelli; Marc De Meyer; Lucie Vaníčková
Source: Self-asserted source
Ales Machara

Evolution of Linoleic Acid Biosynthesis Paved the Way for Ecological Success of Termites

Molecular Biology and Evolution
2023-04-04 | Journal article
DOI: 10.1093/molbev/msad087
Part of ISSN: 0737-4038
Part of ISSN: 1537-1719
Contributors: Stanislav Macháček; Michal Tupec; Natan Horáček; Martina Halmová; Amit Roy; Aleš Machara; Pavlína Kyjaková; Ondřej Lukšan; Iva Pichová; Robert Hanus
Source: Self-asserted source
Ales Machara

Characterization of Triacylglycerol Estolide Isomers Using High-Resolution Tandem Mass Spectrometry with Nanoelectrospray Ionization

Biomolecules
2023-03-03 | Journal article
DOI: 10.3390/biom13030475
Contributors: Lukáš Cudlman; Aleš Machara; Vladimír Vrkoslav; Miroslav Polášek; Zuzana Bosáková; Stephen J. Blanksby; Josef Cvačka
Source: check_circle
Crossref
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Preferred source (of 2)‎

Understanding desaturation/hydroxylation activity of castor stearoyl Δ9-Desaturase through rational mutagenesis

Computational and Structural Biotechnology Journal
2022 | Journal article
DOI: 10.1016/j.csbj.2022.03.010
Contributors: Michal Tupec; Martin Culka; Aleš Machara; Stanislav Macháček; Daniel Bím; Aleš Svatoš; Lubomír Rulíšek; Iva Pichová
Source: check_circle
Crossref

Thermodynamic and structural characterization of an optimized peptide-based inhibitor of the influenza polymerase PA-PB1 subunit interaction

Antiviral Research
2022-12 | Journal article
DOI: 10.1016/j.antiviral.2022.105449
Part of ISSN: 0166-3542
Contributors: Kateřina Radilová; Václav Zima; Michal Kráľ; Aleš Machara; Pavel Majer; Jan Hodek; Jan Weber; Jiří Brynda; Timotej Strmeň; Jan Konvalinka et al.
Source: Self-asserted source
Ales Machara

Diketo–Ketoenol Tautomers in Curcuminoids: Synthesis, Separation of Tautomers, and Kinetic and Structural Studies

The Journal of Organic Chemistry
2022-08-05 | Journal article
DOI: 10.1021/acs.joc.2c01357
Contributors: Zuzana Osifová; Robert Reiberger; Ivana Císařová; Aleš Machara; Martin Dračínský
Source: check_circle
Crossref

Binding of de novo synthesized radiolabeled juvenile hormone (JH III) by JH receptors from the Cuban subterranean termite Prorhinotermes simplex and the German cockroach Blattella germanica

Insect Biochemistry and Molecular Biology
2021-12 | Journal article
DOI: 10.1016/j.ibmb.2021.103671
Part of ISSN: 0965-1748
Contributors: Matej Milacek; Lenka Bittova; Sarka Tumova; Ondrej Luksan; Robert Hanus; Pavlina Kyjakova; Ales Machara; Ales Marek; Marek Jindra
Source: Self-asserted source
Ales Machara

Synthesis and In Vitro Evaluation of C-7 and C-8 Luteolin Derivatives as Influenza Endonuclease Inhibitors

International Journal of Molecular Sciences
2021-07-20 | Journal article
DOI: 10.3390/ijms22147735
Contributors: Robert Reiberger; Kateřina Radilová; Michal Kráľ; Václav Zima; Pavel Majer; Jiří Brynda; Martin Dračínský; Jan Konvalinka; Milan Kožíšek; Aleš Machara
Source: check_circle
Crossref
grade
Preferred source (of 2)‎

structural characterization of the interaction between the C-terminal domain of the influenza polymerase PA subunit and an optimized small peptide inhibitor

