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The Elowitz Lab

Keywords

Synthetic Biology, Systems Biology

Activities

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Employment (6)

California Institute of Technology: Pasadena, CA, US

2010 to present | Professor (BBE)
Employment
Source: Self-asserted source
Michael B. Elowitz

Howard Hughes Medical Institute: Chevy Chase, MD, US

2008 to present | Investigator
Employment
Source: Self-asserted source
Michael B. Elowitz

California Institute of Technology: Pasadena, CA, US

2009 to 2010 | Associate Professor (Biology and Biological Engineering)
Employment
Source: Self-asserted source
Michael B. Elowitz

California Institute of Technology: Pasadena, CA, US

2003 to 2009 | Assistant Professor (Biology and Applied Physics)
Employment
Source: Self-asserted source
Michael B. Elowitz

Rockefeller University: New York, NY, US

2000 to 2003 | Fellow (Center for Studies in Physics and Biology)
Employment
Source: Self-asserted source
Michael B. Elowitz

Princeton University: Princeton, NJ, US

1999 to 2000 | Postdoctoral Fellow (Physics)
Employment
Source: Self-asserted source
Michael B. Elowitz

Education and qualifications (2)

Princeton University: Princeton, NJ, US

1993 to 1999 | Ph.D. (Physics)
Education
Source: Self-asserted source
Michael B. Elowitz

University of California Berkeley: Berkeley, CA, US

1988 to 1992 | B.A. (Physics)
Education
Source: Self-asserted source
Michael B. Elowitz

Works (44)

The lives of cells, recorded

Nature Reviews Genetics
2025-03 | Journal article
DOI: 10.1038/s41576-024-00788-w
Contributors: Amjad Askary; Wei Chen; Junhong Choi; Lucia Y. Du; Michael B. Elowitz; James A. Gagnon; Alexander F. Schier; Sophie Seidel; Jay Shendure; Tanja Stadler et al.
Source: check_circle
Crossref

Diversity in Notch ligand-receptor signaling interactions

eLife
2025-01-03 | Journal article
DOI: 10.7554/eLife.91422
Contributors: Rachael Kuintzle; Leah A Santat; Michael B Elowitz
Source: check_circle
Crossref

Diversity in Notch ligand-receptor signaling interactions

eLife
2025-01-03 | Journal article
DOI: 10.7554/eLife.91422.3
Contributors: Rachael Kuintzle; Leah A Santat; Michael B Elowitz
Source: check_circle
Crossref

A synthetic protein-level neural network in mammalian cells

Science
2024-12-13 | Journal article
DOI: 10.1126/science.add8468
Contributors: Zibo Chen; James M. Linton; Shiyu Xia; Xinwen Fan; Dingchen Yu; Jinglin Wang; Ronghui Zhu; Michael B. Elowitz
Source: check_circle
Crossref

Diversity in Notch ligand-receptor signaling interactions

2024-10-18 | Preprint
DOI: 10.7554/eLife.91422.2
Contributors: Rachael Kuintzle; Leah A Santat; Michael B Elowitz
Source: check_circle
Crossref

Simultaneous Protein and RNA Analysis in Single Extracellular Vesicles, Including Viruses

ACS Nano
2024-10-01 | Journal article
DOI: 10.1021/acsnano.4c03679
Contributors: Zach Troyer; Olesia Gololobova; Aakash Koppula; Zhaohao Liao; Felix Horns; Michael B. Elowitz; Juan Pablo Tosar; Mona Batish; Kenneth W. Witwer
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Crossref

Cellular and molecular networks of intercellular signaling in bone marrow hematopoiesis

2024-08-26 | Preprint
DOI: 10.1101/2024.08.25.609544
Contributors: Zachary V. Thomas; Bowen Wang; Wade R. Boohar; Mary Vergel; Jiya Eerdeng; Dayeon J. Shon; Michael B. Elowitz; Rong Lu
Source: check_circle
Crossref

