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Scopus Author ID: 6506284157

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Education and qualifications (2)

University of Oxford: Oxford, Oxfordshire, GB

1997 to 2001 | D. Phil. (Biochemistry)
Education
Source: Self-asserted source
Nathan Zaccai

University of Edinburgh: Edinburgh, Edinburgh, GB

1993 to 1997 | Bsc. (Hon) (Physics)
Education
Source: Self-asserted source
Nathan Zaccai

Works (48)

Insights into the Self-Assembly and Interaction of SARS-CoV-2 Fusion Peptides with Biomimetic Plasma Membrane Models

2024-12-31 | Preprint
DOI: 10.26434/chemrxiv-2024-265qk-v2
Contributors: Nisha Pawar; Andreas Santamaria; Brigida Romano; Krishna C. Batchu; Valerie Laux; Eduardo Guzman; Nathan R. Zaccai; Alberto Alvarez-Fernandez; Armando Maestro
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Insights into the Self-Assembly and Interaction of SARS-CoV-2 Fusion Peptides with Biomimetic Plasma Membrane Models

2024-12-30 | Preprint
DOI: 10.26434/chemrxiv-2024-265qk
Contributors: Nisha Pawar; Andreas Santamaria; Brigida Romano; Krishna C. Batchu; Valerie Laux; Eduardo Guzman; Natham R. Zaccai; Alberto Alvarez-Fernandez; Armando Maestro
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Combined thermodynamic and time-resolved structural analysis of interactions between AP2 and biomimetic plasma membranes provides insights into clathrin-mediated endocytosis

2024-04-24 | Preprint
DOI: 10.1101/2024.04.19.590255
Contributors: Armando Maestro; Nathan R. Zaccai; J.F. Gonzalez-Martinez; P. Sanchez-Puga; J. Tajuelo; M. A. Rubio; Andreas Santamaria; J. Carrascosa-Tejedor; D. Pereira; I. Marín-Montesinos et al.
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Stable endocytic structures navigate the complex pellicle of apicomplexan parasites

Nature Communications
2023-04-15 | Journal article
DOI: 10.1038/s41467-023-37431-x
Contributors: Ludek Koreny; Brandon N. Mercado-Saavedra; Christen M. Klinger; Konstantin Barylyuk; Simon Butterworth; Jennifer Hirst; Yolanda Rivera-Cuevas; Nathan R. Zaccai; Victoria J. C. Holzer; Andreas Klingl et al.
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Investigation on the relationship between lipid composition and structure in model membranes composed of extracted natural phospholipids

ChemRxiv
2022 | Other
DOI: 10.26434/chemrxiv-2022-mrfmx
EID:

2-s2.0-85135870046

Part of ISSN: 25732293
Contributors: Santamaria, A.; Batchu, K.C.; Fragneto, G.; Laux, V.; Haertlein, M.; Darwish, T.A.; Russell, R.A.; Zaccai, N.R.; Guzmán, E.; Maestro, A.
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Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by SNR, SANS, QENS, and NSE experiments

Neutron News
2022 | Journal article
DOI: 10.1080/10448632.2022.2091400
EID:

2-s2.0-85133533502

Part of ISSN: 19317352 10448632
Contributors: Zaccai, N.R.; Maestro, A.
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Nathan Zaccai via Scopus - Elsevier
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Unravelling the orientation of the inositol-biphosphate ring and its dependence on phosphatidylinositol 4,5-bisphosphate cluster formation in model membranes.

Journal of colloid and interface science
2022-09 | Journal article
DOI: 10.1016/j.jcis.2022.09.095
PMID: 36195018
Contributors: Santamaria A; Carrascosa-Tejedor J; Guzmán E; Zaccai NR; Maestro A
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Stable and ancient endocytic structures navigate the complex pellicle of apicomplexan parasites

2022-06-02 | Preprint
DOI: 10.1101/2022.06.02.494549
Contributors: Ludek Koreny; Brandon N. Mercado-Saavedra; Christen M. Klinger; Konstantin Barylyuk; Simon Butterworth; Jennifer Hirst; Yolanda Rivera-Cuevas; Nathan R. Zaccai; Victoria J. C. Holzer; Andreas Klingl et al.
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FCHO controls AP2’s initiating role in endocytosis through a PtdIns(4,5)P 2 -dependent switch