Antiviral Research
2021-01 | Journal article
DOI: 10.1016/j.antiviral.2020.104971
Part of ISSN: 0166-3542
Contributors: Jakub Hejdánek; Kateřina Radilová; Petr Pachl; Jan Hodek; Aleš Machara; Jan Weber; Pavlína Řezáčová; Jan Konvalinka; Milan Kožíšek
Source: Self-asserted source
Ales Machara

Putative ligand binding sites of two functionally characterized bark beetle odorant receptors

BMC Biology
2021-01-26 | Journal article
DOI: 10.1186/s12915-020-00946-6
Part of ISSN: 1741-7007
Contributors: Jothi K. Yuvaraj; Rebecca E. Roberts; Yonathan Sonntag; Xiao-Qing Hou; Ewald Grosse-Wilde; Aleš Machara; Dan-Dan Zhang; Bill S. Hansson; Urban Johanson; Christer Löfstedt et al.
Source: Self-asserted source
Ales Machara

Př́ıručka laboratorńı organické chemie

2020 | Book
ISBN: 9788074440762
Contributors: Vesel̀y, J.; Machara, A.; Univerzita Karlova. Př́ırodovědecká fakulta
Source: Self-asserted source
Ales Machara

Unraveling the anti-influenza effect of flavonoids: Experimental validation of luteolin and its congeners as potent influenza endonuclease inhibitors

European Journal of Medicinal Chemistry
2020-12 | Journal article | Author
DOI: 10.1016/j.ejmech.2020.112754
Part of ISSN: 0223-5234
Contributors: Václav Zima; Kateřina Radilová; Milan Kožíšek; Carlos Berenguer Albiñana; Elena Karlukova; Jiří Brynda; Jindřich Fanfrlík; Miroslav Flieger; Jan Hodek; Jan Weber et al.
Source: Self-asserted source
Ales Machara

Investigation of flexibility of neuraminidase 150-loop using tamiflu derivatives in influenza A viruses H1N1 and H5N1

Bioorganic & Medicinal Chemistry
2019-07 | Journal article
DOI: 10.1016/j.bmc.2019.05.024
Part of ISSN: 0968-0896
Contributors: Václav Zima; Carlos Berenguer Albiñana; Kateřina Rojíková; Jana Pokorná; Petr Pachl; Pavlína Řezáčová; Jason Hudlicky; Václav Navrátil; Pavel Majer; Jan Konvalinka et al.
Source: Self-asserted source
Ales Machara

DNA-linked inhibitor antibody assay (DIANA) as a new method for screening influenza neuraminidase inhibitors

Biochemical Journal
2018-12-12 | Journal article
DOI: 10.1042/bcj20180764
Part of ISSN: 0264-6021
Part of ISSN: 1470-8728
Contributors: Milan Kožíšek; Václav Navrátil; Kateřina Rojíková; Jana Pokorná; Carlos Berenguer Albiñana; Petr Pachl; Jitka Zemanová; Aleš Machara; Pavel Šácha; Jason Hudlický et al.
Source: Self-asserted source
Ales Machara

Identification and Enantiodivergent Synthesis of (5Z,9S)-Tetradec-5-en-9-olide, a Queen-Specific Volatile of the Termite Silvestritermes minutus

Journal of Natural Products
2018-10-26 | Journal article
DOI: 10.1021/acs.jnatprod.8b00632
Contributors: Aleš Machara; Jan Křivánek; Klára Dolejšová; Jana Havlíčková; Lucie Bednárová; Robert Hanus; Pavel Majer; Pavlína Kyjaková
Source: check_circle
Crossref
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Kinetic, Thermodynamic, and Structural Analysis of Drug Resistance Mutations in Neuraminidase from the 2009 Pandemic Influenza Virus

Viruses
2018-06-21 | Journal article
DOI: 10.3390/v10070339
Part of ISSN: 1999-4915
Contributors: Jana Pokorná; Petr Pachl; Elena Karlukova; Jakub Hejdánek; Pavlina Rezacova; Aleš Machara; Jason Hudlický; Jan Konvalinka; Milan Kožíšek
Source: Self-asserted source
Ales Machara