Lineage motifs as developmental modules for control of cell type proportions

Developmental Cell
2024-03 | Journal article
DOI: 10.1016/j.devcel.2024.01.017
Contributors: Martin Tran; Amjad Askary; Michael B. Elowitz
Source: check_circle
Crossref

Synthetic dosage-compensating miRNA circuits for quantitative gene therapy

2024-03-14 | Preprint
DOI: 10.1101/2024.03.13.584179
Contributors: Michael James Flynn; Acacia M. Mayfield; Rongrong Du; Viviana Gradinaru; Michael B Elowitz
Source: check_circle
Crossref

miRNA circuit modules for precise, tunable control of gene expression

2024-03-12 | Preprint
DOI: 10.1101/2024.03.12.583048
Contributors: Rongrong Du; Michael J. Flynn; Monique Honsa; Ralf Jungmann; Michael B. Elowitz
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Crossref

Simultaneous protein and RNA analysis in single extracellular vesicles, including viruses: SPIRFISH

2024-02-22 | Preprint
DOI: 10.1101/2024.02.21.581401
Contributors: Zach Troyer; Olesia Gololobova; Aakash Koppula; Zhaohao Liao; Felix Horns; Michael B Elowitz; Juan Pablo Tosar; Mona Batish; Kenneth W. Witwer
Source: check_circle
Crossref

Combinatorial expression motifs in signaling pathways

Cell Genomics
2024-01 | Journal article
DOI: 10.1016/j.xgen.2023.100463
Contributors: Alejandro A. Granados; Nivedita Kanrar; Michael B. Elowitz
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Crossref

Diversity in Notch ligand-receptor signaling interactions

2023-11-13 | Preprint
DOI: 10.7554/eLife.91422.1
Contributors: Rachael Kuintzle; Leah A. Santat; Michael B. Elowitz
Source: check_circle
Crossref

Principles of Computation by Competitive Protein Dimerization Networks

2023-11-02 | Preprint
DOI: 10.1101/2023.10.30.564854
Contributors: Jacob Parres-Gold; Matthew Levine; Benjamin Emert; Andrew Stuart; Michael B. Elowitz
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Crossref

Tuning Methylation-Dependent Silencing Dynamics by Synthetic Modulation of CpG Density

ACS Synthetic Biology
2023-09-15 | Journal article
DOI: 10.1021/acssynbio.3c00078
Contributors: Yitong Ma; Mark W. Budde; Junqin Zhu; Michael B. Elowitz
Source: check_circle
Crossref

Diversity in Notch ligand-receptor signaling interactions

2023-08-25 | Preprint
DOI: 10.1101/2023.08.24.554677
Contributors: Rachael Kuintzle; Leah A. Santat; Michael B. Elowitz
Source: check_circle
Crossref

Reconstitution of morphogen shuttling circuits

Science Advances
2023-07-14 | Journal article
DOI: 10.1126/sciadv.adf9336
Contributors: Ronghui Zhu; Leah A. Santat; Joseph S. Markson; Nagarajan Nandagopal; Jan Gregrowicz; Michael B. Elowitz
Source: check_circle
Crossref

The computational capabilities of many-to-many protein interaction networks

Cell Systems
2023-06 | Journal article
DOI: 10.1016/j.cels.2023.05.001
Contributors: Heidi E. Klumpe; Jordi Garcia-Ojalvo; Michael B. Elowitz; Yaron E. Antebi
Source: check_circle
Crossref

Lineage motifs: developmental modules for control of cell type proportions

2023-06-07 | Preprint
DOI: 10.1101/2023.06.06.543925
Contributors: Martin Tran; Amjad Askary; Michael B. Elowitz
Source: check_circle
Crossref

Tuning methylation-dependent silencing dynamics by synthetic modulation of CpG density

2023-06-01 | Preprint
DOI: 10.1101/2023.05.30.542205
Contributors: Yitong Ma; Mark W. Budde; Junqin Zhu; Michael B. Elowitz
Source: check_circle
Crossref