Science Advances
2022-04-29 | Journal article
DOI: 10.1126/sciadv.abn2018
Contributors: Nathan R. Zaccai; Zuzana Kadlecova; Veronica Kane Dickson; Kseniya Korobchevskaya; Jan Kamenicky; Oleksiy Kovtun; Perunthottathu K. Umasankar; Antoni G. Wrobel; Jonathan G. G. Kaufman; Sally R. Gray et al.
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FCHO controls AP2’s critical endocytic roles through a PtdIns4,5P2 membrane-dependent switch

2022-04-03 | Preprint
DOI: 10.1101/2022.04.02.486817
Contributors: Nathan R. Zaccai; Zuzana Kadlecova; Veronica Kane Dickson; Kseniya Korobchevskaya; Jan Kamenicky; Oleksiy Kovtun; Perunthottathu K. Umasankar; Antoni G. Wrobel; Jonathan G.G. Kaufman; Sally Gray et al.
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Strikingly Different Roles of SARS-CoV-2 Fusion Peptides Uncovered by Neutron Scattering.

Journal of the American Chemical Society
2022-02 | Journal article
DOI: 10.1021/jacs.1c09856
PMID: 35157798
PMC: PMC8862744
Contributors: Santamaria A; Batchu KC; Matsarskaia O; Prévost SF; Russo D; Natali F; Seydel T; Hoffmann I; Laux V; Haertlein M et al.
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Strikingly different roles of SARS-CoV-2 fusion peptides uncovered by neutron scattering

2021-08 | Preprint
DOI: 10.1101/2021.08.30.458099
PPR: PPR389099
Contributors: Santamaria A; Batchu KC; Matsarskaia O; Prévost SF; Russo D; Natali F; Seydel T; Hoffmann I; Laux V; Haertlein M et al.
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD

Nature Communications
2021-08-18 | Journal article
DOI: 10.1038/s41467-021-25076-7
Contributors: Luke A. Perera; Steffen Preissler; Nathan R. Zaccai; Sylvain Prévost; Juliette M. Devos; Michael Haertlein; David Ron
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Structures of a deAMPylation complex rationalise the switch between antagonistic catalytic activities of FICD (14/96/109)

2021-04-20 | Preprint
DOI: 10.1101/2021.04.20.440599
Contributors: Luke A. Perera; Steffen Preissler; Nathan R Zaccai; Sylvain Prévost; Juliette M Devos; Michael Haertlein; David Ron
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Mechanism and evolution of the Zn-fingernail required for interaction of VARP with VPS29.

Nature communications
2020-10 | Journal article
DOI: 10.1038/s41467-020-18773-2
PMID: 33024112
PMC: PMC7539009
Contributors: Crawley-Snowdon H; Yang JC; Zaccai NR; Davis LJ; Wartosch L; Herman EK; Bright NA; Swarbrick JS; Collins BM; Jackson LP et al.
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Navigating the Structural Landscape of De Novo α-Helical Bundles

Journal of the American Chemical Society
2019-06-05 | Journal article
DOI: 10.1021/jacs.8b13354
Contributors: Guto G. Rhys; Christopher W. Wood; Joseph L. Beesley; Nathan R. Zaccai; Antony J. Burton; R. Leo Brady; Andrew R. Thomson; Derek N. Woolfson
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Navigating the structural landscape of de novo α–helical bundles

2018-12-21 | Other
DOI: 10.1101/503698
Contributors: Guto G. Rhys; Christopher W. Wood; Joseph L. Beesley; Nathan R. Zaccai; Antony J. Burton; R. Leo Brady; Andrew R. Thomson; Derek N. Woolfson
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Methods in Molecular Biophysics: Structure, Dynamics, Function for Biology and Medicine

Methods in Molecular Biophysics: Structure, Dynamics, Function for Biology and Medicine
2017 | Book
DOI: 10.1017/9781107297227
EID:

2-s2.0-85122596728
Contributors: Zaccai, N.R.; Serdyuk, I.N.; Zaccai, J.
Source: Self-asserted source
Nathan Zaccai via Scopus - Elsevier
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Contribution of the clathrin adaptor AP-1 subunit µ1 to acidic cluster protein sorting.