Palladium(II) Complexes of Homologated Ferrocene Phosphanylether and Thioether Ligands

European Journal of Inorganic Chemistry
2017-11-09 | Journal article
DOI: 10.1002/ejic.201701057
Part of ISSN: 1434-1948
Part of ISSN: 1099-0682
Contributors: Martin Zábranský; Aleš Machara; Ivana Císařová; Petr Štěpnička
Source: Self-asserted source
Ales Machara

ADVANCES IN N- and O-DEMETHYLATION OF OPIATES

Targets in Heterocyclic Systems. Vol. 20
2016 | Journal article
DOI: 10.17374/targets.2017.20.113
Contributors: Aleš Machara; Tomáš Hudlický
Source: Self-asserted source
Ales Machara

Synthesis of Noroxymorphone by N-Demethylation/ Intramolecular Acylation of Oxymorphone Catalyzed by Iron(II) Chloride

HETEROCYCLES
2016 | Journal article
DOI: 10.3987/com-15-s(t)63
Part of ISSN: 0385-5414
Contributors: Tomas Hudlicky; Mary Ann A. Endoma-Arias; Ales Machara; D. Phillip Cox
Source: Self-asserted source
Ales Machara

Kinetic, thermodynamic and structural analysis of tamiphosphor binding to neuraminidase of H1N1 (2009) pandemic influenza

European Journal of Medicinal Chemistry
2016-10 | Journal article
DOI: 10.1016/j.ejmech.2016.05.016
Part of ISSN: 0223-5234
Contributors: Carlos Berenguer Albiñana; Aleš Machara; Pavlína Řezáčová; Petr Pachl; Jan Konvalinka; Milan Kožíšek
Source: Self-asserted source
Ales Machara

Synthesis and evaluation of 2-pyridinylpyrimidines as inhibitors of HIV-1 structural protein assembly

Bioorganic & Medicinal Chemistry Letters
2016-08 | Journal article | Author
DOI: 10.1016/j.bmcl.2016.06.039
Part of ISSN: 0960-894X
Contributors: Milan Kožíšek; Ondřej Štěpánek; Kamil Parkan; Carlos Berenguer Albiñana; Marcela Pávová; Jan Weber; Hans-Georg Krӓusslich; Jan Konvalinka; Ales Machara
Source: Self-asserted source
Ales Machara
grade
Preferred source (of 2)‎

Synthesis of Nororipavine and Noroxymorphone via N- and O-Demethylation of Iron Tricarbonyl Complex of Thebaine

Synthesis
2016-04-19 | Journal article
DOI: 10.1055/s-0035-1561435
Part of ISSN: 0039-7881
Part of ISSN: 1437-210X
Contributors: Aleš Machara; Tomáš Hudlický; Mary Endoma-Arias; Ivana Císařova; D. Cox
Source: Self-asserted source
Ales Machara

Direct Synthesis of Noroxymorph­one from Thebaine: Unusual Ce<sup>IV</sup> Oxidation of a Methoxydiene‐Iron Complex to an Enone‐γ‐Nitrate

European Journal of Organic Chemistry
2016-03 | Journal article
DOI: 10.1002/ejoc.201600153
Part of ISSN: 1434-193X
Part of ISSN: 1099-0690
Contributors: Ales Machara; Mary Ann A. Endoma‐Arias; Ivana Císařová; D. Phillip Cox; Tomas Hudlicky
Source: Self-asserted source
Ales Machara

Reinvestigation of acetylation of 3,4-dihydroxybenzaldehyde and reconciliation of previously reported analytical data

Tetrahedron Letters
2016-03 | Journal article
DOI: 10.1016/j.tetlet.2016.01.075
Part of ISSN: 0040-4039
Contributors: Carlos Berenguer Albiñana; John J. Hayward; Tomas Hudlicky; Ales Machara
Source: Self-asserted source
Ales Machara

