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Works (19)

Gene-replacement therapy in neurodevelopmental disorders: progress and challenges

Journal of Clinical Investigation
2025-02-03 | Journal article
DOI: 10.1172/JCI188703
Contributors: Holger Lerche; Ulrike B.S. Hedrich; Thomas V. Wuttke
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Voltage‐gated calcium channels in genetic epilepsies

Journal of Neurochemistry
2024-12 | Journal article
DOI: 10.1111/jnc.15983
Contributors: Robert J. Lauerer; Holger Lerche
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N‐of‐1 trials in epilepsy: A systematic review and lessons paving the way forward

Epilepsia
2024-11 | Journal article
DOI: 10.1111/epi.18068
Contributors: Victoria M. Defelippe; Eva H. Brilstra; Willem M. Otte; Helen J. Cross; Finbar O'Callaghan; Valentina De Giorgis; Annapurna Poduri; Holger Lerche; Sanjay Sisodiya; Kees P. J. Braun et al.
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Effective excitability captures network dynamics across development and phenotypes

2024-08-21 | Preprint
DOI: 10.1101/2024.08.21.608974
Contributors: Oleg Vinogradov; Emmanouil Giannakakis; Victor Buendía; Betül Uysal; Shlomo Ron; Eyal Weinreb; Niklas Schwarz; Holger Lerche; Elisha Moses; Anna Levina
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Retigabine and gabapentin restore channel function and neuronal firing in a cellular model of an epilepsy-associated dominant-negative KCNQ5 variant

Neuropharmacology
2024-06 | Journal article
DOI: 10.1016/j.neuropharm.2024.109892
Contributors: Johanna Krüger; Holger Lerche
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Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

Journal of Cell Science
2023-06-15 | Journal article
DOI: 10.1242/jcs.260600
Contributors: Nevena Stajković; Yuanyuan Liu; Aleksandra Arsić; Ning Meng; Hang Lyu; Nan Zhang; Dirk Grimm; Holger Lerche; Ivana Nikić-Spiegel
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Gentherapien für Epilepsie: Klinische Studien sind auf dem Weg

Fortschritte der Neurologie · Psychiatrie
2023-04 | Journal article
DOI: 10.1055/a-1995-5405
Contributors: Peter Müller; Holger Lerche
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Retigabine and gabapentin restore channel function and neuronal firing of an epilepsy-associated dominant-negativeKCNQ5variant

2023-03-25 | Preprint
DOI: 10.1101/2023.03.24.534091
Contributors: Johanna Krüger; Holger Lerche
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Precision medicine for genetic epilepsy on the horizon: Recent advances, present challenges, and suggestions for continued progress

Epilepsia
2022-10 | Journal article
DOI: 10.1111/epi.17332
Contributors: Juliet K. Knowles; Ingo Helbig; Cameron S. Metcalf; Laura S. Lubbers; Lori L. Isom; Scott Demarest; Ethan M. Goldberg; Alfred L. George, Jr; Holger Lerche; Sarah Weckhuysen et al.
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Learning with phenotypic similarity improves the prediction of functional effects of missense variants in voltage-gated sodium channels

2022-09-30 | Preprint
DOI: 10.1101/2022.09.29.510111
Contributors: Christian Malte Boßelmann; Ulrike B.S. Hedrich; Holger Lerche; Nico Pfeifer
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Linking neuronal and hemodynamic network signatures in the resting human brain

2022-08-28 | Preprint
DOI: 10.1101/2022.08.28.505586
Contributors: Adham Elshahabi; Silke Ethofer; Holger Lerche; Daniel van de Velden; Hans Wehrl; Christian la Fougère; Christoph Braun; Niels K. Focke
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Direct fluorescent labeling of NF186 and NaV1.6 in living primary neurons using bioorthogonal click chemistry

2022-03-03 | Preprint
DOI: 10.1101/2022.03.01.480798
Contributors: Nevena Stajković; Yuanyuan Liu; Aleksandra Arsić; Ning Meng; Hang Lyu; Nan Zhang; Dirk Grimm; Holger Lerche; Ivana Nikić-Spiegel
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Predicting the functional effects of voltage-gated potassium channel missense variants with multi-task learning

2021-12-03 | Preprint
DOI: 10.1101/2021.12.02.470894
Contributors: Christian Malte Boßelmann; Ulrike B.S. Hedrich; Peter Müller; Lukas Sonnenberg; Shridhar Parthasarathy; Ingo Helbig; Holger Lerche; Nico Pfeifer
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Heritability of Magnetoencephalography Phenotypes Among Patients With Genetic Generalized Epilepsy and Their Siblings

Neurology
2021-07-13 | Journal article
DOI: 10.1212/WNL.0000000000012144
Contributors: Christina Stier; Adham Elshahabi; Yiwen Li Hegner; Raviteja Kotikalapudi; Justus Marquetand; Christoph Braun; Holger Lerche; Niels K. Focke
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In vitroeffects of S-Licarbazepine as a potential precision therapy onSCN8Avariants causing neuropsychiatric disorders

2021-04-26 | Preprint
DOI: 10.1101/2021.04.24.441205
Contributors: Erva Bayraktar; Yuanyuan Liu; Ulrike B.S. Hedrich; Yildirim Sara; Holger Lerche; Thomas V Wuttke; Stephan Lauxmann
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Dravet variantSCN1AA1783Vimpairs interneuron firing predominantly by altered channel activation

2021-04-23 | Preprint
DOI: 10.1101/2021.04.23.440874
Contributors: N. Layer; L. Sonnenberg; E. Pardo González; J. Benda; H. Lerche; H. Koch; TV. Wuttke
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Ultra-rare constrained missense variants in the epilepsies: Shared and specific enrichment patterns in neuronal gene-sets

2021-04-19 | Preprint
DOI: 10.1101/2021.04.18.440264
Contributors: Mahmoud Koko; Roland Krause; Thomas Sander; Dheeraj Reddy Bobbili; Michael Nothnagel; Patrick May; Holger Lerche
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Drug-resistant epilepsy — time to target mechanisms

Nature Reviews Neurology
2020-11 | Journal article
DOI: 10.1038/s41582-020-00419-y
Contributors: Holger Lerche
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Desynchronization of temporal lobe theta-band activity during effective anterior thalamus deep brain stimulation in epilepsy

NeuroImage
2020-09 | Journal article
DOI: 10.1016/j.neuroimage.2020.116967
Contributors: Maximillian Scherer; Luka Milosevic; Robert Guggenberger; Volker Maus; Georgios Naros; Florian Grimm; Iancu Bucurenciu; Bernhard J. Steinhoff; Yvonne G. Weber; Holger Lerche et al.
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