The Journal of cell biology
2017-07 | Journal article
DOI: 10.1083/jcb.201602058
PMID: 28743825
PMC: PMC5584140
Contributors: Navarro Negredo P; Edgar JR; Wrobel AG; Zaccai NR; Antrobus R; Owen DJ; Robinson MS
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Downsizing Proto-oncogene cFos to Short Helix-Constrained Peptides That Bind Jun.

ACS chemical biology
2017-06 | Journal article
DOI: 10.1021/acschembio.7b00303
PMID: 28636317
Contributors: Baxter D; Perry SR; Hill TA; Kok WM; Zaccai NR; Brady RL; Fairlie DP; Mason JM
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Structural Basis of the Mispairing of an Artificially Expanded Genetic Information System

Chem
2016 | Journal article
DOI: 10.1016/j.chempr.2016.11.009
EID:

2-s2.0-85006304235

Part of ISSN: 24519294
Contributors: Reichenbach, L.F.; Sobri, A.A.; Zaccai, N.R.; Agnew, C.; Burton, N.; Eperon, L.P.; de Ornellas, S.; Eperon, I.C.; Brady, R.L.; Burley, G.A.
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Nathan Zaccai via Scopus - Elsevier
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A central cavity within the holo-translocon suggests a mechanism for membrane protein insertion.

Scientific reports
2016-12 | Journal article
DOI: 10.1038/srep38399
PMID: 27924919
PMC: PMC5141469
Contributors: Botte M; Zaccai NR; Nijeholt JL; Martin R; Knoops K; Papai G; Zou J; Deniaud A; Karuppasamy M; Jiang Q et al.
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Nathan Zaccai via Europe PubMed Central
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Skp Trimer Formation Is Insensitive to Salts in the Physiological Range.

Biochemistry
2015-11 | Journal article
DOI: 10.1021/acs.biochem.5b00806
PMID: 26579730
PMC: PMC4905700
Contributors: Sandlin CW; Zaccai NR; Fleming KG
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Nathan Zaccai via Europe PubMed Central
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Deuterium Labeling Together with Contrast Variation Small-Angle Neutron Scattering Suggests How Skp Captures and Releases Unfolded Outer Membrane Proteins.

Methods in enzymology
2015-08 | Journal article
DOI: 10.1016/bs.mie.2015.06.041
PMID: 26791979
PMC: PMC4913355
Contributors: Zaccai NR; Sandlin CW; Hoopes JT; Curtis JE; Fleming PJ; Fleming KG; Krueger S
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Modular Design of Self-Assembling Peptide-Based Nanotubes.

Journal of the American Chemical Society
2015-08 | Journal article
DOI: 10.1021/jacs.5b03973
PMID: 26219086
Contributors: Burgess NC; Sharp TH; Thomas F; Wood CW; Thomson AR; Zaccai NR; Brady RL; Serpell LC; Woolfson DN
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Nathan Zaccai via Europe PubMed Central
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Outer membrane β-barrel protein folding is physically controlled by periplasmic lipid head groups and BamA.

Proceedings of the National Academy of Sciences of the United States of America
2014-04 | Journal article
DOI: 10.1073/pnas.1322473111
PMID: 24715731
PMC: PMC4000854
Contributors: Gessmann D; Chung YH; Danoff EJ; Plummer AM; Sandlin CW; Zaccai NR; Fleming KG
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Membrane protein thermodynamic stability may serve as the energy sink for sorting in the periplasm.

Proceedings of the National Academy of Sciences of the United States of America
2013-02 | Journal article
DOI: 10.1073/pnas.1212527110
PMID: 23440211
PMC: PMC3600475
Contributors: Moon CP; Zaccai NR; Fleming PJ; Gessmann D; Fleming KG
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Nathan Zaccai via Europe PubMed Central
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Cryo-transmission electron microscopy structure of a gigadalton peptide fiber of de novo design.

Proceedings of the National Academy of Sciences of the United States of America
2012-07 | Journal article
DOI: 10.1073/pnas.1118622109
PMID: 22847414
PMC: PMC3421226
Contributors: Sharp TH; Bruning M; Mantell J; Sessions RB; Thomson AR; Zaccai NR; Brady RL; Verkade P; Woolfson DN
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Nathan Zaccai via Europe PubMed Central
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A basis set of de novo coiled-coil peptide oligomers for rational protein design and synthetic biology.