A Modular Synthesis of <i>N</i>‐Benzotriazole Ureas Using Alkylation of 5‐Nitrobenzotriazole

ChemistrySelect
2016-01 | Journal article
DOI: 10.1002/slct.201600025
Part of ISSN: 2365-6549
Part of ISSN: 2365-6549
Contributors: Aleš Machara; Jan Konvalinka; Martin Kotora
Source: Self-asserted source
Ales Machara

Specific Inhibitors of HIV Capsid Assembly Binding to the C-Terminal Domain of the Capsid Protein: Evaluation of 2-Arylquinazolines as Potential Antiviral Compounds

Journal of Medicinal Chemistry
2016-01-28 | Journal article
DOI: 10.1021/acs.jmedchem.5b01089
Part of ISSN: 0022-2623
Part of ISSN: 1520-4804
Contributors: Aleš Machara; Vanda Lux; Milan Kožíšek; Klára Grantz Šašková; Ondřej Štěpánek; Martin Kotora; Kamil Parkan; Marcela Pávová; Bärbel Glass; Peter Sehr et al.
Source: Self-asserted source
Ales Machara

Synthesis of Naltrexone and (R)-Methylnaltrexone from Oripavine via Direct Oxidation of Its Quaternary Salts

Synlett
2015-07-10 | Journal article
DOI: 10.1055/s-0034-1378808
Part of ISSN: 0936-5214
Part of ISSN: 1437-2096
Contributors: Tomas Hudlicky; Ales Machara; Lukas Werner; Hannes Leisch; Robert Carroll; David Adams; D. Haque; D. Cox
Source: Self-asserted source
Ales Machara

Conversion of Thebaine to Oripavine and Other Useful Intermediates for the Semisynthesis of Opiate‐Derived Agents: Synthesis of Hydromorphone

Advanced Synthesis &amp; Catalysis
2014-08-11 | Journal article
DOI: 10.1002/adsc.201400445
Part of ISSN: 1615-4150
Part of ISSN: 1615-4169
Contributors: Brennan Murphy; Ivan Šnajdr; Aleš Machara; Mary Ann A. Endoma‐Arias; Theocharis C. Stamatatos; D. Phillip Cox; Tomáš Hudlický
Source: Self-asserted source
Ales Machara

Synthesis of Nalbuphine from Oripavine via N-Demethylation of N-Cyclobutylmethyl Oripavine

HETEROCYCLES
2012 | Journal article
DOI: 10.3987/com-11-s(p)32
Part of ISSN: 0385-5414
Contributors: Tomas Hudlicky; Ales Machara; D. Phillip Cox
Source: Self-asserted source
Ales Machara

Direct Synthesis of Naltrexone by Palladium‐Catalyzed <i>N</i>‐Demethylation/Acylation of Oxymorphone: The Benefit of CH Activation and the Intramolecular Acyl Transfer from C‐14 Hydroxy

Advanced Synthesis &amp; Catalysis
2012-10-08 | Journal article
DOI: 10.1002/adsc.201200677
Part of ISSN: 1615-4150
Part of ISSN: 1615-4169
Contributors: Ales Machara; D. Phillip Cox; Tomas Hudlicky
Source: Self-asserted source
Ales Machara

Unexpected <i>N</i>‐Demethylation of Oxymorphone and Oxycodone <i>N</i>‐Oxides Mediated by the Burgess Reagent: Direct Synthesis of Naltrexone, Naloxone, and Other Antagonists from Oxymorphone

Advanced Synthesis &amp; Catalysis
2012-10-08 | Journal article
DOI: 10.1002/adsc.201200676
Part of ISSN: 1615-4150
Part of ISSN: 1615-4169
Contributors: Lukas Werner; Martina Wernerova; Ales Machara; Mary Ann Endoma‐Arias; Jan Duchek; David R. Adams; D. Phillip Cox; Tomas Hudlicky
Source: Self-asserted source
Ales Machara

Improved Synthesis of Buprenorphine from Thebaine and/or Oripavine <i>via</i> Palladium‐Catalyzed N‐Demethylation/Acylation and/or Concomitant O‐Demethylation

