Thomas J. Hudson (0000-0002-1376-4849)

Personal information

Biography

Dr. Thomas J. Hudson is President and Scientific Director of the Ontario Institute for Cancer Research. He is implementing the Institute’s Strategic Plan, working with cancer research institutions across Ontario to leverage existing strengths. The Plan focuses on prevention, early diagnosis, cancer targets and new therapeutics. Its innovation platforms include imaging and interventions, bio-repositories and pathology, genomics and high-throughput screening, and informatics and biocomputing.

Activities

Collapse all

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

Cell Stem Cell

2013 | Journal article

DOI:

10.1016/j.stem.2012.12.011

Thomas J. Hudson

https://orcid.org/0000-0002-1376-4849

Personal information

Other IDs

Keywords

Biography

Activities

Works (47)

A Pan-BCL2 Inhibitor Renders Bone-Marrow-Resident Human Leukemia Stem Cells Sensitive to Tyrosine Kinase Inhibition

Analysis of early C2C12 myogenesis identifies stably and differentially expressed transcriptional regulators whose knock-down inhibits myoblast differentiation

A targeted association study in systemic lupus erythematosus identifies multiple susceptibility alleles

A cis-acting regulatory variant in the IL2RA locus

A combined watershed and level set method for segmentation of brightfield cell images

Analyses of associations with asthma in four asthma population samples from Canada and Australia

A common RET variant is associated with reduced newborn kidney size and function

A genome-wide approach to identifying novel-imprinted genes

Allele-specific expression in the germline of patients with familial pancreatic cancer: An unbiased approach to cancer gene discovery

Allele-specific expression in the germline of patients with familial pancreatic cancer: an unbiased approach to cancer gene discovery.

1α,25-dihydroxy-vitamin D3 stimulation of bronchial smooth muscle cells induces autocrine, contractility, and remodeling processes

A common variant of the PAX2 gene is associated with reduced newborn kidney size

A genetic linkage map of the vervet monkey (Chlorocebus aethiops sabaeus)

A genome-wide association study identifies novel risk loci for type 2 diabetes

A second generation human haplotype map of over 3.1 million SNPs

An extremes of outcome strategy provides evidence that multiple sclerosis severity is determined by alleles at the HLA-DRB1 locus

An evaluation of the performance of tag SNPs derived from HapMap in a Caucasian population

A haplotype map of the human genome

A predominant role for the HLA class II region in the association of the MHC region with multiple sclerosis

A predominantly clonal multi-institutional outbreak of Clostridium difficile - Associated diarrhea with high morbidity and mortality

An atypical form of erythrokeratodermia variabilis maps to chromosome 7q22

A survey of genes differentially expressed in subcutaneous and visceral adipose tissue in men

A survey of genetic and epigenetic variation affecting human gene expression

A Combinatorial Network of Evolutionarily Conserved Myelin Basic Protein Regulatory Sequences Confers Distinct Glial-Specific Phenotypes

5′ flanking variants of resistin are associated with obesity

A missense mutation (R565W) in Cirhin (FLJ14728) in North American Indian childhood cirrhosis

ABCA1 regulatory variants influence coronary artery disease independent of effects on plasma lipid levels

A distal upstream enhancer from the myelin basic protein gene regulates expression in myelin-forming schwann cells

A genomewide linkage-disequilibrium scan localizes the Saguenay-Lac-Saint-Jean cytochrome oxidase deficiency to 2p16

A novel syndrome affecting multiple mitochondrial functions, located by microcell-mediated transfer to chromosome 2p14-2p13

A progressive autosomal recessive cataract locus maps to chromosome 9q13-q22

A radiation hybrid map of mouse genes

A second-generation association study of the 5q31 cytokine gene cluster and the interleukin-4 receptor in asthma

A sequence variation in the mitochondrial glycerol-3-phosphate dehydrogenase gene is associated with increased plasma glycerol and free fatty acid concentrations among French Canadians

A susceptibility locus for asthma-related traits on chromosome 7 revealed by genome-wide scan in a founder population

An optimized set of human telomere clones for studying telomere integrity and architecture

ARSACS, a spastic ataxia common in northeastern Quebec, is caused by mutations in a new gene encoding an 11.5-kb ORF

A YAC-based physical map of the mouse genome

A map of 75 human ribosomal protein genes

A physical map of 30,000 human genes

Absence of linkage between inflammatory bowel disease and selected loci on chromosomes 3, 7, 12, and 16

A gene map of the human genome

An integrated BAC/PAC molecular cytogenetic resource for human genetics: Applications to disease

A YAC contig map of the human genome

An STS-Based map of the human genome

A PCR-based linkage map of human chromosome 1

Adverse reaction to the recombinant hepatitis B vaccine