ACS synthetic biology
2012-05 | Journal article
DOI: 10.1021/sb300028q
PMID: 23651206
Contributors: Fletcher JM; Boyle AL; Bruning M; Bartlett GJ; Vincent TL; Zaccai NR; Armstrong CT; Bromley EH; Booth PJ; Brady RL et al.
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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FKBP12 activates the cardiac ryanodine receptor Ca2+-release channel and is antagonised by FKBP12.6.

PloS one
2012-02 | Journal article
DOI: 10.1371/journal.pone.0031956
PMID: 22363773
PMC: PMC3283708
Contributors: Galfré E; Pitt SJ; Venturi E; Sitsapesan M; Zaccai NR; Tsaneva-Atanasova K; O'Neill S; Sitsapesan R
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Nathan Zaccai via Europe PubMed Central
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A de novo peptide hexamer with a mutable channel.

Nature chemical biology
2011-10 | Journal article
DOI: 10.1038/nchembio.692
PMID: 22037471
PMC: PMC3223406
Contributors: Zaccai NR; Chi B; Thomson AR; Boyle AL; Bartlett GJ; Bruning M; Linden N; Sessions RB; Booth PJ; Brady RL et al.
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Nathan Zaccai via Europe PubMed Central
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Correlation of in situ mechanosensitive responses of the Moraxella catarrhalis adhesin UspA1 with fibronectin and receptor CEACAM1 binding.

Proceedings of the National Academy of Sciences of the United States of America
2011-08 | Journal article
DOI: 10.1073/pnas.1106341108
PMID: 21876142
PMC: PMC3174611
Contributors: Agnew C; Borodina E; Zaccai NR; Conners R; Burton NM; Vicary JA; Cole DK; Antognozzi M; Virji M; Brady RL
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Ig-superfold and its variable uses in molecular recognition

Handbook of Cell Signaling, 2/e
2010 | Book chapter
Part of DOI: 10.1016/B978-0-12-374145-5.00008-5
EID:

2-s2.0-84882881846
Contributors: Zaccai, N.R.; Yvonne Jones, E.
Source: Self-asserted source
Nathan Zaccai via Scopus - Elsevier
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Intrinsic fluorescence as an analytical probe of virus-like particle assembly and maturation.

Biochemical and biophysical research communications
2008-08 | Journal article
DOI: 10.1016/j.bbrc.2008.08.019
PMID: 18706394
Contributors: Hanslip SJ; Zaccai NR; Middelberg AP; Falconer RJ
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Single-channel characterization of the rabbit recombinant RyR2 reveals a novel inactivation property of physiological concentrations of ATP.

The Journal of membrane biology
2008-03 | Journal article
DOI: 10.1007/s00232-008-9102-z
PMID: 18418540
Contributors: Stewart R; Song L; Carter SM; Sigalas C; Zaccai NR; Kanamarlapudi V; Bhat MB; Takeshima H; Sitsapesan R
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Nathan Zaccai via Europe PubMed Central
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Crystal structure of a 3-oxoacyl-(acylcarrier protein) reductase (BA3989) from Bacillus anthracis at 2.4-A resolution.

Proteins
2008-02 | Journal article
DOI: 10.1002/prot.21624
PMID: 17894349
Contributors: Zaccai NR; Carter LG; Berrow NS; Sainsbury S; Nettleship JE; Walter TS; Harlos K; Owens RJ; Wilson KS; Stuart DI et al.
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Refolding of a membrane protein in a microfluidics reactor.

European biophysics journal : EBJ
2007-01 | Journal article
DOI: 10.1007/s00249-006-0125-z
PMID: 17226042
Contributors: Zaccai NR; Yunus K; Matthews SM; Fisher AC; Falconer RJ
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Nathan Zaccai via Europe PubMed Central
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Crystallographic and in silico analysis of the sialoside-binding characteristics of the Siglec sialoadhesin.

Journal of molecular biology
2006-10 | Journal article
DOI: 10.1016/j.jmb.2006.10.084
PMID: 17137591
Contributors: Zaccai NR; May AP; Robinson RC; Burtnick LD; Crocker PR; Brossmer R; Kelm S; Jones EY
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Nathan Zaccai via Europe PubMed Central
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Application of high-throughput technologies to a structural proteomics-type analysis of Bacillus anthracis.