Advanced Synthesis &amp; Catalysis
2012-03 | Journal article
DOI: 10.1002/adsc.201100807
Part of ISSN: 1615-4150
Part of ISSN: 1615-4169
Contributors: Ales Machara; Lukas Werner; Mary Ann Endoma‐Arias; D. Phillip Cox; Tomas Hudlicky
Source: Self-asserted source
Ales Machara

Several Generations of Chemoenzymatic Synthesis of Oseltamivir (Tamiflu): Evolution of Strategy, Quest for a Process-Quality Synthesis, and Evaluation of Efficiency Metrics

The Journal of Organic Chemistry
2011-12-16 | Journal article
DOI: 10.1021/jo2018872
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Contributors: Lukas Werner; Ales Machara; Bradford Sullivan; Ignacio Carrera; Michael Moser; David R. Adams; Tomas Hudlicky; John Andraos
Source: Self-asserted source
Ales Machara

Synthesis of Buprenorphine from Oripavine via N-Demethylation of Oripavine Quaternary Salts

The Journal of Organic Chemistry
2011-06-03 | Journal article
DOI: 10.1021/jo200567n
Part of ISSN: 0022-3263
Part of ISSN: 1520-6904
Contributors: Lukas Werner; Ales Machara; David R. Adams; D. Phillip Cox; Tomas Hudlicky
Source: Self-asserted source
Ales Machara

Short Chemoenzymatic Azide‐Free Synthesis of Oseltamivir (Tamiflu): Approaching the Potential for Process Efficiency

Advanced Synthesis &amp; Catalysis
2010-01-04 | Journal article
DOI: 10.1002/adsc.200900844
Part of ISSN: 1615-4150
Part of ISSN: 1615-4169
Contributors: Lukas Werner; Ales Machara; Tomas Hudlicky
Source: Self-asserted source
Ales Machara
grade
Preferred source (of 2)‎

Preparation and rearrangement study of novel thiophenium- and selenophenium-ylides

Collection of Czechoslovak Chemical Communications
2009 | Journal article
DOI: 10.1135/cccc2009001
Part of ISSN: 0010-0765
Part of ISSN: 1212-6950
Contributors: Aleš Machara; Václav Kozmík; Michaela Pojarová; Hana Dvořáková; Jiří Svoboda
Source: Self-asserted source
Ales Machara

Synthesis and Cycloaddition Reaction of 3-Vinylthieno[3,2-b][1]benzothiophene

Collection of Czechoslovak Chemical Communications
2007 | Journal article
DOI: 10.1135/cccc20070952
Part of ISSN: 0010-0765
Part of ISSN: 1212-6950
Contributors: Aleš Machara; Michaela Pojarová; Jiří Svoboda
Source: Self-asserted source
Ales Machara

A nonconcerted cycloaddition of fused 2-vinylthiophenes with dimethyl acetylenedicarboxylate

Tetrahedron Letters
2004-03 | Journal article
DOI: 10.1016/j.tetlet.2004.01.030
Part of ISSN: 0040-4039
Contributors: Aleš Machara; Milan Kurfürst; Václav Kozmı́k; Hana Petřı́čková; Hana Dvořáková; Jiřı́ Svoboda
Source: Self-asserted source
Ales Machara

A method of preparation of lysegric acid amides and their derivatives

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

Compounds for use in inhibiting HIV capsid assembly

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

Compounds for use in inhibiting HIV capsid assembly

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

Methods for one-pot N-demethylation/N-functionalization of morphine and tropane alkaloids

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

Methods for the preparation of hydromorphone from thebaine via oripavine

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara

Preparation of benzodioxole derivatives for treatment of influenza

Patent
Contributors: Ales Machara
Source: Self-asserted source
Ales Machara
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Peer review (6 reviews for 2 publications/grants)

Review activity for Journal of medicinal chemistry. (2)
Review activity for Journal of natural products. (4)
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