Periodic spatial patterning with a single morphogen

Cell Systems
2022-12 | Journal article
DOI: 10.1016/j.cels.2022.11.001
Contributors: Sheng Wang; Jordi Garcia-Ojalvo; Michael B. Elowitz
Source: check_circle
Crossref

Combinatorial expression motifs in signaling pathways

2022-08-22 | Preprint
DOI: 10.1101/2022.08.21.504714
Contributors: Alejandro A. Granados; Nivedita Kanrar; Michael B. Elowitz
Source: check_circle
Crossref

A synthetic protein-level neural network in mammalian cells

2022-07-11 | Preprint
DOI: 10.1101/2022.07.10.499405
Contributors: Zibo Chen; James M. Linton; Ronghui Zhu; Michael B. Elowitz
Source: check_circle
Crossref

Periodic spatial patterning with a single morphogen

2022-03-22 | Preprint
DOI: 10.1101/2022.03.21.484932
Contributors: Sheng Wang; Jordi Garcia-Ojalvo; Michael B. Elowitz
Source: check_circle
Crossref

Protease-controlled secretion and display of intercellular signals

Nature Communications
2022-02-17 | Journal article
DOI: 10.1038/s41467-022-28623-y
Contributors: Alexander E. Vlahos; Jeewoo Kang; Carlos A. Aldrete; Ronghui Zhu; Lucy S. Chong; Michael B. Elowitz; Xiaojing J. Gao
Source: check_circle
Crossref

Synthetic multistability in mammalian cells

Science
2022-01-21 | Journal article
DOI: 10.1126/science.abg9765
Contributors: Ronghui Zhu; Jesus M. del Rio-Salgado; Jordi Garcia-Ojalvo; Michael B. Elowitz
Source: check_circle
Crossref

Protease-controlled secretion and display of intercellular signals

2021-10-19 | Other
DOI: 10.1101/2021.10.18.464444
Contributors: Alexander E. Vlahos; Jeewoo Kang; Carlos A. Aldrete; Ronghui Zhu; Lucy S. Chong; Michael B. Elowitz; Xiaojing J. Gao
Source: check_circle
Crossref

Ratiometric RNA labeling allows dynamic multiplexed analysis of gene circuits in single cells

2021-09-23 | Other
DOI: 10.1101/2021.09.23.461487
Contributors: Shuhui Xu; Kai Li; Liang Ma; Jianhan Zhang; Shinae Yoon; Michael B. Elowitz; Yihan Lin
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Crossref

Synthetic multistability in mammalian cells

2021-02-11 | Other
DOI: 10.1101/2021.02.10.430659
Contributors: Ronghui Zhu; Jesus M. del Rio-Salgado; Jordi Garcia-Ojalvo; Michael B. Elowitz
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Crossref

Ligand-receptor promiscuity enables cellular addressing

2020-12-09 | Preprint
DOI: 10.1101/2020.12.08.412643
Contributors: Christina J. Su; Arvind Murugan; James M. Linton; Akshay Yeluri; Justin Bois; Heidi Klumpe; Yaron E. Antebi; Michael B. Elowitz
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Crossref

The context-dependent, combinatorial logic of BMP signaling

2020-12-08 | Preprint
DOI: 10.1101/2020.12.08.416503
Contributors: Heidi Klumpe; Matthew A. Langley; James M. Linton; Christina J. Su; Yaron E. Antebi; Michael B. Elowitz
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Crossref

Synthetic mammalian signaling circuits for robust cell population control

2020-09-03 | Preprint
DOI: 10.1101/2020.09.02.278564
Contributors: Yitong Ma; Mark W. Budde; Michaëlle N. Mayalu; Junqin Zhu; Andrew C. Lu; Richard M. Murray; Michael B. Elowitz
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Crossref