Acta crystallographica. Section D, Biological crystallography
2006-09 | Journal article
DOI: 10.1107/s0907444906033555
PMID: 17001104
Contributors: Au K; Berrow NS; Blagova E; Boucher IW; Boyle MP; Brannigan JA; Carter LG; Dierks T; Folkers G; Grenha R et al.
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Nathan Zaccai via Europe PubMed Central
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Assembly of human papillomavirus type-16 virus-like particles: multifactorial study of assembly and competing aggregation.

Biotechnology progress
2006-03 | Journal article
DOI: 10.1021/bp0502781
PMID: 16599576
Contributors: Hanslip SJ; Zaccai NR; Middelberg AP; Falconer RJ
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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The crystal structure of human CD1b with a bound bacterial glycolipid.

Journal of immunology (Baltimore, Md. : 1950)
2004-02 | Journal article
DOI: 10.4049/jimmunol.172.4.2382
PMID: 14764708
Contributors: Batuwangala T; Shepherd D; Gadola SD; Gibson KJ; Zaccai NR; Fersht AR; Besra GS; Cerundolo V; Jones EY
Source: Self-asserted source
Nathan Zaccai via Europe PubMed Central
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Ig-Superfold and Its Variable Uses in Molecular Recognition

Handbook of Cell Signaling
2003 | Book chapter
Part of DOI: 10.1016/B978-012124546-7/50370-3
EID:

2-s2.0-84943246114
Contributors: Zaccai, N.R.; Yvonne Jones, E.
Source: Self-asserted source
Nathan Zaccai via Scopus - Elsevier
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Generation of CD1 tetramers as a tool to monitor glycolipid-specific T cells.

Philosophical transactions of the Royal Society of London. Series B, Biological sciences
2003-05 | Journal article
DOI: 10.1098/rstb.2003.1267
PMID: 12803920
PMC: PMC1693178
Contributors: Gadola SD; Karadimitris A; Zaccai NR; Salio M; Dulphy N; Shepherd D; Jones EY; Cerundolo V
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Nathan Zaccai via Europe PubMed Central
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Structure-guided design of sialic acid-based Siglec inhibitors and crystallographic analysis in complex with sialoadhesin.

Structure (London, England : 1993)
2003-05 | Journal article
DOI: 10.1016/s0969-2126(03)00073-x
PMID: 12737821
Contributors: Zaccai NR; Maenaka K; Maenaka T; Crocker PR; Brossmer R; Kelm S; Jones EY
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Nathan Zaccai via Europe PubMed Central
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Structure of human CD1b with bound ligands at 2.3 A, a maze for alkyl chains.

Nature immunology
2002-07 | Journal article
DOI: 10.1038/ni821
PMID: 12118248
Contributors: Gadola SD; Zaccai NR; Harlos K; Shepherd D; Castro-Palomino JC; Ritter G; Schmidt RR; Jones EY; Cerundolo V
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Nathan Zaccai via Europe PubMed Central
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CD4 T cells selected by antigen under Th2 polarizing conditions favor an elongated TCR alpha chain complementarity-determining region 3.

Journal of immunology (Baltimore, Md. : 1950)
2002-02 | Journal article
DOI: 10.4049/jimmunol.168.3.1018
PMID: 11801634
Contributors: Boyton RJ; Zaccai N; Jones EY; Altmann DM
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Nathan Zaccai via Europe PubMed Central
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HLA-B27 and disease pathogenesis: new structural and functional insights.

Expert reviews in molecular medicine
1999-10 | Journal article
DOI: 10.1017/s1462399499001118
PMID: 14585119
Contributors: Bowness P; Zaccai N; Bird L; Jones EY
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Nathan Zaccai via Europe PubMed Central
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Killer cell immunoglobulin receptors and T cell receptors bind peptide-major histocompatibility complex class I with distinct thermodynamic and kinetic properties.

The Journal of biological chemistry
1999-10 | Journal article
DOI: 10.1074/jbc.274.40.28329
PMID: 10497191
Contributors: Maenaka K; Juji T; Nakayama T; Wyer JR; Gao GF; Maenaka T; Zaccai NR; Kikuchi A; Yabe T; Tokunaga K et al.
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Peer review (1 review for 1 publication/grant)

Review activity for Journal of chemical information and modeling. (1)
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