Engineering multiple levels of specificity in an RNA viral vector

2020-05-27 | Preprint
DOI: 10.1101/2020.05.27.119909
Contributors: Xiaojing J. Gao; Lucy S. Chong; Michaela H. Ince; Matthew S. Kim; Michael B. Elowitz
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Crossref

Publisher Correction: In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription

Nature Biotechnology
2020-02-27 | Journal article
DOI: 10.1038/s41587-020-0432-4
Contributors: Amjad Askary; Luis Sanchez-Guardado; James M. Linton; Duncan M. Chadly; Mark W. Budde; Long Cai; Carlos Lois; Michael B. Elowitz
Source: check_circle
Crossref

In situ readout of DNA barcodes and single base edits facilitated by in vitro transcription

Nature Biotechnology
2020-01-01 | Journal article
DOI: 10.1038/s41587-019-0299-4
Contributors: Amjad Askary; Luis Sanchez-Guardado; James M. Linton; Duncan M. Chadly; Mark W. Budde; Long Cai; Carlos Lois; Michael B. Elowitz
Source: check_circle
Crossref

Constitutive splicing and economies of scale in gene expression

Nature Structural & Molecular Biology
2019-06-27 | Journal article
DOI: 10.1038/s41594-019-0226-x
Contributors: Fangyuan Ding; Michael B. Elowitz
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Crossref

Communication codes in developmental signaling pathways

Development
2019-06-15 | Journal article
DOI: 10.1242/dev.170977
Contributors: Pulin Li; Michael B. Elowitz; Allon Klein; Barbara Treutlein
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Cis-activation in the Notch signaling pathway

eLife
2019-01-10 | Journal article
DOI: 10.7554/eLife.37880
Contributors: Nagarajan Nandagopal; Leah A Santat; Michael B Elowitz
Source: check_circle
Crossref

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

eLife
2018-11-13 | Journal article
DOI: 10.7554/eLife.37851
Contributors: Kenneth KH Ng; Mary A Yui; Arnav Mehta; Sharmayne Siu; Blythe Irwin; Shirley Pease; Satoshi Hirose; Michael B Elowitz; Ellen V Rothenberg; Hao Yuan Kueh
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Crossref

Programmable protein circuits in living cells

Science
2018-09-21 | Journal article
DOI: 10.1126/science.aat5062
Contributors: Xiaojing J. Gao; Lucy S. Chong; Matthew S. Kim; Michael B. Elowitz
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Crossref

Metabolic interactions between dynamic bacterial subpopulations

eLife
2018-05-29 | Journal article
DOI: 10.7554/eLife.33099
Contributors: Adam Z Rosenthal; Yutao Qi; Sahand Hormoz; Jin Park; Sophia Hsin-Jung Li; Michael B Elowitz
Source: check_circle
Crossref

A stochastic epigenetic switch controls the dynamics of T-cell lineage commitment

2018-05-10 | Other
DOI: 10.1101/318675
Contributors: Kenneth K.H. Ng; Mary A. Yui; Arnav Mehta; Sharmayne Siu; Blythe Irwin; Shirley Pease; Satoshi Hirose; Michael B. Elowitz; Ellen V. Rothenberg; Hao Yuan Kueh
Source: check_circle
Crossref

Morphogen gradient reconstitution reveals Hedgehog pathway design principles

Science
2018-05-04 | Journal article
DOI: 10.1126/science.aao0645
Contributors: Pulin Li; Joseph S. Markson; Sheng Wang; Siheng Chen; Vipul Vachharajani; Michael B. Elowitz
Source: check_circle
Crossref

Cis-activation in the Notch signaling pathway

2018-05-02 | Other
DOI: 10.1101/313171
Contributors: Nagarajan Nandagopal; Leah A. Santat; Michael B. Elowitz
Source: check_circle
Crossref

Peer review (2 reviews for 2 publications/grants)

Review activity for iScience. (1)
Review activity for PLoS computational biology. (1)
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